The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
Open accessAbstract
Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as signaling molecules in intercellular communication. Here, we report the surprising finding that exogenous plant miRNAs are present in the sera and tissues of various animals and that these exogenous plant miRNAs are primarily acquired orally, through food intake. MIR168a is abundant in rice and is one of the most highly enriched exogenous plant miRNAs in the sera of Chinese subjects. Functional studies in vitro and in vivo demonstrated that MIR168a could bind to the human/mouse low-density lipoprotein receptor adapter protein 1 (LDLRAP1) mRNA, inhibit LDLRAP1 expression in liver, and consequently decrease LDL removal from mouse plasma. These findings demonstrate that exogenous plant miRNAs in food can regulate the expression of target genes in mammals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A consequent disruption of general metabolism in the GMO cannot be excluded, which could lead, for example, to the production of other potentially active compounds such as miRNAs (Zhang et al., 2012) or leukotoxin diols (Markaverich et al., 2005).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Zhang et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355
Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001
Real-time quantification of microRNAs by stem-loop RT-PCR
Chen, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni178 · Cited by 4,989
Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., Guo, J., Zhang, Y., Chen, J., Guo, X., et al. (2008) · Cell Research · doi:10.1038/cr.2008.282 · Cited by 4,560
Self-citation
Flagged first, then by citations
1 of the 56 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 601–700 of 1,000
Role of genetically engineered animals in future food production
McColl, K., Clarke, B. D., & Doran, T. J. (2013) · Australian Veterinary Journal · doi:10.1111/avj.12024 · Cited by 16
Comparative epigenetics in animal physiology: An emerging frontier
Navarro‐Martín, L., Martyniuk, C. J., & Mennigen, J. A. (2020) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2020.100745 · Cited by 17
International scientific workshop ‘Risk assessment considerations for RNAi‐based GM plants’
(EFSA), E. F. S. A. (2014) · EFSA Supporting Publications · doi:10.2903/sp.efsa.2014.en-705 · Cited by 17
Fang, Y., Yang, Y., Yao, Z., Lei, X., Dong, Z., Zhang, M., Yao, R., & Tian, B. (2023) · ACS Sensors · doi:10.1021/acssensors.3c01967 · Cited by 15
Milk‐Derived Extracellular Vesicles and microRNAs : Potential Modulators of Intestinal Homeostasis
Husseini, Z., & Gilbert, C. (2025) · The FASEB Journal · doi:10.1096/fj.202501630r · Cited by 15
Bio-objects as “boundary crawlers:” the case of microRNAs
Chrupek, M., Siipi, H., & Martinelli, L. (2012) · Croatian Medical Journal · doi:10.3325/cmj.2012.53.285 · Cited by 16
Wu, F., Huang, Y., Jiang, W., & Jin, W. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1072181 · Cited by 15
Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1
Kumazoe, M., Ogawa, F., Hikida, A., Shimada, Y., Yoshitomi, R., Watanabe, R., Onda, H., Fujimura, Y., & Tachibana, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-29188-6 · Cited by 15
Kopcho, S., McDew‐White, M., Naushad, W., Mohan, M., & Okeoma, C. M. (2023) · Viruses · doi:10.3390/v15030622 · Cited by 15
Kelley, L. (2023) · The MIT Press eBooks · doi:10.7551/mitpress/14255.001.0001 · Cited by 15
The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis
Jiang, J., Фанилевич, Г. И., Ilyasova, T., Shumadalova, A. V., Du, W., & Yang, B. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.01.001 · Cited by 15
Wang, Y., Li, X., Zhu, C., Yi, S., Zhang, Y., & Hong, Z. (2024) · Pest Management Science · doi:10.1002/ps.8138 · Cited by 15
Self-citationHuang, H., Roh, J. W., Davis, C. D., & Wang, T. T. Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175429 · Cited by 15
Cavallini, A., Minervini, F., Garbetta, A., Lippolis, C., Scamarcio, G., Franco, C. D., & D’Alessandro, R. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.08.007 · Cited by 15
Ergün, S. (2019) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2019.02.010 · Cited by 15
Possible connection between diet and microRNA in cancer scenario
Otsuka, K., & Ochiya, T. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.014 · Cited by 16
