Circular RNAs: splicing’s enigma variations

Circular RNAs are a large class of animal RNAs with regulatory potency

Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985

Circular RNAs are abundant, conserved, and associated with ALU repeats

Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132

Circular transcripts of the testis-determining gene Sry in adult mouse testis

Capel, B., Swain, A., Nicolis, S. K., Hacker, A., Walter, M. A., Koopman, P. A., Goodfellow, P. N., & Lovell-Badge, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90279-y · Cited by 1,112

miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996

Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766

Emerging Roles for Natural MicroRNA Sponges

Ebert, M. S., & Sharp, P. A. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.052 · Cited by 490

Targeted RNA sequencing reveals the deep complexity of the human transcriptome

Mercer, T. R., Gerhardt, D. J., Dinger, M. E., Crawford, J., Trapnell, C., Jeddeloh, J. A., Mattick, J. S., & Rinn, J. L. (2011) · Nature Biotechnology · doi:10.1038/nbt.2024 · Cited by 490

Circular RNA circ_001350 regulates glioma cell proliferation, apoptosis, and metastatic properties by acting as a miRNA sponge

Liu, Y., Ma, C., Qin, X., Yu, H., Shen, L., & Jin, H. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28795 · Cited by 30

Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms

Heydarnia, E., Dorostgou, Z., Hedayati, N., Mousavi, V., Yahyazadeh, S., Alimohammadi, M., Gheibi, M., Heidari, P., Igder, S., Mafi, A., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01494-0 · Cited by 30

Genome-wide analysis of circular RNAs involved in Marek’s disease tumourigenesis in chickens

Wang, L., You, Z., Wang, M., Yuan, Y., Liu, C., Yang, N., Zhang, H., & Lian, L. (2020) · RNA Biology · doi:10.1080/15476286.2020.1713538 · Cited by 30

Methods to study circRNA-protein interactions

Ulshöfer, C. J., Pfafenrot, C., Bindereif, A., & Schneider, T. P. (2021) · Methods · doi:10.1016/j.ymeth.2021.04.014 · Cited by 31

Circ-PTPDC1 promotes the Progression of Gastric Cancer through Sponging Mir-139-3p by Regulating ELK1 and Functions as a Prognostic Biomarker

Li, Z., Cheng, Y., Fu, K., Lin, Q., Zhao, T., Tang, W., Xi, L., Sheng, L., Zhang, H., & Sun, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62732 · Cited by 30

Identification of human genetic variants controlling circular RNA expression

Ahmed, I., Karedath, T., Al-Dasim, F. M., & Malek, J. A. (2019) · RNA · doi:10.1261/rna.071654.119 · Cited by 30

CircRNA expression profiles in human visceral preadipocytes and adipocytes

Sun, W., Sun, X., Chu, W., Yu, S., Dong, F., & Xu, G. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10886 · Cited by 30

Hsa_circ_0007534 as a blood-based marker for the diagnosis of colorectal cancer and its prognostic value.

Zhang, W., Yang, S., Liu, Y., Wang, Y., Lin, T., Li, Y., & Zhang, R. (2018) · PubMed Central · Cited by 29

Identifying the sequence specificities of circRNA-binding proteins based on a capsule network architecture

Wang, Z., & Lei, X. (2021) · BMC Bioinformatics · doi:10.1186/s12859-020-03942-3 · Cited by 29

Circular RNA circMYL1 Inhibit Proliferation and Promote Differentiation of Myoblasts by Sponging miR-2400

Elnour, I. E., Wang, X., Zhansaya, T., Akhatayeva, Z., Khan, R., Cheng, J., Hung, Y., Lan, X., Lei, C., & Chen, H. (2021) · Cells · doi:10.3390/cells10010176 · Cited by 29

The profiles and networks of miRNA, lncRNA, mRNA, and circRNA in benzo(a)pyrene-transformed bronchial epithelial cells

Jiang, X., Wu, X., Chen, F., He, W., Chen, X., Liu, L., & Tang, H. (2018) · The Journal of Toxicological Sciences · doi:10.2131/jts.43.281 · Cited by 28

Circular RNA circ‐TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR ‐452‐5p/ DAG1 axis

Xu, R., Ding, P., Zhao, X., Li, Z., Liu, F., Gu, L., Zheng, Y., Sang, M., & Meng, L. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13432 · Cited by 28

Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts

Jeong, A., Lim, Y., Kook, T., Kwon, D., Cho, Y. K., Ryu, J., Lee, Y.-G., Shin, S., Choe, N., Kim, Y. S., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102071 · Cited by 29

