The consequences of tetraploidy and aneuploidy
Abstract
Polyploidy, an increased number of chromosome sets, is a surprisingly common phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in specific tissues as part of terminal differentiation. Changes in ploidy can also result from pathophysiological events that are caused by viral-induced cell fusion or erroneous cell division. Tetraploidization can initiate chromosomal instability (CIN), probably owing to supernumerary centrosomes and the doubled chromosome mass. CIN, in turn, might persist or soon give way to a stably propagating but aneuploid karyotype. Both CIN and stable aneuploidy are commonly observed in cancers. Recently, it has been proposed that an increased number of chromosome sets can promote cell transformation and give rise to an aneuploid tumor. Here, we review how tetraploidy can occur and describe the cellular responses to increased ploidy. Furthermore, we discuss how the specific physiological changes that are triggered by polyploidization might be used as novel targets for cancer therapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Polyploidy is considered a prerequisite to aneuploidy.
“Polyploidy is considered a prerequisite to aneuploidy (Fujiwara et al., 2005, Ganem et al., 2007, Storchova and Kuffer, 2008, Thompson et al., 2010, Vitale et al., 2010)”
From Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression (2011) · cites this paper as Storchova and Kuffer, 2008
Cites
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161 · see citing works
The advantages and disadvantages of being polyploid
Comai, L. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1711 · Cited by 2,308 · see citing works
The spindle-assembly checkpoint in space and time
Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227 · see citing works
Genetic instability in colorectal cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386623a0 · Cited by 1,995 · see citing works
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
Livingstone, L. R., White, A., Sprouse, J., Livanos, E., Jacks, T., & Tlsty, T. D. (1992) · Cell · doi:10.1016/0092-8674(92)90243-6 · Cited by 1,333 · see citing works
The Evolutionary Consequences of Polyploidy
Otto, S. P. (2007) · Cell · doi:10.1016/j.cell.2007.10.022 · Cited by 1,188 · see citing works
On the road to cancer: aneuploidy and the mitotic checkpoint
Kops, G. J. P. L., Weaver, B. A. A., & Cleveland, D. W. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1714 · Cited by 1,188 · see citing works
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
Fujiwara, T., Bandi, M., Nitta, M., Ivanova, E. V., Bronson, R. T., & Pellman, D. (2005) · Nature · doi:10.1038/nature04217 · Cited by 1,067 · see citing works
Edgar, B. A., & Orr‐Weaver, T. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00334-8 · Cited by 843 · see citing works
From polyploidy to aneuploidy, genome instability and cancer
Štorchová, Z., & Pellman, D. S. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1276 · Cited by 810 · see citing works
Centrosome aberrations: cause or consequence of cancer progression?
Nigg, E. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc924 · Cited by 733 · see citing works
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729 · see citing works
A cytogenetic study of 1000 spontaneous abortions
Hassold, T. J., Chen, N., Funkhouser, J. G., et al. (1980) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1980.tb00955.x · Cited by 686 · see citing works
A p53-Dependent Mouse Spindle Checkpoint
Cross, S. M., Sanchez, C. A., Morgan, C. A., Schimke, M. K., Ramel, S., Idzerda, R. L., Raskind, W. H., & Reid, B. J. (1995) · Science · doi:10.1126/science.7871434 · Cited by 660 · see citing works
Plk4-Induced Centriole Biogenesis in Human Cells
Kleylein-Sohn, J., Westendorf, J., Clech, M. L., Habedanck, R., Stierhof, Y., & Nigg, E. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.07.002 · Cited by 659 · see citing works
Meraldi, P., Honda, R., & Nigg, E. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.483 · Cited by 659 · see citing works
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomesPreprint
Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Théry, M., & Pellman, D. S. (2008) · Genes & Development · doi:10.1101/gad.1700908 · Cited by 654 · see citing works
The role of hepatocytes and oval cells in liver regeneration and repopulation
Fausto, N., & Campbell, J. S. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00338-6 · Cited by 646 · see citing works
