Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

Havel, Peter J.

doi:10.1111/j.1753-4887.2005.tb00132.x

Cited by 607Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityBiochemical Analysis and Sensing Techniques

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

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Havel, Peter J.·2005·Nutrition Reviews

DOI 10.1111/j.1753-4887.2005.tb00132.x

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Abstract

Fructose intake and the prevalence of obesity have both increased over the past two to three decades. Compared with glucose, the hepatic metabolism of fructose favors lipogenesis, which may contribute to hyperlipidemia and obesity. Fructose does not increase insulin and leptin or suppress ghrelin, which suggests an endocrine mechanism by which it induces a positive energy balance. This review examines the available data on the effects of dietary fructose on energy homeostasis and lipid/carbohydrate metabolism. Recent publications, studies in human subjects, and areas in which additional research is needed are emphasized.

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Foods that contain potent substrates for triglyceride production such as simple sugars, fructose, and alcohol can substantially increase triglyceride levels in susceptible people.
“Foods that contain potent substrates for triglyceride production such as simple sugars, fructose, and alcohol can substantially increase triglyceride levels in susceptible people (80, 81).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [80]
The “Fructose and Lipids” section reports increased triglycerides after fructose and high-sucrose diets, including dose-dependent effects in hyperinsulinemic subjects. “Fructose Metabolism” explains how fructose supplies substrates for triglyceride production. Our copy does not establish the claim’s additional point about alcohol. (LLM, conf=0.88)
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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids
Trumbo, P., Schlicker, S., Yates, A. A., & Poos, M. (2002) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(02)90346-9 · Cited by 5,993 · see citing works
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Hedley, A. A., Ogden, C., Johnson, C. L., Carroll, M., Curtin, L. R., & Flegal, K. (2004) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.291.23.2847 · Cited by 4,670 · see citing works
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
Cummings, D., Weigle, D., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,499 · see citing works
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494 · see citing works
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346 · see citing works
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works
Circulating Ghrelin Levels Are Decreased in Human Obesity
Tschöp, M. H., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, É., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 1,992 · see citing works
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990 · see citing works
Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies
Hokanson, J. E., & Austin, M. A. (1996) · Journal of Cardiovascular Risk · doi:10.1097/00043798-199604000-00014 · Cited by 1,706 · see citing works
Modern Nutrition in Health and Disease
Solomons, N. W. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.4.643 · Cited by 1,690 · see citing works
Sugar-Sweetened Beverages, Weight Gain, and Incidence of Type 2 Diabetes in Young and Middle-Aged Women
Schulze, M. B. (2004) · JAMA · doi:10.1001/jama.292.8.927 · Cited by 1,639 · see citing works
Inhibition of Food Intake in Obese Subjects by Peptide YY <sub>3–36</sub>
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works
Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482 · see citing works
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411 · see citing works
Disordered Fat Storage and Mobilization in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
Lewis, G. F., Carpentier, A. C., Adeli, K., & Giacca, A. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.2.0461 · Cited by 1,328 · see citing works
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
Boden, G., & Shulman, G. I. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.32.s3.3.x · Cited by 1,300 · see citing works
Leptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · see citing works
Ghrelin causes hyperphagia and obesity in rats.
Wren, A., Small, C., Abbott, C., Dhillo, W., Seal, L., Cohen, M., Batterham, R., Taheri, S., Stanley, S., Ghatei, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2540 · Cited by 1,197 · see citing works
A Prospective Study of Triglyceride Level, Low-Density Lipoprotein Particle Diameter, and Risk of Myocardial Infarction
Stampfer, M. J. (1996) · JAMA · doi:10.1001/jama.1996.03540110036029 · Cited by 1,085 · see citing works
Hypertriglyceridemia as a cardiovascular risk factor
Austin, M. A., Hokanson, J. E., & Edwards, K. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00031-9 · Cited by 1,066 · see citing works
Human distribution and release of a putative new gut hormone, peptide YY
Adrian, T. E., Ferri, G., Bacarese-Hamilton, A. J., Fuessl, H. S., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90211-2 · Cited by 1,064 · see citing works
Fructose, weight gain, and the insulin resistance syndrome,,
Elliott, S. S., Keim, N. L., Stern, J. S., Teff, K. L., & Havel, P. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.911 · Cited by 1,031 · see citing works
Self-citation
Autonomic regulation of islet hormone secretion – Implications for health and disease
Bo, A.-R. (2000) · Diabetologia · doi:10.1007/s001250051322 · Cited by 843 · see citing works
Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial
James, J., Thomas, P., Cavan, D., & Kerr, D. (2004) · BMJ · doi:10.1136/bmj.38077.458438.ee · Cited by 827 · see citing works
Effect of fasting on serum leptin in normal human subjects
Boden, G. (1996) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.9.3419 · Cited by 809 · see citing works
Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects.
Sinha, M. K., Ohannesian, J. P., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Magosin, S., Marco, C. C., & Caro, J. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118551 · Cited by 785 · see citing works
Soft Drink Consumption Among US Children and Adolescents
HARNACK, L., STANG, J., & STORY, M. (1999) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(99)00106-6 · Cited by 777 · see citing works
Dietary Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women
Teff, K. L., Elliott, S. S., Tschöp, M. H., Kieffer, T. J., Rader, D. J., Heiman, M. L., Townsend, R. R., Keim, N. L., D’Alessio, D. D., & Havel, P. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031855 · Cited by 738 · see citing works
Self-citation
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736 · see citing works
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-861 · Cited by 719 · see citing works
The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members
Joost, H.-G., & Thorens, B. (2001) · Molecular Membrane Biology · doi:10.1080/09687680110090456 · Cited by 719 · see citing works
Triglyceride Concentration and Ischemic Heart Disease
Jeppesen, J., Hein, H. O., Suadicani, P., & Gyntelberg, F. (1998) · Circulation · doi:10.1161/01.cir.97.11.1029 · Cited by 673 · see citing works
Intermediary metabolism of fructose
Mayes, P. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.754s · Cited by 669 · see citing works
Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects
Raben, A., Vasilaras, T. H., Møller, A. C., & Astrup, A. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.721 · Cited by 667 · see citing works
Update on Adipocyte Hormones
Havel, P. J. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s143 · Cited by 625 · see citing works
Self-citation
Elevated plasma ghrelin levels in Prader–Willi syndrome
Cummings, D. E., Clément, K., Purnell, J., Vaisse, C., Foster, K. E., Frayo, R. S., Schwartz, M., Basdevant, A., & Weigle, D. (2002) · Nature Medicine · doi:10.1038/nm0702-643 · Cited by 622 · see citing works
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · cited 1× · see citing works
“These effects are associated with reduced triglyceride deposition in liver and skeletal muscle.(164,165) It is now abundantly clear that leptin has a crucial role in the”
Background
Contribution of Polyol Pathway to Diabetes-Induced Oxidative Stress
Chung, S. S. M., Ho, E. C. M., Lam, K. S. L., & Chung, S. K. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000077408.15865.06 · Cited by 610 · see citing works
Consequences of cellular cholesterol accumulation: basic concepts and physiological implications
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16452 · Cited by 600 · see citing works
Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.
