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Cited by 97Lipoproteins and Cardiovascular HealthFood composition and propertiesNatural Products and Biological Research

Time- and dose-dependent effect of psyllium on serum lipids in mild-to-moderate hypercholesterolemia: a meta-analysis of controlled clinical trials

Wei, Z-h, Wang, H, Chen, X-y, Wang, B-s, Rong, Z-x, Wang, B-s, Su, B-h, Chen, H-z·2009·European Journal of Clinical Nutrition
DOI 10.1038/ejcn.2008.49
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Abstract

Objectives Evidences from randomized clinical trials and meta-analysis have claimed an association between the use of soluble dietary fiber from psyllium and a cholesterol-lowering effect. However, there is still uncertainty as to the dose-response relationship and its long-term lipid-lowering efficacy. This meta-analysis was primarily conducted to address the dose-response relationship between psyllium and serum cholesterol level and time-dependent effect of psyllium in mild-to-moderate hypercholesterolemic subjects.Methods Twenty-one studies, which enrolled a total of 1030 and 687 subjects receiving psyllium or placebo, respectively, were included in the meta-analysis. The studies were randomized placebo-controlled trials, double blinded or open label, on subjects with mild-to-moderate hypercholesterolemia. The dose of psyllium was between 3.0 and 20.4 g per day and intervention period was more than 2 weeks. Any type of diet background was permitted. Diet lead-in period was between 0 and 8 weeks.Results Compared with placebo, consumption of psyllium lowered serum total cholesterol by 0.375 mmol/l (95% CI: 0.257-0.494 mmol/l), and LDL cholesterol by 0.278 mmol/l (95% CI: 0.213-0.312 mmol/l). With random-effect meta-regression, a significant dose-response relationship were found between doses (3-20.4 g/day) and total cholesterol or LDL cholesterol changes. Regression model of total cholesterol was -0.0222+0.2061 x log (dose+1), and that of LDL cholesterol was 0.0485+0.1390 x log (dose+1). There was a time effect of psyllium on total cholesterol (equation: 6.3640-0.0316 x treatment period) and on LDL cholesterol (equation: 4.3134-0.0162 x treatment period), suggesting that psyllium reduced serum total cholesterol more quickly than LDL cholesterol.Conclusions Psyllium could produce dose- and time-dependent serum cholesterol-lowering effect in mild and moderate hypercholesterolemic patients and would be useful as an adjunct to dietary therapy for the treatment of hypercholesterolemia.

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Authors
Wei, Z.-H., Wang, H., Chen, X.-Y., Wang, B.-S., Rong, Z.-X., Wang, B.-S., Su, B.-H., & Chen, H.-Z.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Chen, H-z
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2008-11-05
Volume
63
Issue
7
Pages
821-827
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/ejcn.2008.49
OpenAlex
W1968963621
Cited by
96
References
42
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 13 · 2017: 11 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 6
FWCI
0.11
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
Keywords
psyllium, soluble dietary fiber, hypercholesterolemia, serum cholesterol, LDL cholesterol, total cholesterol, dose-response relationship, time-dependent effects, cholesterol-lowering effect, randomized controlled trials, meta-regression, treatment duration, dietary fiber supplementation, cardiovascular risk reduction, dietary fiber intake
MeSH terms
Anticholesteremic Agents, Cholesterol, Dose-Response Relationship, Drug, Food, Fortified, Humans, Hypercholesterolemia, Cholesterol, HDL, Cholesterol, LDL, Psyllium, Time Factors, Triglycerides, Randomized Controlled Trials as Topic, Laxatives

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