Pirro, S., Matić, I., Colizzi, V., & Galgani, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-88617-6 · Cited by 15
Li, X., Wang, M., Liu, S., Chen, X., Qiao, Y., Yang, X., Yao, J., & Wu, S. (2022) · Animal nutrition · doi:10.1016/j.aninu.2022.07.002 · Cited by 16
Self-citationHerbal small RNAs in patients with COVID-19 linked to reduced DEG expression
Qiao, X., Huang, F., Shi, X., Deng, X., Zhang, C., Mei, S., Wang, Z., Zhou, C., Jiang, C., & Tan, X. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2225-3 · Cited by 15
Self-citationTang, K., Wang, X., Zhao, Y., Li, X., Jiang, Z., Mei, S., Chen, M., Ma, Y., Du, X., Qiao, X., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2275-3 · Cited by 15
Self-citationDiet-Derived MicroRNAs: Separating the Dream from Reality
Cottrill, K. A., & Chan, S. Y. (2014) · microRNA Diagnostics and Therapeutics · doi:10.2478/micrnat-2014-0001 · Cited by 15
Nutritive implications of dietary microRNAs: facts, controversies, and perspectives
Li, J., Lei, L., Ye, F., Zhou, Y., Chang, H., & Zhao, G. (2019) · Food & Function · doi:10.1039/c9fo00216b · Cited by 15
Self-citationSecretory and circulating bacterial small RNAs: a mini-review of the literature
Wang, Y., & Fu, J. X. (2019) · ExRNA · doi:10.1186/s41544-019-0015-z · Cited by 15
Analysis of Panax ginseng miRNAs and Their Target Prediction Based on High-Throughput Sequencing
Wang, Y., Peng, M., Chen, Y., Wang, W., He, Z., Yang, Z., Lin, Z., Gong, M., Yin, Y.-Q., & Zeng, Y. (2019) · Planta Medica · doi:10.1055/a-0989-7302 · Cited by 15
Self-citationFrom herbal small RNAs to one medicine
Ji, C., Kriaučionis, S., Kessler, B. M., & Jiang, C. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-9513-y · Cited by 15
Regulation of Intestinal Inflammation by Walnut-Derived Bioactive Compounds
Dai, K., Agarwal, N., Rodriguez-Palacios, A., & Basson, A. (2024) · Nutrients · doi:10.3390/nu16162643 · Cited by 13
Ginseng exosomal miRNA ameliorates rheumatoid arthritis by mediating KRAS-MAPK signaling
Wang, X., Liu, H., Fan, H., Han, B., Ye, H., Ye, X., Zhang, D., Ma, F., Huang, Q., Cheng, L., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115046 · Cited by 14
Self-citationPlant vs mammal extracellular vesicles: new tools in therapeutic drug delivery
Maricchiolo, E., Creanza, P., Osnato, M., Tiboni, M., Casettari, L., Aluigi, A., & Pompa, A. (2025) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2025.100352 · Cited by 15
Fan, X., Zhang, W., Zhang, K., Zhang, J., Long, Q., Wu, Y., Zhang, K., Zhu, L., Chen, D., & Guo, R. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1003294 · Cited by 14
Self-citationGastrodia elata specific miRNA attenuates neuroinflammation via modulating NF-κB signaling pathway
Fu, J., Lu, Z., Wu, G., Yang, Z.-C., Wu, X., Wang, D., Nie, Z., & Sheng, Q. (2023) · International Journal of Neuroscience · doi:10.1080/00207454.2023.2280835 · Cited by 14
Xu, Q., Wang, J., Zhang, Y., Li, Y., Qin, X., Xin, Y., Li, Y., Xu, K., Yang, X., & Wang, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09511 · Cited by 14
Self-citationChen, J., Lin, J., Wang, W., Huang, H., Pan, Z., Ye, G., Dong, S., Lin, Y., Lin, C., & Huang, Q. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12442 · Cited by 17
Self-citationSarkar, A., Saquib, M., Chakraborty, D., Mann, S., Malik, S., Agnihotri, P., Joshi, L., Malhotra, R., & Biswas, S. (2024) · Bioscience Reports · doi:10.1042/bsr20240311 · Cited by 14
Small RNA Profiles from Virus-Infected Fresh Market Vegetables
Frizzi, A., Zhang, Y., Kao, J., Hagen, C., & Huang, S. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf503756v · Cited by 14
Self-citationIdentification of microRNA-like RNAs in Ophiocordyceps sinensis
Zhang, W., Li, X., Ma, L., Ur-Rehman, U., Bao, X., Zhang, Y., Zhang, C., Hou, D., & Zhou, Z. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9277-9 · Cited by 14
Self-citationHuang, H., Pham, Q., Davis, C. D., Yu, L. L., & Wang, T. T. Y. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1672 · Cited by 14
Exploring the MiRnome of Carica papaya: A cross kingdom approach
Jha, N., Mangukia, N., Patel, M. P., Bhavsar, M., Gadhavi, H., Rawal, R., & Patel, S. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101089 · Cited by 14
Are Dietary Extracellular Vesicles Bioavailable and Functional in Consuming Organisms?
