The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women
Open accessAbstract
Background/objectives The results of short-term studies in humans suggest that, compared with glucose, acute consumption of fructose leads to increased postprandial energy expenditure and carbohydrate oxidation and decreased postprandial fat oxidation. The objective of this study was to determine the potential effects of increased fructose consumption compared with isocaloric glucose consumption on substrate utilization and energy expenditure following sustained consumption and under energy-balanced conditions.Subjects/methods As part of a parallel arm study, overweight/obese male and female subjects, 40-72 years, consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Energy expenditure and substrate utilization were assessed using indirect calorimetry at baseline and during the 10th week of intervention.Results Consumption of fructose, but not glucose, led to significant decreases of net postprandial fat oxidation and significant increases of net postprandial carbohydrate oxidation (P<0.0001 for both). Resting energy expenditure (REE) decreased significantly from baseline values in subjects consuming fructose (P=0.031) but not in those consuming glucose.Conclusions Increased consumption of fructose for 10 weeks leads to marked changes of postprandial substrate utilization including a significant reduction of net fat oxidation. In addition, we report that REE is reduced compared with baseline values in subjects consuming fructose-sweetened beverages for 10 weeks.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“fructose contained in sugar sweetened beverages is suggested to likely induce the onset of obesity by reducing resting energy expenditure and promoting leptin resistance.102 103”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [102]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982
New methods for calculating metabolic rate with special reference to protein metabolism
Weir, J. B. D. V. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004363 · Cited by 5,688
A new predictive equation for resting energy expenditure in healthy individuals
Mifflin, M., St Jeor, S., Hill, L., Scott, B., Daugherty, S., & Koh, Y. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.2.241 · Cited by 2,544 · cited 10×
“Daily energy intake was calculated at baseline using the Mifflin equation to estimate REE (Mifflin et al., 1990) and adjusted for activity using a multiplication factor of 1.”
MethodInfluentialCalculation of substrate oxidation rates in vivo from gaseous exchange.
Frayn, K. N. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.2.628 · Cited by 2,365
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765
Self-citationFructose, weight gain, and the insulin resistance syndrome,,
Elliott, S. S., Keim, N. L., Stern, J. S., Teff, K. L., & Havel, P. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.911 · Cited by 1,031
Self-citationIntermediary metabolism of fructose
Mayes, P. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.754s · Cited by 669
Havel, P. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00132.x · Cited by 607
Self-citationMechanisms for the acute effect of fructose on postprandial lipemia
Chong, M. F., Fielding, B. A., & Frayn, K. N. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1511 · Cited by 367
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–132 of 132
Casperson, S. L., Hall, C., & Roemmich, J. N. (2017) · BMC Nutrition · doi:10.1186/s40795-017-0170-2 · Cited by 6
“This acute effect on net fat oxidation leads to preferential increases in visceral adipose tissue when consumed daily over long periods [12, 13].”
BackgroundPrice, C. A., Medici, V., Nuñez, M. V., Lee, V., Sigala, D. M., Benyam, Y., Keim, N. L., Mason, A. E., Chen, S., Parenti, M., et al. (2021) · Nutrients · doi:10.3390/nu13030760 · Cited by 5
Self-citationVieira, F. O., Leal, V. D. O., Stockler‐Pinto, M. B., Barros, A. D. F., Borges, N. A., Lobo, J. C., & Mafra, D. (2014) · PubMed · doi:10.3305/nh.2015.31.2.7796 · Cited by 6
Nogueira, S., Garcez, F., Sá, S., Moutinho, L. C., Cardoso, A., Soares, R. A., Fonseca, B. M., & Leal, S. M. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02092-2 · Cited by 4
“Indeed, it is documented that the consumption of fructose-sweetened beverage and high-fat/ high-glucose diet can decrease the urea cycle in adult rats (Cox et al. 2012; Moreno-Fernández et al. 2018).”
BackgroundGugliucci, A. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14103559 · Cited by 3
“Increased hepatic DNL (the metabolic pathway that produces new fatty acids from precursor molecules) has been related to these changes in the liver and circulating TG levels [28,54,55,69,78–81].”
Abe, T., Yamamoto, S., Konishi, T., Takahashi, Y., & Oishi, K. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.07.003 · Cited by 3
Alireza, H. (2021) · International Journal of Membrane Science and Technology · doi:10.15379/2410-1869.2021.08.02.04 · Cited by 3
Glucose- and Fructose-Induced Toxicity in the Liver and Brain
Farooqui, A. A. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7318-3_2 · Cited by 3
Strober, J. W., Fernandez, S., Ye, H., & Brady, M. (2022) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00174.2021 · Cited by 2
Exploring Glyoxalase Strategies for Managing Sugar-Induced Chronic Diseases
Gugliucci, A. (2025) · Life · doi:10.3390/life15050794 · Cited by 2
Native American Ancestry and Susceptibility to Mesoamerican Nephropathy
Sato, Y., Yracheta, J., Roncal-Jiménez, C. A., Li, A., & Johnson, R. J. (2025) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2025.05.003 · Cited by 2
Neurochemical Effects of Long Term Consumption of Simple Carbohydrates
Farooqui, A. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-15254-7_3 · Cited by 2
A Short-Term Sucrose Diet Impacts Cell Proliferation of Neural Precursors in the Adult Hypothalamus
Recabal, A., López, S., Salgado, M., Palma, A., Obregón, A. M., Elizondo-Vega, R. J., Sáez, J. C., & García, M. D. L. Á. (2022) · Nutrients · doi:10.3390/nu14132564 · Cited by 2
“Indeed, subjects consuming fructose-sweetened beverages have decreased postprandial fat oxidation along with decreased resting energy expenditure, compared with subjects consuming an equivalent level of calories in glucose-sweetened beverages [26].”
