The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · see citing works

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840 · see citing works

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,244 · see citing works

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,336 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093 · see citing works

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80439-2 · Cited by 1,629 · see citing works

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

Niethammer, P., Grabher, C., Look, A. T., & Mitchison, T. J. (2009) · Nature · doi:10.1038/nature08119 · Cited by 1,541 · see citing works

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497 · see citing works

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,424 · see citing works

Macrophage-mediated inflammation in metabolic disease

Chawla, A., Nguyen, K. D., & Goh, Y. P. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3071 · Cited by 1,314 · see citing works

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W. L., Love-Gregory, L. D., Lam, W. Y., O’Neill, C. M., et al. (2014) · Nature Immunology · doi:10.1038/ni.2956 · Cited by 1,215 · see citing works

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

Rodríguez-Prados, J.-C., Través, P. G., Cuenca, J., Rico, D., Aragonés, J., Martín-Sanz, P., Cascante, M., & Boscá, L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901698 · Cited by 1,022 · see citing works

Differential macrophage programming in the tumor microenvironment

Ruffell, B., Affara, N. I., & Coussens, L. M. (2012) · Trends in Immunology · doi:10.1016/j.it.2011.12.001 · Cited by 855 · see citing works

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

Zhou, D., Huang, C., Lin, Z., Zhan, S., Kong, L., Fang, C., & Li, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.004 · Cited by 778 · see citing works

Macrophage phenotypes in atherosclerosis

Colin, S., Chinetti‐Gbaguidi, G., & Staels, B. (2014) · Immunological Reviews · doi:10.1111/imr.12218 · Cited by 657 · see citing works

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655 · see citing works

Macrophage subsets in atherosclerosis

Chinetti, G., Colin, S., & Staels, B. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.173 · Cited by 646 · see citing works

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635 · see citing works

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

Haschemi, A., Kosma, P., Gille, L., Evans, C. R., Burant, C. F., Starkl, P., Knapp, B., Haas, R., Schmid, J. A., Jandl, C., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.023 · Cited by 635 · see citing works

Stem cells and the impact of ROS signaling

Bigarella, C. L., Liang, R. H.-S., & Ghaffari, S. (2014) · Development · doi:10.1242/dev.107086 · Cited by 627 · see citing works

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works

Orchestration of Metabolism by Macrophages

Biswas, S. K., & Mantovani, A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.013 · Cited by 586 · see citing works

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration

Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

Zhang, Y., Choksi, S., Chen, K., Pobezinskaya, E. L., Linnoila, I. R., & Liu, Z.-G. (2013) · Cell Research · doi:10.1038/cr.2013.75 · Cited by 575 · see citing works

NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia

Qin, L., Liu, Y., Wang, T., Wei, S.-J., Block, M. L., Wilson, B., Liu, B., & Hong, J.-S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307657200 · Cited by 574 · see citing works

Hydrogen Peroxide Activates NF-κB through Tyrosine Phosphorylation of IκBα and Serine Phosphorylation of p65

Takada, Y., Mukhopadhyay, A., Kundu, G. C., Mahabeleshwar, G. H., Singh, S., & Aggarwal, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212389200 · Cited by 495 · see citing works

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

Nardo, D. D., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2784 · Cited by 463 · see citing works

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

Chang, M.-K., Bergmark, C., Laurila, A., Hörkkö, S., Han, K., Friedman, P., Dennis, E. A., & Witztum, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6353 · Cited by 456 · see citing works

Metabolism of stromal and immune cells in health and disease

Ghesquière, B., Wong, B. W., Kuchnio, A., & Carmeliet, P. (2014) · Nature · doi:10.1038/nature13312 · Cited by 451 · see citing works

Differential regulation of iron homeostasis during human macrophage polarized activation

Recalcati, S., Locati, M., Marini, A., Santambrogio, P., Zaninotto, F., De Pizzol, M., Zammataro, L., Girelli, D., & Cairo, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200939889 · Cited by 438 · see citing works

Redox regulation of glial inflammatory response to lipopolysaccharide and interferonγ

Pawate, S., Shen, Q., Fan, F., & Bhat, N. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20180 · Cited by 428 · see citing works

Targeted Liposomal Drug Delivery to Monocytes and Macrophages

Kelly, C., Jefferies, C. A., & Cryan, S. (2010) · Journal of Drug Delivery · doi:10.1155/2011/727241 · Cited by 426 · see citing works

The mitochondrial citrate carrier: a new player in inflammation

Infantino, V., Convertini, P., Cucci, L., Panaro, M. A., Noia, M. A. D., Calvello, R., Palmieri, F., & Iacobazzi, V. (2011) · Biochemical Journal · doi:10.1042/bj20111275 · Cited by 386 · see citing works

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

Prieur, X., Mok, C. Y. L., Velagapudi, V. R., Núñez, V., Fuentes, L., Montaner, D., Ishikawa, K., Camacho, A., Barbarroja, N., O’Rahilly, S., et al. (2011) · Diabetes · doi:10.2337/db10-0705 · Cited by 381 · see citing works

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

Tan, Z., Xie, N., Cui, H., Moellering, D. R., Abraham, E. H., Thannickal, V. J., & Liu, G. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402469 · Cited by 320 · see citing works

Three pathways to mature macrophages in the early mouse yolk sac

Bertrand, J. Y., Jalil, A., Klaine, M., Jung, S., Cumano, A., & Godin, I. (2005) · Blood · doi:10.1182/blood-2005-02-0461 · Cited by 315 · see citing works

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 302 · see citing works

SHIP Represses the Generation of Alternatively Activated Macrophages

Rauh, M. J., Ho, V. W., Pereira, C. C., Sham, A. P., Sly, L. M., Lam, V., Huxham, L. A., Minchinton, A. I., Mui, A., & Krystal, G. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.003 · Cited by 298 · see citing works

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?

Gregory, C. D., & Devitt, A. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01959.x · Cited by 285 · see citing works

Macrophage Polarization in Obesity and Type 2 Diabetes: Weighing Down Our Understanding of Macrophage Function?

