Caspase deficiency alters the murine gut microbiome
Open accessAbstract
Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp)1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The differences in microbiota composition after minocycline or chronic restraint stress resemble those reported in caspase-1-deficient mice, such as an increase in the relative abundance of Lachnospiraceae.
“The differences in microbiota composition resemble the ones reported in caspase-1–deficient mice, such as an increase in the relative abundance of Lachnospiraceae (198).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [198]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 20,617 · see citing works
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 19,770 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Self-citationChimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR ampliconsPreprint
Haas, B. J., Gevers, D., Earl, A. M., Feldgarden, M., Ward, D. V., Giannoukos, G., Ciulla, D., Tabbaa, D., Highlander, S. K., Sodergren, E. J., et al. (2011) · Genome Research · doi:10.1101/gr.112730.110 · Cited by 3,480 · see citing works
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
Assessment of Soil Microbial Community Structure by Use of Taxon-Specific Quantitative PCR Assays
Fierer, N., Jackson, J. A., Vilgalys, R. J., & Jackson, R. B. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.4117-4120.2005 · Cited by 1,571 · see citing works
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509 · see citing works
Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C. G., McDowell, J., Paskind, M. P., Rodman, L., Salfeld, J. G., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90490-5 · Cited by 1,408 · see citing works
Kunin, V., Engelbrektson, A., Ochman, H., & Hugenholtz, P. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02051.x · Cited by 1,280 · see citing works
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
Lakhani, S. A., Masud, A. J., Kuida, K., Porter, G. A., Jr., Booth, C. J., Mehal, W. Z., Inayat, I., & Flavell, R. A. (2006) · Science · doi:10.1126/science.1115035 · Cited by 1,175 · see citing works
Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M., & Kanneganti, T.-D. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.003 · Cited by 989 · see citing works
Rapidly denoising pyrosequencing amplicon reads by exploiting rank-abundance distributions
Reeder, J., & Knight, R. D. (2010) · Nature Methods · doi:10.1038/nmeth0910-668b · Cited by 679 · see citing works
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677 · see citing works
Self-citationLepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592 · see citing works
Caspases in cell survival, proliferation and differentiation
Lamkanfi, M., Festjens, N., Declercq, W., Berghe, T. V., & Vandenabeele, P. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402047 · Cited by 564 · see citing works
Self-citationDupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517 · see citing works
Guo, X., Xia, X., Tang, R., Zhou, J., Zhao, H., & Wang, K. (2008) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2008.02408.x · Cited by 502 · see citing works
IL-1β Processing in Host Defense: Beyond the Inflammasomes
Netea, M. G., Simon, A., van de Veerdonk, F. L., Kullberg, B. J., van der Meer, J. W. M., & Joosten, L. A. B. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000661 · Cited by 496 · see citing works
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis
Behar, S. M., Martin, C. J., Booty, M. G., Nishimura, T., Zhao, X., Gan, H.-X., Divangahi, M., & Remold, H. G. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.3 · Cited by 447 · see citing works
Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health?