Sanwlani, R., Fonseka, P., & Mathivanan, S. (2021) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-67171-6_21 · Cited by 14
Mangukia, N., Rao, P., Patel, K. R., Pandya, H., & Rawal, R. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.105502 · Cited by 14
Exogenous miRNAs from Moringa oleifera Lam. recover a dysregulated lipid metabolism
Roglia, V., Potestà, M., Minchella, A., Bruno, S. P., Bernardini, R., Lettieri‐Barbato, D., Iacovelli, F., Gismondi, A., Aquilano, K., Canini, A., et al. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1012359 · Cited by 14
Qin, X., Wang, X., Xu, K., Zhang, Y., Tian, H., Li, Y., Qi, B., & Yang, X. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.12.015 · Cited by 14
Self-citationMicroRNA (miRNA) in food resources and medicinal plant
Ražná, K., Bežo, M., Hlavačková, L., Žiarovská, J., Miko, M., Gažo, J., & Habán, M. (2016) · Potravinarstvo Slovak Journal of Food Sciences · doi:10.5219/583 · Cited by 14
Liang, H., Kidder, K., & Liu, Y. (2019) · ExRNA · doi:10.1186/s41544-019-0009-x · Cited by 14
Pollen-derived RNAs Are Found in the Human Circulation
Koupenova, M., Mick, E. O., Corkrey, H. A., Singh, A., Tanriverdi, S. E., Vitseva, O. I., Levy, D. A., Keeler, A. M., Mirhashemi, M. E., ElMallah, M. K., et al. (2019) · iScience · doi:10.1016/j.isci.2019.08.035 · Cited by 14
Roles of Regulatory RNAs in Nutritional Control
McNeill, E. M., & Hirschi, K. D. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-035633 · Cited by 14
Emerging evidence on the effects of plant-derived microRNAs in colorectal cancer: a review
Zhang, W. J., Li, Y. Y., Xiang, Z. H., Deng, J., Li, W., Lin, Q. L., Fang, Y., Liu, F., Bai, J., Zhang, L., et al. (2022) · Food & Function · doi:10.1039/d2fo03477h · Cited by 13
Self-citationRen, F., Cao, K., Gong, R., Yu, M.-L., Tao, P., Xiao, Y., & Jiang, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.327 · Cited by 13
Plant-derived cross-kingdom gene regulation benefits human health
Li, Y., Teng, Z., & Zhao, D. (2023) · Trends in Plant Science · doi:10.1016/j.tplants.2023.03.004 · Cited by 13
Advances in the Study of Plant-Derived Vesicle-Like Nanoparticles in Inflammatory Diseases
Tan, X., Xu, Y., Zhou, S., Pan, M., Cao, Y., Cai, X., Zhao, Q., & Zhao, K. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s421124 · Cited by 13
Self-citationDíez-Sainz, E., Lorente‐Cebrián, S., Aranaz, P., Amri, E., Riezu‐Boj, J. I., & Milagro, F. I. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1287312 · Cited by 13
Lin, Y., Sun, N., Liu, D., Yang, X., Dong, Y., & Jiang, C. (2024) · IUBMB Life · doi:10.1002/iub.2858 · Cited by 13
Circulating microRNA trafficking and regulation: computational principles and practice
Cui, J., & Shu, J. (2019) · Briefings in Bioinformatics · doi:10.1093/bib/bbz079 · Cited by 13
Hu, C., Li, Y., Pan, D., Wang, J., Zhu, L., Lin, Y. H., Zhu, S., & Pan, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652395 · Cited by 13
Self-citationOne microRNA has the potential to target whole viral mRNAs in a given human coronavirus
Xu, T., Li, L.-X., Jia, Y., Wu, Q., Zhu, W., Zhou, X., Zheng, B., & Lu, X. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1035044 · Cited by 13
Role of MicroRNAs in Dietary Interventions for Obesity and Obesity-Related Diseases
Zhang, J.-Y., Ren, C., Cao, Y.-N., Ren, Y., Zou, L., Zhou, C., & Peng, L. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03042 · Cited by 13
Self-citationSpinler, J. K., Karri, V., & Hirschi, K. D. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.12.001 · Cited by 13