Kraakman, M. J., Murphy, A. J., Jandeleit-Dahm, K. A. M., & Kammoun, H. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00470 · Cited by 278 · see citing works

Anti‐tumour strategies aiming to target tumour‐associated macrophages

Tang, X., Mo, C., Wang, Y., Wei, D., & Xiao, H. (2012) · Immunology · doi:10.1111/imm.12023 · Cited by 278 · see citing works

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

Hall, C. J., Boyle, R. H., Astin, J. W., Flores, M. V., Oehlers, S. H., Sanderson, L. E., Ellett, F., Lieschke, G. J., Crosier, K. E., & Crosier, P. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.018 · Cited by 266 · see citing works

Dynamics of macrophage polarization reveal new mechanism to inhibit IL‐1β release through pyrophosphates

Pelegrı́n, P., & Surprenant, A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.163 · Cited by 265 · see citing works

High-Resolution Transcriptome of Human Macrophages

Beyer, M., Mallmann, M. R., Xue, J., Staratschek‐Jox, A., Vorholt, D., Krebs, W., Sommer, D. D., Sander, J., Mertens, C., Niño‐Castro, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045466 · Cited by 255 · see citing works

Induction of NAD(P)H Oxidase by Oxidized Low-Density Lipoprotein in Human Endothelial Cells

Rueckschloss, U., Galle, J., Holtz, J., Zerkowski, H., & Morawietz, H. (2001) · Circulation · doi:10.1161/hc4001.097056 · Cited by 252 · see citing works

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

Fortes, G. B., Alves, L. S., de Oliveira, R., Dutra, F. F., Rodrigues, D., Fernandez, P. L., Souto-Padron, T., De Rosa, M. J., Kelliher, M., Golenbock, D., et al. (2012) · Blood · doi:10.1182/blood-2011-08-375303 · Cited by 246 · see citing works

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

Allam, R., Lawlor, K. E., Yu, E. C.-W., Mildenhall, A., Moujalled, D. M., Lewis, R. S., Ke, F., Mason, K. D., White, M. J., Stacey, K. J., et al. (2014) · EMBO Reports · doi:10.15252/embr.201438463 · Cited by 238 · see citing works

The polarization of Th1/Th2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production

Murata, Y., Shimamura, T., & Hamuro, J. (2002) · International Immunology · doi:10.1093/intimm/14.2.201 · Cited by 232 · see citing works

The Recently Identified P2Y-Like Receptor GPR17 Is a Sensor of Brain Damage and a New Target for Brain Repair

Lecca, D., Trincavelli, M. L., Gelosa, P., Sironi, L., Ciana, P., Fumagalli, M., Villa, G. C. F., Verderio, C., Grumelli, C., Guerrini, U., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003579 · Cited by 227 · see citing works

Inhibition of NADPH oxidase promotes alternative and anti‐inflammatory microglial activation during neuroinflammation

Choi, S., Aïd, S., Kim, H., Jackson, S. H., & Bosetti, F. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07572.x · Cited by 222 · see citing works

Contrasting phagosome pH regulation and Maturation in Human M1 and M2 macrophages

Canton, J., Khezri, R., Glogauer, M., & Grinstein, S. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-0967 · Cited by 221 · see citing works

Lipid signaling in adipose tissue: Connecting inflammation & metabolism

Masoodi, M., Kuda, O., Rossmeisl, M., Flachs, P., & Kopecký, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.023 · Cited by 218 · see citing works

ROS and innate immunity.

Kohchi, C., Inagawa, H., Nishizawa, T., & Soma, G. (2009) · PubMed · Cited by 214 · see citing works

Curcumin Modulates Macrophage Polarization Through the Inhibition of the Toll-Like Receptor 4 Expression and its Signaling Pathways

Zhou, Y., Zhang, T., Wang, X., Wei, X., Chen, Y., Guo, L., Zhang, J., & Wang, C. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430126 · Cited by 209 · see citing works

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?

Bordt, E. A., & Polster, B. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.033 · Cited by 202 · see citing works

Pivotal Roles of GM‐CSF in Autoimmunity and Inflammation

Shiomi, A., & Usui, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/568543 · Cited by 200 · see citing works

The Type I NADH Dehydrogenase of Mycobacterium tuberculosis Counters Phagosomal NOX2 Activity to Inhibit TNF-α-Mediated Host Cell Apoptosis

Miller, J. L., Velmurugan, K., Cowan, M. J., & Briken, V. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000864 · Cited by 194 · see citing works

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

Tang, Z., Gan, Y. X., Liu, Q., Yin, J., Liu, Q., Shi, J., & Shi, F. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-26 · Cited by 192 · see citing works

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

Bauer, M., Goldstein, M., Christmann, M., Becker, H., Heylmann, D., & Kaina, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111919109 · Cited by 187 · see citing works

Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages

Schilling, J. D., Machkovech, H. M., Li, H., Sidhu, R., Fujiwara, H., Weber, K., Ory, D. S., & Schaffer, J. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.419978 · Cited by 181 · see citing works

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

Kapoor, N., Niu, J., Saad, Y., Kumar, S., Sirakova, T. D., Becerra, E., Li, X., & Kolattukudy, P. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402797 · Cited by 179 · see citing works

Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages

Emre, Y., Hurtaud, C., Nübel, T., Criscuolo, F., Ricquier, D., & Cassard, A. (2007) · Biochemical Journal · doi:10.1042/bj20061430 · Cited by 172 · see citing works

Defective mitochondrial fission augments NLRP3 inflammasome activation

Park, S., Won, J.-H., Hwang, I., Hong, S., Lee, H. K., & Yu, J. (2015) · Scientific Reports · doi:10.1038/srep15489 · Cited by 166 · see citing works

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity

Hucke, S., Eschborn, M., Liebmann, M., Herold, M. V. B., Freise, N., Engbers, A., Ehling, P., Meuth, S. G., Roth, J., Kuhlmann, T., et al. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.11.001 · Cited by 158 · see citing works

LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner

Nishi, K., Oda, T., Takabuchi, S., Oda, S., Fukuda, K., Adachi, T., Semenza, G. L., Shingu, K., & Hirota, K. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1825 · Cited by 156 · see citing works

Oxidative modifications of S100 proteins: functional regulation by redox

Lim, S. Y., Raftery, M. J., Goyette, J., Hsu, K., & Geczy, C. L. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008608 · Cited by 156 · see citing works

Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin

Tan, H.-Y., Wang, N., Man, K., Tsao, S., Che, C., & Feng, Y. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.271 · Cited by 154 · see citing works

NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

Rybicka, J. M., Balce, D. R., Khan, M. F., Krohn, R. M., & Yates, R. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914867107 · Cited by 153 · see citing works

Hyperhomocysteinemia Promotes Inflammatory Monocyte Generation and Accelerates Atherosclerosis in Transgenic Cystathionine β-Synthase–Deficient Mice