McGarry, J., Leatherman, G. F., & Foster, D. W. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34693-8 · Cited by 591 · see citing works
Key enzyme in leptin-induced anorexia
Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585 · see citing works
Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575 · see citing works
Self-citation
Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective
Horváth, T. L., Diano, S., Sótonyi, P., Heiman, M. L., & Tschöp, M. H. (2001) · Endocrinology · doi:10.1210/endo.142.10.8490 · Cited by 570 · see citing works
Consequences of cellular cholesterol accumulation: basic concepts and physiological implications
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216452 · Cited by 541 · see citing works
Food Fails to Suppress Ghrelin Levels in Obese Humans
English, P., Ghatei, M. A., Malik, I., Bloom, S. R., & Wilding, J. P. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8738 · Cited by 535 · see citing works
Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms
Parks, E. J., & Hellerstein, M. K. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.412 · Cited by 530 · see citing works
Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
Cummings, D. E., Frayo, R. S., Marmonier, C., Aubert, R., & Chapelot, D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2003 · Cited by 528 · see citing works
Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome
Grundy, S. M. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00033-2 · Cited by 525 · see citing works
Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects.
Faraj, M., Havel, P., Phélis, S., Blank, D., Sniderman, A., & Cianflone, K. (2003) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2002-021309 · Cited by 520 · see citing works
Self-citation
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Havel, P. J. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122601102 · Cited by 476 · see citing works
Self-citation
Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus
Niswender, K. D., Morrison, C. D., Clegg, D. J., Olson, R., Baskin, D. G., Myers, M. G., Seeley, R. J., & Schwartz, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.2.227 · Cited by 476 · see citing works
Dietary Carbohydrate (Amount and Type) in the Prevention and Management of Diabetes
Sheard, N. F., Clark, N. G., Brand-Miller, J. C., Franz, M. J., Pi-Sunyer, F. X., Mayer-Davis, E., Kulkarni, K., & Geil, P. (2004) · Diabetes Care · doi:10.2337/diacare.27.9.2266 · Cited by 475 · see citing works
Ghrelin Increases Energy Intake in Cancer Patients with Impaired Appetite: Acute, Randomized, Placebo-Controlled Trial
Neary, N. M., Small, C. J., Wren, A., Lee, J. L., Druce, M. R., Palmieri, C., Frost, G. S., Ghatei, M. A., Coombes, R. C., & Bloom, S. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031768 · Cited by 456 · see citing works
Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight
Tordoff, M. G., & Alleva, A. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/51.6.963 · Cited by 444 · see citing works
Manufacturing, composition, and applications of fructose
Hanover, L. M., & White, J. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.724s · Cited by 443 · see citing works
Entrainment of the diurnal rhythm of plasma leptin to meal timing.
Schoeller, D. A., Cella, L. K., Sinha, M. K., & Caro, J. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119717 · Cited by 433 · see citing works
Evidence That Glucose Metabolism Regulates Leptin Secretion from Cultured Rat Adipocytes
Mueller, W. M., Gregoire, F. M., Stanhope, K. L., Mobbs, C. V., Mizuno, T. M., Warden, C. H., Stern, J. S., & Havel, P. J. (1998) · Endocrinology · doi:10.1210/endo.139.2.5716 · Cited by 427 · see citing works
Self-citation
Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities
Niswender, K. D., & Schwartz, M. W. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00105-x · Cited by 421 · see citing works
Partial leptin deficiency and human adiposity
Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S. (2001) · Nature · doi:10.1038/35102112 · Cited by 407 · see citing works
Low Dose Leptin Administration Reverses Effects of Sustained Weight-Reduction on Energy Expenditure and Circulating Concentrations of Thyroid Hormones
Rosenbaum, M., Murphy, E. M., Heymsfield, S. B., Matthews, D. E., & Leibel, R. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.5.2391 · Cited by 407 · see citing works
Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss
Havel, P. J., Kasim-karakas, S., Mueller, W. M., Johnson, P. R., Gingerich, R. L., & Stern, J. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.12.8954050 · Cited by 406 · see citing works
Self-citation
Serum Ghrelin Levels Are Inversely Correlated with Body Mass Index, Age, and Insulin Concentrations in Normal Children and Are Markedly Increased in Prader-Willi Syndrome
Haqq, A. M., Farooqi, I. S., O’Rahilly, S., Stadler, D. D., Rosenfeld, R. G., Pratt, K. L., LAFRANCHI, S. H., & Purnell, J. Q. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021052 · Cited by 374 · see citing works
M <scp>USCLE</scp> T <scp>RIGLYCERIDE AND</scp> I <scp>NSULIN</scp> R <scp>ESISTANCE</scp>
Kelley, D. E., Goodpaster, B. H., & Storlien, L. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102912 · Cited by 364 · see citing works
Two molecular forms of Peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1–36 and PYY 3–36
Grandt, D., Schimiczek, M., Beglinger, C., Layer, P., Goebell, H., Eysselein, V. E., & Reeve, J. R. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90204-6 · Cited by 363 · see citing works
Regulation of Hepatic De Novo Lipogenesis in Humans
Hellerstein, M. K., Schwarz, J.-M., & Neese, R. A. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.002515 · Cited by 349 · see citing works
High Circulating Ghrelin: A Potential Cause for Hyperphagia and Obesity in Prader-Willi Syndrome
DelParigi, A., Tschöp, M. H., Heiman, M. L., Salbe, A. D., de Courten, B. V., Sell, S. M., Bunt, J. C., & Tataranni, P. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020871 · Cited by 348 · see citing works
Mechanisms of Hepatic Very Low Density Lipoprotein Overproduction in Insulin Resistance
Taghibiglou, C., Carpentier, A. C., Iderstine, S. C. V., Chen, B., Rudy, D., Aiton, A., Lewis, G. F., & Adeli, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8416 · Cited by 346 · see citing works
Fat and carbohydrate overfeeding in humans: different effects on energy storage
Horton, T., Drougas, H., Brachey, A., Reed, G., Peters, J., & Hill, J. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.1.19 · Cited by 339 · see citing works
National trends in soft drink consumption among children and adolescents age 6 to 17 years: Prevalence, amounts, and sources, 1977/1978 to 1994/1998
French, S. A., Lin, B., & Guthrie, J. F. (2003) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(03)01076-9 · Cited by 339 · see citing works
Trends in Intake of Energy and Macronutrients—United States, 1971-2000
(2004) · JAMA · doi:10.1001/jama.291.10.1193 · Cited by 321 · see citing works
Effects of dietary fructose on plasma lipids in healthy subjects
Bantle, J. P., Raatz, S. K., Thomas, W. T. B., & Georgopoulos, A. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1128 · Cited by 312 · see citing works
Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?
Tschöp, M., Castañeda, T. R., Joost, H., Thöne-Reineke, C., Ortmann, S., Klaus, S., Hagan, M. M., Chandler, P. C., Oswald, K., Benoit, S. C., et al. (2004) · Nature · doi:10.1038/nature02665 · Cited by 311 · see citing works
Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men,,
Anderson, G. H., Catherine, N. L. A., Woodend, D., & Wolever, T. M. S. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1023 · Cited by 310 · see citing works
Postprandial Glucose and Insulin Responses to Meals Containing Different Carbohydrates in Normal and Diabetic Subjects
Bantle, J. P., Laine, D. C., Castle, G., Thomas, J. W., Hoogwerf, B. J., & Goetz, F. C. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307073090102 · Cited by 306 · see citing works
Fatty acid regulation of very low density lipoprotein production
Lewis, G. F. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199706000-00004 · Cited by 296 · see citing works
Physiological insulinemia acutely modulates plasma leptin.
Saad, M. F., Khan, A. M., Sharma, A., Michael, R., Riad, M. G., Boyadjian, R., Jinagouda, S. D., Steil, G. M., & Kamdar, V. V. (1998) · Diabetes · doi:10.2337/diabetes.47.4.544 · Cited by 295 · see citing works
The Cephalic Insulin Response to Meal Ingestion in Humans Is Dependent on Both Cholinergic and Noncholinergic Mechanisms and Is Important for Postprandial Glycemia
Ahrén, B., & Holst, J. J. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1030 · Cited by 292 · see citing works
Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels
Weigle, D. S. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.2.561 · Cited by 287 · see citing works
Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women
