The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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TEAD mediates YAP-dependent gene induction and growth control

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Elucidation of a universal size-control mechanism in Drosophila and mammals

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The Biology of YAP/TAZ: Hippo Signaling and Beyond

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

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Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

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Regulation of TORC1 by Rag GTPases in nutrient response

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YAP1 increases organ size and expands undifferentiated progenitor cells

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YAP/TAZ upstream signals and downstream responses

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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

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The Hippo Signaling Network and Its Biological Functions

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Interplay between YAP/TAZ and Metabolism

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Regulation of cancer cell metabolism: Oncogenic MYC in the driver’s seat

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Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise

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The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

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Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

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Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis

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The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

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The Hippo Pathway, YAP/TAZ, and the Plasma Membrane

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Regulation of TEAD Transcription Factors in Cancer Biology

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Mechanical stiffness controls dendritic cell metabolism and function

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An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

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Dynamics of PI3K and Hippo signaling pathways during in vitro human follicle activation

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Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

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The Role of Hippo Pathway in Cancer Stem Cell Biology.

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Translational control of stem cell function

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Integration of Hippo-YAP Signaling with Metabolism

Ibar, C., & Irvine, K. D. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.06.025 · Cited by 190

miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1

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Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

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A specific tRNA half, 5’tiRNA-His-GTG, responds to hypoxia via the HIF1α/ANG axis and promotes colorectal cancer progression by regulating LATS2

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YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

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An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

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Hypoxia and cellular metabolism in tumour pathophysiology

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Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival

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Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism

Ge, H., Tian, M., Pei, Q., Tan, F., & Pei, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.631991 · Cited by 139

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growthPreprint

Koo, J. H., Plouffe, S. W., Meng, Z., Lee, D.-H., Yang, D., Lim, D., Wang, C., & Guan, K. (2019) · Genes & Development · doi:10.1101/gad.331546.119 · Cited by 133

A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer

Zhu, C., Li, L., Zhang, Z., Bi, M., Wang, H., Su, W., Hernandez, K., Liu, P., Chen, J., Chen, M., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.010 · Cited by 124

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

Cox, A. G., Tsomides, A., Yimlamai, D., Hwang, K. L., Miesfeld, J. B., Galli, G. G., Fowl, B. H., Fort, M. W., Kimberly, Y., Sullivan, M. R., et al. (2018) · The EMBO Journal · doi:10.15252/embj.2018100294 · Cited by 116

A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth

Ong, Y. T., Andrade, J., Armbruster, M., Shi, C., Castro, M., Costa, A. S. H., Sugino, T., Eelen, G., Zimmermann, B., Wilhelm, K., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00584-y · Cited by 113

A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations

Yamaguchi, H., & Taouk, G. M. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00928 · Cited by 106

The Mammalian Crumbs Complex Defines a Distinct Polarity Domain Apical of Epithelial Tight Junctions

Tan, B., Yatim, S. M. J. M., Peng, S., Gunaratne, J., Hunziker, W., & Ludwig, A. (2020) · Current Biology · doi:10.1016/j.cub.2020.05.032 · Cited by 98

Multifaceted regulation and functions of YAP/TAZ in tumors (Review)

Liu, H., Du, S., Lei, T., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Oncology Reports · doi:10.3892/or.2018.6423 · Cited by 95

The Hippo Tumor Suppressor Pathway (YAP/TAZ/TEAD/MST/LATS) and EGFR-RAS-RAF-MEK in cancer metastasis

Zinatizadeh, M. R., Miri, S. R., Zarandi, P. K., Chalbatani, G. M., Rapôso, C., Mirzaei, H. R., Akbari, M. E., & Mahmoodzadeh, H. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.11.003 · Cited by 98

Glutamine‐utilizing transaminases are a metabolic vulnerability of TAZ/YAP‐activated cancer cells

Yang, C., Stampouloglou, E., Kingston, N. M., Zhang, L., Monti, S., & Varelas, X. (2018) · EMBO Reports · doi:10.15252/embr.201643577 · Cited by 97

Cell-intrinsic PD-1 promotes proliferation in pancreatic cancer by targeting CYR61/CTGF via the hippo pathway

Pu, N., Gao, S., Yin, H., Li, J.-A., Wu, W., Fang, Y., Zhang, L., Rong, Y., Xu, X., Wang, D., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.06.013 · Cited by 91

TEAD1 (TEA Domain Transcription Factor 1) Promotes Smooth Muscle Cell Proliferation Through Upregulating SLC1A5 (Solute Carrier Family 1 Member 5)-Mediated Glutamine Uptake

Osman, I., He, X., Liu, J., Dong, K., Wen, T., Zhang, F., Yu, L., Hu, G., Xin, H., Zhang, W., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314187 · Cited by 89