Differential Circular RNA Expression Profiling During Osteogenic Differentiation of Stem Cells from Apical Papilla

Li, Z., Li, N., Ge, X., Pan, Y., Lu, J., Gobin, R., Yan, M., & Yu, J. (2019) · Epigenomics · doi:10.2217/epi-2018-0184 · Cited by 28

Prognostic and diagnostic significance of circRNAs expression in lung cancer

Huang, X., Zhang, W., & Shao, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28481 · Cited by 27

Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer

Chen, Q., Chen, Z., Cao, S., Guo, B., Chen, Y., Feng, Z., Wang, J., Guo, G., Chen, X., & Huang, X. (2019) · Medical Science Monitor · doi:10.12659/msm.915963 · Cited by 27

Circular RNAs and cancer: Opportunities and challenges

Solé, C., & Lawrie, C. H. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.02.008 · Cited by 27

Circular RNA circFOXO3 regulates KDM2A by targeting miR‐214 to promote tumor growth and metastasis in oral squamous cell carcinoma

Ai, Y., Wu, S., Zou, C., & Wei, H. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16533 · Cited by 27

CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma

Cao, S.-Q., Xue, S.-T., Li, W.-J., Hu, G.-S., Wu, Z., Zheng, J.-C., Zhang, S., Lin, X., Chen, C., Liu, W., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01881-z · Cited by 27

Circular RNA TUBD1 Acts as the miR-146a-5p Sponge to Affect the Viability and Pro-Inflammatory Cytokine Production of LX-2 Cells through the TLR4 Pathway

Niu, H., Zhang, L., Chen, Y., Yuan, B., Wu, Z., Cheng, J. C., Lin, Q., & Zeng, Z. (2020) · Radiation Research · doi:10.1667/rr15550.1 · Cited by 27

Novel circular RNA expression profile of uveal melanoma revealed by microarray

Yang, X., Li, Y., Liu, Y., Xu, X., Wang, Y., Yan, Y., Zhou, W., Yang, J., & Wei, W. (2018) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2018.06.10 · Cited by 26

Circular RNAs in hypertension: challenges and clinical promise

Zaiou, M. (2019) · Hypertension Research · doi:10.1038/s41440-019-0294-7 · Cited by 26

CircFADS2 : A potential prognostic biomarker of colorectal cancer

Xiao, Y.-S., Tong, H., Yuan, X., Xiong, C., Xu, X., & Zeng, Y. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220929965 · Cited by 26

The role of circular RNAs in neuropathic pain

Zheng, Y.-L., Guo, J., Song, G., Yang, Z., Su, X., Chen, P., & Wang, X. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.048 · Cited by 26

Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-β signaling cascade

Zhou, Z., Zhang, R., Li, X., Zhang, W., Zhan, Y., Lang, Z., Tao, Q., Yu, J., Yu, S., Yu, Z., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-05797-3 · Cited by 25

Circular RNAs: epigenetic regulators in cancerous and noncancerous skin diseases

Abi, A., Farahani, N., Molavi, G., & Hayat, S. M. G. (2019) · Cancer Gene Therapy · doi:10.1038/s41417-019-0130-x · Cited by 25

CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1 /2 and p38 MAPK pathway through miR ‐409‐3p/ CDK8 axis

Zhou, B. R., Li, T., Xie, R., Zhou, J., Liu, J., Luo, Y., & Zhang, X. (2021) · Drug Development Research · doi:10.1002/ddr.21816 · Cited by 25

circ‑Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS

Sun, S., Kong, Q., Cai, Z., Wang, M., Zhao, H., & Zhao, C. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5035 · Cited by 25

Suppression of circDcbld1 Alleviates Intimal Hyperplasia in Rat Carotid Artery by Targeting miR-145-3p/Neuropilin-1

Rong, Z., Chang, N., Yao, Q., Li, T., Zhu, X., Cao, Y., Jiang, M.-J., Cheng, Y.-S., Jiang, R., & Jiang, J. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.10.023 · Cited by 25

Unlocking the potential of circular RNA vaccines: a bioinformatics and computational biology perspective

Liu, X., Wang, S., Sun, Y., Liao, Y., Jiang, G., Sun, B., Yu, J., & Zhao, D. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105638 · Cited by 24

Circular RNAs constitute an inherent gene regulatory axis in the mammalian eye and brain

George, A. K., Master, K., Majumder, A., Homme, R. P., Laha, A., Sandhu, H. S., Tyagi, S. C., & Singh, M. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0505 · Cited by 24

High-throughput sequencing reveals circular RNA hsa_circ_0000592 as a novel player in the carcinogenesis of gastric carcinoma

Liang, M., Liu, Z., Lin, H., Shi, B., Li, M., Chen, T., Qin, L., Niu, Q., Yu, G., Jiang, H., et al. (2019) · Bioscience Reports · doi:10.1042/bsr20181900 · Cited by 24

Circular RNA expression profiles in synovial fluid: a promising new class of diagnostic biomarkers for osteoarthritis.

