Glycobiology of cell death: when glycans and lectins govern cell fate
Open accessAbstract
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings.
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Glycosylation state of some death receptors (e.g., FAS) impacts sensitivity of T lymphocytes to extrinsic apoptosis, influencing termination of inflammatory responses.
“Of note, the glycosylation state of some death receptors (e.g., FAS) has been shown to impact on the sensitivity of T lymphocytes to extrinsic apoptosis, hence influencing the termination of inflammatory responses [288–290].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [289]
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Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citation
- Authors
- Lichtenstein, R. G., & Rabinovich, G. A.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Lichtenstein, R G
- Rabinovich, G A
- Venue
- Cell Death & Differentiation
- Published
- 2013-05-24
- Volume
- 20
- Issue
- 8
- Pages
- 976-986
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC3705604
- OpenAlex
- W2072865927
- Cited by
- 107
- References
- 125
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 6 · 2017: 16 · 2016: 10 · 2015: 4 · 2014: 5 · 2013: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- National Multiple Sclerosis Society
- Multiple Sclerosis Society
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Ministry of Industry, Trade and Labor
- Universidad de Buenos Aires (CONICET)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Keywords
- cell death, glycans, lectins, glycosylation, glycan-binding proteins, cell fate, intracellular signaling, apoptosis, necrosis
- MeSH terms
- Animals, Glycosylation, Humans, Polysaccharides, Signal Transduction, Cell Death, Apoptosis, Lectins
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