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Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women
Open accessAbstract
Background/objectives The results of short-term studies in humans suggest that, compared with glucose, acute consumption of fructose leads to increased postprandial energy expenditure and carbohydrate oxidation and decreased postprandial fat oxidation. The objective of this study was to determine the potential effects of increased fructose consumption compared with isocaloric glucose consumption on substrate utilization and energy expenditure following sustained consumption and under energy-balanced conditions.Subjects/methods As part of a parallel arm study, overweight/obese male and female subjects, 40-72 years, consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Energy expenditure and substrate utilization were assessed using indirect calorimetry at baseline and during the 10th week of intervention.Results Consumption of fructose, but not glucose, led to significant decreases of net postprandial fat oxidation and significant increases of net postprandial carbohydrate oxidation (P<0.0001 for both). Resting energy expenditure (REE) decreased significantly from baseline values in subjects consuming fructose (P=0.031) but not in those consuming glucose.Conclusions Increased consumption of fructose for 10 weeks leads to marked changes of postprandial substrate utilization including a significant reduction of net fat oxidation. In addition, we report that REE is reduced compared with baseline values in subjects consuming fructose-sweetened beverages for 10 weeks.
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“fructose contained in sugar sweetened beverages is suggested to likely induce the onset of obesity by reducing resting energy expenditure and promoting leptin resistance.102 103”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [102]
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Self-citationUric acid in metabolic syndrome: From an innocent bystander to a central player
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Metadata
- Authors
- Cox, C. L., Stanhope, K. L., Schwarz, J. M., Graham, J. L., Hatcher, B., Griffen, S. C., Bremer, A. A., Berglund, L., McGahan, J. P., Havel, P. J., & Keim, N. L.
- Affiliations
- University of California, Davis (US)
- Touro University California (US)
- Vanderbilt University (US)
- United States Department of Agriculture (US)
- Corresponding author
- Keim, N L
- Venue
- European Journal of Clinical Nutrition
- Published
- 2011-09-28
- Volume
- 66
- Issue
- 2
- Pages
- 201-208
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- PMC
- PMC3252467
- OpenAlex
- W2121517321
- Cited by
- 132
- References
- 30
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 11 · 2022: 13 · 2021: 5 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 10 · 2013: 11 · 2012: 6
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Diabetes Association (UL1 RR024146)
- U.S. Department of Agriculture (5306‐51530‐019‐00D, UL1 RR024146, 5306‐51530‐019)
- National Institutes of Health (5r01hl075675-05, 5r01hl091333-02, HL‐091333, RR024146)
- University of California, Davis (RR024146, UL1 RR024146)
- Agricultural Research Service
- National Heart, Lung, and Blood Institute (R01 HL-075675, R01 HL-091333, HL-091333, R01HL107256)
- National Center for Research Resources (UL1RR024146)
- National Center for Complementary and Integrative Health (AT0-02993, AT0-03545, AT 002599, R21AT002993, R21AT002599)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- fructose, glucose, fat oxidation, energy expenditure, resting energy expenditure, substrate utilization, carbohydrate oxidation, overweight, obesity, energy balance, postprandial metabolism
- MeSH terms
- Aged, Basal Metabolism, Beverages, Energy Intake, Energy Metabolism, Female, Fructose, Glucose, Humans, Male, Middle Aged, Obesity, Oxidation-Reduction, Sweetening Agents, Dietary Sucrose, Carbohydrate Metabolism, Lipid Metabolism
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