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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
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“While the TET domain is expected to be positioned on the opposite side of the DNA relative to the four DBDs,65,66,68”
From Mapping Interactions of the Intrinsically Disordered C-Terminal Regions of Tetrameric p53 by Segmental Isotope Labeling and NMR (2022) · cites this paper as [68]
In the citing paper
“Some p53/DNA structures reveal that loop L1 of two p53 subunits adopts a conformational switch from an extended conformation where Lys120 interacts directly with DNA to a recessed conformation where there is no direct DNA contact.301”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [301]
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Cites
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
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“Several structures of p53 with DNA have been previously determined (Cho et al, 1994; Ho et al, 2006; Malecka et al, 2009; Chen et al, 2010; Kitayner et al, 2006, 2010).”
BackgroundMethodInfluentialActivation of the DNA damage checkpoint and genomic instability in human precancerous lesions
Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009
Self-citationAcetylation of the p53 DNA-binding domain regulates apoptosis induction.
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Kalodimos, C. G., Boelens, R., & Kaptein, R. (2004) · Chemical Reviews · doi:10.1021/cr0304065 · Cited by 79
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Cited by
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Accurate prediction of protein–nucleic acid complexes using RoseTTAFoldNA
Baek, M., McHugh, R., Anishchenko, I., Jiang, H., Baker, D., & DiMaio, F. (2024) · Nature Methods · doi:10.1038/s41592-023-02086-5 · Cited by 372
Degtjarik, O., Golovenko, D., Diskin-Posner, Y., Abrahmsén, L., Rozenberg, H., & Shakked, Z. (2021) · Nature Communications · doi:10.1038/s41467-021-27142-6 · Cited by 78
Geometric deep learning of protein–DNA binding specificity
Mitra, R., Li, J., Sagendorf, J. M., Jiang, Y., Cohen, A. S., Chiu, T.-P., Glasscock, C. J., & Rohs, R. (2024) · Nature Methods · doi:10.1038/s41592-024-02372-w · Cited by 75
Structural Evolution and Dynamics of the p53 Proteins
Chillemi, G., Kehrloesser, S., Bernassola, F., Desideri, A., Dötsch, V., Levine, A. J., & Melino, G. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028308 · Cited by 65
Metadata
- Authors
- Petty, T. J., Emamzadah, S., Costantino, L., Petkova, I., Stavridi, E. S., Saven, J. G., Vauthey, E., & Halazonetis, T. D.
- Venue
- The EMBO Journal
- Published
- 2011-04-26
- Volume
- 30
- Issue
- 11
- Pages
- 2167-2176
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 117
- References
- 5
- Language
- en
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
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- Petty, T. J., Emamzadah, S., Costantino, L., Petkova, I., Stavridi, E. S., Saven, J. G., Vauthey, E., & Halazonetis, T. D. (2011). An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity. The EMBO Journal. https://doi.org/10.1038/emboj.2011.127
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