Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
Open accessAbstract
Autophagy is required in diverse paradigms of lifespan extension, leading to the prevailing notion that autophagy is beneficial for longevity. However, why autophagy is harmful in certain contexts remains unexplained. Here, we show that mitochondrial permeability defines the impact of autophagy on aging. Elevated autophagy unexpectedly shortens lifespan in C. elegans lacking serum/glucocorticoid regulated kinase-1 (sgk-1) because of increased mitochondrial permeability. In sgk-1 mutants, reducing levels of autophagy or mitochondrial permeability transition pore (mPTP) opening restores normal lifespan. Remarkably, low mitochondrial permeability is required across all paradigms examined of autophagy-dependent lifespan extension. Genetically induced mPTP opening blocks autophagy-dependent lifespan extension resulting from caloric restriction or loss of germline stem cells. Mitochondrial permeability similarly transforms autophagy into a destructive force in mammals, as liver-specific Sgk knockout mice demonstrate marked enhancement of hepatocyte autophagy, mPTP opening, and death with ischemia/reperfusion injury. Targeting mitochondrial permeability may maximize benefits of autophagy in aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Knocking down p38 or SGK1 in macrophages using AAV reduces IL-4-induced M2 macrophage polarization in vitro.
“Knocking down p38 or SGK1 in macrophages using Adeno-Associated Virus (AAV) can reduce IL-4-induced M2 macrophage polarization in vitro”
From Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain (2024) · cites this paper as Zhou et al., 2019
The Results section on SGK-1 and autophagy reports SGK1 knockout in hepatocytes, not macrophages. Searches for p38, AAV, IL-4, and M2 polarization found no passage in our copy addressing the claimed macrophage experiment. (LLM, conf=0.78)
Experimental — accuracy not yet measuredThe protective effect of autophagy depends on mTORC2/SGK1 inhibition of mPTP.
“However, the protective effect of autophagy depends on mTORC2/SKG1 inhibition of mPTP.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [27]
Increased activity of mPTP in aging turns autophagy/mitophagy into a destructive process leading to cell aging and death.
“The increased activity of mPTP in aging turns autophagy/mitophagy into a destructive process leading to cell aging and death.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [27]
SGK1/VDAC1 co-immunoprecipitates with nearly all other protein candidates for the mPTP channel (ANT1, ANT3, ATP synthase peptides OSCP and subunit delta, SPG-7 and PiC) but no other mitochondrial proteins.
“A recent study demonstrated the co-immunoprecipitation of SGK1/VDAC1 with nearly all other protein candidates for the mPTP channel, i.e., ANT1, ANT3, two peptides of ATP synthase (OSCP and subunit delta), SPG-7 and PiC, but no other mitochondrial proteins [27].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [27]
Genetic or pharmacological inhibition of mPTP increased the lifespan in these mutants.
“In addition, genetic or pharmacological inhibition of mPTP increased the lifespan in these mutants.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [27]
Genetic inhibition of autophagy in these cells restored the normal lifespan.
“Genetic inhibition of autophagy in these cells restored the normal lifespan.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [27]
The increased lifespan of the calorie-restricted eat-2 C. elegans mutant is dependent on inhibition of mPTP.
“Zhou et al. [27] showed that the increased lifespan of the calorie-restricted eat-2 C. elegans mutant is dependent on the inhibition of mPTP, similar to other autophagy-dependent life extension paradigms.”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton, R., & Sabatini, D. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 3,889 · see citing works
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907 · cited 2× · see citing works
“To determine if facilitatedmPTP opening is sufficient to mitigate the beneficial effects of increased autophagy, we knocked down a member of mitochondrial complex II, sdhb-1, which induces mitochondrial ROS generation and facilitates mPTP opening (Chouchani et al., 2014; Pujol et al., 2013).”
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works
Regulation of autophagy by ROS: physiology and pathology
Scherz-Shouval, R., & Elazar, Z. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.007 · Cited by 1,263 · see citing works
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
Calvo, S. E., Clauser, K. R., & Mootha, V. K. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1003 · Cited by 1,251 · see citing works
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121 · see citing works
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works
García-Martínez, J. M., & Alessi, D. R. (2008) · Biochemical Journal · doi:10.1042/bj20081668 · Cited by 907 · see citing works
Schwartz, D., & Gygi, S. P. (2005) · Nature Biotechnology · doi:10.1038/nbt1146 · Cited by 879 · see citing works
Autophagy as a promoter of longevity: insights from model organisms
Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0033-y · Cited by 754 · see citing works
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.