Keim, N., Stern, J. S., & Havel, P. J. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.4.794 · Cited by 272 · see citing works
Self-citation
High-fat meals reduce 24-h circulating leptin concentrations in women.
Havel, P. J., Townsend, R. R., Chaump, L., & Teff, K. L. (1999) · Diabetes · doi:10.2337/diabetes.48.2.334 · Cited by 268 · see citing works
Self-citation
Impact of dietary fat content and fat oxidation on energy intake in humans
Tremblay, A., Plourde, G., Després, J., & Bouchard, C. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.5.799 · Cited by 247 · see citing works
Peptide YY3–36Inhibits Food Intake in Mice through a Melanocortin-4 Receptor-Independent Mechanism
Halatchev, I. G., Ellacott, K. L. J., Fan, W., & Cone, R. D. (2004) · Endocrinology · doi:10.1210/en.2003-1754 · Cited by 236 · see citing works
Circulating Ghrelin Is Sensitive to Changes in Body Weight during a Diet and Exercise Program in Normal-Weight Young Women
Leidy, H. J., Gardner, J. K., Frye, B. R., Snook, M. L., Schuchert, M. K., Richard, E. L., & Williams, N. I. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031471 · Cited by 235 · see citing works
Low energy reporters vs others: a comparison of reported food intakes
Krebs‐Smith, S., Graubard, B., Kahle, L., Af, S., Cleveland, L., & Ballard-Barbash, R. R. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600936 · Cited by 234 · see citing works
Sugars, hypertriglyceridemia, and cardiovascular disease
Fried, S. K., & Rao, S. P. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.873s · Cited by 232 · see citing works
A COMPARISON OF THE METABOLISM OF FRUCTOSE AND GLUCOSE IN HEPATIC DISEASE AND DIABETES MELLITUS 1
Smith, L. H., Ettinger, R. H., Seligson, D., & Lightcap, S. (1953) · Journal of Clinical Investigation · doi:10.1172/jci102736 · Cited by 231 · see citing works
Differential Responses of Circulating Ghrelin to High-Fat or High-Carbohydrate Meal in Healthy Women
Monteleone, P., Bencivenga, R., Longobardi, N., Serritella, C., & Maj, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030797 · Cited by 228 · see citing works
Foods contributing to energy intake in the US: data from NHANES III and NHANES 1999–2000
Block, G. (2004) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2004.02.007 · Cited by 223 · see citing works
Postprandial Response of Plasma Ghrelin Levels to Various Test Meals in Relation to Food Intake, Plasma Insulin, and Glucose
Erdmann, J., Töpsch, R., Lippl, F., Gussmann, P., & SCHUSDZIARRA, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031610 · Cited by 220 · see citing works
Changes of serum leptin and endocrine and metabolic parameters after 7 days of energy restriction in men and women
Dubuc, G. R., Phinney, S. D., Stern, J. S., & Havel, P. J. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90055-5 · Cited by 217 · see citing works
Self-citation
High Dietary Fructose Induces a Hepatic Stress Response Resulting in Cholesterol and Lipid Dysregulation
Kelley, G., Allan, G., & Azhar, S. (2003) · Endocrinology · doi:10.1210/en.2003-1167 · Cited by 216 · see citing works
Roles of Leptin and Ghrelin in the Loss of Body Weight Caused by a Low Fat, High Carbohydrate Diet
Weigle, D. S., Cummings, D. E., Newby, P. D., Breen, P. A., Frayo, R. S., Matthys, C. C., Callahan, H. S., & Purnell, J. Q. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021262 · Cited by 212 · see citing works
Body Weight Set-Points: Determination and Adjustment
Keesey, R. E., & Hirvonen, M. D. (1997) · Journal of Nutrition · doi:10.1093/jn/127.9.1875s · Cited by 206 · see citing works
Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism.
Consoli, A., Nurjhan, N., Reilly, J. J., Bier, D. M., & Gerich, J. E. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114940 · Cited by 204 · see citing works
Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus.
Nurjhan, N., Consoli, A., & Gerich, J. E. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115558 · Cited by 194 · see citing works
Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat
Lee, M. K., Miles, P. D. G., Khoursheed, M., Gao, K., Moossa, A. R., & Olefsky, J. M. (1994) · Diabetes · doi:10.2337/diabetes.43.12.1435 · Cited by 194 · see citing works
Cholesterol in health and disease
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216381 · Cited by 190 · see citing works
Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.
Truswell, A., Seach, J., & Thorburn, A. (1988) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.6.1424 · Cited by 189 · see citing works
Atherogenic dyslipidemia and the metabolic syndrome.
Soegondo, S. (2005) · PubMed · Cited by 187 · see citing works
Amelioration of high fructose-induced metabolic derangements by activation of PPARα
Nagai, Y., Nishio, Y., Nakamura, T., Maegawa, H., Kikkawa, R., & Kashiwagi, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00471.2001 · Cited by 186 · see citing works
Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects.
Beck-Nielsen, H., Pedersen, O., & Lindskov, H. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.2.273 · Cited by 185 · see citing works
Dietary carbohydrates and insulin sensitivity: a review of the evidence and clinical implications
Daly, M., Vale, C., Walker, M., Kg, A., & Mathers, J. C. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.5.1072 · Cited by 181 · see citing works
The Pediatric Obesity Epidemic: Causes and Controversies
Slyper, A. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031449 · Cited by 174 · see citing works
Synergy Between Leptin and Cholecystokinin (CCK) to Control Daily Caloric Intake
Cannon, C. M., Wiater, M. F., Kuijper, J. L., & Weigle, D. S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00138-1 · Cited by 171 · see citing works
Protein fructosylation: fructose and the Maillard reaction
Dills, W. (1993) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.779s · Cited by 171 · see citing works
Adolescents’ Eating Patterns Influence their Nutrient Intakes
Dwyer, J. T., EVANS, M., Stone, E. J., Feldman, H. A., Lytle, L. A., Hoelscher, D. M., Johnson, C. V., ZIVE, M. M., & YANG, M. (2001) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(01)00198-5 · Cited by 169 · see citing works
A High Fructose Diet Affects the Early Steps of Insulin Action in Muscle and Liver of Rats
Bezerra, R. M. N., Ueno, M., Silva, M. S., Tavares, D. Q., Carvalho, C. R. D. O., & Saad, M. J. A. (2000) · Journal of Nutrition · doi:10.1093/jn/130.6.1531 · Cited by 167 · see citing works
The Role of Carbohydrates in Insulin Resistance
Bessesen, D. H. (2001) · Journal of Nutrition · doi:10.1093/jn/131.10.2782s · Cited by 167 · see citing works
Cholesterol in health and disease
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16381 · Cited by 167 · see citing works
Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose
Hallfrisch, J., Reiser, S., & Prather, E. (1983) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.5.740 · Cited by 159 · see citing works
Dyslipidemia in the metabolic syndrome and type 2 diabetes mellitus.
Brunzell, J. D., & Ayyobi, A. F. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.011 · Cited by 155 · cited 1× · see citing works
“High triglyceride levels are an independent risk factor for coronary heart disease.(57,58) This understanding is based largely on evidence metaanalyses of population-based studies.”
Background
Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?
Goodpaster, B. H., & Kelley, D. E. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0086-2 · Cited by 155 · see citing works
Stimulating Effects of Low-Dose Fructose on Insulin-Stimulated Hepatic Glycogen Synthesis in Humans
Petersen, K. F., Laurent, D., Yu, C., Cline, G. W., & Shulman, G. I. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1263 · Cited by 149 · see citing works
Metabolic Effects of Dietary Fructose and Sucrose in Types I and II Diabetic Subjects
Bantle, J. P. (1986) · JAMA · doi:10.1001/jama.1986.03380230065027 · Cited by 147 · see citing works
Metabolic Effects of Troglitazone on Fructose-Induced Insulin Resistance in the Rat
Lee, M.-K., Miles, P. D. G., Khoursheed, M., Gao, K., Moossa, A. R., & Olefsky, J. M. (1994) · Diabetes · doi:10.2337/diab.43.12.1435 · Cited by 141 · see citing works
Epidemiology of hypertriglyceridemia and cardiovascular disease
Austin, M. A. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00209-x · Cited by 138 · see citing works
Influence of meal composition on postprandial peripheral plasma concentrations of vasoactive peptides in man
Pedersen‐Bjergaard, U., Høt, U., Kelbæk, H., Schifter, S., Rehfeld, J. F., Faber, J. O., & Christensen, N. J. (1996) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519609088805 · Cited by 136 · see citing works
The evaluation of insulin as a metabolic signal influencing behavior via the brain
Woods, S. C., Chavez, M., Park, C. R., Riedy, C. A., Kaiyala, K. J., Richardson, R. D., Figlewicz, D. P., Schwartz, M. W., Porte, D., & Seeley, R. J. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00044-f · Cited by 135 · see citing works