Huang, L., Liu, Y.-N., Li, L.-L., Zhang, M., Miao, X.-Y., Liang, Z., Sun, B., Su, R., Qin, Z., Wen, Z.-F., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157298 · Cited by 12
MicroRNA sensing and regulating microbiota-host crosstalk via diet motivation
Fan, Y., Qin, M., Zhu, J., Chen, X., Luo, J., Chen, T., Sun, J., Zhang, Y., & Xi, Q. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2139220 · Cited by 12
Self-citationInsights into Mobile Small-RNAs Mediated Signaling in Plants
Yan, Y. (2022) · Plants · doi:10.3390/plants11223155 · Cited by 12
Liu, C., Liu, X., Li, H., & Kang, Z. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1173904 · Cited by 12
Cross-kingdom regulation of ginseng miRNA156 on immunity and metabolism
Wang, J., Li, C., Ruan, J., Yang, C., Tian, Y., Lu, B., & Wang, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112577 · Cited by 12
Self-citationRole of microRNAs in immunoregulatory functions of epithelial cells
Jafari, N., & Abediankenari, S. (2024) · BMC Immunology · doi:10.1186/s12865-024-00675-3 · Cited by 12
Cross-kingdom regulation of gene expression in giant pandas via plant-derived miRNA
Tan, H., Wang, C., Feng, L., Peng, Y., Sima, J., Li, Y., Deng, L., Wu, K., Xu, Z., & Zhang, Z. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1509698 · Cited by 12
Self-citationChen, L., Guo, Q., Zhu, Z., Wan, H., Qin, Y., & Zhang, H. (2021) · BMC Plant Biology · doi:10.1186/s12870-021-02861-6 · Cited by 12
Sun, Y., Zhang, L., Hong, L., Zheng, W., Cui, J., Liu, X., & Xu, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734520 · Cited by 12
Self-citationKong, Y., Hu, H., Shan, Y., Zhou, Z., Zen, K., Sun, Y., Yang, R., Fu, Z., & Chen, X. (2022) · Frontiers of Medicine · doi:10.1007/s11684-021-0909-7 · Cited by 12
Self-citationel qassim, L. A., Alonso, J., Zhao, K., Guillou, S. L., Díez, J., Vicente, F., Fernández‐Sanjurjo, M., Iglesias‐Gutiérrez, E., Guan, L. L., & Royo, L. J. (2022) · Veterinary Sciences · doi:10.3390/vetsci9120661 · Cited by 12
The potential of Lycium barbarum miR166a in kidney cancer treatment
Zhang, Q., Xie, Z., Li, Y., Zhu, Q., Shi, H., Zhao, R., Yang, X., Tian, J., & Ma, L. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113455 · Cited by 12
Self-citationSomoza, V., Molyneux, R. J., Chen, Z., Tomás-Barberán, F. A., & Hofmann, T. F. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b04312 · Cited by 12
Peng, C., Chen, X., Wang, X., Xu, X., Wei, W., Wang, C., & Xu, J. (2018) · Scientific Reports · doi:10.1038/s41598-017-18723-x · Cited by 12
Self-citationZaitsev, A. S., Omel'Chenko, O. V., Nyadar, P. M., & Oberemok, V. V. (2015) · Bulletin of the Transilvania University of Brasov Series II Forestry • Wood Industry • Agricultural Food Engineering · Cited by 12
Natural and artificial small RNAs: a promising avenue of nucleic acid therapeutics for cancer
Yadav, S., Shekhawat, M., Jahagirdar, D., & Kumar, S. N. (2017) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2017.0038 · Cited by 12
(2013) · Nature Biotechnology · doi:10.1038/nbt.2748 · Cited by 12
Iqbal, M. A., Reyer, H., Oster, M., Hadlich, F., Trakooljul, N., Perdomo-Sabogal, Á., Schmucker, S. S., Stefanski, V., Roth, C., Camarinha‐Silva, A., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.858232 · Cited by 11
Extraction, detection and determination of dietary microRNA: A review
Guzmán-Lorite, M., Muñoz‐Moreno, L., Marina, M. L., Carmena, M. J., & García, M. C. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.04.001 · Cited by 11
