Cited by 70Gut microbiota and healthGastrointestinal motility and disordersAnimal Nutrition and Physiology

Caspase deficiency alters the murine gut microbiome

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Brinkman, B M, Hildebrand, F, Kubica, M, Goosens, D, Del Favero, J, Declercq, W, Raes, J, Vandenabeele, P·2011·Cell Death & Disease

Abstract

Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp)1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.

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Crossref · 10.1038/cddis.2011.101

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  • The differences in microbiota composition after minocycline or chronic restraint stress resemble those reported in caspase-1-deficient mice, such as an increase in the relative abundance of Lachnospiraceae.

    “The differences in microbiota composition resemble the ones reported in caspase-1–deficient mice, such as an increase in the relative abundance of Lachnospiraceae (198).”

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Authors
Brinkman, B. M., Hildebrand, F., Kubica, M., Goosens, D., Del Favero, J., Declercq, W., Raes, J., & Vandenabeele, P.
Affiliations
  • Vrije Universiteit Brussel (BE)
  • Ghent University (BE)
  • University of Antwerp (BE)
Corresponding author
  • Raes, J
  • Vandenabeele, P
Venue
Cell Death & Disease
Published
2011-10-20
Volume
2
Issue
10
Pages
e220-e220
ISSN
2041-4889 (ISSN-L)
OpenAlex
W2096546937
Cited by
70
References
40
Citations by year
2024: 5 · 2023: 2 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 9 · 2012: 4
FWCI
2.08
Type
journal article
Language
en
Open access
Locations
  • Cell Death and Disease (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
  • VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Funders
  • European Commission (200767)
  • Fonds Wetenschappelijk Onderzoek (G.0875.11, G.0973.11)
  • Universiteit Gent (01M00709)
  • Vlaams Instituut voor Biotechnologie (BOF09/01M00709)
  • Vlaamse regering (BOF09/01M00709)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
caspases, gut microbiota, caspase-1, caspase-3, caspase-7, knockout mice, Firmicutes, Bacteroidetes, Lachnospiraceae, Porphyromonadaceae, Prevotellaceae, host-microbe crosstalk, intestinal homeostasis, apoptosis, inflammation
MeSH terms
Animals, Mice, Inbred C57BL, Apoptosis, Mice, Knockout, Caspases, Gastrointestinal Tract, Mice, Metagenome

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