Reduced insulin secretion: an independent predictor of body weight gain
Schwartz, M. W., Boyko, E. J., Kahn, S. E., Ravussin, É., & Bogardus, C. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.5.7745002 · Cited by 134 · see citing works
Hexose transport and phosphorylation by capillaries isolated from rat brain
Betz, A. L., Csejtey, J., & Goldstein, G. W. (1979) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1979.236.1.c96 · Cited by 133 · see citing works
Two Different Views of the Relationship of Hypertriglyceridemia to Coronary Heart Disease
Grundy, S. M. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.152.1.28 · Cited by 133 · see citing works
Long-Term Fructose Consumption Accelerates Glycation and Several Age-Related Variables in Male Rats
Levi, B., & Werman, M. J. (1998) · Journal of Nutrition · doi:10.1093/jn/128.9.1442 · Cited by 132 · see citing works
Leptin Deficiency Induced by Fasting Impairs the Satiety Response to Cholecystokinin
McMinn, J. E., Sindelar, D. K., Havel, P. J., & Schwartz, M. W. (2000) · Endocrinology · doi:10.1210/endo.141.12.7815 · Cited by 129 · see citing works
Effects of Exogenous Leptin on Satiety and Satiation in Patients with Lipodystrophy and Leptin Insufficiency
McDuffie, J. R., Riggs, P. A., Calis, K. A., Freedman, R. J., Oral, E. A., DePaoli, A. M., & Yanovski, J. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031868 · Cited by 129 · see citing works
Glucose Metabolism Rather Than Insulin Is a Main Determinant of Leptin Secretion in Humans
Wellhoener, P., Fruehwald‐Schultes, B., Kern, W., Dantz, D., Kerner, W., Jan Born, A., Fehm, H. L., & Peters, A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6483 · Cited by 126 · see citing works
High-fructose feeding elicits insulin resistance, hyperinsulinism, and hypertension in normal mongrel dogs.
Martinez, F. J., Rizza, R. A., & Romero, J. C. (1994) · Hypertension · doi:10.1161/01.hyp.23.4.456 · Cited by 126 · see citing works
Effect of Leptin Replacement on Intrahepatic and Intramyocellular Lipid Content in Patients With Generalized Lipodystrophy
Simha, V., Szczepaniak, L. S., Wagner, A. J., DePaoli, A. M., & Garg, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.30 · Cited by 123 · see citing works
Effects of Dietary Fructose on Plasma Glucose and Hormone Responses in Normal and Hyperinsulinemic Men
Hallfrisch, J. G., Ellwood, K. C., Michaelis, O. E., Reiser, S., O’Dorisio, T. M., & Prather, E. S. (1983) · Journal of Nutrition · doi:10.1093/jn/113.9.1819 · Cited by 122 · see citing works
Metabolic effects of dietary fructose in healthy subjects
Swanson, J., Laine, D. C., Thomas, W. T. B., & Bantle, J. P. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.4.851 · Cited by 121 · see citing works
Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men
Westerterp‐Plantenga, M. S., Saris, W. H. M., Hukshorn, C. J., & Campfield, L. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.426 · Cited by 121 · see citing works
Isocaloric exchange of dietary starch and sucrose in humans II. Effect on fasting blood insulin, glucose, and glucagon and on insulin and glucose response to a sucrose load
Reiser, S., Handler, H., Gardner, L., Hallfrisch, J., Michaelis, O., & Prather, E. (1979) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.11.2206 · Cited by 117 · see citing works
Influence of Fructose and Glucose on Serum Lipid Levels in Men and Pre- and Postmenopausal Women
Macdonald, I. A. (1966) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/18.5.369 · Cited by 115 · see citing works
Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase
Park, O. J., Cesar, D., Faix, D. J., Wu, K. K.-Y., Shackleton, C. H. L., & Hellerstein, M. K. (1992) · Biochemical Journal · doi:10.1042/bj2820753 · Cited by 113 · see citing works
Sugars, insulin sensitivity, and the postprandial state
Daly, M. E. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.865s · Cited by 111 · see citing works
Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch diet
Daly, M., Vale, C., Walker, M., Littlefield, A., Kg, A., & Mathers, J. C. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.6.1186 · Cited by 111 · see citing works
Metabolic Effects of Dietary Fructose in Diabetic Subjects
Bantle, J. P., Swanson, J. E., Thomas, W. T. B., & Laine, D. C. (1992) · Diabetes Care · doi:10.2337/diacare.15.11.1468 · Cited by 109 · see citing works
Effects of Mannose and Fructose on the Synthesis and Secretion of Insulin
CURRY, D. L. (1989) · Pancreas · doi:10.1097/00006676-198902000-00002 · Cited by 108 · see citing works
Importance of Early Phase Insulin Secretion to Intravenous Glucose Tolerance in Subjects with Type 2 Diabetes Mellitus
Kahn, S. E., Montgomery, B. K., Howell, W., Ligueros‐Saylan, M., Hsu, C., Devineni, D., McLeod, J. F., Horowitz, A. D., & Foley, J. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8105 · Cited by 105 · see citing works
Worldwide production of high-fructose syrup and crystalline fructose
Vuilleumier, S. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.5.733s · Cited by 104 · see citing works
Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects
Kong, M., Chapman, I. M., Goble, E., Wishart, J. M., Wittert, G., Morris, H. A., & Horowitz, M. (1999) · Peptides · doi:10.1016/s0196-9781(99)00006-6 · Cited by 104 · see citing works
A lifestyle intervention improves plasma insulin levels among Native American high school youth
Ritenbaugh, C., Teufel‐Shone, N. I., Aickin, M. G., Joe, J. R., Poirier, S., Dillingham, D. C., Johnson, D., Henning, S. M., Cole, S., & Cockerham, D. (2003) · Preventive Medicine · doi:10.1016/s0091-7435(02)00015-4 · Cited by 104 · see citing works
Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog.
Shiota, M., Galassetti, P. R., Monohan, M., Neal, D. W., & Cherrington, A. D. (1998) · Diabetes · doi:10.2337/diabetes.47.6.867 · Cited by 103 · see citing works
Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose
Reiser, S., Bohn, E., Hallfrisch, J., Michaelis, O. E., Keeney, M., & Prather, E. S. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.11.2348 · Cited by 102 · see citing works
Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose tolerance
Rask, E., Olsson, T., Söderberg, S., Holst, J. J., Tura, A., Pacini, G., & Åhrén, B. (2004) · Metabolism · doi:10.1016/j.metabol.2003.11.011 · Cited by 101 · see citing works
Atherogenic Lipoprotein Phenotype and Diet-Gene Interactions
Krauss, R. M. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.340s · Cited by 101 · see citing works
Syndromes of Insulin Resistance in the Rat: Inducement by Diet and Amelioration with Benfluorex
Storlien, L. H., Oakes, N. D., Pan, D. A., Kusunoki, M., & Jenkins, A. B. (1993) · Diabetes · doi:10.2337/diab.42.3.457 · Cited by 101 · see citing works
Reassessing the effects of simple carbohydrates on the serum triglyceride responses to fat meals
Cohen, J. C., & Schall, R. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.4.1031 · Cited by 101 · see citing works
Metabolic Consequence of Two-Week Fructose Feeding in Diabetic Subjects
Crapo, P. A., Kolterman, O., & Henry, R. R. (1986) · Diabetes Care · doi:10.2337/diacare.9.2.111 · Cited by 97 · see citing works
Sorbitol Dehydrogenase: Structure, Function and Ligand Design
El-Kabbani, O. A. L., Darmanin, C., & Chung, R. (2004) · Current Medicinal Chemistry · doi:10.2174/0929867043455927 · Cited by 96 · see citing works
Blood Lipids and Their Distribution in Lipoproteins in Hyperinsulinemic Subjects Fed Three Different Levels of Sucrose
Reiser, S., Bickard, M. C., Hallfrisch, J. G., Michaelis, O. E., & Prather, E. S. (1981) · Journal of Nutrition · doi:10.1093/jn/111.6.1045 · Cited by 93 · see citing works
The metabolic effects of 2-week fructose feeding in normal subjects
Crapo, P. A., & Kolterman, O. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/39.4.525 · Cited by 92 · see citing works
Effects of fructose on hepatic glucose metabolism in humans
Dirlewanger, M., Schneiter, P., Jéquier, E., & Tappy, L. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.4.e907 · Cited by 92 · see citing works
Fructose Improves the Ability of Hyperglycemia Per Se to Regulate Glucose Production in Type 2 Diabetes
Hawkins, M. A., Gabriely, I., Wozniak, R., Vilcu, C., Shamoon, H., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.3.606 · Cited by 90 · see citing works
Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses
Mobbs, C. V., Kow, L., & Yang, X.-J. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.4.e649 · Cited by 90 · see citing works
Defining and interpreting intakes of sugars
Sigman‐Grant, M., & Morita, J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.815s · Cited by 89 · see citing works
Glycated proteins in diabetes.
Furth, A. J. (1997) · PubMed · Cited by 88 · see citing works
Postprandial triglyceride and retinyl ester responses to oral fat: effects of fructose