Meijer, K., de Vos, P., & Priebe, M. G. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833eebe5 · Cited by 443 · see citing works
IL-1β-converting enzyme (caspase-1) in intestinal inflammation
Siegmund, B., Lehr, H.-A., Fantuzzi, G., & Dinarello, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231473998 · Cited by 421 · see citing works
Wlodarska, M., Willing, B., Keeney, K. M., Menendez, A., Bergstrom, K. S., Gill, N., Russell, S. L., Vallance, B. A., & Finlay, B. B. (2011) · Infection and Immunity · doi:10.1128/iai.01104-10 · Cited by 382 · see citing works
Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota
Khachatryan, Z., Ktsoyan, Z. A., Manukyan, G. P., Kelly, D., Ghazaryan, K. A., & Aminov, R. I. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003064 · Cited by 317 · see citing works
Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis
Kobori, A., Yagi, Y., Imaeda, H., Ban, H., Bamba, S., Tsujikawa, T., Saito, Y., Fujiyama, Y., & Andoh, A. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0245-1 · Cited by 251 · see citing works
Tang, Y., Chen, Y., Jiang, H., & Nie, D. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.117 · Cited by 202 · see citing works
Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection
Akhter, A., Gavrilin, M. A., Frantz, L. J., Washington, S., Ditty, C., Limoli, D. H., Day, C., Sarkar, A., Newland, C. A., Butchar, J. P., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000361 · Cited by 191 · see citing works
Ferreira, R. B. R., Gill, N., Willing, B. P., Antunes, L. C. M., Russell, S., Croxen, M. A., & Finlay, B. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020338 · Cited by 177 · see citing works
Mitchell, J., Paul-Clark, M., Clarke, G., McMaster, S. K., & Cartwright, N. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0067 · Cited by 153 · see citing works
Rose, F. R. A. J., Bailey, K., Keyte, J. W., Chan, W. C., Greenwood, D. R., & Mahida, Y. R. (1998) · Infection and Immunity · doi:10.1128/iai.66.7.3255-3263.1998 · Cited by 142 · see citing works
Strain-Dependent Neurodevelopmental Abnormalities in Caspase-3-Deficient Mice
Leonard, J. R., Klocke, B. J., D’Sa-Eipper, C., Flavell, R. A., & Roth, K. A. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.8.673 · Cited by 135 · see citing works
The Family Lachnospiraceae, Including the Genera Butyrivibrio, Lachnospira and Roseburia
Cotta, M. A., & Forster, R. J. (2006) · Springer eBooks · doi:10.1007/0-387-30744-3_35 · Cited by 112 · see citing works
Rho, J.-H., Wright, D. P., Christie, D. L., Clinch, K., Furneaux, R. H., & Roberton, A. M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.5.1543-1551.2005 · Cited by 83 · see citing works
Demon, D., Damme, P. V., Berghe, T. V., Deceuninck, A., Durme, J. V., Verspurten, J., Helsens, K., Impens, F., Wejda, M., Schymkowitz, J. W. H., et al. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900310-mcp200 · Cited by 74 · see citing works
Self-citationRolli, J., Loukili, N., Levrand, S., Rosenblatt‐Velin, N., Rignault-Clerc, S., Waeber, B., Feihl, F., Pacher, P., & Liaudet, L. (2010) · Critical Care · doi:10.1186/cc9235 · Cited by 55 · see citing works
The p53-Target Gene Puma Drives Neutrophil-Mediated Protection against Lethal Bacterial Sepsis
Garrison, S. P., Thornton, L. B., Häcker, H., Webby, R. J., Rehg, J. E., Parganas, E., Zambetti, G. P., & TUOMANEN, E. I. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001240 · Cited by 26 · see citing works
Fushuku, S., & Fukuda, K. (2008) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.57.95 · Cited by 21 · see citing works
Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease
Scharl, M. M., & Rogler, G. (2010) · International Journal of Inflammation · doi:10.4061/2010/671258 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · see citing works