Existing and emerging mRNA vaccines and their environmental impact: a transdisciplinary assessment
Mueller, S. (2024) · Environmental Sciences Europe · doi:10.1186/s12302-024-00966-x · Cited by 11
Neuroprotective effect of NSCs-derived extracellular vesicles in Parkinson’s disease models
Díaz-Reyes, M., Gatti, S., Delgado‐Ocaña, S., Ortega, H. H., & Banchio, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-87238-7 · Cited by 14
Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases
Cheng, Z., Lu, W., Shao, W., Zhang, C., She, Y., Song, R., Qi, R., Song, J., Zhang, W., Chang, X., et al. (2025) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2025.101052 · Cited by 11
Self-citationInvolvement of miRNAs in the Cluster of Metabolic Factors of MetS: Nutrition-Genome-MetS Axis
Ağagündüz, D., Çelik, M. N., Güneş, B. D., Atabılen, B., Sarıkaya, B., İçer, M. A., & Budán, F. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124234 · Cited by 11
Omics map of bioactive constituents in Lonicera japonica flowers under salt stress
Cai, Z., Wang, C., Chen, C., Chen, H., Yang, R. L., Chen, J., Chen, J., Tan, M., Mei, Y., Wei, L., et al. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.113526 · Cited by 11
Self-citationDiet-derived transmission of MicroRNAs from host plant into honey bee Midgut
Gharehdaghi, L., Bakhtiarizadeh, M. R., He, K., Harkinezhad, T., Tahmasbi, G., & Li, F. (2021) · BMC Genomics · doi:10.1186/s12864-021-07916-4 · Cited by 11
Long-Term Efficacy and Safety of RNAi-Mediated Virus Resistance in ‘HoneySweet’ Plum
Singh, K., Callahan, A. M., Smith, B. J., Malinowski, T., Scorza, R., Jarošová, J., Beoni, E., Poläk, J., Kundu, J. K., & Dardick, C. D. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.726881 · Cited by 11
Role of Dietary Phytochemicals in Targeting Human miRNAs for Cancer Prevention and Treatment
Kesavan, Y., Srinivasan, S. S., Pathak, S., & Ramalingam, S. (2023) · Current Gene Therapy · doi:10.2174/1566523223666230519124519 · Cited by 11
Liu, Y.-D., Chen, H.-R., Zhang, Y., Yan, G., Yan, H.-J., Zhu, Q., & Peng, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1255668 · Cited by 11
Self-citationChen, L., Liang, J., Zhang, Q., Yang, C., Lu, H., Zhang, R., Chen, K., Wang, S., Li, M., Zhang, S., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.129077 · Cited by 11
Self-citationChen, D., Chen, F., Chen, C., Chen, X., & Mao, Y. (2017) · Science China Life Sciences · doi:10.1007/s11427-017-9065-3 · Cited by 11
Self-citationLu, X., Fan, W., Feng, Q., Qi, Y., Liu, C., & Li, Z. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201805502 · Cited by 11
Xiao, X., Sticht, C., Yin, L., Liu, L., Karakhanova, S., Yin, Y., Georgikou, C., Gladkich, J., Groß, W., Gretz, N., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27527 · Cited by 11
Self-citationKim, Y., Takahashi, S., & Miyao, M. (2022) · Plant Signaling & Behavior · doi:10.1080/15592324.2022.2041280 · Cited by 11
An introduction to microRNAs and their dysregulation in psychiatric disorders
Chao, Y.-L., & Chen, C. (2013) · Tzu Chi Medical Journal · doi:10.1016/j.tcmj.2012.12.003 · Cited by 11
Non-coding RNAs as potent tools for crop improvement
Liu, R., & Zhu, J. (2014) · National Science Review · doi:10.1093/nsr/nwu006 · Cited by 11
First feed affects the expressions of microRNA and their targets in Atlantic cod
Bizuayehu, T. T., Furmanek, T., Karlsen, Ø., van der Meeren, T., Edvardsen, R. B., Rønnestad, I., Hamre, K., Johansen, S., & Babiak, I. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000155 · Cited by 11