Jeppesen, J., Chen, Y. D., Zhou, M., Schaaf, P., Coulston, A. M., & Reaven, G. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.4.787 · Cited by 86 · see citing works
Metabolic Effects of Fructose Supplementation in Diabetic Individuals
Anderson, J. W., Story, L. J., Zettwoch, N. C., Gustafson, N., & Jefferson, B. S. (1989) · Diabetes Care · doi:10.2337/diacare.12.5.337 · Cited by 86 · see citing works
Chemical and neuronal control of feeding motivation
Oomura, Y. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90318-6 · Cited by 86 · see citing works
Effects of Dietary Macronutrient Content on Glucose Metabolism in Children
Sunehag, A. L., TOFFOLO, G. M., Treuth, M. S., Butte, N. F., Cobelli, C., Bier, D. M., & Haymond, M. W. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020674 · Cited by 84 · see citing works
Fructose and insulin sensitivity in patients with type 2 diabetes
Koivisto, V. A., & Yki-Järvinen, H. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00667.x · Cited by 82 · see citing works
Sugars and starch in the nutritional management of diabetes mellitus
Kelley, D. E. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.858s · Cited by 81 · see citing works
Transcriptional Regulation of the Leptin Promoter by Insulin-Stimulated Glucose Metabolism in 3T3-L1 Adipocytes
Moreno-Aliaga, M. J., Stanhope, K. L., & Havel, P. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4822 · Cited by 81 · see citing works
Self-citation
Effects of Metformin and Vanadium on Leptin Secretion from Cultured Rat Adipocytes
Mueller, W. M., Stanhope, K. L., Gregoire, F. M., Evans, J. L., & Havel, P. J. (2000) · Obesity Research · doi:10.1038/oby.2000.66 · Cited by 80 · see citing works
Self-citation
Metabolic Effects of Dietary Sucrose and Fructose in Type II Diabetic Subjects
Malerbi, D. A. C., Paiva, E. S. A., Duarte, A. L., & WAJCHENBERG, B. L. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1249 · Cited by 76 · see citing works
Inclusion of Low Amounts of Fructose With an Intraduodenal Glucose Load Markedly Reduces Postprandial Hyperglycemia and Hyperinsulinemia in the Conscious Dog
Shiota, M., Moore, M. C., Galassetti, P. R., Monohan, M., Neal, D. W., Shulman, G. I., & Cherrington, A. D. (2002) · Diabetes · doi:10.2337/diabetes.51.2.469 · Cited by 76 · see citing works
Reduced LDL particle size in children consuming a very-low-fat diet is related to parental LDL-subclass patterns
Dreon, D. M., Fernstrom, H. A., Williams, P. T., & Krauss, R. M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1611 · Cited by 72 · see citing works
Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects
Abraha, A., Humphreys, S. M., Clark, M. L., Matthews, D. R., & Frayn, K. N. (1998) · British Journal Of Nutrition · doi:10.1017/s000711459800107x · Cited by 69 · see citing works
Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon.
Figlewicz, D. P., Sipols, A. J., Seeley, R. J., Chavez, M., Woods, S. C., & Porte, D. (1995) · Behavioral Neuroscience · doi:10.1037//0735-7044.109.3.567 · Cited by 68 · see citing works
Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle
Furuhashi, M., Ura, N., Murakami, H., Hyakukoku, M., Yamaguchi, K., Higashiura, K., & Shimamoto, K. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1740321 · Cited by 66 · see citing works
Programming obesity in childhood
Ludwig, D. S., & Gortmaker, S. L. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16688-9 · Cited by 65 · see citing works
Effect of dietary fructose on triglyceride transport and glucoregulatory hormones in hypertriglyceridemic men
Turner, J., Bierman, E. L., Brunzell, J., & Chait, A. (1979) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.5.1043 · Cited by 65 · see citing works
Metabolic effects of fructose as a natural sweetener in the physiologic meals of ambulatory obese patients with type II diabetes
Osei, K., Falko, J. M., Bossetti, B. M., & Holland, G. C. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90693-0 · Cited by 64 · see citing works
Lack of Detectable Deleterious Effects on Metabolic Control of Daily Fructose Ingestion for 2 Mo in NIDDM Patients
Grigoresco, C., Rizkalla, S. W., Halfon, P., Bornet, F. R. J., Fontvieille, A. M., Bros, M., Dauchy, F., Tchobroutsky, G., & Slama, G. (1988) · Diabetes Care · doi:10.2337/diacare.11.7.546 · Cited by 64 · see citing works
Influence of α‐lipoic acid on lipid peroxidation and antioxidant defence system in blood of insulin‐resistant rats
Thirunavukkarasu, V., & Anuradha, C. V. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00332.x · Cited by 63 · see citing works
Insulin release from human pancreatic islets in vitro
Grant, A. M., Christie, M. R., & Ashcroft, S. J. H. (1980) · Diabetologia · doi:10.1007/bf00421856 · Cited by 62 · see citing works
Low insulin secretion and high fasting insulin and C-peptide levels predict increased visceral adiposity. 5-year follow-up among initially nondiabetic Japanese-American men.
Boyko, E. J., Leonetti, D. L., Bergstrom, R. W., Newell-Morris, L., & Fujimoto, W. Y. (1996) · Diabetes · doi:10.2337/diab.45.8.1010 · Cited by 61 · see citing works
Glutamine and Alanine Metabolism in NIDDM
Stümvoll, M., Perriello, G., Nurjhan, N., Welle, S. L., Gerich, J. E., Bucci, A., Jansson, P., DAILEY, G. E., Bier, D. M., Jenssen, T. G., et al. (1996) · Diabetes · doi:10.2337/diab.45.7.863 · Cited by 60 · see citing works
Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans
Rayner, C. K., Park, H. S., Wishart, J. M., Kong, M., Doran, S., & Horowitz, M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.2.r360 · Cited by 59 · see citing works
Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets
Sato, Y., Ito, T., Udaka, N., Kanisawa, M., Noguchi, Y., Cushman, S. W., & Satoh, S. (1996) · Tissue and Cell · doi:10.1016/s0040-8166(96)80067-x · Cited by 59 · see citing works
Autonomic Dysfunction of the β-Cell and the Pathogenesis of Obesity
Lustig, R. H. (2003) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1021819318484 · Cited by 58 · see citing works
High-fructose diet decreases catalase mRNA levels in rat tissues
Cavarape, A., Feletto, F., Mercuri, F., Quagliaro, L., Damante, G., & Ceriello, A. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343940 · Cited by 57 · see citing works
Diminished insulin receptors on monocytes and erythrocytes in hypertriglyceridemia
Bieger, W. P., Michel, G., Barwich, D., Biehl, K., & Wirth, A. G. (1984) · Metabolism · doi:10.1016/0026-0495(84)90224-5 · Cited by 56 · see citing works
Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon.
Figlewicz, D. P., Sipols, A. J., Seeley, R. J., et al. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.3.567 · Cited by 56 · see citing works
Impaired very low-density lipoprotein-triglyceride catabolism in acute and chronic fructose-fed rats
Hirano, T., Mamo, J. C. L., Poapst, M. E., Kuksis, A., & Steiner, G. A. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.4.e559 · Cited by 54 · see citing works
Negative Relationship between Fasting Plasma Ghrelin Concentrations andad LibitumFood Intake
Salbe, A. D., Tschöp, M. H., DelParigi, A., Venti, C. A., & Tataranni, P. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032145 · Cited by 52 · see citing works
Accumulation of Advanced Glycation Endproducts in Aging Male Fischer 344 Rats during Long-Term Feeding of Various Dietary Carbohydrates
Lingelbach, L. B., Mitchell, A. E., Rucker, R. B., & McDonald, R. B. (2000) · Journal of Nutrition · doi:10.1093/jn/130.5.1247 · Cited by 52 · see citing works
Dietary Fructose as a Natural Sweetener in Poorly Controlled Type 2 Diabetes: a 12‐month Crossover Study of Effects on Glucose, Lipoprotein and Apolipoprotein Metabolism
Osei, K., & Bossetti, B. M. (1989) · Diabetic Medicine · doi:10.1111/j.1464-5491.1989.tb01218.x · Cited by 51 · see citing works
Lipid metabolism in non-insulin-dependent diabetes: effects of long-term treatment with fructose-supplemented mixed meals
Thorburn, A. W., Crapo, P. A., Beltz, W. F., Wallace, P., Witztum, J. L., & Henry, R. R. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1015 · Cited by 50 · see citing works
Soft Drink Consumption Among US Children and Adolescents: Nutritional Consequences
Maloney, M. J., Harnack, L., Stang, J. L., & Story, M. T. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199910000-00027 · Cited by 50 · see citing works
Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch
Reiser, S., Powell, A. S., Scholfield, D. J., Panda, P., Fields, M., & Canary, J. J. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1008 · Cited by 49 · see citing works
Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, Liver Glycogen synthase activity, and β-oxidation in fructose-fed rats
Inoue, I., Takahashi, K., Katayama, S., Harada, Y., Negishi, K., Itabashi, A., & Ishii, J. (1995) · Metabolism · doi:10.1016/0026-0495(95)90085-3 · Cited by 45 · see citing works
Effect of diet on lipid metabolism in experimental animals and man.
Rh, H., Zakim, D., & Stifel, F. B. (1970) · PubMed · Cited by 44 · see citing works