“…al., 2012) using both metagenomic and 16S rDNA sequencing approaches, whereas the standard choice for mouse studies is mostly 16S rDNA sequencing (Brinkman et al., 2011; Brinkman et al., 2013; Hildebrand et al., 2013; Kellermayer et al., 2011; Riboulet-Bisson et al., 2012; Ubeda et al., 2013;…”
MethodSelf-citationThe gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology
Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works
Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition
Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works
Hildebrand, F., Nguyen, T. L. A., Brinkman, B. M. N., Yunta, R. G., Cauwe, B., Vandenabeele, P., Liston, A., & Raes, J. (2013) · Genome biology · doi:10.1186/gb-2013-14-1-r4 · Cited by 465 · see citing works
Self-citationApoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium
Günther, C., Neumann, H., Neurath, M. F., & Becker, C. (2013) · Gut · doi:10.1136/gutjnl-2011-301364 · Cited by 462 · see citing works
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
Laukens, D., Brinkman, B. M. N., Raes, J., Vos, M. D., & Vandenabeele, P. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv036 · Cited by 378 · see citing works
Self-citationApoptotic cell death in disease—Current understanding of the NCCD 2023
Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01153-w · Cited by 359 · see citing works
Bioinformatic challenges for DNA metabarcoding of plants and animals
Coissac, É., Riaz, T., & Puillandre, N. (2012) · Molecular Ecology · doi:10.1111/j.1365-294x.2012.05550.x · Cited by 347 · see citing works
Host Genetics and Gut Microbiome: Challenges and Perspectives
Kurilshikov, A., Wijmenga, C., Fu, J., & Zhernakova, A. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.06.003 · Cited by 309 · see citing works
The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry
Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 234 · see citing works
Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
Ruder, B., Atreya, R., & Becker, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081887 · Cited by 228 · see citing works
“Interestingly, mice lacking the apoptosis executioner caspase-3 do not show any morphological changes of the gut structure and colon length in comparison to controls [111], suggesting that epithelial turnover in the gut and cell shedding at least under steady state conditions are not mediated by caspase-3-triggered ap…”
BackgroundEcotoxicology inside the gut: impact of heavy metals on the mouse microbiome
Breton, J., Massart, S., Vandamme, P., De Brandt, E., Pot, B., & Foligné, B. (2013) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-14-62 · Cited by 213 · see citing works
Liang, D., Leung, R. K., Guan, W., & Au, W. W. (2018) · Gut Pathogens · doi:10.1186/s13099-018-0230-4 · Cited by 198 · see citing works
Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174 · see citing works
Nunes, T., Bernardazzi, C., & de Souza, H. S. P. (2014) · BioMed Research International · doi:10.1155/2014/218493 · Cited by 169 · see citing works
den Bossche, L. V., Hindryckx, P., Devisscher, L., Devriese, S., Welden, S. V., Holvoet, T., Vilchez‐Vargas, R., Vital, M., Pieper, D. H., Bussche, J. V., et al. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.02766-16 · Cited by 146 · see citing works
Madore, C., Leyrolle, Q., Lacabanne, C., Benmamar-Badel, A., Joffre, C., Nadjar, A., & Layé, S. (2016) · Neural Plasticity · doi:10.1155/2016/3597209 · Cited by 141 · see citing works
Hanafi, N. I., Mohamed, A. S., Kadir, S. H. S. A., & Othman, M. H. D. (2018) · Biomolecules · doi:10.3390/biom8040159 · Cited by 134 · see citing works
The Microbiota-Inflammasome Hypothesis of Major Depression
Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays · doi:10.1002/bies.201800027 · Cited by 134 · see citing works