Current Advances in 3D Bioprinting for Cancer Modeling and Personalized Medicine

Germain, N., Dhayer, M., Dekiouk, S., & Marchetti, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073432 · Cited by 95

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

Xing, N., Du, Q., Guo, S., Xiang, G., Zhang, Y., Meng, X., Li, X., & Wang, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01407-z · Cited by 91

KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops

Eibl, G., & Rozengurt, E. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.10.007 · Cited by 88

Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma

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The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae

Rausch, V., Bostrom, J. R., Park, J., Bravo, I. R., Feng, Y., Hay, D. C., Link, B. A., & Hansen, C. G. (2018) · Current Biology · doi:10.1016/j.cub.2018.11.066 · Cited by 90

The Hippo Pathway in Prostate Cancer

Salem, O., & Hansen, C. G. (2019) · Cells · doi:10.3390/cells8040370 · Cited by 89

Promotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

Chen, S., Zheng, Y., Zhang, S., Jia, L., & Zhou, Y. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.01.028 · Cited by 82

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

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SLC3A2 promotes tumor‐associated macrophage polarization through metabolic reprogramming in lung cancer

Li, Z., Chen, S., He, X., Gong, S., Sun, L., & Weng, L. (2023) · Cancer Science · doi:10.1111/cas.15760 · Cited by 86

Regulation of the Hippo pathway in cancer biology

Moon, S., Park, S. Y., & Park, H. W. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2804-1 · Cited by 77

Enzymatic potential for the valorization of agro-industrial by-products

Barcelos, M. C. S., Ramos, C. L., Kuddus, M., Rodríguez‐Couto, S., Srivastava, N., Ramteke, P. W., Mishra, P. K., & Molina, G. (2020) · Biotechnology Letters · doi:10.1007/s10529-020-02957-3 · Cited by 75

The polycystic ovary syndrome-associated gene Yap1 is regulated by gonadotropins and sex steroid hormones in hyperandrogenism-induced oligo-ovulation in mouse

Ji, S., Liu, X., Li, B.-T., Zhang, Y., Liu, H., Zhang, Y., Chen, Z., Liu, J., & Fan, H. (2017) · Molecular Human Reproduction · doi:10.1093/molehr/gax046 · Cited by 70

The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth

Gonzalez, S., & Rallis, C. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00061 · Cited by 70

Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting

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Dysregulation of the Hippo pathway signaling in aging and cancer

Yeung, Y. T., Guerrero‐Castilla, A., Cano, M., Muñoz, M. F., Ayala, A., & Argüelles, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.018 · Cited by 62

Crosstalk between Hypoxia and Extracellular Matrix in the Tumor Microenvironment in Breast Cancer

Dekker, Y., Dévédec, S. E. L., Danen, E. H. J., & Liu, Q. (2022) · Genes · doi:10.3390/genes13091585 · Cited by 66

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

Kandasamy, P., Zlobec, I., Nydegger, D. T., Pujol‐Giménez, J., Bhardwaj, R., Shirasawa, S., Tsunoda, T., & Hediger, M. A. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12999 · Cited by 60

In Vitro Activation Early Follicles: From the Basic Science to the Clinical Perspectives

Vo, K., & Kawamura, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073785 · Cited by 60

WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendotheliomaPreprint

Driskill, J. H., Zheng, Y., Wu, B.-K., Wang, L., Cai, J., Rakheja, D., Dellinger, M. T., & Pan, D. (2021) · Genes & Development · doi:10.1101/gad.348221.120 · Cited by 57

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Kaya-Çopur, A., Marchianò, F., Hein, M. Y., Alpern, D., Russeil, J., Luis, N. M., Mann, M., Deplancke, B., Habermann, B. H., & Schnorrer, F. (2021) · eLife · doi:10.7554/elife.63726 · Cited by 56

Activity of sirolimus in patients with progressive epithelioid hemangioendothelioma: A case‐series analysis within the Italian Rare Cancer Network

Stacchiotti, S., Simeone, N., Vullo, S. L., Baldi, G. G., Brunello, A., Vincenzi, B., Palassini, E., Dagrada, G. P., Collini, P., Morosi, C., et al. (2020) · Cancer · doi:10.1002/cncr.33247 · Cited by 55

High-Intensity Functional Training: Molecular Mechanisms and Benefits

Ben-Zeev, T., & Okun, E. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08638-8 · Cited by 60

Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway

Watt, K. I., Harvey, K. F., & Gregorevic, P. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00942 · Cited by 51

YAP accelerates vascular senescence via blocking autophagic flux and activating mTOR

Pan, X., Wu, B., Fan, X., Xu, G., Ou, C., & Chen, M. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15902 · Cited by 51

