Cited by 1,381Gut microbiota and healthGastrointestinal motility and disordersMicrobial Metabolites in Food Biotechnology

Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

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Canani, Roberto Berni·2011·World Journal of Gastroenterology

Abstract

The multiple beneficial effects on human health of the short-chain fatty acid butyrate, synthesized from non-absorbed carbohydrate by colonic microbiota, are well documented. At the intestinal level, butyrate plays a regulatory role on the transepithelial fluid transport, ameliorates mucosal inflammation and oxidative status, reinforces the epithelial defense barrier, and modulates visceral sensitivity and intestinal motility. In addition, a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer. At the extraintestinal level, butyrate exerts potentially useful effects on many conditions, including hemoglobinopathies, genetic metabolic diseases, hypercholesterolemia, insulin resistance, and ischemic stroke. The mechanisms of action of butyrate are different; many of these are related to its potent regulatory effects on gene expression. These data suggest a wide spectrum of positive effects exerted by butyrate, with a high potential for a therapeutic use in human medicine.

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  1. Scharlau D, Borowicki A, Habermann N, Hofmann T, Kle- now S, Miene C, Munjal U, Stein K, Glei M. Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Mutat Res 2009; 682: 39-53 47
  2. Jobin C, Sartor RB. The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection. Am J Physiol Cell Physiol 2000; 278: C451-C462
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Authors
Canani, R. B.
Affiliations
Federico II University Hospital (IT)
Corresponding author
Canani, Roberto Berni
Venue
World Journal of Gastroenterology
Published
2011
Volume
17
Issue
12
Pages
1519
ISSN
1007-9327 (ISSN-L)
OpenAlex
W2136759951
Cited by
1,381
References
110
Citations by year
2026: 101 · 2025: 136 · 2024: 131 · 2023: 122 · 2022: 136 · 2021: 142 · 2020: 129 · 2019: 115 · 2018: 92 · 2017: 72 · 2016: 70 · 2015: 48 · 2014: 31 · 2013: 22 · 2012: 26
FWCI
2.50
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Funders
Agenzia Italiana del Farmaco, Ministero della Salute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
butyrate, short-chain fatty acids, colonic microbiota, intestinal epithelial barrier, mucosal inflammation, oxidative stress, visceral sensitivity, intestinal motility, colorectal cancer prevention, hemoglobinopathies, inborn errors of metabolism, hypercholesterolemia, insulin resistance, ischemic stroke, gene expression regulation, therapeutic potential
MeSH terms
Butyrates, Gastrointestinal Agents, Humans, Intestinal Diseases, Intestinal Mucosa, Intestines, Evidence-Based Medicine

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