Cited by 462Cell death mechanisms and regulationInflammatory Bowel DiseaseDigestive system and related health

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

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Günther, Claudia, Neumann, Helmut, Neurath, Markus F, Becker, Christoph·2013·Gut

Abstract

Intestinal epithelial cells (IEC) are organised as a single cell layer which covers the intestine. Their primary task is to absorb nutrients present in the intestinal lumen. However, IEC also play an important role in the immune defence of our body by building a barrier that separates the bowel wall from potentially hazardous bacteria present in the gut lumen. The life cycle of IEC is determined by the time span in which cells migrate from their place of origin at the crypt base to the villus tip, from where they are shed into the lumen. Cell death in the intestinal epithelium has to be tightly regulated and irregularities might cause pathologies. Excessive cell death has been associated with chronic inflammation as seen in patients with Crohn's disease and ulcerative colitis. While until recently apoptosis was discussed as being essential for epithelial turnover and tissue homeostasis in the intestinal epithelium, recent data using gene deficient mice have challenged this concept. Moreover, an apoptosis-independent mode of programmed cell death, termed necroptosis, has been identified and described in the intestinal epithelium. The following article reviews previous studies on cell death regulation in IEC and a potential role of necroptosis for gut homeostasis.

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Crossref · 10.1136/gutjnl-2011-301364

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  • Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are required for normal cell turnover and tissue homeostasis.

    “Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are required for normal cell turnover and tissue homeostasis.”

    From Programmed cell death in aging (2015) · cites this paper as Gunther et al., 2013

  • In the adult, PCD is required for the normal turnover of cells in numerous tissues that are maintained by cell division, including the intestinal epithelium, the blood, the epidermis, kidney and lungs.

    “In the adult, PCD is required for the normal turnover of cells in numerous tissues that are maintained by cell division, including the intestinal epithelium, the blood, the epidermis, kidney and lungs(Elmore, 2007; Gunther et al., 2013; Kile, 2014).”

    From Programmed cell death in aging (2015) · cites this paper as Gunther et al., 2013

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Research works printed but not linked: 2

  1. Ziv E, Bendayan M. Intestinal absorption of peptides through the enterocytes. Microsc Res Tech 2000;49:346e52.
  2. Iwamoto M, Koji T, Makiyama K, et al. Apoptosis of crypt epithelial cells in ulcerative colitis. J Pathol 1996;180:152e9.

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Authors
Günther, C., Neumann, H., Neurath, M. F., & Becker, C.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
Becker, Christoph
Venue
Gut
Publisher
BMJ
Published
2012-06-11
Volume
62
Issue
7
Pages
1062-1071
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
OpenAlex
W2167862372
Cited by
462
References
143
Citations by year
2026: 23 · 2025: 30 · 2024: 54 · 2023: 43 · 2022: 48 · 2021: 57 · 2020: 41 · 2019: 34 · 2018: 24 · 2017: 24 · 2016: 22 · 2015: 27 · 2014: 24 · 2013: 8 · 2012: 2
FWCI
1.78
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
Keywords
apoptosis, necrosis, necroptosis, intestinal epithelial cells, cell death regulation, intestinal homeostasis, epithelial cell turnover, intestinal barrier, Crohn's disease, ulcerative colitis, chronic intestinal inflammation, programmed cell death
MeSH terms
Cell Cycle, Epithelial Cells, Humans, Intestinal Mucosa, Necrosis, Inflammatory Bowel Diseases, Cell Death, Apoptosis

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