Yu, F., Xie, C., Sun, J., Feng, H., & Huang, X. (2018) · PubMed Central · Cited by 24

CircRNA SMARCC1 Sponges MiR-140-3p to Regulate Cell Progression in Colorectal Cancer

Chen, M.-S., Lin, C.-H., Huang, L., & Qiu, X. (2020) · Cancer Management and Research · doi:10.2147/cmar.s254185 · Cited by 24

Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells

Chen, F., Wang, X., Fu, S., Wang, S., Fu, Y., Liu, Z., & Zhang, J. (2020) · Cancer Management and Research · doi:10.2147/cmar.s259393 · Cited by 24

Circulating expression levels of CircHIPK3 and CDR1as circular-RNAs in type 2 diabetes patients

Rezaeinejad, F., Mirzaei, A., Khalvati, B., Sabz, G., & Alipoor, B. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06850-8 · Cited by 24

Approaches for identification and analysis of plant circular RNAs and their role in stress responses

Kalwan, G., Gill, S. S., Priyadarshini, P., Gill, R., Yadava, Y. K., Yadav, S., Baruah, P. M., Agarwala, N., Gaikwad, K., & Jain, P. K. (2022) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2022.105099 · Cited by 24

MicroRNAs as the critical regulators of autophagy-mediated cisplatin response in tumor cells

Ghasaban, F. T., Maharati, A., Akhlaghipour, I., & Moghbeli, M. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02925-7 · Cited by 27

Prognostic and diagnostic significance of circRNAs expression in hepatocellular carcinoma patients: A meta‐analysis

Huang, X., Zhang, W., & Shao, Z. (2019) · Cancer Medicine · doi:10.1002/cam4.1939 · Cited by 24

Circular RNAs act as regulators of autophagy in cancer

Zhou, Z., Zhang, Y., Gao, J., Hao, X., Shan, C., Li, J., Liu, C., Wang, Y., & Li, P. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.04.007 · Cited by 24

Smooth Muscle Differentiation Control Comes Full Circle

Weiser‐Evans, M. C. M. (2017) · Circulation Research · doi:10.1161/circresaha.117.311722 · Cited by 24

Discovering circRNA-microRNA Interactions from CLIP-Seq Data

Zhang, X., & Yang, J. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7562-4_16 · Cited by 23

Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p

Fang, L., Ye, T., & An, Y. (2021) · Journal of Immunology Research · doi:10.1155/2021/8050993 · Cited by 23

Maternal obesity alters circRNA expression and the potential role of mmu_circRNA_0000660 via sponging miR_693 in offspring liver at weaning age

Chen, Q., Liu, M., Luo, Y., Yu, H., Zhang, J., Li, D., & He, Q. (2020) · Gene · doi:10.1016/j.gene.2020.144354 · Cited by 23

CircHN1 affects cell proliferation and migration in gastric cancer

Zhang, Y., Wang, M., Zang, X., Mao, Z., Chen, Y., Mao, F., Qian, H., Xu, W., & Zhang, X. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23433 · Cited by 23

Progress in Understanding the Relationship Between Circular RNAs and Neurological Disorders

Wang, Q., Qu, L., Chen, X., Zhao, Y., & Luo, Q. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1125-z · Cited by 22

Prenatal Alcohol Exposure Results in Sex-Specific Alterations in Circular RNA Expression in the Developing Mouse Brain

Paudel, P., Pierotti, C. E., Lozano, E., Amoah, S. K., Gardiner, A. S., Caldwell, K. K., Allan, A. M., & Mellios, N. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.581895 · Cited by 22

Identification and characterization of circular RNAs in mammary gland tissue from sheep at peak lactation and during the nonlactating period

Wang, J., Zhou, H., Hickford, J. G. H., Hao, Z., Gong, H., Hu, J., Liu, X., Li, S., Shen, J., Ke, N., et al. (2020) · Journal of Dairy Science · doi:10.3168/jds.2020-18911 · Cited by 22

Circular RNAs function as competing endogenous RNAs in multiple types of cancer (Review)