Zhang, D., Jiang, X., Fang, P., Yan, Y., Song, J., Gupta, S., Schafer, A. I., Durante, W., Kruger, W. D., Yang, X., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.866889 · Cited by 141 · see citing works

Toxicity of oxysterols to human monocyte-macrophages

CLARE, K. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05594-m · Cited by 139 · see citing works

Reactive oxygen species mediate cyclooxygenase-2 induction during monocyte to macrophage differentiation: Critical role of nadph oxidase

Barbieri, S. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00365-1 · Cited by 138 · see citing works

Postprandial lipoproteins and the molecular regulation of vascular homeostasis

Botham, K. M., & Wheeler-Jones, C. P. D. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.06.001 · Cited by 133 · see citing works

Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms

Balce, D. R., Li, B., Allan, E. R. O., Rybicka, J. M., Krohn, R. M., & Yates, R. M. (2011) · Blood · doi:10.1182/blood-2011-01-328906 · Cited by 131 · see citing works

Tumor-Specific Bacteriophages Induce Tumor Destruction through Activation of Tumor-Associated Macrophages

Eriksson, F., Tsagozis, P., Lundberg, K., Parsa, R., Mangsbo, S. M., Persson, M. A. A., Harris, R. A., & Pisa, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0800224 · Cited by 130 · see citing works

Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

He, C., Ryan, A. J., Murthy, S., & Carter, A. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410720 · Cited by 128 · see citing works

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

Lee, H., & Surh, Y. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.002 · Cited by 119 · see citing works

PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment

Lam, W., Jiang, Z., Guan, F., Huang, X., Hu, R., Wang, J., Bussom, S., Liu, S.-H., Zhao, H., Yen, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep09384 · Cited by 110 · see citing works

Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes

Padgett, L. E., Burg, A. R., Lei, W., & Tse, H. M. (2014) · Diabetes · doi:10.2337/db14-0929 · Cited by 110 · see citing works

TLR4-Mediated Survival of Macrophages Is MyD88 Dependent and Requires TNF-α Autocrine Signalling

Lombardo, E., Alvarez, A. M., Maroto, B., Boscá, L., & Knaus, U. G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.6.3731 · Cited by 108 · see citing works

Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer

Yang, H., Kim, C., Kim, M.-J., Schwendener, R. A., Alitalo, K. K., Heston, W., Kim, I., Kim, W., & Koh, G. Y. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-36 · Cited by 108 · see citing works

Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine

Kagan, V. E., Borisenko, G. G., Serinkan, B. F., Tyurina, Y. Y., Tyurin, V. A., Jiang, J., Liu, S. X., Shvedova, A. A., Fabisiak, J. P., Uthaisang, W., et al. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00365.2002 · Cited by 105 · see citing works

MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity

Pei, Z., Pang, H., Qian, L., Yang, S., Wang, T., Zhang, W., Wu, X., Dallas, S., Wilson, B., Reece, J. M., et al. (2007) · Glia · doi:10.1002/glia.20545 · Cited by 105 · see citing works

Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages

Im, D. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.094 · Cited by 104 · see citing works

Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels

Rowlands, D. J., Islam, M. N., Das, S., Huertas, A., Quadri, S. K., Horiuchi, K., Inamdar, N. M., Emin, M. T., Lindert, J., Ten, V. S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43839 · Cited by 102 · see citing works

Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

Lim, Y.-J., Choi, J., Choi, H., Cho, S., Kim, H., Jo, E., Park, J., & Song, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028531 · Cited by 97 · see citing works

Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression

Lin, H.-Y., Shen, S., Lin, C., Yang, L., & Chen, Y. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.04.008 · Cited by 94 · see citing works

LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner

西, 憲. (2008) · Medical Entomology and Zoology · Cited by 93 · see citing works

Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic ‘eat-me’ signals: cleavage and inhibition of phagocytosis by Lp-PLA2

Tyurin, V. A., Balasubramanian, K., Winnica, D., Tyurina, Y. Y., Vikulina, A. S., He, R., Kapralov, A. A., Macphee, C. H., & Kagan, V. E. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.1 · Cited by 92 · see citing works

Reshaping of Human Macrophage Polarization through Modulation of Glucose Catabolic Pathways

Izquierdo, E., Cuevas, V. D., Fernández‐Arroyo, S., Riera-Borrull, M., Orta‐Zavalza, E., Joven, J., Rial, E., Corbí, A. L., & Escribese, M. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403045 · Cited by 90 · see citing works

Role of sestrin2 in peroxide signaling in macrophages

Essler, S., Dehne, N., & Brüne, B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.017 · Cited by 90 · see citing works

Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock

Liu, L., Gong, L.-K., Wang, H., Xiao, Y., Wu, X.-F., Zhang, Y.-H., Xue, X., Qi, X.-M., & Ren, J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.10.009 · Cited by 89 · see citing works

The Connection of Monocytes and Reactive Oxygen Species in Pain

Hackel, D., Pflücke, D., Neumann, A., Viebahn, J., Mousa, S. A., Wischmeyer, E., Roewer, N., Brack, A., & Rittner, H. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063564 · Cited by 88 · see citing works

Reactive Oxygen Species and Thiol Redox Signaling in the Macrophage Biology of Atherosclerosis

Tavakoli, S., & Asmis, R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4638 · Cited by 87 · see citing works

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

Lee, A. S., Jung, Y. J., Kim, D., Nguyen, T. T., Kang, K. P., Lee, S., Park, S. K., & Kim, W. B. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.135 · Cited by 85 · see citing works

NADPH Oxidase NOX2 Mediates Rapid Cellular Oxidation following ATP Stimulation of Endotoxin-Primed Macrophages

Moore, S., & Mackenzie, A. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900394 · Cited by 83 · see citing works

Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-γ and attenuates the oxidative burst

Johann, A. M., von Knethen, A., Lindemann, D., & Brüne, B. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401832 · Cited by 83 · see citing works

Age‐associated changes in long‐chain fatty acid profile during healthy aging promote pro‐inflammatory monocyte polarization via PPAR γ

Pararasa, C., Ikwuobe, J., Shigdar, S. M., Boukouvalas, A., Nabney, I. T., Brown, J. E. P., Devitt, A., Bailey, C. J., Bennett, S. J., & Griffiths, H. R. (2015) · Aging Cell · doi:10.1111/acel.12416 · Cited by 81 · see citing works

Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells

Choi, J.-A., Lim, Y.-J., Cho, S.-N., Lee, J.-H., Jeong, J. A., Kim, E., Park, J. B., Kim, S., Park, H. S., Kim, H.-J., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.489 · Cited by 81 · see citing works

HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

Hoshino, S., Konishi, M., Mori, M., Shimura, M., Nishitani, C., Kuroki, Y., Koyanagi, Y., Kano, S., Itabe, H., & Ishizaka, Y. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0809547 · Cited by 80 · see citing works

Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4

Park, S.-J., Lee, K., Kang, S., Lee, J., Sato, K., Chung, H. Y., Okajima, F., & Im, D. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.009 · Cited by 79 · see citing works

Nitrosative Stress Inhibits the Aminophospholipid Translocase Resulting in Phosphatidylserine Externalization and Macrophage Engulfment

Tyurina, Y. Y., Basova, L. V., Konduru, N. V., Tyurin, V. A., Potapovich, A. I., Cai, P., Bayır, H., Stoyanovsky, D. A., Pitt, B. R., Shvedova, A. A., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606950200 · Cited by 77 · see citing works

Lipid Antioxidant, Etoposide, Inhibits Phosphatidylserine Externalization and Macrophage Clearance of Apoptotic Cells by Preventing Phosphatidylserine Oxidation

Tyurina, Y. Y., Serinkan, F. B., Tyurin, V. A., Kini, V., Yalowich, J. C., Schroit, A. J., Fadeel, B., & Kagan, V. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309929200 · Cited by 76 · see citing works

Role of macrophages in malignancy

Dhabekar, G., Dandekar, R., & Kingaonkar, A. (2011) · Annals of Maxillofacial Surgery · doi:10.4103/2231-0746.92782 · Cited by 73 · see citing works

Interplay between redox status and inflammasome activation

Rubartelli, A., Gattorno, M., Netea, M. G., & Dinarello, C. A. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.08.005 · Cited by 73 · see citing works

NADPH Oxidase 4 Mediates Monocyte Priming and Accelerated Chemotaxis Induced by Metabolic Stress

Ullevig, S. L., Zhao, Q. D., Lee, C. F., Kim, H. S., Zamora, D. A., & Asmis, R. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.238899 · Cited by 72 · see citing works

Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species

Jiménez-López, C., Collette, J. R., Brothers, K. M., Shepardson, K. M., Cramer, R. A., Wheeler, R. T., & Lorenz, M. C. (2012) · Eukaryotic Cell · doi:10.1128/ec.00290-12 · Cited by 72 · see citing works

Purification, Cloning, and Functional Characterization of a Novel Immunomodulatory Protein from Antrodia camphorata (Bitter Mushroom) That Exhibits TLR2-Dependent NF-κB Activation and M1 Polarization within Murine Macrophages

Sheu, F., Chien, P., Hsieh, K.-Y., Chin, K.-L., Huang, W., Tsao, C.-Y., Chen, Y.-F., Cheng, H.-C., & Chang, H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900469a · Cited by 69 · see citing works

Overexpression of Uncoupling Protein 2 in THP1 Monocytes Inhibits β 2 Integrin-Mediated Firm Adhesion and Transendothelial Migration

Ryu, J.-W., Hong, K. H., Maeng, J. H., Kim, J. B., Ko, J., Park, J. Y., Lee, K., Hong, M., Park, S., Kim, Y. H., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000125705.28058.eb · Cited by 64 · see citing works

Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease

Sanmun, D., Witasp, E., Jitkaew, S., Tyurina, Y. Y., Kagan, V. E., Åhlin, A., Palmblad, J. E. W., & Fadeel, B. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00651.2008 · Cited by 62 · see citing works

The carotenoid lutein enhances matrix metalloproteinase-9 production and phagocytosis through intracellular ROS generation and ERK1/2, p38 MAPK, and RARβ activation in murine macrophages

Lo, H., Chen, C.-L., Yang, C., Wu, P., Tsou, C.-J., Chiang, K.-W., & Wu, W. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512238 · Cited by 61 · see citing works

Role of catalase in monocytic differentiation of U937 cells by TPA: hydrogen peroxide as a second messenger

Yamamoto, T., Sakaguchi, N., Hachiya, M., Nakayama, F., Yamakawa, M., & Akashi, M. (2008) · Leukemia · doi:10.1038/leu.2008.353 · Cited by 59 · see citing works

Caspase-1/ASC Inflammasome-Mediated Activation of IL-1β–ROS–NF-κB Pathway for Control of Trypanosoma cruzi Replication and Survival Is Dispensable in NLRP3−/− Macrophages

Dey, N., Sinha, M., Gupta, S., Gonzalez, M. N., Fang, R., Endsley, J. J., Luxon, B. A., & Garg, N. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111539 · Cited by 56 · see citing works

NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages

Song, M., Ryoo, I.-G., Choi, H.-Y., Choi, B.-H., Kim, S.-T., Heo, T., Lee, J. Y., Park, P., & Kwak, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134235 · Cited by 47 · see citing works

SYNCRIP-Dependent Nox2 mRNA Destabilization Impairs ROS Formation in M2-Polarized Macrophages

Kuchler, L., Giegerich, A. K., Sha, L. K., Knape, T., Wong, M. S. K., Schröder, K., Brandes, R. P., Heide, H., Wittig, I., Brüne, B., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5760 · Cited by 40 · see citing works

Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in vivo monocyte-to-macrophage differentiation

Fuhrman, B., Shiner, M., Volkova, N., & Aviram, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.026 · Cited by 40 · see citing works

Oxidatively modified high density lipoprotein promotes inflammatory response in human monocytes–macrophages by enhanced production of ROS, TNF-α, MMP-9, and MMP-2

Soumyarani, V. S., & Jayakumari, N. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1306-y · Cited by 40 · see citing works

Regulation of Monocyte Adhesion and Migration by Nox4

Lee, C. F., Ullevig, S. L., Kim, H. S., & Asmis, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066964 · Cited by 34 · see citing works

p47phox Directs Murine Macrophage Cell Fate Decisions

Liang, Y., Liu, Q., Orandle, M. S., Sadiq-Ali, S., Koontz, S. M., Choi, U., Torres-Velez, F. J., & Jackson, S. H. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.019 · Cited by 34 · see citing works

Mycobacterium kansasii-induced death of murine macrophages involves endoplasmic reticulum stress responses mediated by reactive oxygen species generation or calpain activation

Lim, Y.-J., Choi, H., Choi, J., Jeong, J. A., Cho, S., Lee, J., Park, J. B., Kim, H., & Song, C. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0792-4 · Cited by 33 · see citing works