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612 · see citing works
Boveri, T. (2007) · Journal of Cell Science · doi:10.1242/jcs.025742 · Cited by 575 · see citing works
Hernando, E., Nahlé, Z., Juan, G., Diaz-Rodriguez, E., Alaminos, M., Hemann, M., Michel, L., Mittal, V., Gerald, W., Benezra, R., et al. (2004) · Nature · doi:10.1038/nature02820 · Cited by 562 · see citing works
Centrosome Amplification Can Initiate Tumorigenesis in Flies
Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A. L., & Raff, J. W. (2008) · Cell · doi:10.1016/j.cell.2008.05.039 · Cited by 562 · see citing works
Brito, D. A., & Rieder, C. L. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.043 · Cited by 541 · see citing works
Requirement of Cdk2-Cyclin E Activity for Repeated Centrosome Reproduction in Xenopus Egg Extracts
Hinchcliffe, E. H., Li, C., Thompson, E. A., Maller, J. L., & Sluder, G. (1999) · Science · doi:10.1126/science.283.5403.851 · Cited by 506 · see citing works
Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption
Lanni, J. S., & Jacks, T. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.1055 · Cited by 493 · see citing works
Spindle Multipolarity Is Prevented by Centrosomal Clustering
Quintyne, N. J., Reing, J. E., Hoffelder, D. R., Gollin, S. M., & Saunders, W. S. (2005) · Science · doi:10.1126/science.1104905 · Cited by 431 · see citing works
Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1
Andreassen, P. R., Lohez, O. D., Lacroix, F., & Margolis, R. L. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1315 · Cited by 429 · see citing works
Ueber asymmetrische Zelltheilung in Epithelkrebsen und deren biologische Bedeutung
Hansemann, D. (1890) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf01882039 · Cited by 406 · see citing works
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines
Shi, Q., & King, R. W. (2005) · Nature · doi:10.1038/nature03958 · Cited by 396 · see citing works
Mitotic repression of the transcriptional machinery
Gottesfeld, J. M. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01045-1 · Cited by 368 · see citing works
Genome-wide genetic analysis of polyploidy in yeast
Štorchová, Z., Breneman, A., Cande, J., Dunn, J. G., Burbank, K. S., O'Toole, E. T., & Pellman, D. S. (2006) · Nature · doi:10.1038/nature05178 · Cited by 360 · see citing works
Galipeau, P. C., Cowan, D., Sanchez, C. A., Barrett, M. T., Emond, M. J., Levine, D. S., Rabinovitch, P. S., & Reid, B. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7081 · Cited by 360 · see citing works
Aurora kinases link chromosome segregation and cell division to cancer susceptibility
Meraldi, P., Honda, R., & Nigg, E. A. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.006 · Cited by 343 · see citing works
Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2
Daniels, M. J., Wang, Y., Lee, M.-Y., et al. (2004) · Science · doi:10.1126/science.1102574 · Cited by 319 · see citing works
Liver Cell Polyploidization: A Pivotal Role for Binuclear Hepatocytes
Guidotti, J.-E., Brégerie, O., Robert, A., Debey, P., Brechot, C., & Desdouets, C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300982200 · Cited by 315 · see citing works
Loss of centrosome integrity induces p38—p53—p21-dependent G1—S arrest
Mikule, K. W., Delaval, B., Kaldis, P., Jurcyzk, A., Hergert, P. J., & Doxsey, S. (2006) · Nature Cell Biology · doi:10.1038/ncb1529 · Cited by 306 · see citing works
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationPreprint
Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., & Oren, M. (2006) · Genes & Development · doi:10.1101/gad.1447006 · Cited by 284 · see citing works
Eiben, B., Bartels, I., Bähr-Porsch, S., Borgmann, S., Gatz, G., Gellert, G., Goebel, R., Hammans, W., Hentemann, M. A., & Osmers, R. (1990) · Europe PMC (PubMed Central) · Cited by 278 · see citing works
Ghadimi, Β. M., Sackett, D. L., Difilippantonio, M. J., Schr�ck, E., Neumann, T., Jauho, A., Auer, G., & Ried, T. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200002)27:2 · Cited by 277 · see citing works
Tetraploidy and chromosomal instability are early events during cervical carcinogenesis
Olaharski, A. J., Sotelo, R., Solorza-Luna, G., Gonsebatt, M. E., Guzmán, P., Mohar, A., & Eastmond, D. A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi218 · Cited by 264 · see citing works
Wang, X., Zhou, Y.-X., Qiao, W., Tominaga, Y., Ouchi, M., Ouchi, T., & Deng, C.-X. (2006) · Oncogene · doi:10.1038/sj.onc.1209707 · Cited by 262 · see citing works
Model for the genetic evolution of human solid tumors.
