The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Human Intestinal Barrier Function in Health and Disease
Open accessAbstract
The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed. In addition, the effect of the frequently prescribed drugs proton pump inhibitors and non-steroidal anti-inflammatory drugs on intestinal permeability, as well as commonly used methods to assess barrier function will be reviewed.
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Cites
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“coli also possess an attaching and effacement locus, but exert less profound effects on the barrier.(16) One reported difference is the increased expression of claudin-2, which forms cationselective channels in the paracellular space, resulting in water transportation across the TJs.”
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Self-citationReview article: the role of butyrate on colonic function
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Self-citationDietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
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Intestinal permeability – a new target for disease prevention and therapy
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Self-citationIncreased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
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So depression is an inflammatory disease, but where does the inflammation come from?
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Cited by
Human gut microbiome: Hopes, threats and promises
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386
Self-citationThe intestinal barrier: a fundamental role in health and disease
Vancamelbeke, M., & Vermeire, S. (2017) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1343143 · Cited by 1,287
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Brain-Gut-Microbiota Axis in Alzheimer’s Disease
Kowalski, K., & Mulak, A. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18087 · Cited by 826
Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway
Singh, R., Chandrashekharappa, S., Bodduluri, S. R., Baby, B. V., Hegde, B., Kotla, N. G., Hiwale, A. A., Saiyed, T., Patel, P., Vijay-Kumar, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07859-7 · Cited by 713
Metadata
- Authors
- König, J., Wells, J., Cani, P. D., García-Ródenas, C. L., MacDonald, T., Mercenier, A., Whyte, J., Troost, F., & Brummer, R.-J.
- Venue
- Clinical and Translational Gastroenterology
- Published
- 2016-10
- Volume
- 7
- Issue
- 10
- Pages
- e196
- ISSN
- 2155-384X (ISSN-L)
- OpenAlex
- W2535932582
- Cited by
- 780
- References
- 28
- FWCI
- 55.42
- Type
- journal article
- Language
- en
- Open access
- gold
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- König, J., Wells, J., Cani, P. D., García-Ródenas, C. L., MacDonald, T., Mercenier, A., Whyte, J., Troost, F., & Brummer, R.-J. (2016). Human Intestinal Barrier Function in Health and Disease. Clinical and Translational Gastroenterology. https://doi.org/10.1038/ctg.2016.54
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