Cellular Adaptation to Anthrax Lethal Toxin-Induced Mitochondrial Cholesterol Enrichment, Hyperpolarization, and Reactive Oxygen Species Generation through Downregulating MLN64 in Macrophages

Ha, S.-D., Park, S., Han, C. Y., Nguyen, M. L., & Kim, S. O. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00494-12 · Cited by 33 · see citing works

Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages

Kato, K., Uchino, R., Lillehoj, E. P., Knox, K. S., Lin, Y., & Kim, K. C. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0177oc · Cited by 31 · see citing works

Methemoglobin exposure produces toxicological effects in macrophages due to multiple ROS spike induced apoptosis

Deshmukh, R., & Trivedi, V. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.09.016 · Cited by 29 · see citing works

TPA induces the expression of EC-SOD in human monocytic THP-1 cells: Involvement of PKC, MEK/ERK and NOX-derived ROS

Makino, J., Kamiya, T., Hara, H., & Adachi, T. (2012) · Free Radical Research · doi:10.3109/10715762.2012.664841 · Cited by 28 · see citing works

Divergent Effects on Phagocytosis by Macrophage-Derived Oxygen Radicals

Brown, K. L., Christenson, K., Karlsson, A., Dahlgren, C., & Bylund, J. (2009) · Journal of Innate Immunity · doi:10.1159/000235583 · Cited by 25 · see citing works

The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats

Zhang, Y.-K., Wang, J., Liu, L., Chang, R. C., So, K., & Ju, G. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-67 · Cited by 24 · see citing works

Phagocytic Entry of Legionella pneumophila into Macrophages through Phosphatidylinositol 3,4,5-Trisphosphate-Independent Pathway

Harada, T., Tanikawa, T., Iwasaki, Y., Yamada, M., Imai, Y., & Miyake, M. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b11-00011 · Cited by 11 · see citing works

Macrophage polarisation by fatty acids is PPARgamma-dependent

Pararasa, C., Bailey, C. J., & Griffiths, H. R. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.764 · Cited by 10 · see citing works

5-Lipoxygenase inhibitors potentiate 1α,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway

Stixová, L., Procházková, J., Souček, K., Hofmanová, J., & Kozubı́k, A. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0138-x · Cited by 8 · see citing works

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

Orecchioni, M., Ghosheh, Y., Pramod, A. B., & Ley, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01084 · Cited by 2,063 · see citing works

Mitochondrial metabolism and cancer

Porporato, P. E., Filigheddu, N., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2017) · Cell Research · doi:10.1038/cr.2017.155 · Cited by 1,292 · see citing works

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works

Reactive Oxygen Species: Drivers of Physiological and Pathological Processes

Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,022 · see citing works

Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

Xia, Y., Rao, L., Yao, H., Wang, Z., Ning, P., & Chen, X. (2020) · Advanced Materials · doi:10.1002/adma.202002054 · Cited by 949 · see citing works

PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism

Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 648 · see citing works

The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)

Tanase, D. M., Gosav, E. M., Costea, C. F., Ciocoiu, M., Lacatusu, C. M., Maranduca, M. A., Ouatu, A., & Floria, M. (2020) · Journal of Diabetes Research · doi:10.1155/2020/3920196 · Cited by 627 · see citing works

Metabolic Regulation of Macrophage Polarization in Cancer

Mehla, K., & Singh, P. K. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.10.007 · Cited by 622 · see citing works

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

Kuo, C., Babuharisankar, A. P., Lin, Y.-C., Lien, H.-W., Lo, Y.-K., Chou, H.-Y., Tangeda, V., Cheng, L.-C., Cheng, A., & Lee, A. (2022) · Journal of Biomedical Sciences · doi:10.1186/s12929-022-00859-2 · Cited by 316 · see citing works

Tumour treating fields therapy for glioblastoma: current advances and future directions

Rominiyi, O., Vanderlinden, A., Clenton, S. J., Bridgewater, C. H., Al-Tamimi, Y., & Collis, S. J. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01136-5 · Cited by 319 · see citing works

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

Geeraerts, X., Bolli, E., Fendt, S., & Ginderachter, J. A. V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00289 · Cited by 315 · see citing works

Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance

Tsai, C., Chen, G., Chen, Y.-C., Shen, C., Lu, D., Yang, L., Chen, J.-H., & Yeh, W. (2021) · Nutrients · doi:10.3390/nu14010067 · Cited by 317 · see citing works

Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma

Devanney, N. A., Stewart, A. N., & Gensel, J. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113310 · Cited by 311 · see citing works

Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective

Pérez, S., & Rius-Pérez, S. (2022) · Antioxidants · doi:10.3390/antiox11071394 · Cited by 312 · see citing works

Macrophage Related Chronic Inflammation in Non-Healing Wounds

Li, M.-R., Hou, Q., Zhong, L.-Z., Zhao, Y.-L., & Fu, X.-B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 289 · see citing works

Dual Roles of Graphene Oxide To Attenuate Inflammation and Elicit Timely Polarization of Macrophage Phenotypes for Cardiac Repair

Han, J., Kim, Y. S., Lim, M.-Y., Kim, H. Y., Kong, S., Kang, M., Choo, Y. W., Jun, J. H., Ryu, S., Jeong, H.-Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09107 · Cited by 261 · see citing works

Hyperglycemia modulates M1/M2 macrophage polarization via reactive oxygen species overproduction in ligature‐induced periodontitis

Zhang, B., Yang, Y., Yi, J., Zhao, Z., & Ye, R. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12912 · Cited by 256 · see citing works

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. D. (2022) · Antioxidants · doi:10.3390/antiox11020408 · Cited by 249 · see citing works

A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization

Sun, Y. L., Sun, X., Li, X., Li, W., Li, C., Zhou, Y., Wang, L., & Dong, B. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120614 · Cited by 247 · see citing works

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

Santoni, M., Romagnoli, E., Saladino, T., Foghini, L., Guarino, S., Capponi, M., Giannini, M., Cognigni, P. D., Ferrara, G., & Battelli, N. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.10.007 · Cited by 238 · see citing works

Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups

Sun, Y., Li, J., Xie, X., Gu, F., Sui, Z., Zhang, K., & Yu, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.778078 · Cited by 235 · see citing works

Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators

Piccinin, E., Villani, G., & Moschetta, A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0089-3 · Cited by 230 · see citing works

The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials

Duan, H., Wang, L., Huangfu, M., & Li, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115276 · Cited by 241 · see citing works

