Cited by 3,505NF-κB Signaling PathwaysRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Crosstalk of reactive oxygen species and NF-κB signaling

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Morgan, Michael J, Liu, Zheng-gang·2011·Cell Research

DOI 10.1038/cr.2010.178PMC PMC3193400

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Abstract

NF-κB proteins are a family of transcription factors that are of central importance in inflammation and immunity. NF-κB also plays important roles in other processes, including development, cell growth and survival, and proliferation, and is involved in many pathological conditions. Reactive Oxygen Species (ROS) are created by a variety of cellular processes as part of cellular signaling events. While certain NF-κB-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-κB signaling. Here we review the regulation of ROS levels by NF-κB targets and various ways in which ROS have been proposed to impact NF-κB signaling pathways.

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Authors: Morgan, M. J., & Liu, Z.-G.
Affiliations: National Institutes of Health (US)
Corresponding author: Liu, Zheng-gang
ORCID: Liu, Zheng-gang
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2010-12-28
Volume: 21
Issue: 1
Pages: 103-115
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2010.178
PMC: PMC3193400
OpenAlex: W2086667809
Cited by: 3,505
References: 165
Citations by year: 2026: 409 · 2025: 401 · 2024: 364 · 2023: 321 · 2022: 330 · 2021: 282 · 2020: 234 · 2019: 210 · 2018: 229 · 2017: 179 · 2016: 139 · 2015: 113 · 2014: 96 · 2013: 81 · 2012: 92
FWCI: 5.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: reactive oxygen species, NF-κB signaling, redox signaling, inflammation, immunity, transcription factors, NF-κB target genes
MeSH terms: Antioxidants, Humans, Signal Transduction, NF-kappa B, Reactive Oxygen Species, Oxidative Stress

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