Ishii, N., Fujii, M., Hartman, P. S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., & Suzuki, K. (1998) · Nature · doi:10.1038/29331 · Cited by 687 · cited 1× · see citing works
“In a short-lived mitochondrial complex II mutant mev-1(kn1) background (Ishii et al., 1998), RNAi of bec-1 does not extend the lifespan of sgk-1mutants (Figure 6D).”
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630 · see citing works
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622 · see citing works
The mitochondrial permeability transition initiates autophagy in rat hepatocytes
Elmore, S. P., Qian, T., Grissom, S. F., & Lemasters, J. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0206fje · Cited by 607 · see citing works
Park, J., Leong, M., Buse, P., Maiyar, A. C., Firestone, G. L., & Hemmings, B. (1999) · EMBO Journal · doi:10.1093/emboj/18.11.3024 · Cited by 588 · see citing works
Betz, C., Stracka, D., Prescianotto-Baschong, C., Frieden, M., Demaurex, N., & Hall, M. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302455110 · Cited by 538 · see citing works
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
Lapierre, L. R., Filho, C. D. D. M., McQuary, P. R., Chu, C., Visvikis, O., Chang, J. T., Gelino, S., Ong, B., Davis, A. E. M., Irazoqui, J. E., et al. (2013) · Nature Communications · doi:10.1038/ncomms3267 · Cited by 533 · see citing works
Mitochondrial fission facilitates the selective mitophagy of protein aggregates
Burman, J. L., Pickles, S., Wang, C., Sekine, S., Vargas, J. N. S., Zhang, Z., Youle, A. M., Nezich, C. L., Wu, X., Hammer, J. A., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201612106 · Cited by 479 · see citing works
Han, S. K., Lee, D.-Y., Lee, H., Kim, D., Son, H. G., Yang, J., Lee, S., & Kim, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11269 · Cited by 468 · see citing works
Essential role for autophagy in life span extension
Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73946 · Cited by 464 · see citing works
Physiological and Pathological Roles of the Mitochondrial Permeability Transition Pore in the Heart
Kwong, J. Q., & Molkentin, J. D. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.001 · Cited by 463 · see citing works
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegansPreprint
Soukas, A. A., Kane, E., Carr, C. E., Melo, J. A. T., & Ruvkun, G. (2009) · Genes & Development · doi:10.1101/gad.1775409 · Cited by 410 · see citing works
Ong, S., Samangouei, P., Kalkhoran, S. B., & Hausenloy, D. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.11.005 · Cited by 323 · see citing works
The role of the autophagy in myocardial ischemia/reperfusion injury
Ma, S., Wang, Y., Chen, Y., & Cao, F. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.010 · Cited by 306 · see citing works
Isolation and Culture of Adult Mouse Hepatocytes
Li, W., Ralphs, K. L., & Tosh, D. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-019-5_13 · Cited by 303 · see citing works
Dual roles of autophagy in the survival of <i>Caenorhabditis elegans</i> during starvation
Kang, C., You, Y.-J., & Avery, L. (2007) · Genes & Development · doi:10.1101/gad.1573107 · Cited by 294 · see citing works
Rottenberg, H., & Hoek, J. B. (2017) · Aging Cell · doi:10.1111/acel.12650 · Cited by 275 · see citing works
Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy
Gottlieb, R. A., & Mentzer, R. M. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135757 · Cited by 267 · see citing works
Batandier, C., Leverve, X., & Fontaine, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310329200 · Cited by 264 · see citing works
Yang, W., & Hekimi, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00571.x · Cited by 251 · see citing works
Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging
Chang, J. T., Kumsta, C., Hellman, A. B., Adams, L. M., & Hansen, M. (2017) · eLife · doi:10.7554/elife.18459 · Cited by 241 · see citing works
A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors
Matecic, M., Smith, D. L., Pan, X., Maqani, N., Bekiranov, S., Boeke, J. D., & Smith, J. S. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000921 · Cited by 224 · see citing works
Castel, P., Ellis, H., Bago, R., Toska, E., Razavi, P., Carmona, F. J., Kannan, S., Verma, C. S., Dickler, M. N., Chandarlapaty, S., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.06.004 · Cited by 223 · see citing works
SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore
Shanmughapriya, S., Rajan, S., Hoffman, N. E., Higgins, A. M., Tomar, D., Nemani, N., Hines, K. J., Smith, D. J., Eguchi, A., Vallem, S., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.009 · Cited by 209 · see citing works
Bhamra, G. S., Hausenloy, D. J., Davidson, S. M., Carr, R. D., Paiva, M. S. A., Wynne, A. M., Mocanu, M. M., & Yellon, D. M. (2007) · Basic Research in Cardiology · doi:10.1007/s00395-007-0691-y · Cited by 207 · see citing works
Coupling of Homologous Recombination and the Checkpoint by ATR
Buisson, R., Joshi, N., Rodrigue, A., Ho, C. K., Kreuzer, J., Foo, T. K., Hardy, É. J.-L., Dellaire, G., Haas, W., Xia, B., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.007 · Cited by 181 · see citing works
Tomasello, F., Messina, A., Lartigue, L., Schembri, L., Medina, C., Reina, S., Thoraval, D., Crouzet, M., Ichas, F., De Pinto, V., et al. (2009) · Cell Research · doi:10.1038/cr.2009.98 · Cited by 161 · see citing works
Guidelines for monitoring autophagy in Caenorhabditis elegans
Zhang, H., Chang, J. T., Guo, B., Hansen, M., Jia, K.-L., Kovács, A. L., Kumsta, C., Lapierre, L. R., Legouis, R., Lin, L., et al. (2015) · Autophagy · doi:10.1080/15548627.2014.1003478 · Cited by 160 · see citing works
Manil-Ségalen, M., Lefebvre, C., Jenzer, C., Trichet, M., Boulogne, C., Satiat‐Jeunemaître, B., & Legouis, R. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.11.022 · Cited by 154 · see citing works
Briston, T., Roberts, M., Lewis, S., Powney, B., M. Staddon, J., Szabadkai, G., & Duchen, M. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-10673-8 · Cited by 152 · see citing works
Epithelial Na+channel activation and processing in mice lacking SGK1
Fejes‐Tóth, G., Frindt, G., Náray‐Fejes‐Tóth, A., & Palmer, L. G. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00579.2007 · Cited by 132 · see citing works
Cristofano, A. D. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.11.006 · Cited by 101 · see citing works
Autophagy and Its Effects: Making Sense of Double-Edged Swords
Thorburn, A. M. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001967 · Cited by 100 · see citing works
m TORC 2‐ SGK ‐1 acts in two environmentally responsive pathways with opposing effects on longevity
Mizunuma, M., Neumann‐Haefelin, E., Moroz, N., Li, Y., & Blackwell, T. K. (2014) · Aging Cell · doi:10.1111/acel.12248 · Cited by 93 · see citing works
Fang, H., Liu, A.-X., Dahmen, U., & Dirsch, O. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.225 · Cited by 90 · see citing works
Hofer, T., Servais, S., Seo, A. Y., Marzetti, E., Hiona, A., Upadhyay, S. J., Wohlgemuth, S. E., & Leeuwenburgh, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.01.004 · Cited by 87 · see citing works
Schiavi, A., Torgovnick, A., Kell, A. M., Megalou, E. V., Castelein, N., Guccini, I., Marzocchella, L., Gelino, S., Hansen, M., Malisan, F., et al. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.12.002 · Cited by 75 · see citing works
Caenorhabditis elegans integrates food and reproductive signals in lifespan determination
Crawford, D. K., Libina, N., & Kenyon, C. J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00327.x · Cited by 72 · see citing works
The unpredictability of prolonged activation of stress response pathways
Lamech, L. T., & Haynes, C. M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201503107 · Cited by 72 · see citing works
Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence
Wang, M. C., Oakley, H. D., Carr, C. E., Sowa, J. N., & Ruvkun, G. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004752 · Cited by 51 · see citing works
Succinate Dehydrogenase Upregulation Destabilize Complex I and Limits the Lifespan of gas-1 Mutant
Pujol, C., Hench, I. B., Sumakovic, M., Hench, J., Mourier, A., Baumann, L. C., Pavlenko, V., & Trifunović, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059493 · Cited by 40 · see citing works
Intracellular Assessment of ATP Levels in Caenorhabditis elegans
Palikaras, K., & Tavernarakis, N. (2016) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2048 · Cited by 39 · see citing works
O'Keeffe, B. A., Cilia, S., Maiyar, A. C., Vaysberg, M., & Firestone, G. L. (2013) · Biochimie · doi:10.1016/j.biochi.2013.01.019 · Cited by 27 · see citing works
Cordas, E., Náray‐Fejes‐Tóth, A., & Fejes‐Tóth, G. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2006 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Di Cristofano A (2017). SGK1: The Dark Side of PI3K Signaling. Curr Top Dev Biol 123, 49– 71. 28236975 PMC5658788
Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works
