The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
Crosstalk of reactive oxygen species and NF-κB signaling
Open accessAbstract
NF-κB proteins are a family of transcription factors that are of central importance in inflammation and immunity. NF-κB also plays important roles in other processes, including development, cell growth and survival, and proliferation, and is involved in many pathological conditions. Reactive Oxygen Species (ROS) are created by a variety of cellular processes as part of cellular signaling events. While certain NF-κB-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-κB signaling. Here we review the regulation of ROS levels by NF-κB targets and various ways in which ROS have been proposed to impact NF-κB signaling pathways.
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“NF-κB can be co-regulated by multiple pathways including MAPK and PI3K/Akt to enhance transcriptional activity, thus promoting the expression of pro-inflammatory and pro-oxidant enzyme genes.239,243,244”
From Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies. (2024) · cites this paper as [244]
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“The elevated concentrations of TNF-alpha, TNF-beta, LPS, IL-1beta and CD40 in peritoneal fluid in women with endometriosis promote processes such as adhesion, invasion, proliferation and angiogenesis that stimulate the development of the disease [155].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [155]
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Metadata
- Authors
- Morgan, M. J., & Liu, Z.-G.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Liu, Zheng-gang
- ORCID
- Liu, Zheng-gang
- Venue
- Cell Research
- Published
- 2010-12-28
- Volume
- 21
- Issue
- 1
- Pages
- 103-115
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3193400
- OpenAlex
- W2086667809
- Cited by
- 3,505
- References
- 165
- Citations by year
- 2026: 409 · 2025: 401 · 2024: 364 · 2023: 321 · 2022: 330 · 2021: 282 · 2020: 234 · 2019: 210 · 2018: 229 · 2017: 179 · 2016: 139 · 2015: 113 · 2014: 96 · 2013: 81 · 2012: 92
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- reactive oxygen species, NF-κB signaling, redox signaling, inflammation, immunity, transcription factors, NF-κB target genes
- MeSH terms
- Antioxidants, Humans, Signal Transduction, NF-kappa B, Reactive Oxygen Species, Oxidative Stress
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