Shackney, S. E., Smith, C., Miller, B. W., Burholt, D. R., Murtha, K., Giles, H. R., Ketterer, D. M., & Pollice, A. A. (1989) · PubMed · Cited by 252 · see citing works
Terminal phase of cytokinesis in D-98S cells
Mullins, J., & Biesele, J. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.73.3.672 · Cited by 251 · see citing works
Pancreatic Neoplasia Induced by SV40 T-Antigen Expression in Acinar Cells of Transgenic Mice
Ornitz, D. M., Hammer, R. E., Messing, A., Palmiter, R. D., & Brinster, R. L. (1987) · Science · doi:10.1126/science.2821617 · Cited by 241 · see citing works
Jeganathan, K. B., Malureanu, L. A., Baker, D., Abraham, S., & van Deursen, J. (2007) · Journal of Cell Biology · doi:10.1083/jcb.200706015 · Cited by 238 · see citing works
G1 tetraploidy checkpoint and the suppression of tumorigenesis
Margolis, R. L., Lohez, O. D., & Andreassen, P. R. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10411 · Cited by 231 · see citing works
Cell cycle progression after cleavage failure
Uetake, Y., & Sluder, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403014 · Cited by 203 · see citing works
Limiting the Proliferation of Polyploid Cells
Ganem, N. J., & Pellman, D. S. (2007) · Cell · doi:10.1016/j.cell.2007.10.024 · Cited by 174 · see citing works
Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability
Shin, H.-J., Baek, K., Jeon, A.-H., Park, M.-T., Lee, S., Kang, C.-M., Lee, H., Yoo, S.-H., Chung, D.-H., Sung, Y., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00302-7 · Cited by 173 · see citing works
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
Dikovskaya, D., Schiffmann, D., Newton, I. P., Oakley, A., Kroboth, K., Sansom, O. J., Jamieson, T. J., Méniel, V. S., Clarke, A. R., & Näthke, I. S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200610099 · Cited by 169 · see citing works
APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in <i>Min</i> mice
Caldwell, C. M., Green, R. A., & Kaplan, K. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703186 · Cited by 164 · see citing works
Elhajouji, A., Cunha, M., & Kirsch‐Volders, M. (1998) · Mutagenesis · doi:10.1093/mutage/13.2.193 · Cited by 163 · see citing works
High levels of chromosome instability in polyploids of Saccharomyces cerevisiae
Mayer, V. W., & Aguilera, A. (1990) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(90)90024-x · Cited by 160 · see citing works
A Virus Causes Cancer by Inducing Massive Chromosomal Instability through Cell Fusion
Duelli, D. M., Padilla‐Nash, H. M., Berman, D. M., Murphy, K. M., Ried, T., & Lazebnik, Y. A. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.049 · Cited by 157 · see citing works
The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity
Oshimori, N., Ohsugi, M., & Yamamoto, T. S. (2006) · Nature Cell Biology · doi:10.1038/ncb1474 · Cited by 156 · see citing works
Overexpression of Eg5 Causes Genomic Instability and Tumor Formation in Mice
Castillo, A., Morse, H. C., Godfrey, V., Naeem, R., & Justice, M. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0326 · Cited by 150 · see citing works
Extra centrosomes and/or chromosomes prolong mitosis in human cells
Yang, Z., Lončarek, J., Khodjakov, A. L., & Rieder, C. L. (2008) · Nature Cell Biology · doi:10.1038/ncb1738 · Cited by 143 · see citing works
Wong, C., & Stearns, T. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-6 · Cited by 136 · see citing works
Nicklas, R. B., Waters, J. C., Salmon, E. D., et al. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.23.4173 · Cited by 131 · see citing works
Mikhailov, A. V., & Gundersen, G. G. (1998) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1998)41:4 · Cited by 98 · see citing works
A primate virus generates transformed human cells by fusion
Duelli, D. M., Hearn, S., Myers, M. P., & Lazebnik, Y. A. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507069 · Cited by 96 · see citing works
Polyploidy in non-neoplastic tissues.
