Viral hijacking of host caspases: an emerging category of pathogen–host interactions

Connolly, Patrick F; Fearnhead, Howard O

doi:10.1038/cdd.2017.59

Cited by 44Cell death mechanisms and regulationCancer-related Molecular PathwaysInflammasome and immune disorders

Viral hijacking of host caspases: an emerging category of pathogen–host interactions

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Connolly, Patrick F, Fearnhead, Howard O·2017·Cell Death & Differentiation

DOI 10.1038/cdd.2017.59PMC PMC5520459

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Abstract

Viruses co-evolve with their hosts, and many viruses have developed mechanisms to suppress or modify the host cell apoptotic response for their own benefit. Recently, evidence has emerged for the opposite strategy. Some viruses have developed the ability to co-opt apoptotic caspase activity to facilitate their own proliferation. In these strategies, viral proteins are cleaved by host caspases to create cleavage products with novel activities which facilitate viral replication. This represents a novel and interesting class of viral-host interactions, and also represents a new group of non-apoptotic roles for caspases. Here we review the evidence for such strategies, and discuss their origins and their implications for our understanding of the relationship between viral pathogenesis and programmed cell death.

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Immunogenicity of RCD is suppressed by CASP8 and CASP3 via multiple mechanisms.
“Of note, the immunogenicity of RCD is robustly suppressed by some caspases, notably CASP8 and CASP3, by a variety of mechanisms [7, 924].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [924]

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Authors: Connolly, P. F., & Fearnhead, H. O.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Fearnhead, Howard O
ORCID: Fearnhead, Howard O
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2017-05-12
Volume: 24
Issue: 8
Pages: 1401-1410
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/cdd.2017.59
PMC: PMC5520459
OpenAlex: W2616336186
Cited by: 44
References: 121
Citations by year: 2025: 5 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 3
FWCI: 0.51
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Galway
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: viral replication, programmed cell death, apoptosis, host-virus interaction, viral pathogenesis, non-apoptotic caspase function
MeSH terms: Animals, Gene Expression Regulation, Humans, Protein Biosynthesis, Viral Proteins, Virus Diseases, Virus Replication, Viruses, Signal Transduction, Apoptosis, Caspases, Host-Pathogen Interactions, Proteolysis

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Viral hijacking of host caspases: an emerging category of pathogen–host interactions

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