Autophagy in healthy aging and disease
Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works
Self-citationMolecular mechanisms and consequences of mitochondrial permeability transition
Bonora, M., Giorgi, C., & Pinton, P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00433-y · Cited by 549 · see citing works
Bernardi, P., Gerle, C., Halestrap, A. P., Jonas, E. A., Karch, J. M., Mnatsakanyan, N., Pavlov, E. V., Sheu, S., & Soukas, A. A. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01187-0 · Cited by 482 · see citing works
Autophagy in metabolic disease and ageing
Kitada, M., & Koya, D. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00551-9 · Cited by 413 · see citing works
The mTOR–Autophagy Axis and the Control of Metabolism
Deleyto-Seldas, N., & Efeyan, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.655731 · Cited by 360 · see citing works
Nutrition, longevity and disease: From molecular mechanisms to interventions
Longo, V. D., & Anderson, R. M. (2022) · Cell · doi:10.1016/j.cell.2022.04.002 · Cited by 342 · see citing works
Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury
Zhang, Q., Jia, M., Wang, Y., Wang, Q., & Wu, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03697-8 · Cited by 295 · see citing works
Wu, M., Luo, Q., Nie, R., Yang, X., Tang, Z., & Chen, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1773390 · Cited by 207 · see citing works
Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging
Wu, N. N., Zhang, Y., & Ren, J. T. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9825061 · Cited by 196 · see citing works
Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan
Bradshaw, P. C. (2021) · Antioxidants · doi:10.3390/antiox10040572 · Cited by 185 · see citing works
mTORC2: The other mTOR in autophagy regulation
Ballesteros‐Álvarez, J., & Andersen, J. K. (2021) · Aging Cell · doi:10.1111/acel.13431 · Cited by 182 · see citing works
Mitochondrial dysfunction in the regulation of aging and aging-related diseases
Zhang, X., Gao, Y., Zhang, S., Wang, Y., Pei, X., Chen, Y., Zhang, J., Zhang, Y., Du, Y., Hao, S., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02308-7 · Cited by 175 · see citing works
The mitochondrial permeability transition pore: an evolving concept critical for cell life and death
Morciano, G., Naumova, N., Koprowski, P., Valente, S. A., Sardão, V. A., Potes, Y., Rimessi, A., Wieckowski, M. R., & Oliveira, P. J. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12764 · Cited by 158 · see citing works
TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
Blackwell, T., Sewell, A. K., Wu, Z.-Y., & Han, M. (2019) · Genetics · doi:10.1534/genetics.119.302504 · Cited by 145 · see citing works
Mitochondrial quality control in intervertebral disc degeneration
Song, Y., Lu, S., Geng, W., Feng, X., Luo, R., Li, G., & Cao, Y. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00650-7 · Cited by 131 · see citing works
Hepatocytes: A key role in liver inflammation
Gong, J., Tu, W., Liu, J., & Tian, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1083780 · Cited by 128 · see citing works
The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
Yen, K., Mehta, H. H., Kim, S., Lue, Y., Hoang, J., Guerrero, N., Port, J. M., Bi, Q., Navarrete, G., Brandhorst, S., et al. (2020) · Aging · doi:10.18632/aging.103534 · Cited by 110 · see citing works
Liu, H., & Man, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158210 · Cited by 108 · see citing works
Evidence and perspectives of cell senescence in neurodegenerative diseases
Si, Z., Sun, L., & Wang, X. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111327 · Cited by 105 · see citing works
Kent, A. C., Baradie, K. B. Y. E., & Hamrick, M. W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6626484 · Cited by 107 · see citing works
The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease
Varughese, J. T., Buchanan, S. K., & Pitt, A. S. (2021) · Cells · doi:10.3390/cells10071737 · Cited by 101 · see citing works
Loss of Metabolic Plasticity Underlies Metformin Toxicity in Aged Caenorhabditis Elegans
Espada, L., Dakhovnik, A., Chaudhari, P., Martirosyan, A., Miek, L., Poliezhaieva, T., Schaub, Y., Nair, A., Döring, N., Rahnis, N., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00307-1 · Cited by 100 · see citing works
The mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94 · see citing works
“ANT1, ANT3, two peptides of ATP synthase (OSCP and subunit delta), SPG-7 and PiC but no other mitochondrial proteins (27).”
BackgroundResultInfluentialMitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition
Li, Y., Sun, J., Wu, R., Bai, J., Hou, Y., Zeng, Y., Zhang, Y., Wang, X., Wang, Z., & Meng, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00352 · Cited by 91 · see citing works
Mitophagy in the Pathogenesis of Liver Diseases
Ke, P. (2020) · Cells · doi:10.3390/cells9040831 · Cited by 89 · see citing works
Macroautophagy and aging: The impact of cellular recycling on health and longevity
Nieto-Torres, J. L., & Hansen, M. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101020 · Cited by 91 · see citing works
Song, Y., Liang, H., Li, G., Ma, L., Zhu, D., Zhang, W., Tong, B., Li, S., Gao, Y., Wu, X., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2274205 · Cited by 85 · see citing works
Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
Peng, W., Minakaki, G., Nguyen, M., & Krainc, D. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00742-3 · Cited by 79 · see citing works
Nesci, S., Trombetti, F., Pagliarani, A., Ventrella, V., Algieri, C., Tioli, G., & Lenaz, G. (2021) · Life · doi:10.3390/life11030242 · Cited by 80 · see citing works
Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans
Aspernig, H., Heimbucher, T., Qi, W., Gangurde, D., Curic, S., Yan, Y., von Gromoff, E. D., Baumeister, R., & Thien, A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.072 · Cited by 75 · see citing works
Meng, L., Lu, C., Wu, B., Lan, C., Mo, L., Chen, C., Wang, X., Zhang, N., Li, L., Wang, Q., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.648913 · Cited by 75 · see citing works
SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics
Karthik, R., Maity, S., Muthukumar, A. R., Kandala, S., Tomar, D., El‐Aziz, T. M. A., Allen, C., Sun, Y., Venkatesan, M., Madaris, T. R., et al. (2022) · iScience · doi:10.1016/j.isci.2021.103722 · Cited by 72 · see citing works
Bjedov, I., Cochemé, H. M., Foley, A., Wieser, D., Woodling, N. S., Castillo-Quan, J. I., Norvaišas, P., Lujan, C., Regan, J. C., Toivonen, J. M., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009083 · Cited by 68 · see citing works
mTORC2: a multifaceted regulator of autophagy
Sun, Y., Wang, H. H., Qu, T., Luo, J., An, P., Ren, F., Luo, Y., & Li, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-00859-7 · Cited by 68 · see citing works
Chen, Y., Wan, X., Wu, D., Ouyang, Y., Gao, L., Chen, Z., El-Seedi, H. R., Wang, M.-F., Chen, X., & Zhao, C. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.09.041 · Cited by 64 · see citing works
The mitochondrial permeability transition pore in Ca2+ homeostasis
Carraro, M., & Bernardi, P. (2023) · Cell Calcium · doi:10.1016/j.ceca.2023.102719 · Cited by 64 · see citing works
Mitochondrion: a sensitive target for Pb exposure
Han, Q., Zhang, W. K., Guo, J., Zhu, Q., Chen, H., Xia, Y., & Zhu, G. (2021) · The Journal of Toxicological Sciences · doi:10.2131/jts.46.345 · Cited by 61 · see citing works
Gu, Y., Zhao, X., Zhang, N., Yang, Y., Yi, Y., Shao, Q.-H., Liu, M.-X., & Zhang, X.-L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102577 · Cited by 58 · see citing works
Agephagy – Adapting Autophagy for Health During Aging
Stead, E. R., Castillo-Quan, J. I., Martinez-Miguel, V. E., Lujan, C., Ketteler, R., Kinghorn, K. J., & Bjedov, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00308 · Cited by 59 · see citing works
Ballesteros‐Álvarez, J., Nguyen, W., Sivapatham, R., Rane, A., & Andersen, J. K. (2022) · GeroScience · doi:10.1007/s11357-022-00708-y · Cited by 56 · see citing works
Emerging regulatory mechanisms and functions of autophagy in fish
Xia, X., Wang, X., Qin, W., Jiang, J., & Cheng, L. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734212 · Cited by 54 · see citing works
Peng, K., Zeng, C., Gao, Y., Liu, B., Li, L., Xu, K., Yin, Y., Qiu, Y., Zhang, M., Ma, F., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.03.019 · Cited by 52 · see citing works
Autophagy in cardiovascular health and disease
Abdellatif, M., Ljubojević-Holzer, S., Madeo, F., & Sedej, S. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.04.022 · Cited by 53 · see citing works
