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Cited by 170Dialysis and Renal Disease ManagementChronic Kidney Disease and DiabetesFood composition and properties

Dietary fiber effects in chronic kidney disease: a systematic review and meta-analysis of controlled feeding trials

Chiavaroli, L, Mirrahimi, A, Sievenpiper, J L, Jenkins, D J A, Darling, P B·2015·European Journal of Clinical Nutrition
DOI 10.1038/ejcn.2014.237
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Abstract

Background/objectives Chronic kidney disease (CKD) is a major health concern associated with increased risk of cardiovascular disease, morbidity and mortality. Current CKD practice guidelines overlook dietary fiber, which is chronically low in the renal diet. However, increasing dietary fiber has been proposed to ameliorate the progress of CKD. We therefore conducted a systematic review and meta-analysis on the effect of dietary fiber intake on serum urea and creatinine as classical markers of renal health in individuals with CKD.Subjects/methods We searched MEDLINE, EMBASE, CINHAL and the Cochrane Library for relevant clinical trials with a follow-up ⩾7 days. Data were pooled by the generic inverse variance method using random-effects models and expressed as mean difference (MD) with 95% confidence intervals (95% CIs). Heterogeneity was assessed by the Cochran Q statistic and quantified by I(2).Results A total of 14 trials involving 143 participants met the eligibility criteria. Dietary fiber supplementation significantly reduced serum urea and creatinine levels in the primary pooled analyses (MD, -1.76 mmol/l (95% CI, -3.00, -0.51), P<0.01 and MD, -22.83 mmol/l (95% CI, -42.63, -3.02), P=0.02, respectively) with significant evidence of interstudy heterogeneity only in the analysis of serum urea.Conclusions This is the first study to summarize the potential beneficial effects of dietary fiber in the CKD population demonstrating a reduction in serum urea and creatinine, as well as highlighting the lack of clinical trials on harder end points. Larger, longer, higher-quality clinical trials measuring a greater variety of uremic toxins in CKD are required (NCT01844882).

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  • A meta-analysis of 14 controlled feeding trials involving 143 participants with chronic kidney disease showed that supplementation of dietary fibre significantly reduces serum levels of uraemic toxins, urea and creatinine.

    “A meta-analysis of 14 controlled feeding trials involving 143 participants with CKD showed that supplementation of dietary fibre intake significantly reduced serum levels of uraemic toxins, urea and creatinine212.”

    From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [212]

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Authors
Chiavaroli, L., Mirrahimi, A., Sievenpiper, J. L., Jenkins, D. J. A., & Darling, P. B.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Darling, P B
ORCID
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2014-11-12
Volume
69
Issue
7
Pages
761-768
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/ejcn.2014.237
OpenAlex
W2061510481
Cited by
170
References
75
Citations by year
2026: 6 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 19 · 2021: 23 · 2020: 23 · 2019: 16 · 2018: 13 · 2017: 16 · 2016: 8 · 2015: 5
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Keywords
dietary fiber, chronic kidney disease, serum urea, serum creatinine, renal diet, dietary supplementation, uremic toxins, renal function markers
MeSH terms
Gastrointestinal Microbiome, Combined Modality Therapy, Creatinine, Dietary Fiber, Fermentation, Renal Dialysis, Humans, Urea, Biomarkers, Practice Guidelines as Topic, Disease Progression, Cross-Over Studies, Controlled Clinical Trials as Topic, Dietary Supplements, Renal Insufficiency, Chronic

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