Illicit survival of cancer cells during polyploidization and depolyploidization
Open accessAbstract
Tetraploidy and the depolyploidization of tetraploid cells may contribute to oncogenesis. Several mechanisms have evolved to avoid the generation, survival, proliferation and depolyploidization of tetraploids. Cells that illicitly survive these checkpoints are prone to chromosomal instability and aneuploidization. Along with their replication, tetraploids constantly undergo chromosomal rearrangements that eventually lead to pseudodiploidy by two non-exclusive mechanisms: (i) multipolar divisions and (ii) illicit bipolar divisions in the presence of improper microtubule-kinetochore attachments. Here, we describe the regulation and the molecular mechanisms that underlie such a 'polyploidization-depolyploidization' cascade, while focusing on the role of oncogenes and tumor suppressor genes in tetraploidy-driven tumorigenesis. We speculate that the identification of signaling/metabolic cascades that are required for the survival of tetraploid or aneuploid (but not diploid) cancer cells may pave the way for the development of novel broad-spectrum anticancer agents.
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Entotic invasion has been suggested to favor aneuploidization and polyploidization through cytokinesis failure of engulfing cells.
“entotic invasion has also been suggested to favor aneuploidization and polyploidization (which promote tumor progression) [711–713] through a mechanism involving cytokinesis failure of engulfing cells [714, 715].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [712]
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Self-citation
- Authors
- Vitale, I., Galluzzi, L., Senovilla, L., Criollo, A., Jemaà, M., Castedo, M., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Université Paris-Sud (FR)
- Corresponding author
- Kroemer, G
- Venue
- Cell Death & Differentiation
- Published
- 2010-11-12
- Volume
- 18
- Issue
- 9
- Pages
- 1403-1413
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3178421
- OpenAlex
- W2067424975
- Cited by
- 159
- References
- 80
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 7 · 2023: 13 · 2022: 3 · 2021: 9 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 14 · 2014: 16 · 2013: 17 · 2012: 8
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Agence Nationale de la Recherche
- Institut National Du Cancer
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- tetraploidy, polyploidization, aneuploidy, chromosomal instability, pseudodiploidy, multipolar mitosis, oncogenes, tumor suppressor, carcinogenesis, tumor cell survival, anticancer drug targets
- MeSH terms
- Aneuploidy, Animals, Cell Survival, Cell Transformation, Neoplastic, DNA Replication, Humans, Mitosis, Neoplasms, Oncogenes, Tumor Suppressor Protein p53, Chromosome Segregation, Chromosomal Instability, Tetraploidy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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