Moigneu, C., Abdellaoui, S., Ramos-Brossier, M., Pfaffenseller, B., Wollenhaupt-Aguiar, B., Cardoso, T. D. A., Camus, C., Chiche, A., Kuperwasser, N., da Silva, R. A., et al. (2023) · Nature Aging · doi:10.1038/s43587-022-00352-3 · Cited by 54 · see citing works
Common methods in mitochondrial research (Review)
Yin, Y., & Shen, H. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5182 · Cited by 52 · see citing works
Ishikawa, M., Takaseki, S., Yoshitomi, T., Covey, D. F., Zorumski, C. F., & Izumi, Y. (2020) · Autophagy · doi:10.1080/15548627.2020.1731270 · Cited by 50 · see citing works
Dong, L., Li, Y., Chen, Q., Liu, Y., Wu, Z., Pan, D., Yan, N., & Liu, L. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2213768 · Cited by 49 · see citing works
Ke, W., Saba, J. A., Yao, C.-H., Hilzendeger, M. A., Drangowska-Way, A., Joshi, C. J., Mony, V. K., Benjamin-Davalos, S., Zhang, S., Locasale, J. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16220-w · Cited by 48 · see citing works
Metabolic control of mitophagy
Zimmermann, A., Madeo, F., Diwan, A., Sadoshima, J., Sedej, S., Kroemer, G., & Abdellatif, M. (2023) · European Journal of Clinical Investigation · doi:10.1111/eci.14138 · Cited by 47 · see citing works
Oxidative stress-mediated protein sulfenylation in human diseases: Past, present, and future
Mu, B., Zeng, Y., Luo, L., & Wang, K. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103332 · Cited by 48 · see citing works
Rottenberg, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512295 · Cited by 44 · see citing works
Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy
Zhang, S., Wang, Y., Yu, M., Shang, Y., Chang, Y., Zhao, H. L., Kang, Y., Zhao, L., Xu, L., Zhao, X., et al. (2021) · Advanced Science · doi:10.1002/advs.202101485 · Cited by 44 · see citing works
An energetics perspective on geroscience: mitochondrial protonmotive force and aging
Berry, B. J., & Kaeberlein, M. R. (2021) · GeroScience · doi:10.1007/s11357-021-00365-7 · Cited by 43 · see citing works
Methionine transsulfuration pathway is upregulated in long-lived humans
Mota-Martorell, N., Jové, M., Borrás, C., Berdún, R., Obis, È., Sol, J., Cabré, R., Pradas, I., Galo-Licona, J. D., Puig, J., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.11.026 · Cited by 43 · see citing works
The hunger strikes back: an epigenetic memory for autophagy
González-Rodríguez, P., Füllgrabe, J., & Joseph, B. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01159-4 · Cited by 42 · see citing works
Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review
Panda, V. K., Mishra, B., Mahapatra, S., Swain, B., Malhotra, D., Saha, S., Khanra, S., Mishra, P., Majhi, S., Kumari, K., et al. (2025) · Cancers · doi:10.3390/cancers17020234 · Cited by 40 · see citing works
Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury
Tang, J., Zhuo, Y., & Li, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720288 · Cited by 38 · see citing works
Zhou, B. Z., Zhang, Y., Li, S., Wu, L., Fejes‐Tóth, G., Náray‐Fejes‐Tóth, A., & Soukas, A. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109785 · Cited by 38 · see citing works
Targeting the Mitochondria-Proteostasis Axis to Delay Aging
Zimmermann, A., Madreiter‐Sokolowski, C. T., Stryeck, S., & Abdellatif, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.656201 · Cited by 40 · see citing works
Geng, J., Khaket, T. P., Pan, J., Li, W., Zhang, Y., Ping, Y., Cobos, I., & Lu, B. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.03.002 · Cited by 36 · see citing works
Mota‐Martorell, N., Jové, M., Pradas, I., Sánchez, I. P., Gómez, J., Naudí, A., Barja, G., & Pamplona, R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101539 · Cited by 37 · see citing works
Discovery and molecular basis of subtype-selective cyclophilin inhibitors
Peterson, A. A., Rangwala, A. M., Thakur, M. K., Ward, P. S., Hung, C., Outhwaite, I. R., Chan, A. I., Usanov, D. L., Mootha, V. K., Seeliger, M. A., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01116-1 · Cited by 37 · see citing works
mTOR in metabolic homeostasis and disease.
