The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Suppression of cell growth and invasion by miR-205 in breast cancer
Open accessAbstract
MicroRNAs (miRNAs) are endogenous, small, non-coding RNAs, which are capable of silencing gene expression at the post-transcriptional level. In this study, we report that miR-205 is significantly underexpressed in breast tumor compared to the matched normal breast tissue. Similarly, breast cancer cell lines, including MCF-7 and MDA-MB-231, express a lower level miR-205 than the non-malignant MCF-10A cells. Of interest, ectopic expression of miR-205 significantly inhibits cell proliferation and anchorage independent growth, as well as cell invasion. Furthermore, miR-205 was shown to suppress lung metastasis in an animal model. Finally, western blot combined with the luciferase reporter assays demonstrate that ErbB3 and vascular endothelial growth factor A (VEGF-A) are direct targets for miR-205, and this miR-205-mediated suppression is likely through the direct interaction with the putative miR-205 binding site in the 3′-untranslated region (3′-UTR) of ErbB3 and VEGF-A. Together, these results suggest that miR-205 is a tumor suppressor in breast cancer.
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“Since invasion is one of the key steps in metastasis (33), suppression of invasion by miR-205 in MDA-MB-231 cells suggests that miR-205 may also affect breast cancer metastasis.”
BackgroundCombinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Cited by
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
Iorio, M. V., & Croce, C. M. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201100209 · Cited by 1,739
MicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
MicroRNAs in Cancer: Small Molecules With a Huge Impact
Iorio, M. V., & Croce, C. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.0317 · Cited by 959
Wang, T., Shao, W., Huang, Z., Tang, H., Zhang, J., Ding, Z., & Huang, K. (2021) · Nature Communications · doi:10.1038/s41467-021-23774-w · Cited by 671
Zhang, Y., Xie, R.-L., Croce, C. M., Stein, J. L., Lian, J. B., van Wijnen, A. J., & Stein, G. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018493108 · Cited by 423
Metadata
- Authors
- Wu, H., Zhu, S., & Mo, Y.-Y.
- Venue
- Cell Research
- Published
- 2009-02-24
- Volume
- 19
- Issue
- 4
- Pages
- 439-448
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2044880285
- Cited by
- 358
- References
- 59
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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