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Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
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“In some p53/DNA structures, the central A-T doublet of each half-site shows noncanonical Hoogsteen base-pairing geometry instead of standard Watson-Crick base pairs.299,300”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [299]
In the citing paper
“p53 binds to a full consensus DNA response element as a tetramer through a highly cooperative self-assembling mechanism (Fig. 7b).”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [299]
In the citing paper
“Two DBDs bind each decameric half-site as a symmetrical dimer (A-B), and two such dimers (A-B and C-D) constitute a tetramer on a full DNA response element via protein-protein and base stacking interactions.11,70,295–299”
From Targeting p53 pathways: mechanisms, structures, and advances in therapy (2023) · cites this paper as [299]
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Cites
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Cited by
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Absence of a simple code: how transcription factors read the genome
Slattery, M., Zhou, T., Yang, L., Dantas Machado, A. C., Gordân, R., & Rohs, R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.07.002 · Cited by 537
Self-citationTransient Hoogsteen base pairs in canonical duplex DNA
Nikolova, E. N., Kim, E., Wise, A. A., O’Brien, P. J., Andricioaei, I., & Al-Hashimi, H. M. (2011) · Nature · doi:10.1038/nature09775 · Cited by 344
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
Uversky, V. N., Davé, V., Iakoucheva, L. M., Malaney, P., Metallo, S. J., Pathak, R. R., & Joerger, A. C. (2014) · Chemical Reviews · doi:10.1021/cr400713r · Cited by 288
Metadata
- Authors
- Kitayner, M., Rozenberg, H., Rohs, R., Suad, O., Rabinovich, D., Honig, B., & Shakked, Z.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-04
- Volume
- 17
- Issue
- 4
- Pages
- 423-429
- ISSN
- 1545-9993
- 1545-9985
- Cited by
- 229
- References
- 10
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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