Liu, X., Guo, B., Li, Q., & Nie, J. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114173 · Cited by 35 · see citing works
Small molecules as modulators of regulated cell death against ischemia/reperfusion injury
Chen, D., Guo, Y. P., Li, X., Zhang, G., & Li, P. (2022) · Medicinal Research Reviews · doi:10.1002/med.21917 · Cited by 37 · see citing works
Wang, W., Zhou, C., Ma, Z., Zeng, L., Wang, H., Cheng, X., Zhang, C., Xue, Y., Yuan, Y., Li, J., et al. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116121 · Cited by 32 · see citing works
Chen, W., Zai, W., Fan, J., Zhang, X., Zeng, X. L., Luan, J., Wang, Y., Shen, Y., Wang, Z., Dai, S., et al. (2020) · Theranostics · doi:10.7150/thno.43894 · Cited by 32 · see citing works
Zhao, Z., Song, X., Wang, Y., Yu, L., Huang, G., Li, Y., Zong, R., Liu, T., Ji, Q., Zheng, Y., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01334-1 · Cited by 32 · see citing works
Liu, S., Xiao, X., La, Z., Wang, J., Zhao, W., Liu, H., Liao, R., Li, Z., Xu, M., Guo, J., et al. (2023) · Theranostics · doi:10.7150/thno.88061 · Cited by 28 · see citing works
Sulfur signaling pathway in cardiovascular disease
Song, Y., Xu, Z., Zhong, Q., Zhang, R., Sun, X., & Chen, G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1303465 · Cited by 29 · see citing works
Zhang, L., Soni, S., Hekimoglu, E., Berkelhamer, S. K., & Çataltepe, S. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0445oc · Cited by 28 · see citing works
Amino Acids in Autophagy: Regulation and Function
Shen, Z., Wu, G., & Guo, S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-74180-8_4 · Cited by 28 · see citing works
Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway
Li, L., Liu, F., Feng, C., Chen, Z., Zhang, N., & Mao, J. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003022 · Cited by 27 · see citing works
Guo, M., Liu, R., Zhang, F., Qu, J., Yang, Y., & Li, X. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107409 · Cited by 28 · see citing works
Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling
Mallick, A., Ranawade, A., van den Berg, W., & Gupta, B. P. (2020) · iScience · doi:10.1016/j.isci.2020.101843 · Cited by 24 · see citing works
Jakubek, P., Pakula, B., Rossmeisl, M., Pinton, P., Rimessi, A., & Wieckowski, M. R. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-024-03700-w · Cited by 25 · see citing works
Berry, B. J., Mjelde, E., Carreno, F., Gilham, K., Hanson, E. J., Na, E., & Kaeberlein, M. R. (2023) · GeroScience · doi:10.1007/s11357-023-00766-w · Cited by 25 · see citing works
Autophagy in aquatic animals: mechanisms, implications, and future directions
Kawsar, M. A., Adikari, D., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1612178 · Cited by 25 · see citing works
Hernando‐Rodríguez, B., Hernando‐Rodríguez, B., Rodríguez-Palero, M., Pla, A., Martínez‐Bueno, M. D., Pla, A., Gatsi, R., & Artal‐Sanz, M. (2021) · Aging Cell · doi:10.1111/acel.13359 · Cited by 25 · see citing works
Kadam, A. A., Jadiya, P., & Tomar, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1196466 · Cited by 23 · see citing works
Li, X., Wang, S., Zhang, M., & Li, M. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109582 · Cited by 24 · see citing works
Nie, S., Shi, Z., Shi, M., Li, H., Qian, X., Peng, C., Ding, X., Zhang, S., Lv, Y., Wang, L., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.745554 · Cited by 22 · see citing works
Gu, Z., Wang, L., Yao, X., Qian, L., Lee, K., Li, J., Yue, D., Yang, S., Liu, Y., Li, N., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03107-3 · Cited by 22 · see citing works
A lysosomal surveillance response to stress extends healthspan
Li, T. Y., Gao, A. W., Yang, R., Sun, Y., Lei, Y., Li, X., Chen, L., Liu, Y. J., Arey, R. N., Morales, K., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01693-y · Cited by 25 · see citing works
The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species
Frigo, E., Tommasin, L., Lippe, G., Carraro, M., & Bernardi, P. (2023) · Cells · doi:10.3390/cells12101409 · Cited by 21 · see citing works
Patra, S., Mahapatra, K. K., Praharaj, P. P., Panigrahi, D. P., Bhol, C. S., Mishra, S. R., Behera, B. P., Singh, A., Jena, M., & Bhutia, S. K. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.01.002 · Cited by 20 · see citing works
MIRO‐1 interacts with VDAC‐1 to regulate mitochondrial membrane potential in Caenorhabditis elegans
Ren, X., Zhou, H., Sun, Y., Fu, H., Ran, Y., Yang, B., Yang, F., Björklund, M., & Xu, S. (2023) · EMBO Reports · doi:10.15252/embr.202256297 · Cited by 19 · see citing works
