The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Reciprocal influence of the p53 and the hypoxic pathways
Open accessAbstract
When cells sense a decrease in oxygen availability (hypoxia), they develop adaptive responses in order to sustain this condition and survive. If hypoxia lasts too long or is too severe, the cells eventually die. Hypoxia is also known to modulate the p53 pathway, in a manner dependent or not of HIF-1 (hypoxia-inducible factor-1), the main transcription factor activated by hypoxia. The p53 protein is a transcription factor, which is rapidly stabilised by cellular stresses and which has a major role in the cell responses to these stresses. The aim of this review is to compile what has been reported until now about the interconnection between these two important pathways. Indeed, according to the cell line, the severity and the duration of hypoxia, oxygen deficiency influences very differently p53 protein level and activity. Conversely, p53 is also described to affect HIF-1α stability, one of the two subunits of HIF-1, and HIF-1 activity. The direct and indirect interactions between HIF-1α and p53 are described as well as the involvement in this complex network of their respective ubiquitin ligases von Hippel Lindau protein and murine double minute 2. Finally, the synergistic or antagonistic effects of p53 and HIF-1 on some important cellular pathways are discussed.
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Cites
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · cited 4×
“Although HIF-1b is constitutively expressed, HIF-1a is precisely regulated by hypoxia.(1) On the other hand, p53”
BackgroundInfluentialThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Regulation of p53 stability by Mdm2
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“As previously described, pVHL has a negative role on HIF-1a(98) and MDM2 on p53.(5,6) However HIF-1a has a positive role on pVHL(99) and p53 on MDM2(100) because these regulators are target genes of the Reciprocal influence of p53 and hypoxia A Sermeus and C Michiels”
BackgroundHypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
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p53 Regulates Mitochondrial Respiration
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Cytoplasmic functions of the tumour suppressor p53
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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
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Cited by
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
Jing, X., Yang, F., Shao, C., Wei, K., Xie, M., Shen, H., & Shu, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1089-9 · Cited by 2,054
Senescence and aging: the critical roles of p53
Rufini, A., Tucci, P., Celardo, I., & Melino, G. (2013) · Oncogene · doi:10.1038/onc.2012.640 · Cited by 798
Cancer metabolism: current perspectives and future directions
Muñoz-Pinedo, C., El Mjiyad, N., & Ricci, J.-E. (2012) · Cell Death & Disease · doi:10.1038/cddis.2011.123 · Cited by 385
HIF-1 in cancer therapy: two decade long story of a transcription factor
Soni, S., & Padwad, Y. S. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1301680 · Cited by 251
Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
Zhu, F., Li, Y., Zhang, J., Piao, C., Liu, T., Li, H.-H., & Du, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074535 · Cited by 201
Metadata
- Authors
- Sermeus, A., & Michiels, C.
- Venue
- Cell Death & Disease
- Published
- 2011-05-26
- Volume
- 2
- Issue
- 5
- Pages
- e164-e164
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2087145462
- Cited by
- 265
- References
- 18
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- gold
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