Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells

Functions of natural killer cells

Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943

The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z., Beiman, M., Dassa, L., Achdout, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903474106 · Cited by 3,524

Up on the tightrope: natural killer cell activation and inhibition

Lanier, L. L. (2008) · Nature Immunology · doi:10.1038/ni1581 · Cited by 1,656

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

Yu, X., Harden, K., C Gonzalez, L., Francesco, M., Chiang, E., Irving, B., Tom, I., Ivelja, S., Refino, C. J., Clark, H., et al. (2009) · Nature Immunology · doi:10.1038/ni.1674 · Cited by 1,491

Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule

Bottino, C., Castriconi, R., Pende, D., Rivera, P., Nanni, M., Carnemolla, B., Cantoni, C., Grassi, J., Marcenaro, S., Reymond, N., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030788 · Cited by 875

Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation

Takai, Y., Miyoshi, J., Ikeda, W., & Ogita, H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2457 · Cited by 586

Cutting Edge: TIGIT Has T Cell-Intrinsic Inhibitory Functions

Joller, N., Hafler, J. P., Brynedal, B., Kassam, N., Spoerl, S., Levin, S. D., Sharpe, A. H., & Kuchroo, V. K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003081 · Cited by 581

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

Ono, M., Okada, H., Bolland, S., Yanagi, S., Kurosaki, T., & Ravetch, J. V. (1997) · Cell · doi:10.1016/s0092-8674(00)80337-2 · Cited by 499

Natural Killer Cell Education and Tolerance

Orr, M. T., & Lanier, L. L. (2010) · Cell · doi:10.1016/j.cell.2010.08.031 · Cited by 441

Negative signaling by inhibitory receptors: the NK cell paradigm

Long, E. O. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00660.x · Cited by 370

Vstm3 is a member of the CD28 family and an important modulator of T‐cell function

Levin, S. D., Taft, D. W., Brandt, C. S., Bucher, C., Howard, E. D., Chadwick, E. M., Johnston, J., Hammond, A., Bontadelli, K., Ardourel, D., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201041136 · Cited by 356

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

Jiang, K., Zhong, B., Gilvary, D. L., Corliss, B. C., Hong-Geller, E., Wei, S., & Djeu, J. Y. (2000) · Nature Immunology · doi:10.1038/80859 · Cited by 347

Sequential Involvement of Lck and SHP-1 with MHC-Recognizing Receptors on NK Cells Inhibits FcR-Initiated Tyrosine Kinase Activation

Binstadt, B. A., Brumbaugh, K. M., Dick, C. J., Scharenberg, A. M., Williams, B. L., Colonna, M., Lanier, L. L., Kinet, J.-P., Abraham, R. T., & Leibson, P. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80276-9 · Cited by 338

Unifying concepts of MHC-dependent natural killer cell education

Elliott, J. M., & Yokoyama, W. M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.001 · Cited by 279

A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

Boles, K. S., Vermi, W., Facchetti, F., Fuchs, A., Wilson, T. J., Diacovo, T. G., Cella, M., & Colonna, M. (2009) · European Journal of Immunology · doi:10.1002/eji.200839116 · Cited by 268

CD155/PVR plays a key role in cell motility during tumor cell invasion and migration

Sloan, K. E., Eustace, B. K., Stewart, J. K., Zehetmeier, C., Torella, C., Simeone, M., Roy, J. E., Unger, C., Louis, D. N., Ilag, L. L., et al. (2004) · BMC Cancer · doi:10.1186/1471-2407-4-73 · Cited by 244

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

Fan, Z., Beresford, P. J., Zhang, D., Xu, Z., Novina, C. D., Yoshida, A., Pommier, Y., & Lieberman, J. (2003) · Nature Immunology · doi:10.1038/ni885 · Cited by 240

Current perspectives of natural killer cell education by MHC class I molecules

Höglund, P., & Brodin, P. (2010) · Nature Reviews Immunology · doi:10.1038/nri2835 · Cited by 237

A new self: MHC-class-I-independent Natural-killer-cell self-tolerance

Kumar, V., & McNerney, M. E. (2005) · Nature Reviews Immunology · doi:10.1038/nri1603 · Cited by 187

Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

Wang, J.-W., Howson, J. M., Ghansah, T., Desponts, C., Ninos, J. M., May, S. L., Nguyen, K. H. T., Toyama-Sorimachi, N., & Kerr, W. G. (2002) · Science · doi:10.1126/science.1068438 · Cited by 178

Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor–intrinsic costimulation to class-switched B cells

Engels, N., König, L. M., Heemann, C., Lutz, J., Tsubata, T., Griep, S., Schrader, V., & Wienands, J. (2009) · Nature Immunology · doi:10.1038/ni.1764 · Cited by 177

NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors

Fan, Z., Yu, P., Wang, Y., Wang, Y., Fu, M. L., Liu, W., Sun, Y., & Fu, Y.-X. (2006) · Blood · doi:10.1182/blood-2005-08-3485 · Cited by 170

Signal Transduction During Activation and Inhibition of Natural Killer Cells

Watzl, C., & Long, E. O. (2010) · Current Protocols in Immunology · doi:10.1002/0471142735.im1109bs90 · Cited by 165

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

Ong, C. J., Ming-Lum, A., Nodwell, M., Ghanipour, A., Yang, L., Williams, D. E., Kim, J., Demirjian, L., Qasimi, P., Ruschmann, J., et al. (2007) · Blood · doi:10.1182/blood-2007-03-079699 · Cited by 158

Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity

Chen, X., Trivedi, P. P., Ge, B.-X., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611655104 · Cited by 155

CD22 Regulates B Cell Receptor-mediated Signals via Two Domains That Independently Recruit Grb2 and SHP-1*

Otipoby, K., Draves, K. E., & Clark, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105446200 · Cited by 126

The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors

Sakisaka, T., Ikeda, W., Ogita, H., Fujita, N., & Takai, Y. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.09.007 · Cited by 120

NK cells: elusive players in autoimmunity

Johansson, S., Berg, L., Hall, H., & Höglund, P. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.08.008 · Cited by 118

JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity

Li, C., Ge, B., Nicotra, M. L., Stern, J. N. H., Kopcow, H. D., Chen, X., & Strominger, J. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712310105 · Cited by 116

An essential function for β-arrestin 2 in the inhibitory signaling of natural killer cells

Yu, M., Su, L., Zou, L., Liu, Y., Wu, N., Kong, L., Zhuang, Z., Sun, L., Liu, H., Hu, J., et al. (2008) · Nature Immunology · doi:10.1038/ni.1635 · Cited by 88

LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate phosphatidylinositol 3-kinase

Martí, F., Xu, C., Selvakumar, A., Brent, R., Dupont, B., & King, P. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11810 · Cited by 66

Inhibition of the Jun N-Terminal Protein Kinase Pathway by SHIP-1, a Lipid Phosphatase That Interacts with the Adaptor Molecule Dok-3

Robson, J. D., Davidson, D., & Veillette, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.6.2332-2343.2004 · Cited by 60

The B‐lymphoid Grb2 interaction code

Neumann, K., Oellerich, T., Urlaub, H., & Wienands, J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00845.x · Cited by 54

Inappropriate Recruitment and Activity by the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP1) Is Responsible for Receptor Dominance in the SHIP-Deficient NK Cell

Wahle, J. A., Paraiso, K. H. T., Kendig, R. D., Lawrence, H. R., Chen, L., Wu, J., & Kerr, W. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8009 · Cited by 52

Inositol Phospholipid Signaling and the Biology of Natural Killer Cells

Kerr, W. G., & Colucci, F. (2011) · Journal of Innate Immunity · doi:10.1159/000323920 · Cited by 50

Cleavage of Survivin by Granzyme M Triggers Degradation of the Survivin-X-linked Inhibitor of Apoptosis Protein (XIAP) Complex to Free Caspase Activity Leading to Cytolysis of Target Tumor Cells

Hu, D., Liu, S., Shi, L., Li, C., Wu, L., & Fan, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083170 · Cited by 49

Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells

Zhong, C., Li, C., Wang, X., Toyoda, T., Gao, G., & Fan, Z. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.178 · Cited by 45

The signaling tool box for tyrosine-based costimulation of lymphocytes

Engels, N., & Wienands, J. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.01.005 · Cited by 39

Granzyme H of Cytotoxic Lymphocytes Is Required for Clearance of the Hepatitis B Virus through Cleavage of the Hepatitis B Virus X Protein

Tang, H., Li, C., Wang, L., Zhang, H., & Fan, Z. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102205 · Cited by 37

Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation

Anderson, A. C., Joller, N., & Kuchroo, V. K. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.001 · Cited by 2,096

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

Morad, G., Helmink, B. A., Sharma, P., & Wargo, J. A. (2021) · Cell · doi:10.1016/j.cell.2021.09.020 · Cited by 1,648

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

Gur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490

Immune checkpoint signaling and cancer immunotherapy

He, X., & Xu, C. (2020) · Cell Research · doi:10.1038/s41422-020-0343-4 · Cited by 1,371

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

Qin, S., Xu, L., Yi, M., Yu, S., Wu, K., & Luo, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1091-2 · Cited by 1,145