A Glimmer of Hope: Maintain Mitochondrial Homeostasis to Mitigate Alzheimer’s Disease
Li, W., Kui, L., Tsirukis, D. I., Gong, X., & Tang, M. (2020) · Aging and Disease · doi:10.14336/ad.2020.0105 · Cited by 20 · see citing works
Future foods, dietary factors and healthspan
Li, K., Wang, C., Wang, Y., Fu, L., & Zhang, N. (2023) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.12.001 · Cited by 20 · see citing works
UBA52 Attunes VDAC1-Mediated Mitochondrial Dysfunction and Dopaminergic Neuronal Death
Tiwari, S., Singh, A., Gupta, P., Amrutha, K., & Singh, S. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00579 · Cited by 19 · see citing works
Feng, D., Gui, Z., Xu, Z., Zhang, J., Ni, B., Wang, Z., Liu, J., Fei, S., Chen, H., Sun, L., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1686 · Cited by 18 · see citing works
Physical exercise elicits UPRmt in the skeletal muscle: The role of c-Jun N-terminal kinase
Gaspar, R. S., Katashima, C. K., Crisol, B., Carneiro, F. S., Sampaio, I. H., Silveira, L. R., da Silva, A. S. R., Cintra, D. E., Pauli, J. R., & Ropelle, E. R. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101816 · Cited by 20 · see citing works
The functional duality of SGK1 in the regulation of hyperglycemia
Yang, C., Li, J., Sun, F., Zhou, H., Yang, J., & Yang, C. (2020) · Endocrine Connections · doi:10.1530/ec-20-0225 · Cited by 18 · see citing works
Lv, B., Peng, H., Qiu, B., Zhang, L., Ge, M., Bu, D., Li, K., Yu, X., Du, J., Yang, L., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.784799 · Cited by 18 · see citing works
Feng, C., Hu, Z., Zhao, M., Leng, C., Li, G., Yang, F., & Fan, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1579507 · Cited by 17 · see citing works
Zhao, J., Hou, L., Dery, K. J., Yuan, X., Kim, K. H., Kupiec‐Weglinski, J. W., Hall, D. R., Thornley, C. J., Hobeika, M. J., Eltzschig, H. K., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001609 · Cited by 17 · see citing works
Wong, S. Q., Ryan, C. J., Bonal, D. M., Mills, J., & Lapierre, L. R. (2022) · Aging Cell · doi:10.1111/acel.13741 · Cited by 17 · see citing works
Packialakshmi, B., Stewart, I. J., Burmeister, D. M., Feng, Y., McDaniel, D. P., Chung, K. K., & Zhou, X. (2022) · Physiological Reports · doi:10.14814/phy2.15181 · Cited by 17 · see citing works
Jayaraman, S., Eswaran, A., Rajagopal, P., Palanisamy, C. P., Veerakumar, P., Veeraraghavan, V. P., & Sirasanagandla, S. R. (2026) · Biogerontology · doi:10.1007/s10522-026-10402-7 · Cited by 17 · see citing works
Combinatorial Approach Using Caenorhabditis elegans and Mammalian Systems for Aging Research
Lee, G., Sohn, J., & Lee, S. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0080 · Cited by 16 · see citing works
- Authors
- Zhou, B., Kreuzer, J., Kumsta, C., Wu, L., Kamer, K. J., Cedillo, L., Zhang, Y., Li, S., Kacergis, M. C., Webster, C. M., Fejes-Toth, G., Naray-Fejes-Toth, A., Das, S., Hansen, M., Haas, W., & Soukas, A. A.
- Affiliations
- Broad Institute (US)
- Massachusetts General Hospital (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Soukas, Alexander A.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 177
- Issue
- 2
- Pages
- 299-314.e16
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC6610881
- OpenAlex
- W2922624791
- Cited by
- 220
- References
- 59
- Citations by year
- 2026: 21 · 2025: 39 · 2024: 29 · 2023: 35 · 2022: 23 · 2021: 32 · 2020: 26 · 2019: 15
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (P40OD010440, K08DK087941, R01DK101522, R01AG038664, R21AG058038)
- NIDDK (P30DK040561, P30DK057521)
- Ellison Medical Foundation New Scholar in Aging Award
- Howard M. Goodman Fellowship
- Charles H. Hood Foundation Child Health Research Award
- Weissman Family MGH Research Scholar Award
- Glenn Award for Research in Biological Mechanisms of Aging
- The Ellison Medical Foundation/AFAR
- MGH ECOR
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- autophagy, lifespan extension, mitochondrial permeability, mitochondrial permeability transition pore, SGK1, aging, caloric restriction, germline stem cells, ischemia-reperfusion injury, longevity
- MeSH terms
- Mitochondrial Permeability Transition Pore, Aging, Animals, Autophagy, Humans, Longevity, Male, Mitochondria, Permeability, Signal Transduction, Reperfusion Injury, Caenorhabditis elegans, Protein Serine-Threonine Kinases, Mice, Knockout, Caenorhabditis elegans Proteins, Caloric Restriction, Mitochondrial Membrane Transport Proteins, Mitochondrial Membranes, Mice, HEK293 Cells, Primary Cell Culture
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