Quercetin‐Loaded Ceria Nanocomposite Potentiate Dual‐Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation

Wang, Y., Li, C., Wan, Y., Qi, M., Chen, Q., Sun, Y. L., Sun, X., Fang, J., Fu, L., Xu, L. H., et al. (2021) · Small · doi:10.1002/smll.202101505 · Cited by 228 · see citing works

Macrophages and bone inflammation

Gu, Q., Yang, H., & Shi, Q. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.002 · Cited by 221 · see citing works

The hormetic dose-response mechanism: Nrf2 activation

Calabrese, E. J., & Kozumbo, W. J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105526 · Cited by 216 · see citing works

New Perspectives in Biofilm Eradication

Wolfmeier, H., Pletzer, D., Mansour, S., & Hancock, R. E. W. (2017) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00170 · Cited by 198 · see citing works

Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease

Yang, Y. M., Cho, Y. E., & Hwang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020774 · Cited by 199 · see citing works

Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression

Griess, B., Mir, S. U. R., Datta, K., & Teoh-Fitzgerald, M. L. T. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.018 · Cited by 200 · see citing works

Antibacterial Zeolite Imidazole Frameworks with Manganese Doping for Immunomodulation to Accelerate Infected Wound Healing

Wan, Y., Fang, J., Wang, Y., Sun, J., Sun, Y. L., Sun, X., Qi, M., Li, W., Li, C., Zhou, Y., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101515 · Cited by 175 · see citing works

Iron induces anti-tumor activity in tumor-associated macrophages

Costa da Silva, M., Breckwoldt, M. O., Vinchi, F., Correia, M. P., Stojanovic, A., Thielmann, C. M., Meister, M., Muley, T., Warth, A., Platten, M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01479 · Cited by 164 · see citing works

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 170 · see citing works

Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages

Marrocco, A., & Ortiz, L. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.936167 · Cited by 166 · see citing works

Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition

Yuan, Y., Chen, Y., Peng, T., Li, L., Zhu, W., Liu, F., Liu, S., An, X., Luo, R., Cheng, J., et al. (2019) · Clinical Science · doi:10.1042/cs20190672 · Cited by 161 · see citing works

Role of Reactive Oxygen Species in Inflammation: A Minireview

Chelombitko, M. A. (2018) · Moscow University Biological Sciences Bulletin · doi:10.3103/s009639251804003x · Cited by 161 · see citing works

The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment

Wang, X., Fan, D., Cao, X., Ye, Q., Wang, Q., Zhang, M., & Xiao, C. (2022) · Antioxidants · doi:10.3390/antiox11061153 · Cited by 165 · see citing works

Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell–Derived Endothelial Cells

Lee, W. H., Ong, S., Zhou, Y., Tian, L., Bae, H. R., Baker, N., Whitlatch, A., Mohammadi, L., Guo, H., Nadeau, K. C., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.476 · Cited by 157 · see citing works

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

Bojková, B., Winklewski, P. J., & Wszędybył-Winklewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114114 · Cited by 158 · see citing works

Reactive Oxygen Species and Antitumor Immunity—From Surveillance to Evasion

Kotsafti, A., Scarpa, M., Castagliuolo, I., & Scarpa, M. (2020) · Cancers · doi:10.3390/cancers12071748 · Cited by 157 · see citing works

The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration

Santa, F. D., Vitiello, L., Torcinaro, A., & Ferraro, E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7420 · Cited by 154 · see citing works

Adipose oxidative stress and protein carbonylation

Hauck, A. K., Huang, Y., Hertzel, A. V., & Bernlohr, D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r118.003214 · Cited by 152 · see citing works

Dual detoxification and inflammatory regulation by ceria nanozymes for drug-induced liver injury therapy

Li, F., Qiu, Y., Xia, F., Sun, H., Liao, H., Xie, A., Lee, J., Lin, P., Wei, M., Shao, Y., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100925 · Cited by 148 · see citing works

Signaling pathways in macrophages: molecular mechanisms and therapeutic targets

Li, M., Wang, M., Wen, Y., Zhang, H., Zhao, G., & Gao, Q. (2023) · MedComm · doi:10.1002/mco2.349 · Cited by 153 · see citing works

Redox Homeostasis Strategy for Inflammatory Macrophage Reprogramming in Rheumatoid Arthritis Based on Ceria Oxide Nanozyme-Complexed Biopolymeric Micelles

Zhou, F., Li, M., Chen, M., Chen, M., Chen, X., Luo, Z. Y., Cai, K., & Hu, Y. (2023) · ACS Nano · doi:10.1021/acsnano.2c09127 · Cited by 140 · see citing works

Precise modulation and use of reactive oxygen species for immunotherapy

Li, X., Gao, J., Wu, C., Wang, C., Zhang, R., He, J., Xia, Z. J., Joshi, N., Karp, J. M., & Kuai, R. (2024) · Science Advances · doi:10.1126/sciadv.adl0479 · Cited by 140 · see citing works

Epigallocatechin gallate-based nanoparticles with reactive oxygen species scavenging property for effective chronic periodontitis treatment

Tian, M., Chen, G., Xu, J., Lin, Y., Zeng, Y., Chen, X., Li, X., & Chen, S. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132197 · Cited by 137 · see citing works

Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy

Figueiredo, P., Lepland, A., Scodeller, P., Fontana, F., Torrieri, G., Tiboni, M., Shahbazi, M., Casettari, L., Kostiainen, M. A., Hirvonen, J. J., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.038 · Cited by 137 · see citing works

Immune Tumor Microenvironment in Breast Cancer and the Participation of Estrogen and Its Receptors in Cancer Physiopathology

Mendoza, M. S., & Morales‐Montor, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00348 · Cited by 133 · see citing works

Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis

Ren, Y., Wang, R., Weng, S., Xu, H., Zhang, Y., Chen, S., Liu, S., Ba, Y., Zhou, Z., Luo, P., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01831-w · Cited by 138 · see citing works

Ceria-based nanotheranostic agent for rheumatoid arthritis

Kalashnikova, I. V., Chung, S., Nafiujjaman, M., Hill, M. L., Siziba, M. E., Contag, C. H., & Kim, T. (2020) · Theranostics · doi:10.7150/thno.49069 · Cited by 131 · see citing works

Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming

Zeng, W., Li, F., Jin, S., Ho, P., Liu, P.-S., & Xie, X. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02832-9 · Cited by 131 · see citing works

Macrophages in osteoarthritis: pathophysiology and therapeutics.