Flagged first, then by citations

4 of the 230 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

Bowman SA. Diets of individuals based on energy intakes from added sugars. Fam Econ Nutr Rev. 1999;12:31-38.
Schwarz JM, Neese RA, Basinger A, et al. Effect of oral fructose on lipolysis, fat oxidation, fractional and absolute de novo lipogenesis (DNL) using mass isotopomer distribution analysis (MIDA). FASEB J. 1993;7:A867.
Jonkers IJ, Smelt AH, van der Laarse A. Hypertri- glyceridemia: associated risks and effect of drug treatment. Am J Cardiovasc Drugs. 2001;1:455- 466.
Kelley DE, Goodpaster BH, Storlien L. Muscle tri- glyceride and insulin resistance. Annu Rev Nutr. 2002;22:325-346.
Nagai Y, Nishio Y, Nakamura T, Maegawa H, Kikkawa R, Kashiwagi A. Amelioration of high fruc- tose-induced metabolic derangements by activa- tion of PPARalpha. Am J Physiol Endocrinol Metab. 2002;282:E1180 -E1190.

Sorted by citations

Uric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,443 · see citing works
Intake of sugar-sweetened beverages and weight gain: a systematic review
Malik, V. S., Schulze, M. B., & Hu, F. B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.274 · Cited by 2,100 · see citing works
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765 · see citing works
Self-citation
Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641 · see citing works
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328 · see citing works
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Dietary Sugars Intake and Cardiovascular Health: A Scientific Statement From the American Heart Association
Johnson, R. K., Appel, L. J., Brands, M., Howard, B. V., Lefevre, M., Lustig, R. H., Sacks, F., Steffen, L. M., & Wylie-Rosett, J. (2009) · Circulation · doi:10.1161/circulationaha.109.192627 · Cited by 1,207 · see citing works
Sugar-sweetened beverages and risk of obesity and type 2 diabetes: epidemiologic evidence
Hu, F. B., & Malik, V. S. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.01.036 · Cited by 909 · see citing works
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Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887 · see citing works
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Maersk, M., Belza, A., Stødkilde-Jørgensen, H., Ringgaard, S., Chabanova, E., Thomsen, H., Pedersen, S. B., Astrup, A., & Richelsen, B. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.022533 · Cited by 603 · see citing works
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Johnson, R. J., Perez-Pozo, S. E., Sautin, Y. Y., Manitius, J., Sánchez‐Lozada, L. G., Feig, D. I., Shafiu, M., Segal, M. S., Glassock, R. J., Shimada, M., et al. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0033 · Cited by 500 · see citing works
Regulation of the fructose transporter GLUT5 in health and disease
Douard, V., & Ferraris, R. P. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90245.2008 · Cited by 477 · see citing works
National Estimates of Dietary Fructose Intake Increased from 1977 to 2004 in the United States
Marriott, B. P., Cole, N., & Lee, E. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.098277 · Cited by 473 · see citing works
Slowly Digestible Starch: Concept, Mechanism, and Proposed Extended Glycemic Index
Zhang, G., & Hamaker, B. R. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372466 · Cited by 464 · see citing works
Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey.
Vos, M. B., Kimmons, J. E., Gillespie, C., Welsh, J. A., & Blanck, H. M. (2008) · PubMed Central · Cited by 456 · see citing works
Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
Zivkovic, A. M., German, J. B., & Sanyal, A. J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.285 · Cited by 418 · see citing works
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Page, K. A., Chan, O., Arora, J., Belfort-DeAguiar, R., Dzuira, J., Roehmholdt, B., Cline, G. W., Naik, S., Sinha, R., Constable, R. T., et al. (2013) · JAMA · doi:10.1001/jama.2012.116975 · Cited by 379 · see citing works
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Kohli, R., Kirby, M., Xanthakos, S. A., Softic, S., Feldstein, A. E., Saxena, V., Tang, P., Miles, L., Miles, M. V., Balistreri, W. F., et al. (2010) · Hepatology · doi:10.1002/hep.23797 · Cited by 377 · see citing works
Low to moderate sugar-sweetened beverage consumption impairs glucose and lipid metabolism and promotes inflammation in healthy young men: a randomized controlled trial
Aeberli, I., Gerber, P. A., Hochuli, M., Kohler, S., Haile, S. R., Gouni-Berthold, I., Berthold, H. K., Spinas, G. A., & Berneis, K. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.013540 · Cited by 372 · see citing works
Fructose and metabolic diseases: New findings, new questions
Tappy, L., Lê, K., Tran, C., & Paquot, N. (2010) · Nutrition · doi:10.1016/j.nut.2010.02.014 · Cited by 365 · see citing works
The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension
Tran, L. T., Yuen, V. G., & McNeill, J. H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0184-4 · Cited by 359 · see citing works
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Vos, M. B., & Lavine, J. E. (2013) · Hepatology · doi:10.1002/hep.26299 · Cited by 316 · see citing works
High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels
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Weiss, R., Bremer, A. A., & Lustig, R. H. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12030 · Cited by 306 · see citing works
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Shapiro, A. M., Mu, W., Roncal, C., Cheng, K., Johnson, R. J., & Scarpace, P. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00195.2008 · Cited by 305 · see citing works
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Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses
Teff, K. L., Grudziak, J., Townsend, R. R., Dunn, T. N., Grant, R. W., Adams, S. H., Keim, N. L., Cummings, B. P., Stanhope, K. L., & Havel, P. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2192 · Cited by 301 · see citing works
Self-citation
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Self-citation
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Self-citation
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Welsh, J. A., Sharma, A. J., Cunningham, S. A., & Vos, M. B. (2011) · Circulation · doi:10.1161/circulationaha.110.972166 · Cited by 269 · see citing works
Hypertriglyceridemia
Brunzell, J. D. (2007) · New England Journal of Medicine · doi:10.1056/nejmcp070061 · Cited by 268 · see citing works
Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies
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Fast Food, Central Nervous System Insulin Resistance, and Obesity
ISGANAITIS, E. M., & Lustig, R. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000186208.06964.91 · Cited by 261 · see citing works
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
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Aragno, M., & Mastrocola, R. (2017) · Nutrients · doi:10.3390/nu9040385 · Cited by 239 · see citing works
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Self-citation
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Self-citation
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Role of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome
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Energy and Fructose From Beverages Sweetened With Sugar or High-Fructose Corn Syrup Pose a Health Risk for Some People
Bray, G. A. (2013) · Advances in Nutrition · doi:10.3945/an.112.002816 · Cited by 222 · see citing works
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Li, X., Qian, X., Peng, L.-X., Jiang, Y., Hawke, D. H., Zheng, Y., Xia, Y., Lee, J.-H., Cote, G. J., Wang, H., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3338 · Cited by 215 · see citing works
Liquid calories, sugar, and body weight
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Kawasaki, T., Igarashi, K., Koeda, T., Sugimoto, K., Nakagawa, K., Hayashi, S., Yamaji, R., Inui, H., Fukusato, T., & Yamanouchi, T. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105858 · Cited by 206 · see citing works