Sun, J., Xiong, J., Yao, L., Chen, T., Luo, J., Xi, Q., & Zhang, Y. (2018) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12993 · Cited by 11
Self-citationFucheng, Y., Zhang, Z., Lin, Y., Yang, L., Zhang, L., Jiaxian, P., Zhang, W., Shumin, Z., & Senlin, L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.210 · Cited by 11
Self-citationDisentangling sRNA-Seq data to study RNA communication between species
Bermúdez‐Barrientos, J. R., Ramírez‐Sánchez, O., Chow, F. W., Buck, A. H., & Abreu‐Goodger, C. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1198 · Cited by 11
Considerations for the Human Health Risk Assessment of Externally Applied dsRNA-Based Pesticides
OECD (2023) · Series on pesticides and on biocides · doi:10.1787/54852048-en · Cited by 11
Host-dependent alteration of the gut microbiota: the role of luminal microRNAs
Cuinat, C., Pan, J., & Comelli, E. M. (2025) · Microbiome Research Reports · doi:10.20517/mrr.2024.46 · Cited by 11
Peng, Y., Demidchik, V. V., Li, Y., Lei, X., Lin, Y., Zhang, Y., & Zhou, D. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112014 · Cited by 10
Self-citationYu, Y., Tan, N., Xu, Z., Tan, Z., Wang, T., Liu, H., Xu, L., Lu, D., Tang, Y., & Mai, H. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04103-z · Cited by 10
Cong, L., Zhao, Y., Pogue, A. I., & Lukiw, W. J. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918090031 · Cited by 10
Metadata
- Authors
- Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., Yin, Y., Wang, C., Zhang, T., Zhu, D., Zhang, D., Xu, J., Chen, Q., Ba, Y., Liu, J., Wang, Q., Chen, J., Wang, J., Wang, M., Zhang, Q., Zhang, J., Zen, K., & Zhang, C.-Y.
- Affiliations
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- National University of Defense Technology (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Corresponding author
- Zhang, Junfeng
- Zen, Ke
- Zhang, Chen-Yu
- ORCID
- Venue
- Cell Research
- Published
- 2011-09-20
- Volume
- 22
- Issue
- 1
- Pages
- 107-126
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3351925
- OpenAlex
- W2165374397
- Cited by
- 1,216
- References
- 56
- Citations by year
- 2026: 77 · 2025: 89 · 2024: 95 · 2023: 94 · 2022: 86 · 2021: 96 · 2020: 85 · 2019: 76 · 2018: 66 · 2017: 72 · 2016: 78 · 2015: 82 · 2014: 77 · 2013: 84 · 2012: 55
- FWCI
- 23.66
- Type
- journal article
- Language
- en
- Update notices
- erratum (2011-11-08)
- Open access
- bronze
- doi.org
- Locations
- Cell Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- Yale University
- National Natural Science Foundation of China (30771036, 973 Program, 30890032, 90608010, 30772484, 31000323, 30890044, 31071232, 30725008, 90813035)
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province (BK2008021)
- National Institutes of Health
- National Key Research and Development Program of China (2006CB503909)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- LDLRAP1, cross-kingdom regulation, serum microRNA, rice, liver, intercellular communication, biomarkers
- MeSH terms
- Adult, Animals, Diet, Female, Gene Expression Regulation, Humans, Liver, Male, Mice, Inbred C57BL, Middle Aged, Plasmids, Oryza, RNA, Messenger, Substrate Specificity, Transfection, RNA, Plant, Computational Biology, Secretory Vesicles, RNA, Untranslated, MicroRNAs, Asian People, Chromatin Immunoprecipitation, Adaptor Proteins, Signal Transducing, Mice, Young Adult, Hep G2 Cells, Herbivory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review