Cited by 363Microtubule and mitosis dynamicsChromosomal and Genetic VariationsCancer-related Molecular Pathways

The consequences of tetraploidy and aneuploidy

Storchova, Zuzana, Kuffer, Christian·2008·Journal of Cell Science

Abstract

Polyploidy, an increased number of chromosome sets, is a surprisingly common phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in specific tissues as part of terminal differentiation. Changes in ploidy can also result from pathophysiological events that are caused by viral-induced cell fusion or erroneous cell division. Tetraploidization can initiate chromosomal instability (CIN), probably owing to supernumerary centrosomes and the doubled chromosome mass. CIN, in turn, might persist or soon give way to a stably propagating but aneuploid karyotype. Both CIN and stable aneuploidy are commonly observed in cancers. Recently, it has been proposed that an increased number of chromosome sets can promote cell transformation and give rise to an aneuploid tumor. Here, we review how tetraploidy can occur and describe the cellular responses to increased ploidy. Furthermore, we discuss how the specific physiological changes that are triggered by polyploidization might be used as novel targets for cancer therapy.

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Crossref · 10.1242/jcs.039537

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Authors
Storchova, Z., & Kuffer, C.
Affiliations
  • Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
  • Max Planck Society (DE)
Venue
Journal of Cell Science
Published
2008-12-01
Volume
121
Issue
23
Pages
3859-3866
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
OpenAlex
W2122382992
Cited by
363
References
88
Citations by year
2026: 5 · 2025: 7 · 2024: 18 · 2023: 14 · 2022: 13 · 2021: 23 · 2020: 20 · 2019: 16 · 2018: 24 · 2017: 28 · 2016: 23 · 2015: 26 · 2014: 20 · 2013: 29 · 2012: 33
FWCI
1.71
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cell Science (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
tetraploidy, aneuploidy, polyploidy, polyploidization, chromosomal instability, supernumerary centrosomes, cell transformation, cancer therapy targets, terminal differentiation, fungi
MeSH terms
Aneuploidy, Animals, Cell Division, Humans, Models, Biological, Neoplasms, Polyploidy, Chromosomal Instability

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