Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease
Abstract
Background/objectives Children with celiac disease (CD) are at risk for decreased bone mineral density (BMD) because of fat-soluble vitamin malabsorption, inflammation and/or under-nutrition. The study objective was to determine the interrelationships between vitamin K/D status and lifestyle variables on BMD in children and adolescents with CD at diagnosis and after 1 year on the gluten-free diet (GFD). Subjects/methods Children and adolescents aged 3-17 years with biopsy proven CD at diagnosis and after 1 year on the GFD were studied. BMD was measured using dual-energy X-ray absorptiometry. Relevant variables included: anthropometrics, vitamin D/K status, diet, physical activity and sunlight exposure. Results Whole-body and lumbar-spine BMD-z scores were low ( 10 years) when compared with younger children ( Conclusions Children and adolescents with CD are at risk for suboptimal bone health at time of diagnosis and after 1 year on GFD; likely due in part to suboptimal vitamin D/K status. Therapeutic strategies aimed at optimizing vitamin K/D intake may contribute to improved BMD in children with CD.
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Bone health may be compromised in coeliac disease patients.
“Bone health may be compromised in CD patients (28)”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [28]
In most cases, one year on a strict gluten-free diet is sufficient to restore bone mass in children with coeliac disease.
“Although a longer followup might be needed in some cases to ensure a proper BMD recovery (33), in most cases, one year on a strict GFD is sufficient to restore bone mass (12, 14, 28).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [28]
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Celiac & Gluten Intolerance: A Wellness Perspective
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Martín‐Masot, R., Soto, L. G., Nestares, M. T., & Maldonado, J. (2019) · Nutrición Hospitalaria · doi:10.20960/nh.02633 · Cited by 2 · see citing works
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- Authors
- Mager, D. R., Qiao, J., & Turner, J.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Mager, D R
- ORCID
- Venue
- European Journal of Clinical Nutrition
- Published
- 2011-10-05
- Volume
- 66
- Issue
- 4
- Pages
- 488-495
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2026771830
- Cited by
- 75
- References
- 40
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 2 · 2016: 2 · 2015: 8 · 2014: 6 · 2013: 2 · 2012: 2
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- celiac disease, vitamin D status, vitamin K status, bone mineral density, bone accrual, gluten-free diet, children and adolescents, 25-hydroxyvitamin D, bone health, sun exposure, physical activity, dietary intake
- MeSH terms
- Adolescent, Anthropometry, Bone and Bones, Celiac Disease, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Life Style, Lumbar Vertebrae, Male, Motor Activity, Surveys and Questionnaires, Vitamin D, Vitamin K, Vitamins, Biomarkers, Absorptiometry, Photon, Bone Density, Multivariate Analysis, Logistic Models, Diet, Gluten-Free
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