The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications

Kahlhofer, J., & Teis, D. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13821 · Cited by 51

Prostaglandin E 2 secreted by mesenchymal stem cells protects against acute liver failure via enhancing hepatocyte proliferation

Liu, Y., Ren, H., Wang, J., Yang, F., Li, J., Zhou, Y., Yuan, X., Zhu, W., & Shi, X. (2018) · The FASEB Journal · doi:10.1096/fj.201801349rr · Cited by 50

Hippo‐Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior

van Soldt, B. J., & Cardoso, W. V. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.371 · Cited by 50

The Hippo signal transduction network for exercise physiologists

Gabriel, B. M., Hamilton, D. L., Tremblay, A. M., & Wackerhage, H. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01076.2015 · Cited by 48

Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential

Lv, L., & Zhou, X. (2023) · MedComm · doi:10.1002/mco2.375 · Cited by 46

YAP regulates cell size and growth dynamics via non-cell autonomous mediators

Mugahid, D., Kalocsay, M., Liu, X., Gruver, J. S., Peshkin, L., & Kirschner, M. W. (2020) · eLife · doi:10.7554/elife.53404 · Cited by 52

Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma

Molina, E. R., Chim, L. K., Salazar, M. C., Mehta, S. M., Menegaz, B. A., Lamhamedi-Cherradi, S.-E., Satish, T., Mohiuddin, S., McCall, D. C., Zaske, A. M., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.09.029 · Cited by 48

The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer

Lu, X. (2019) · Current Cancer Drug Targets · doi:10.2174/1568009619666190802135714 · Cited by 46

Exercise-specific adaptations in human skeletal muscle: Molecular mechanisms of making muscles fit and mighty

Thomas, A. C. Q., Stead, C. A., Burniston, J. G., & Phillips, S. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.010 · Cited by 57

Epithelioid Hemangioendothelioma as a Model of YAP/TAZ-Driven Cancer: Insights from a Rare Fusion Sarcoma

Lamar, J. M., Nehru, V. M., & Weinberg, G. L. (2018) · Cancers · doi:10.3390/cancers10070229 · Cited by 42

Amino Acid Transporters Are a Vital Focal Point in the Control of mTORC1 Signaling and Cancer

Cormerais, Y., Vučetić, M., Parks, S. K., & Pouysségur, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010023 · Cited by 45

Together we stand, apart we fall: how cell-to-cell contact/interplay provides resistance to ferroptosis

Vučetić, M., Daher, B., Cassim, S., Meira, W., & Pouysségur, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02994-w · Cited by 40

Induction of miR-15a expression by tripterygium glycosides caused premature ovarian failure by suppressing the Hippo-YAP/TAZ signaling effector Lats1

Ai, A., Xiong, Y., Wu, B., Lin, J., Huang, Y., Cao, Y., & Liu, T. (2018) · Gene · doi:10.1016/j.gene.2018.08.018 · Cited by 39

YAP/TAZ-mediated activation of serine metabolism and methylation regulation is critical for LKB1-deficient breast cancer progression

Wu, Q., Li, J., Sun, S., Chen, X., Zhang, H., Li, B., & Sun, S. (2017) · Bioscience Reports · doi:10.1042/bsr20171072 · Cited by 38

Hippo Pathway and Skeletal Muscle Mass Regulation in Mammals: A Controversial Relationship

Gnimassou, O., Francaux, M., & Deldicque, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00190 · Cited by 38

Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE 2 Cascade

Liu, Y., He, J., Li, B., Meng, Y., Wang, H., Tan, L., Liu, M., Lv, X., Lv, H., Zhang, X., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12834 · Cited by 38

Regulation of Hippo signaling pathway in cancer: A MicroRNA perspective

Samji, P., Rajendran, M. K., Warrier, V. P., Ganesh, A., & Karunagaran, D. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109858 · Cited by 40

Phosphorylated mTOR and YAP serve as prognostic markers and therapeutic targets in gliomas

Liu, M., Lin, Y., Zhang, X.-C., Tan, Y., Yao, Y., Tan, J., Zhang, X., Cui, Y., Liu, X., Wang, Y., et al. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.70 · Cited by 37

The role of extracellular biophysical cues in modulating the Hippo-YAP pathway

Mo, J. (2017) · BMB Reports · doi:10.5483/bmbrep.2017.50.2.199 · Cited by 39

mTOR Signaling Components in Tumor Mechanobiology

Gargalionis, A. N., Papavassiliou, K. A., Basdra, E. K., & Papavassiliou, A. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031825 · Cited by 36

Ubiquitylation and endocytosis of the human LAT1/SLC7A5 amino acid transporter

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Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment

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