Chen, Y., Jiang, W. H., Yong, H., He, M., Yang, Y., Deng, Z., & Li, Y. (2020) · PubMed Central · Cited by 128 · see citing works

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Larionova, I., Kazakova, E., Patysheva, M. R., & Kzhyshkowska, J. G. (2020) · Cancers · doi:10.3390/cancers12061411 · Cited by 124 · see citing works

Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

Jeong, J., Cha, H., Han, M. H., Hwang, S. J., Lee, D.-S., Yoo, J. S., Choi, I., Kim, S., Kim, H., Kim, G., et al. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.272 · Cited by 125 · see citing works

Macrophage-Driven Biomaterial Degradation Depends on Scaffold Microarchitecture

Wissing, T. B., Bonito, V., van Haaften, E. E., van Doeselaar, M., Brugmans, M. C. P., Janssen, H. M., Bouten, C. V. C., & Smits, A. I. P. M. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00087 · Cited by 123 · see citing works

Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy

Orillion, A. R., Damayanti, N. P., Shen, L., Adelaiye-Ogala, R. M., Affronti, H. C., Elbanna, M., Chintala, S., Ciesielski, M. J., Fontana, L., Kao, C. H., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0980 · Cited by 121 · see citing works

Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose

Calabrese, E. J., Dhawan, G., Kapoor, R., & Kozumbo, W. J. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119846925 · Cited by 113 · see citing works

Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway

Shan, M., Qin, J., Jin, F., Han, X., Guan, H., Li, X., Zhang, J., Zhang, H., & Wang, Y. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.021 · Cited by 112 · see citing works

Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus

Labonte, A. C., Kegerreis, B. J., Geraci, N., Bachali, P., Madamanchi, S., Robl, R. D., Catalina, M. D., Lipsky, P. E., & Grammer, A. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208132 · Cited by 110 · see citing works

Synergistic checkpoint-blockade and radiotherapy–radiodynamic therapy via an immunomodulatory nanoscale metal–organic framework

Ni, K., Xu, Z., Culbert, A. A., Luo, T., Guo, N., Yang, K., Pearson, E. A., Preusser, B., Wu, T., Rivière, P. J. L., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00846-w · Cited by 112 · see citing works

Neuroprotective and anti‐inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies

Azzini, E., Peña-Corona, S. I., Hernández-Parra, H., Chandran, D., Saleena, L. A. K., Sawikr, Y., Peluso, I., DHUMAL, S. S., Kumar, M., Leyva-Gómez, G., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8200 · Cited by 103 · see citing works

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection

Baldanta, S., Fernández‐Escobar, M., Acín‐Pérez, R., Albert, M., Camafeita, E., Jorge, I., Vázquez, J., Enrı́quez, J. A., & Guerra, S. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006651 · Cited by 105 · see citing works

Protein damage, ageing and age-related diseases

Kriško, A., & Radman, M. (2019) · Open Biology · doi:10.1098/rsob.180249 · Cited by 108 · see citing works

Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity

Wang, T., Zhang, H., Han, Y., Liu, H., Ren, F. Z., Zeng, J., Sun, Q., Li, Z., & Gao, M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b03541 · Cited by 107 · see citing works

Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm

Sohrab, S. S., Raj, R., Nagar, A., Hawthorne, S. J., Paiva‐Santos, A. C., Kamal, M. A., El-Daly, M. M., Azhar, E. I., & Sharma, A. (2023) · Molecules · doi:10.3390/molecules28114413 · Cited by 107 · see citing works

Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A. K., Wheelan, S. J., Yegnasubramanian, S., & Jaffee, E. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208602 · Cited by 103 · see citing works

Macrophage Polarization and Liver Ischemia-Reperfusion Injury

Wang, H., Xi, Z., Deng, L., Pan, Y., He, K., & Xia, Q. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.52691 · Cited by 106 · see citing works

Chondroitin sulfate microspheres anchored with drug-loaded liposomes play a dual antioxidant role in the treatment of osteoarthritis

He, Y., Sun, M., Wang, J., Yang, X., Lin, C., Ge, L., Ying, C., Xu, K., Liu, A., & Wu, L. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.07.052 · Cited by 106 · see citing works

Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation

Kim, J., Hong, G., Mazaleuskaya, L., Hsu, J. C., Rosario‐Berríos, D. N., Großer, T., Cho-Park, P. F., & Cormode, D. P. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c16126 · Cited by 104 · see citing works

Mitochondrial Reactive Oxygen Species and Type 1 Diabetes

Chen, J., Stimpson, S. E., Fernandez‐Bueno, G. A., & Mathews, C. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7346 · Cited by 100 · see citing works

New Horizons of Macrophage Immunomodulation in the Healing of Diabetic Foot Ulcers

Lin, C., Hung, C., Chen, W. H., Chen, J.-C., Huang, W., Lu, C.-S., Kuo, M.-L., & Chen, S.-G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14102065 · Cited by 99 · see citing works

Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism

Lin, W., Shen, P., Song, Y., Huang, Y., & Tu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635021 · Cited by 97 · see citing works

The Air We Breathe: Air Pollution as a Prevalent Proinflammatory Stimulus Contributing to Neurodegeneration

Jankowska-Kieltyka, M., Roman, A., & Nalepa, I. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.647643 · Cited by 98 · see citing works

IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy

Tsai, M.-L., Tsai, Y., Lin, Y., Hsu, Y., Chen, Y., Tsai, M.-K., Liao, W., Lin, Y.-C., & Hung, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010003 · Cited by 96 · see citing works

Alteration of cellular and immune‐related properties of bone marrow mesenchymal stem cells and macrophages by K562 chronic myeloid leukemia cell derived exosomes

Jafarzadeh, N., Safari, Z., Pornour, M., Amirizadeh, N., Moghadam, M. F., & Sadeghizadeh, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27142 · Cited by 95 · see citing works

Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity

Ma, M., Zhang, Y., Pu, K., & Tang, W. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00679h · Cited by 97 · see citing works

Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy

Gupta, V. G., Yull, F. E., & Khabele, D. (2018) · Cancers · doi:10.3390/cancers10100366 · Cited by 91 · see citing works

Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

Patel, K. D., Keskin‐Erdogan, Z., Sawadkar, P., Sharifulden, N. S. A. N., Shannon, M. R., Patel, M., Silva, L. V. B., Patel, R., Chau, D. Y. S., Knowles, J. C., et al. (2024) · Nanoscale Horizons · doi:10.1039/d4nh00171k · Cited by 90 · see citing works

Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery

He, J., Zhang, W., Zhou, X., Xu, F., Zou, J., Zhang, Q., Zhao, Y., He, H., Yang, H., & Liu, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.041 · Cited by 87 · see citing works

Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NFκB and MAPK Signaling Pathways

Islam, S. U., Lee, J., Shehzad, A., Ahn, E., Lee, Y. J., & Lee, Y. K. (2018) · Molecules · doi:10.3390/molecules23081880 · Cited by 84 · see citing works

Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity

Kwon, D., Lee, H., Park, C., Hong, S., Hong, S.-H., Kim, G.-Y., Cha, H., Kim, S., Kim, H.-S., Hwang, H.-J., et al. (2019) · Antioxidants · doi:10.3390/antiox8090413 · Cited by 81 · see citing works

ROS-Inducing Micelles Sensitize Tumor-Associated Macrophages to TLR3 Stimulation for Potent Immunotherapy

Liu, L., He, H., Liang, R., Yi, H., Meng, X., Chen, Z., Pan, H., Ma, Y., & Cai, L. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00239 · Cited by 83 · see citing works

Oxidative stress in alcoholic liver disease, focusing on proteins, nucleic acids, and lipids: A review

Lai, W., Zhang, J., Sun, J., Min, T., Bai, Y., He, J., Cao, H., Che, Q., Guo, J., & Su, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134809 · Cited by 82 · see citing works

Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related Pathways

Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80 · see citing works

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Luque-Campos, N., Bustamante-Barrientos, F. A., Pradenas, C., García, C., Araya, M. J., Bohaud, C., Contreras-López, R., Elizondo-Vega, R., Djouad, F., Luz-Crawford, P., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624746 · Cited by 82 · see citing works

ROS homeostasis, a key determinant in liver ischemic-preconditioning

Priéto, I., & Monsalve, M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.036 · Cited by 81 · see citing works

Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy

Shi, J., Zhang, Y., Zhang, X., Chen, R., Wei, J., Hou, J., Wang, B., Lai, H., & Huang, Y. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01175-x · Cited by 81 · see citing works

Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis

Yang, K., Deng, X., Jian, S., Zhang, M., Wen, C., Xin, Z., Zhang, L., Tong, A., Ye, S., Liao, P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.813890 · Cited by 79 · see citing works

Effects of magnesium alloy corrosion on biological response – Perspectives of metal-cell interaction

Kim, J., & Pan, H. (2022) · Progress in Materials Science · doi:10.1016/j.pmatsci.2022.101039 · Cited by 80 · see citing works

Improved Immunoregulation of Ultra-Low-Dose Silver Nanoparticle-Loaded TiO2 Nanotubes via M2 Macrophage Polarization by Regulating GLUT1 and Autophagy

Chen, Y., Guan, M., Ren, R., Gao, C., Cheng, H., Li, Y., Gao, B., Wei, Y., Fu, J., Sun, J. S., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s242919 · Cited by 80 · see citing works

Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review

Xin, L., Gao, J., Lin, H., Qu, Y., Shang, C., Wang, Y., Lu, Y., & Cui, X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.583200 · Cited by 79 · see citing works

Reactive oxygen species in immune cells: A new antitumor target

Wang, L., Kuang, Z., Zhang, D., Gao, Y., Ying, M., & Wang, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110978 · Cited by 78 · see citing works

The mineralocorticoid receptor as a modulator of innate immunity and atherosclerosis

van der Heijden, C. D. C. C., Deinum, J., Joosten, L. A. B., Netea, M. G., & Riksen, N. P. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy092 · Cited by 77 · see citing works

Fucoidan inhibits lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and zebrafish larvae

Jeong, J.-W., Hwang, S. J., Han, M. H., Lee, D.-S., Yoo, J. S., Choi, I., Cha, H., Kim, S., Kim, H., Kim, G., et al. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0045-2 · Cited by 76 · see citing works

Hydrogenated silicene nanosheet functionalized scaffold enables immuno‐bone remodeling

Lin, Z., Chen, Z., Chen, Y., Yang, N., Shi, J., Tang, Z., Zhang, C., Lin, H., & Yin, J. (2023) · Exploration · doi:10.1002/exp.20220149 · Cited by 76 · see citing works

Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID

Clough, E., Inigo, J., Chandra, D., Chaves, L., Reynolds, J. L., Aalinkeel, R., Schwartz, S. A., Khmaladze, A., & Mahajan, S. D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10015-6 · Cited by 75 · see citing works

ROS-associated immune response and metabolism: a mechanistic approach with implication of various diseases

Banerjee, S., Ghosh, S., Mandal, A., Ghosh, N., & Sil, P. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02801-7 · Cited by 66 · see citing works

The yin and yang of imaging tumor associated macrophages with PET and MRI

Mukherjee, S., Sonanini, D., Maurer, A., & Daldrup-Link, H. E. (2019) · Theranostics · doi:10.7150/thno.37306 · Cited by 71 · see citing works

LincRNA-p21 knockdown reversed tumor-associated macrophages function by promoting MDM2 to antagonize* p53 activation and alleviate breast cancer development

Zhou, L., Tian, Y., Guo, F., Yu, B., Li, J., Xu, H., & Su, Z. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02511-0 · Cited by 71 · see citing works

Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization

Kimura, T., Tajiri, K., Sato, A., Sakai, S., Wang, Z., Yoshida, T., Uede, T., Hiroe, M., Aonuma, K., Ieda, M., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy244 · Cited by 71 · see citing works

Redox control of inflammation in macrophages

Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A., & Weigert, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4785 · Cited by 377 · see citing works

A review on redox mediated regulation of macrophage function and polarization in human diseases

Sarma, S., & Kashyap, A. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22741142

The Metabolic Prospective and Redox Regulation of Macrophage Polarization

He, C., & Carter, A. (2015) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000371 · Cited by 70 · see citing works

Reactive Oxygen and Nitrogen Species on Monocyte and Macrophage Biology

Jimenez‐Trinidad, F. R., Morini, S., Buffon, A., Prisco, A. D., Galati, G., Ciutiis, A. D., d’Aiello, A., Jiménez‐Altayó, F., Dantas, A. P., Liuzzo, G., et al. (2026) · Antioxidants · doi:10.3390/antiox15030389 · Cited by 6 · see citing works

Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective

Pérez, S., & Rius-Pérez, S. (2022) · Antioxidants · doi:10.3390/antiox11071394 · Cited by 312 · see citing works