Biesterfeld, S., Gerres, K., Fischer-Wein, G., et al. (1994) · Journal of Clinical Pathology · doi:10.1136/jcp.47.1.38 · Cited by 93 · see citing works
Mable, B. K., & Otto, S. P. (2001) · Genetics Research · doi:10.1017/s0016672300004821 · Cited by 88 · see citing works
Human Cancer Cells Commonly Acquire DNA Damage during Mitotic Arrest
Dalton, W. B., Nandan, M. O., Moore, R. T., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-5162 · Cited by 87 · see citing works
Reverte, C. G., Benware, A., Jones, C. W., & LaFlamme, S. E. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603069 · Cited by 80 · see citing works
Barrett, M. T., Pritchard, D. K., Palanca-Wessels, C., Anderson, J., Reid, B. J., & Rabinovitch, P. S. (2003) · PubMed · Cited by 70 · see citing works
Original CIN: reviewing roles for APC in chromosome instability
Rusan, N. M., & Peifer, M. A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200802107 · Cited by 64 · see citing works
Quignon, F., Rozier, L., Lachagès, A.-M., Bieth, A., Simili, M., & Debatisse, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209787 · Cited by 62 · see citing works
Chi, Y., & Jeang, K. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21484 · Cited by 60 · see citing works
Prolonged Mitosis Versus Tetraploid Checkpoint: How p53 Measures the Duration of Mitosis
Blagosklonny, M. V. (2006) · Cell Cycle · doi:10.4161/cc.5.9.2711 · Cited by 59 · see citing works
Surveillance mechanism linking Bub1 loss to the p53 pathway
Gjoerup, O. V., Wu, J., Chandler-Militello, D., Williams, G. L., Zhao, J. J., Schaffhausen, B. S., Jat, P., & Roberts, T. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703164104 · Cited by 54 · see citing works
Methods for comparing Salmonella mutagenicity data sets using nonlinear models
Alvord, W. G., Driver, J., Claxton, L. D., et al. (1990) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(90)90057-9 · Cited by 53 · see citing works
Gisselsson, D., Håkanson, U., Stoller, P. C., Marti, D., Jin, Y., Rosengren, A. H., Stewénius, Y., Kahl, F., & Panagopoulos, I. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001871 · Cited by 52 · see citing works
Multistage carcinogenesis in Barrett's esophagus
Maley, C. C. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.03.018 · Cited by 52 · see citing works
Ha, G., Baek, K., Kim, H. S., Jeong, S.-J., Kim, C., McKeon, F., & Lee, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3392 · Cited by 51 · see citing works
Tumor Suppressor Protein p53 Regulates Megakaryocytic Polyploidization and Apoptosis
Fuhrken, P. G., Apostolidis, P. A., Lindsey, S. C., Miller, W. M., & Papoutsakis, E. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801923200 · Cited by 45 · see citing works
The Gardner syndrome: increased tetraploidy in cultured skin fibroblast.