BackgroundBeraza, N. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.011 · Cited by 2
Do not overlook the role of fructose in obesity
Nakagawa, T., & Johnson, R. J. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01198-2 · Cited by 1
Sugar Shockwaves: How the Fructose–Glucose–ChREBP Pathway Hijacks Liver Metabolism
Gugliucci, A. (2026) · Life · doi:10.3390/life16081313 · Cited by 1
So steuern Sie das Essverhalten Ihrer Patienten in die richtige Richtung
Lechner, K., & Parhofer, K. G. (2016) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-016-8060-0 · Cited by 1
“Bei Übergewichtigen wurde der Konsum von Fruktose im Vergleich zu isokalorischem Konsum von Glukose mit nachteiligen E ̈ekten auf den Sto ̈wechsel [31] sowie der Entwicklung von mehreren Komponenten des metabolischen Syndroms [32, 33] in Zusammenhang gebracht.”
BackgroundStenvinkel, P. (2019) · Springer eBooks · doi:10.1007/978-3-319-97765-2_19 · Cited by 1
Sugar reduction and sweeteners to improve foods
García-Cordero, A. L., Ibarra, I. S., Ferreira, A., Rodríguez, J. A., Pateiro, M., & Santos, E. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15346-4.00004-5 · Cited by 2
Risk Factors for Type II Diabetes: The Role of Ultra-processed Foods
Oh, H. (2025) · Springer eBooks · doi:10.1007/978-3-031-32047-7_71-1 · Cited by 1
Boissons caloriques sucrées et prise de poids : quel mécanisme d’action ?
Fantino, M. (2012) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2012.02.002 · Cited by 1
Camps, S. G., Koh, H. R., Wang, N. X., & Henry, C. J. (2018) · Nutrition · doi:10.1016/j.nut.2018.06.024 · Cited by 1
Stanhope, K. L. (2015) · Wiley eBooks · doi:10.1002/9781119121725.ch5 · Cited by 1
Self-citationFructose, Sugar Consumption, and Metabolic Diseases
Lecoultre, V., & Tappy, L. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch31
Jämförelse mellan glukos–fruktos sirap och sackaros avseende viktutveckling
Lennartsson, E., & Ekman, I. E. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Caloric sweetened beverages and body weight increase: Which mechanism?
Fantino, M. (2012)
Damascena, H. L. (2016) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2016.06.d.21746
Dietary sugar intake: Public health perspective
Margina, D. M., & Ungurianu, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824315-2.00071-3 · Cited by 1
Liu, Z., Huang, H., Xie, J., Hou, L., & Xu, C. (2023) · Figshare · doi:10.6084/m9.figshare.24770264
Guirette, M., Haslam, D. E., Ma, J., Havel, P. J., Stanhope, K. L., Ilkayeva, O., Newgard, C. B., McKeown, N. M., & Herman, M. A. (2026) · Journal of the Endocrine Society · doi:10.1210/jendso/bvag097
Self-citation
Metadata
- Authors
- Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Havel, P. J., & Keim, N. L.
- Affiliations
- University of California, Davis (US)
- Touro University California (US)
- Vanderbilt University (US)
- United States Department of Agriculture (US)
- Corresponding author
- Keim, N L
- Venue
- European Journal of Clinical Nutrition
- Published
- 2011-09-28
- Volume
- 66
- Issue
- 2
- Pages
- 201-208
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- PMC
- PMC3252467
- OpenAlex
- W2121517321
- Cited by
- 132
- References
- 30
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 11 · 2022: 13 · 2021: 5 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 10 · 2013: 11 · 2012: 6
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Diabetes Association (UL1 RR024146)
- U.S. Department of Agriculture (5306‐51530‐019‐00D, UL1 RR024146, 5306‐51530‐019)
- National Institutes of Health (5r01hl075675-05, 5r01hl091333-02, HL‐091333, RR024146)
- University of California, Davis (RR024146, UL1 RR024146)
- Agricultural Research Service
- National Heart, Lung, and Blood Institute (R01 HL-075675, R01 HL-091333, HL-091333, R01HL107256)
- National Center for Research Resources (UL1RR024146)
- National Center for Complementary and Integrative Health (AT0-02993, AT0-03545, AT 002599, R21AT002993, R21AT002599)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- fructose, glucose, fat oxidation, energy expenditure, resting energy expenditure, substrate utilization, carbohydrate oxidation, overweight, obesity, energy balance, postprandial metabolism
- MeSH terms
- Aged, Basal Metabolism, Beverages, Energy Intake, Energy Metabolism, Female, Fructose, Glucose, Humans, Male, Middle Aged, Obesity, Oxidation-Reduction, Sweetening Agents, Dietary Sucrose, Carbohydrate Metabolism, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