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Nagai, Y., Yonemitsu, S., Erion, D. M., Iwasaki, T., Stark, R., Weismann, D., Dong, J., Zhang, D., Jurczak, M. J., Löffler, M. G., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.011 · Cited by 203 · see citing works
Soft drinks consumption and nonalcoholic fatty liver disease
Nseir, W. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i21.2579 · Cited by 201 · see citing works
Health implications of fructose consumption: A review of recent data
Rizkalla, S. W. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-82 · Cited by 205 · see citing works
Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis
Kelishadi, R., Mansourian, M., & Heidari-Beni, M. (2014) · Nutrition · doi:10.1016/j.nut.2013.08.014 · Cited by 199 · see citing works
Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
Mellor, K. M., Bell, J. R., Young, M. J., Ritchie, R. H., & Delbridge, L. M. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.03.002 · Cited by 199 · see citing works
The Role of Diet in the Pathogenesis of Cholesterol Gallstones
Ciaula, A. D., Garruti, G., Frühbeck, G., Angelis, M. D., de Bari, O., Wang, D. Q. ‐., Lammert, F., & Portincasa, P. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170530080636 · Cited by 197 · see citing works
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Rippe, J. M., & Angelopoulos, T. J. (2013) · Advances in Nutrition · doi:10.3945/an.112.002824 · Cited by 194 · see citing works
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Self-citation
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Gao, X., Qi, L., Qiao, N., Choi, H. K., Curhan, G. C., Tucker, K. L., & Ascherio, A. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.091041 · Cited by 187 · see citing works
Toward a unifying hypothesis of metabolic syndrome
Bremer, A. A., Mietus-Snyder, M., & Lustig, R. H. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2912 · Cited by 186 · see citing works
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake
Roncal-Jiménez, C. A., Lanaspa, M. A., Rivard, C. J., Nakagawa, T., Sánchez‐Lozada, L. G., Jalal, D. I., Andrés-Hernando, A., Tanabe, K., Madero, M., Li, N., et al. (2011) · Metabolism · doi:10.1016/j.metabol.2011.01.008 · Cited by 181 · see citing works
Dietary fructose causes tubulointerstitial injury in the normal rat kidney
Nakayama, T., Kosugi, T., Gersch, M. S., Connor, T., Sánchez‐Lozada, L. G., Lanaspa, M. A., Roncal, C., Perez-Pozo, S. E., Johnson, R. J., & Nakagawa, T. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00433.2009 · Cited by 180 · see citing works
The role of sugars and sweeteners in food, diet and health: Alternatives for the future
Edwards, C. H., Rossi, M., Corpe, C. P., Butterworth, P., & Ellis, P. R. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.07.008 · Cited by 177 · see citing works
Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial
Silbernagel, G., Machann, J., Unmuth, S., Schick, F., Stefan, N., Häring, H. U., & Fritsche, A. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000574x · Cited by 172 · see citing works
Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis
Wang, H., Lü, M., Deng, Y., Liu, Y., Wei, X., Liu, M., Zhou, J., Ma, H., Zheng, P., Yuan, J., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.11.018 · Cited by 166 · see citing works
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Glushakova, O. Y., Kosugi, T., Roncal, C., Mu, W., Heinig, M., Cirillo, P., Sánchez‐Lozada, L. G., Johnson, R. J., & Nakagawa, T. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007121304 · Cited by 163 · see citing works
Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease
Spruss, A., & Bergheim, I. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.05.006 · Cited by 162 · see citing works
Pharmacology biochemistry and behavior
A, M. E. B., A, E. S. P., A, N. M. A., & A, B. G. H. (1979) · Brain Research Bulletin · doi:10.1016/s0361-9230(79)80031-3 · Cited by 159 · see citing works
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans
Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Keim, N. L., et al. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-68 · Cited by 155 · see citing works
Self-citation
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Ross, A. P., Bartness, T. J., Mielke, J. G., & Parent, M. B. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.05.007 · Cited by 154 · see citing works
Fructose‐fed Rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes
Bremer, A. A., Stanhope, K. L., Graham, J. L., Cummings, B. P., Wang, W., Saville, B. R., & Havel, P. J. (2011) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2011.00298.x · Cited by 148 · see citing works
Self-citation
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Johnson, R. J., Sautin, Y. Y., Oliver, W. J., Roncal, C., Mu, W., Sánchez‐Lozada, L. G., Rodríguez‐Iturbe, B., Nakagawa, T., & Benner, S. A. (2008) · Journal of Comparative Physiology B · doi:10.1007/s00360-008-0291-7 · Cited by 145 · see citing works
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Ferder, L., Ferder, M., & Inserra, F. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0097-3 · Cited by 144 · see citing works
Impact of Sugar-Sweetened Beverages on Blood Pressure
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White, J. S. (2013) · Advances in Nutrition · doi:10.3945/an.112.003137 · Cited by 139 · see citing works
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Forshee, R. A., Storey, M. L., Allison, D. B., Glinsmann, W. H., Hein, G. L., Lineback, D. R., Miller, S. A., Nicklas, T. A., Weaver, G. A., & White, J. S. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390600846457 · Cited by 138 · see citing works
Insulin Internalizes GLUT2 in the Enterocytes of Healthy but Not Insulin-Resistant Mice
Tobin, V., Gall, M. L., Fioramonti, X., Stolarczyk, É., Blazquez, A. G., Klein, C., Prigent, M., Serradas, P., Cuif, M., Magnan, C., et al. (2007) · Diabetes · doi:10.2337/db07-0928 · Cited by 135 · see citing works
Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works
Intestinal Fructose and Glucose Metabolism in Health and Disease
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Bremer, A. A., Auinger, P., & Byrd, R. S. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.21 · Cited by 132 · see citing works
Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women
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Self-citation
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Bray, G. A. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283346ca2 · Cited by 131 · see citing works
Fructose-induced inflammation and increased cortisol: A new mechanism for how sugar induces visceral adiposity
DiNicolantonio, J. J., Mehta, V., Onkaramurthy, N. J., & O’Keefe, J. H. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.12.001 · Cited by 132 · see citing works
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
Kuhre, R. E., Gribble, F. M., Hartmann, B., Reimann, F. M., Windeløv, J. A., Rehfeld, J. F., & Holst, J. J. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00372.2013 · Cited by 125 · see citing works
Thiazide Diuretics Exacerbate Fructose-Induced Metabolic Syndrome
Reungjui, S., Roncal, C. A., Mu, W., Srinivas, T. R., Sirivongs, D., Johnson, R. J., & Nakagawa, T. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007040416 · Cited by 125 · see citing works
How bad is fructose?1,2
Bray, G. A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.895 · Cited by 125 · see citing works
Potential Health Risks From Beverages Containing Fructose Found in Sugar or High-Fructose Corn Syrup
Bray, G. A. (2012) · Diabetes Care · doi:10.2337/dc12-1631 · Cited by 123 · see citing works
Fructose Consumption: Considerations for Future Research on Its Effects on Adipose Distribution, Lipid Metabolism, and Insulin Sensitivity in Humans
Stanhope, K. L., & Havel, P. J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.106641 · Cited by 123 · see citing works
Self-citation
Correlation of Vitamin E, Uric Acid, and Diet Composition With Histologic Features of Pediatric NAFLD
Vos, M. B., Colvin, R., Belt, P. H., Molleston, J. P., Murray, K. F., Rosenthal, P. J., Schwimmer, J. B., Tonascia, J. A., Ünalp, A., & Lavine, J. E. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318229da1a · Cited by 122 · see citing works

