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Ras guanine nucleotide-releasing protein-4 promotes renal inflammatory injury in type 2 diabetes mellitus

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Actuation of single downstream nodes in growth factor network steers immune cell migration

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Potential role of diacylglycerol kinases in immune-mediated diseases

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Beyond Lipid Signaling: Pleiotropic Effects of Diacylglycerol Kinases in Cellular Signaling

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Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils

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How cells sense and integrate information from different sources

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Nerve Growth Factor and Autoimmune Diseases

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Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration

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PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans

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Regulation of Connexin-Based Channels by Fatty Acids

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Knockdown of PLCB2 expression reduces melanoma cell viability and promotes melanoma cell apoptosis by altering Ras/Raf/MAPK signals

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RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors

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Ras Guanine Nucleotide–Releasing Protein 4 Is Aberrantly Expressed in the Fibroblast‐like Synoviocytes of Patients With Rheumatoid Arthritis and Controls Their Proliferation

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Ras inhibitor CAPRI enables neutrophil-like cells to chemotax through a higher-concentration range of gradients

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RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils

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Genetic Factors Regulating Lung Vasculature and Immune Cell Functions Associate with Resistance to Pneumococcal Infection

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The CXCL8-CXCR2 axis promotes M2 macrophage polarization in ovarian cancer via RASGRP4-mediated mTOR-STAT3 signaling

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range

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DGKα in Neutrophil Biology and Its Implications for Respiratory Diseases

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Mutated RAS-associating proteins and ERK activation in relapse/refractory diffuse large B cell lymphoma

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Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement

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RasGRP4 aggravates ischemia-reperfusion injury in diabetic kidneys by mediating communication between macrophages and T cells

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Class I PI3K Biology

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Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

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Tear-derived extracellular vesicles as diagnostic biomarkers for ocular and neurodegenerative diseases: opportunities and challenges

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G protein-coupled receptor–mediated membrane targeting of PLCγ2 is essential for neutrophil chemotaxis

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RasGRP4 Exacerbates Diabetic Kidney Fibrosis via Aloxe3‐Mediated Oxidative Stress and Scar‐Associated Macrophage Activation

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Ras inhibitors gate chemoattractant concentration range for chemotaxis through controlling GPCR-mediated adaptation and cell sensitivity

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PLCγ2 controls neutrophil-like cell sensitivity through calcium oscillation and gates chemoattractant concentration range for chemotaxis

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In Utero Exposure to Lead is Associated with Neural Tube Defects via Disturbing the Expression of Endocannabinoid Retrograde Signaling-Related Genes

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Phospholipase C Beta 2 as a Key Regulator of Tumor Progression and Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Renal Cell Carcinoma

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Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

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Measurement of Phospholipid Metabolism in Intact Neutrophils

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Ras GEF Mouse Models for the Analysis of Ras Biology and Signaling

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Ras Inhibitor CAPRI Enables Neutrophils to Chemotax Through a Higher-Concentration Range of GradientsPreprint

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Bioactivity and in silico insights into 2-(2-phenylethyl)-4H-chromen-4-one and sesquiterpenoid constituents from agarwood (Aquilaria sinensis) as anti-inflammatory agents

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The DAG-responsive C1 domain as a drug target : structure-activity and in vitro pharmacology of isophthalate derivatives

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Neutrophil migration in the healthy elderly : causes and consequences for the resolution of inflammation

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Inositides—confusion and clarification in Shangri‐La

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Investigating the effect of emetic and aversive compounds on Dictyostelium identifies a novel non-sentient model for bitter tastant research

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Characterizing the mechanisms that regulate cell polarity during eukaryotic chemotaxis

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GPCR-mediated Activation of PLCγ2 Initiates Dysregulated Recruitment of Neutrophils in Cold-induced Urticaria in PLAID PatientsPreprint

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Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases

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Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPasesPreprint

Duewell, B. R., Wilson, N. E., Bailey, G. M., Peabody, S. E., & Hansen, S. D. (2024) · eLife · doi:10.7554/elife.88991.2

PLCγ2 Controls Neutrophil Sensitivity through Calcium Oscillation and Gates Chemoattractant Concentration Range for ChemotaxisPreprint

Xu, X., Kim, W. S., Lee, A. M., & Jin, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.07.647573

Harnessing lipid metabolism through diacylglycerol kinases: implications for immune modulation and cancer therapy

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Structural Insights into Phospholipase Cε Function

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RASGRP4 is a key factor in the KRAS activation mediated by SOS in tumor Y1 adrenocortical cell lines

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Rôle et modes d'action de la Tétraspanine 8 dans l'invasion précoce du mélanome cutané

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Rôle de la phosphoinositide 3-kinase de classe II beta dans la dysfonction endothéliale lors d'un accident vasculaire cérébral ischémique

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Identification des mécanismes moléculaires de neuroprotection modulés par l’activité dans deux maladies du motoneurone

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Strain differences in estrogen-induced pituitary proliferative response and gene expression patterns between Fischer 344 and Brown Norway rats

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Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils

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Chemotactic Peptide-induced Activation of Ras in Human Neutrophils Is Associated with Inhibition of p120-GAP Activity

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PI3K Class IB Pathway in Neutrophils

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