The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates
Open accessAbstract
In acute inflammation, extracellular ATP activates P2X(7) ion channel receptors (P2X(7)R) on M1 polarized macrophages to release pro-inflammatory IL-1beta through activation of the caspase-1/nucleotide-binding domain and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome. In contrast, M2 polarized macrophages are critical to the resolution of inflammation but neither actions of P2X(7)R on these macrophages nor mechanisms by which macrophages switch from pro-inflammatory to anti-inflammatory phenotypes are known. Here, we investigated extracellular ATP signalling over a dynamic macrophage polarity gradient from M1 through M2 phenotypes. In macrophages polarized towards, but not at, M2 phenotype, in which intracellular IL-1beta remains high and the inflammasome is intact, P2X(7)R activation selectively uncouples to the NLRP3-inflammasome activation but not to upstream ion channel activation. In these intermediate M1/M2 polarized macrophages, extracellular ATP now acts through its pyrophosphate chains, independently of other purine receptors, to inhibit IL-1beta release by other stimuli through two independent mechanisms: inhibition of ROS production and trapping of the inflammasome complex through intracellular clustering of actin filaments.
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Alternative activation of macrophages
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Cited by
Alternative activation of macrophages: mechanism and functions
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Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
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Understanding the mechanism of IL-1β secretion
Lopez-Castejon, G., & Brough, D. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.10.001 · Cited by 1,519
Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2795090 · Cited by 657
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Metadata
- Authors
- Pelegrin, P., & Surprenant, A.
- Venue
- The EMBO Journal
- Published
- 2009-06-18
- Volume
- 28
- Issue
- 14
- Pages
- 2114-2127
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2013471060
- Cited by
- 264
- References
- 10
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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