The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Many faces of DAMPs in cancer therapy
Open accessAbstract
A new concept of immunogenic cell death (ICD) has recently been proposed. The immunogenic characteristics of this cell death mode are mediated mainly by molecules called 'damage-associated molecular patterns' (DAMPs), most of which are recognized by pattern recognition receptors. Some DAMPs are actively emitted by cells undergoing ICD (e.g. calreticulin (CRT) and adenosine triphosphate (ATP)), whereas others are emitted passively (e.g. high-mobility group box 1 protein (HMGB1)). Recent studies have demonstrated that these DAMPs play a beneficial role in anti-cancer therapy by interacting with the immune system. The molecular pathways involved in translocation of CRT to the cell surface and secretion of ATP from tumor cells undergoing ICD are being elucidated. However, it has also been shown that the same DAMPs could contribute to progression of cancer and promote resistance to anticancer treatments. In this review, we will critically evaluate the beneficial and detrimental roles of DAMPs in cancer therapy, focusing mainly on CRT, ATP and HMGB1.
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1 retracted
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RetractedTolerance, Danger, and the Extended Family
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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
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Immunogenic cell death and DAMPs in cancer therapy
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Self-citationCalreticulin exposure dictates the immunogenicity of cancer cell death
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“During the past few years, it has become clear that cells undergoing different types of cell death passively release or actively secrete ATP.2,11,31–33 Several mechanisms of ATP secretion in dying/dead/stressed cells have been reported.11,34–36 Like the exposure of CRT, the mechanism for ATP secretion in ICD strongly…”
BackgroundInfluentialGhiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
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Cited by
Detection of immunogenic cell death and its relevance for cancer therapy
Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03221-2 · Cited by 1,138
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002
Self-citationConsensus guidelines for the detection of immunogenic cell death
Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832
Self-citationModulation of inflammation by autophagy: Consequences for human disease
Netea-Maier, R. T., Plantinga, T. S., van de Veerdonk, F. L., Smit, J. W., & Netea, M. G. (2016) · Autophagy · doi:10.1080/15548627.2015.1071759 · Cited by 349
Exploiting replicative stress to treat cancer
Dobbelstein, M., & Sørensen, C. S. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4553 · Cited by 302
Metadata
- Authors
- Krysko, O., Løve Aaes, T., Bachert, C., Vandenabeele, P., & Krysko, D. V.
- Venue
- Cell Death & Disease
- Published
- 2013-05-16
- Volume
- 4
- Issue
- 5
- Pages
- e631-e631
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2004593104
- Cited by
- 296
- References
- 78
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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