Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Open accessAbstract
The multiple beneficial effects on human health of the short-chain fatty acid butyrate, synthesized from non-absorbed carbohydrate by colonic microbiota, are well documented. At the intestinal level, butyrate plays a regulatory role on the transepithelial fluid transport, ameliorates mucosal inflammation and oxidative status, reinforces the epithelial defense barrier, and modulates visceral sensitivity and intestinal motility. In addition, a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer. At the extraintestinal level, butyrate exerts potentially useful effects on many conditions, including hemoglobinopathies, genetic metabolic diseases, hypercholesterolemia, insulin resistance, and ischemic stroke. The mechanisms of action of butyrate are different; many of these are related to its potent regulatory effects on gene expression. These data suggest a wide spectrum of positive effects exerted by butyrate, with a high potential for a therapeutic use in human medicine.
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SCFAs prevent mucosal degradation that can occur as a result of intense exercise due to hypoperfusion and ischemia.
“They also serve as a primary energy source, about 60-70%, for colonocytes [74], which prevents mucosal degradation [79] that can occur as a result of intense exercise due to hypoperfusion and ischemia for example.”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [79]
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- Authors
- Canani, R. B.
- Affiliations
- Federico II University Hospital (IT)
- Corresponding author
- Canani, Roberto Berni
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2011
- Volume
- 17
- Issue
- 12
- Pages
- 1519
- ISSN
- 1007-9327 (ISSN-L)
- PMC
- PMC3070119
- OpenAlex
- W2136759951
- Cited by
- 1,381
- References
- 110
- Citations by year
- 2026: 101 · 2025: 136 · 2024: 131 · 2023: 122 · 2022: 136 · 2021: 142 · 2020: 129 · 2019: 115 · 2018: 92 · 2017: 72 · 2016: 70 · 2015: 48 · 2014: 31 · 2013: 22 · 2012: 26
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Gastroenterology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Agenzia Italiana del Farmaco, Ministero della Salute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- butyrate, short-chain fatty acids, colonic microbiota, intestinal epithelial barrier, mucosal inflammation, oxidative stress, visceral sensitivity, intestinal motility, colorectal cancer prevention, hemoglobinopathies, inborn errors of metabolism, hypercholesterolemia, insulin resistance, ischemic stroke, gene expression regulation, therapeutic potential
- MeSH terms
- Butyrates, Gastrointestinal Agents, Humans, Intestinal Diseases, Intestinal Mucosa, Intestines, Evidence-Based Medicine
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