Danes, B. S. (1976) · Journal of Medical Genetics · doi:10.1136/jmg.13.1.52 · Cited by 43 · see citing works
Forces on chromosomal DNA during anaphase
Jannink, G., Duplantier, B., & Sikorav, J. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79247-0 · Cited by 39 · see citing works
Centrosome replication in hydroxyurea-arrested CHO cells expressing GFP-tagged centrin2
Kuriyama, R., Terada, Y., Lee, K. S., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.008938 · Cited by 39 · see citing works
Isolation and Analysis of Somatic Hybrids Derived from Two Human Diploid Cells
Migeon, B. R., Norum, R. A., & Corsaro, C. M. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.937 · Cited by 35 · see citing works
Cell-Cycle Progression without an Intact Microtubule Cytoskeleton
Uetake, Y., & Sluder, G. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.065 · Cited by 34 · see citing works
Changes in DNA Content During In Vitro Transformation of Mouse Salivary Gland Epithelium2
Cowell, J. K., & Wigley, C. B. (1980) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/64.6.1443 · Cited by 30 · see citing works
Polyploidization increases the sensitivity to DNA‐damaging agents in mammalian cells
Hau, P. M., Siu, W. Y., Wong, N., Lai, P. B. S., & Poon, R. Y. C. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.059 · Cited by 29 · see citing works
Q-BANDING OF CHROMOSOMES IN HUMAN SPONTANEOUS ABORTIONS
Carr, D. H., & Gedeon, M. M. (1978) · Canadian Journal of Genetics and Cytology · doi:10.1139/g78-048 · Cited by 29 · see citing works
Polyploidies in abortion material decrease with maternal age
Neuber, M., Rehder, H., Zuther, C., et al. (1993) · Human Genetics · doi:10.1007/bf00205080 · Cited by 24 · see citing works
No maternal age relationship for polyploidy
Warburton, D., Kline, J. K., & Kinney, A. M. (1994) · Human Genetics · doi:10.1007/bf00201586 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitotic catastrophe: a mechanism for avoiding genomic instability
Vitale, I., Galluzzi, L., Castedo, M., & Kroemer, G. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3115 · Cited by 834 · see citing works
Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy
Davoli, T., Denchi, E. L., & de Lange, T. (2010) · Cell · doi:10.1016/j.cell.2010.01.031 · Cited by 298 · see citing works
Davoli, T., & de Lange, T. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.03.044 · Cited by 242 · see citing works
Illicit survival of cancer cells during polyploidization and depolyploidization
Vitale, I., Galluzzi, L., Senovilla, L., Criollo, A., Jemaà, M., Castedo, M., & Kroemer, G. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.145 · Cited by 159 · see citing works
Eischen, C. M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026096 · Cited by 161 · see citing works
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
Vitale, I., Senovilla, L., Jemaà, M., Michaud, M., Galluzzi, L., Kepp, O., Nanty, L., Criollo, A., Rello‐Varona, S., Manic, G., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.11 · Cited by 146 · see citing works
Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution
Todd, R. T., Forche, A., & Selmecki, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0051-2016 · Cited by 121 · see citing works
Mitotic catastrophe and cancer drug resistance: A link that must to be broken
Denisenko, T. V., Sorokina, I. V., Gogvadze, V., & Zhivotovsky, B. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2015.11.002 · Cited by 108 · see citing works
Matsa, E., Ahrens, J. H., & Wu, J. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00036.2015 · Cited by 105 · see citing works
Genome amplification and cellular senescence are hallmarks of human placenta development
Velicky, P., Meinhardt, G., Plessl, K., Vondra, S., Weiss, T., Haslinger, P., Lendl, T., Aumayr, K., Mairhofer, M., Zhu, X., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007698 · Cited by 102 · see citing works
Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression
Lushnikova, T., Bouska, A., Odvody, J., Dupont, W. D., & Eischen, C. M. (2011) · Oncogene · doi:10.1038/onc.2011.172 · Cited by 40 · see citing works
- Authors
- Storchova, Z., & Kuffer, C.
- Affiliations
- Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
- Max Planck Society (DE)
- ORCID
- Kuffer, Christian
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-12-01
- Volume
- 121
- Issue
- 23
- Pages
- 3859-3866
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2122382992
- Cited by
- 363
- References
- 88
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 18 · 2023: 14 · 2022: 13 · 2021: 23 · 2020: 20 · 2019: 16 · 2018: 24 · 2017: 28 · 2016: 23 · 2015: 26 · 2014: 20 · 2013: 29 · 2012: 33
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- tetraploidy, aneuploidy, polyploidy, polyploidization, chromosomal instability, supernumerary centrosomes, cell transformation, cancer therapy targets, terminal differentiation, fungi
- MeSH terms
- Aneuploidy, Animals, Cell Division, Humans, Models, Biological, Neoplasms, Polyploidy, Chromosomal Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review