Pascoe, E. L., Hauffe, H. C., Marchesi, J. R., & Perkins, S. E. (2017) · The ISME Journal · doi:10.1038/ismej.2017.133 · Cited by 113 · see citing works
Chen, X., Song, P., Fan, P. F., He, T., Jacobs, D. R., Levesque, C. L., Johnston, L. J., Ji, L., Ma, N., Chen, Y., et al. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00246 · Cited by 106 · see citing works
Complex Roles of Caspases in the Pathogenesis of Inflammatory Bowel Disease
Becker, C., Watson, A. J. M., & Neurath, M. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.11.035 · Cited by 107 · see citing works
Elolimy, A. A., Alharthi, A. S., Zeineldin, M. M., Parys, C., & Loor, J. J. (2020) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-019-0406-x · Cited by 93 · see citing works
Quan, J., Cai, G., Yang, M. J., Zeng, Z., Ding, R., Wang, X., Zhuang, Z., Zhou, S., Li, S., Yang, H., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00052 · Cited by 81 · see citing works
Brenna, Ø., Furnes, M. W., Drozdov, I. A., Granlund, A. V. B., Flatberg, A., Sandvik, A. K., Zwiggelaar, R. T., Mårvik, R., Nordrum, I. S., Kidd, M. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054543 · Cited by 76 · see citing works
Becker, A. A. M. J., Hesta, M., Hollants, J., Janssens, G. P., & Huys, G. R. B. (2014) · BMC Microbiology · doi:10.1186/1471-2180-14-43 · Cited by 75 · see citing works
Gut Microbiota Affects Sensitivity to Acute DSS-induced Colitis Independently of Host Genotype
Brinkman, B. M. N., Becker, A. A. M. J., Ayiseh, R. B., Hildebrand, F., Raes, J., Huys, G. R. B., & Vandenabeele, P. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a8759a · Cited by 71 · see citing works
Self-citationLee, S. Y., Lee, D. Y., Kang, J. H., Kim, J. H., Jeong, J. W., Kim, H. W., Oh, D. H., Yoon, S. H., & Hur, S. J. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111327 · Cited by 67 · see citing works
Park, H. J., Kim, S. A., Kang, W. S., & Kim, J. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041899 · Cited by 59 · see citing works
Walsh, J., Olavarría‐Ramírez, L., Lach, G., Boehme, M., Dinan, T. G., Cryan, J. F., Griffin, B. T., Hyland, N. P., & Clarke, G. A. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00026.2020 · Cited by 52 · see citing works
Potential Link between Gut Microbiota and Deoxynivalenol-Induced Feed Refusal in Weaned Piglets
Wang, S., Yang, J., Zhang, B., Zhang, L., Wu, K., Ao, Y., Li, C., Wang, Y., Zhang, J., & Qi, D. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01037 · Cited by 52 · see citing works
Wall of Resilience: How the Intestinal Epithelium Prevents Inflammatory Onslaught in the Gut
Liebing, E., Krug, S. M., Neurath, M. F., Siegmund, B., & Becker, C. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101423 · Cited by 52 · see citing works
Kelly, S. A., Nzakizwanayo, J., Rodgers, A. M., Zhao, L. M., Weiser, R., Tekko, I. A., McCarthy, H. O., Ingram, R. J., Jones, B. V., Donnelly, R. F., et al. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00081 · Cited by 49 · see citing works
Herrmann, E., Young, W., Reichert-Grimm, V., Weis, S., Riedel, C. U., Rosendale, D., Stoklosinski, H. M., Hunt, M., & Egert, M. (2018) · Nutrients · doi:10.3390/nu10020179 · Cited by 43 · see citing works
Regulation and pathophysiological role of epithelial turnover in the gut
Günther, C., Buchen, B., Neurath, M. F., & Becker, C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.06.004 · Cited by 38 · see citing works
Ma, W., Zhang, Y., Yu, M., Wang, B., Xu, S., Zhang, J., Li, X., & Ye, X. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106787 · Cited by 36 · see citing works
Chen, R., Roos, M. M., Zhong, Y., Marsh, T. L., Bustamante, M., Hernández‐Ascencio, W., Uribe, L., Uribe‐Lorío, L., Kirk, D., Reinhold, D. M., et al. (2015) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2015.11.028 · Cited by 35 · see citing works