Fructose, insulin resistance, and metabolic dyslipidemia
Basciano, H., Federico, L. M., & Adeli, K. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-5 · Cited by 838 · see citing works
High dietary fructose load aggravates lipid metabolism in the liver of Wistar rats through imbalance between lipogenesis and fatty acid oxidation
Teofilović, A., Bursać, B. N., Djordjevic, A. D., Milutinović, D. V., Matić, G. M., & Veličković, N. A. (2016) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1512-40 · Cited by 3 · see citing works
Dietary Fructose and Metabolic Syndrome and Diabetes
Bantle, J. P. (2009) · Journal of Nutrition · doi:10.3945/jn.108.098020 · Cited by 234 · see citing works
Fructose Intake: Metabolism and Role in Diseases
He, L., Babar, G., Redel, J. M., Young, S. L., Chagas, C. E., Moore, W. V., & Yan, Y. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95754 · Cited by 7 · see citing works
Effect of dietary fructose on lipid metabolism, body weight and glucose tolerance in humans
Vasankari, T. J., & Vasankari, T. (2006) · Food & Nutrition Research · doi:10.3402/fnr.v50i2.1559 · Cited by 8 · see citing works

Authors: Havel, P. J.
Affiliations: University of California, Davis (US)
Corresponding author: Havel, Peter J.
ORCID: Havel, Peter J.
Venue: Nutrition Reviews
Publisher: Oxford University Press (OUP)
Published: 2005-05
Volume: 63
Issue: 5
Pages: 133-157
ISSN: 0029-6643 (ISSN-L)
1753-4887
DOI: 10.1111/j.1753-4887.2005.tb00132.x
OpenAlex: W2162627097
Cited by: 607
References: 230
Citations by year: 2026: 5 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 20 · 2019: 28 · 2018: 32 · 2017: 23 · 2016: 46 · 2015: 54 · 2014: 42 · 2013: 48 · 2012: 37
FWCI: 15.31
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Nutrition Reviews (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: American Diabetes Association
U.S. Department of Agriculture
Dairy Management
National Institutes of Health (5r01hl075675-05, 58108, HL‐075675)
National Heart, Lung, and Blood Institute (HL 075675, R01 HL-091333, R01HL107256)
National Institute of Diabetes and Digestive and Kidney Diseases (R03DK058108, DK-58108)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: dietary fructose, energy homeostasis, lipid metabolism, carbohydrate metabolism, obesity, hepatic lipogenesis, hyperlipidemia, insulin, leptin, ghrelin, energy balance
MeSH terms: Beverages, Diabetes Mellitus, Type 2, Energy Metabolism, Fructose, Glucose, Humans, Hyperlipidemias, Insulin, Insulin Resistance, Obesity, Leptin, Peptide Hormones, Ghrelin

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Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

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