Bai, S., Wang, W., Ting, W., Li, J., Zhang, S., Chen, Z., Qi, X., Chen, J., Cheng, K., & Xie, P. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01130-8 · Cited by 33 · see citing works
Interplay between Gut Microbiota and NLRP3 Inflammasome in Intracerebral Hemorrhage
Zhang, Y., Yu, W., Flynn, C., Chang, W., Zhang, L., Wang, M., Zheng, W., & Li, P. (2022) · Nutrients · doi:10.3390/nu14245251 · Cited by 33 · see citing works
Zhao, J., Hu, J., & Ma, X. (2021) · Food & Function · doi:10.1039/d1fo01975a · Cited by 32 · see citing works
Ghazavi, F., Huysentruyt, J., Coninck, J. D., Kourula, S., Martens, S., Hassannia, B., Wartewig, T., Divert, T., Roelandt, R., Popper, B., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024508119 · Cited by 31 · see citing works
Self-citationComparative proteomic study of dog and human saliva
Sanguansermsri, P., Jenkinson, H., Thanasak, J., Chairatvit, K., Roytrakul, S., Kittisenachai, S., Puengsurin, D., & Surarit, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208317 · Cited by 20 · see citing works
Shang, Q., Ma, X., Liu, H., Liu, S., & Piao, X. (2019) · Archives of Animal Nutrition · doi:10.1080/1745039x.2019.1684148 · Cited by 30 · see citing works
Fujimoto, M., Crossman, J. A., Scribner, K. T., & Marsh, T. L. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0256-6 · Cited by 29 · see citing works
Zhou, J., Wang, Y., Zeng, X., Zhang, T., Li, P., Yao, B., Wang, L., Qiao, S., & Zeng, X. (2019) · Food & Function · doi:10.1039/c9fo02724f · Cited by 28 · see citing works
Microbiota, natural products, and human health: exploring interactions for therapeutic insights
Qadri, H., Shah, A. H., Almilaibary, A., & Mir, M. A. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1371312 · Cited by 29 · see citing works
Wang, K., Qin, L., Cao, J., Zhang, L., Liu, M., Qu, C., & Miao, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054672 · Cited by 26 · see citing works
Metabolome-Microbiome Responses of Growing Pigs Induced by Time-Restricted Feeding
Wang, H., Xia, P., Lu, Z., Su, Y., & Zhu, W. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.681202 · Cited by 24 · see citing works
Yuvaraj, S., Sasikumar, S., Puhari, S. S. M., Ramprasath, T., Baskaran, N., Vasudevan, V., & Selvam, G. S. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14349 · Cited by 24 · see citing works
Inserra, A., Choo, J. M., Lewis, M. D., Rogers, G. B., Wong, M., & Licinio, J. (2019) · Scientific Reports · doi:10.1038/s41598-018-38055-8 · Cited by 23 · see citing works
Pent, M., Hiltunen, M., Põldmaa, K., Furneaux, B., Hildebrand, F., Johannesson, H., Ryberg, M. K., & Bahram, M. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14069 · Cited by 21 · see citing works
Self-citationThe Role of the Microbiota in Regeneration-Associated Processes
Díaz-Díaz, L. M., Rodríguez-Villafañe, A., & García‐Arrarás, J. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.768783 · Cited by 21 · see citing works
Liu, H., Xu, K., Wang, H., Lin, H., Yang, X., Wang, X., Zhao, J., Ma, B., Shu, Q., Lu, Y., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104375 · Cited by 18 · see citing works
Molecular pathways driving disease-specific alterations of intestinal epithelial cells
López-Posadas, R., Neurath, M. F., & Atreya, I. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2363-2 · Cited by 15 · see citing works
Xie, Y., Chen, J., Wu, B., He, T., Xie, L., & Liu, Z. (2021) · Gut Pathogens · doi:10.1186/s13099-021-00449-x · Cited by 14 · see citing works
Lee, S. Y., Byun, H. J., Choi, H., Won, J., Han, J., Park, S., Kim, D., & Sung, J. H. (2022) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-021-0268-x · Cited by 14 · see citing works
Becker, A. A. M. J., Janssens, G. P. J., Snauwaert, C., Hesta, M., & Huys, G. R. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123933 · Cited by 13 · see citing works
Brenna, Ø., Furnes, M. W., Drozdov, I. A., Granlund, A. V. B., Flatberg, A., Sandvik, A. K., Zwiggelaar, R. T., Mårvik, R., Nordrum, I. S., Kidd, M. S., et al. (2013) · PLoS ONE · doi:10.1371/annotation/af20399c-993e-436c-ad06-e0d8a657a7b4 · Cited by 13 · see citing works
Liu, T., Lu, X., Gao, W., Zhai, Y., Li, H., Li, S., Yang, L., Ma, F., Zhan, Y., & Mao, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113159 · Cited by 12 · see citing works
Adámková, P., Hradicka, P., Gancarčíková, S., Kassayová, M., Ambro, Ľ., Bertková, I., Marônek, M., Iannaccone, S. F., & Demeckova, V. (2021) · Pathogens · doi:10.3390/pathogens10020152 · Cited by 9 · see citing works
Hybridization alters red deer gut microbiome and metabolites
Wei, L., Zeng, B., Li, B., Guo, W., Mu, Z., Gan, Y., & Li, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1387957 · Cited by 8 · see citing works
Annual Fasting; the Early Calories Restriction for Cancer Prevention
Eslami, S., Barzgari, Z., Saliani, N., Saeedi, N., & Barzgari, A. (2012) · Europe PMC (PubMed Central) · doi:10.5681/bi.2012.028 · Cited by 8 · see citing works
Alternative to ZnO to establish balanced intestinal microbiota for weaning piglets
Juhász, Á., Molnár-Nagy, V., Bata, Z., Tso, K.-H., Mayer, Z., & Posta, K. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265573 · Cited by 8 · see citing works
Xing, R., Zhang, H.-C., Gao, Q., Zhang, F., Chi, X., & Chen, S. (2022) · International Microbiology · doi:10.1007/s10123-022-00286-1 · Cited by 8 · see citing works
Hu, B., Liu, T., Xia, B., Dong, Y., Liu, M., & Zhou, J. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.05.010 · Cited by 4 · see citing works
Autoimmune diseases and apoptosis: Targets, challenges, and innovations
Mahajan, A., Sharma, G., Thakur, K., Raza, K., Singh, G., & Katare, O. P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815762-6.00009-3 · Cited by 3 · see citing works
Exploring host–microbiota interactions in animal models and humansPreprint
Kostic, A. D., Howitt, M. R., & Garrett, W. S. (2013) · Genes & Development · doi:10.1101/gad.212522.112 · Cited by 491 · see citing works
Inflammasomes and Cytotoxic Lymphocytes Clear Bacteria From Different Intracellular Niches
Maltez, V. I. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/1sz6-ya65
Xie, Y., Chen, J., Wu, B., He, T., Xie, L., & Liu, Z. (2021) · Figshare · doi:10.6084/m9.figshare.15178806
- Authors
- Brinkman, B. M., Hildebrand, F., Kubica, M., Goosens, D., Del Favero, J., Declercq, W., Raes, J., & Vandenabeele, P.
- Affiliations
- Vrije Universiteit Brussel (BE)
- Ghent University (BE)
- University of Antwerp (BE)
- Corresponding author
- Raes, J
- Vandenabeele, P
- Venue
- Cell Death & Disease
- Published
- 2011-10-20
- Volume
- 2
- Issue
- 10
- Pages
- e220-e220
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC3219086
- OpenAlex
- W2096546937
- Cited by
- 70
- References
- 40
- Citations by year
- 2024: 5 · 2023: 2 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 9 · 2012: 4
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Cell Death and Disease (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- European Commission (200767)
- Fonds Wetenschappelijk Onderzoek (G.0875.11, G.0973.11)
- Universiteit Gent (01M00709)
- Vlaams Instituut voor Biotechnologie (BOF09/01M00709)
- Vlaamse regering (BOF09/01M00709)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- caspases, gut microbiota, caspase-1, caspase-3, caspase-7, knockout mice, Firmicutes, Bacteroidetes, Lachnospiraceae, Porphyromonadaceae, Prevotellaceae, host-microbe crosstalk, intestinal homeostasis, apoptosis, inflammation
- MeSH terms
- Animals, Mice, Inbred C57BL, Apoptosis, Mice, Knockout, Caspases, Gastrointestinal Tract, Mice, Metagenome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review