Ji, Q., Zhang, C., Sun, X., & Li, Q. (2017) · Oncology Letters · doi:10.3892/ol.2017.7348 · Cited by 22

Circular RNA circ-102,166 acts as a sponge of miR-182 and miR-184 to suppress hepatocellular carcinoma proliferation and invasion

Li, R., Deng, Y., Liang, J., Hu, Z., Li, X., Liu, H., Wang, G., Fu, B., Zhang, T., Zhang, Q., et al. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00564-y · Cited by 22

Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation

Yang, T. B., Fang, Y., Liu, W. F., Yang, Y. H., Yang, C. Z., & Sun, J. (2020) · Journal of Cancer · doi:10.7150/jca.48998 · Cited by 22

Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma.

Wang, Y., Huang, L., Li, D., Shao, J., Xiong, S., Wang, C., & Lu, S. (2017) · PubMed Central · Cited by 21

Loss of circSRY reduces γH2AX level in germ cells and impairs mouse spermatogenesis

Song, Y., Chen, M., Zhang, Y., Li, J., Liu, B., Li, N., Chen, M., Qiao, M., Wang, N., Cao, Y., et al. (2022) · Life Science Alliance · doi:10.26508/lsa.202201617 · Cited by 21

Circ_0000003 promotes the proliferation and metastasis of non-small cell lung cancer cells via miR-338-3p/insulin receptor substrate 2

Li, S., Niu, X., Li, H., Liang, Y., Sun, Z., & Yan, Y. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1690883 · Cited by 21

Circ_0000215 Increases the Expression of CXCR2 and Promoted the Progression of Glioma Cells by Sponging miR-495-3p

Mutalifu, N., Du, P., Zhang, J., Akbar, H., Yan, B., Alimu, S., Tong, L., & Luan, X. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820957026 · Cited by 21

A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus Replication

Du, L., Wang, X., Liu, J., Li, J., Wang, S., Lei, J., Zhou, J., & Gu, J. (2021) · mBio · doi:10.1128/mbio.02984-21 · Cited by 20

Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma

Deng, W., Peng, W., Wang, T., Chen, J., Qiu, X., Fu, L., & Zhu, S. (2019) · Oncology Reports · doi:10.3892/or.2019.7369 · Cited by 20

Circular RNA Foxo3 enhances progression of ovarian carcinoma cells

Wang, L., Chen, J., & Lu, C. (2021) · Aging · doi:10.18632/aging.203550 · Cited by 20

Navigating the Landscape of Liquid Biopsy in Colorectal Cancer: Current Insights and Future Directions

Ziranu, P., Pretta, A., Saba, G., Spanu, D., Donisi, C., Ferrari, P. A., Cau, F., D’Agata, A. P., Piras, M., Mariani, S., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157619 · Cited by 19

Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis

Li, X., Xie, C., Xiao, F., Su, H., Li, Z., Weng, J., Huang, Y., & He, P. (2022) · Aging · doi:10.18632/aging.204018 · Cited by 19

Circular Sponge against miR-21 Enhances the Antitumor Activity of Doxorubicin against Breast Cancer Cells

Rama, A. R., Lara, P., Mesas, C., Quiñonero, F., Vélez, C., Melguizo, C., & Prados, J. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314803 · Cited by 19

Circular RNAs: Diversity of Functions and a Regulatory Nova in Oral Medicine: A Pilot Review

Wang, H., Cheng, F., Wang, M., Yang, S., & Wei, F. (2019) · Cell Transplantation · doi:10.1177/0963689719837917 · Cited by 19

CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage

Li, C., Chen, X., Liu, X., Liu, X., Junlin, H., Ding, Y., Tong, C., Peng, C. X., Wang, Y., & Gao, R. (2019) · Genes & Diseases · doi:10.1016/j.gendis.2019.06.003 · Cited by 19

Circ-HIPK3 plays an active role in regulating myoblast differentiation

Yao, R., Yao, Y., Li, C., Li, X., Ni, W., Quan, R., Liu, L., Li, H., Xu, Y., Zhang, M., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.119 · Cited by 19

Knockdown of hsa_circ_0023028 inhibits cell proliferation, migration, and invasion in laryngeal cancer by sponging miR-194-5p

Chen, X., Su, X., Zhu, C., & Zhou, J. (2019) · Bioscience Reports · doi:10.1042/bsr20190177 · Cited by 18

Unraveling diverse roles of noncoding RNAs in various human papillomavirus negative cancers

Chen, X., Liu, Y., Liu, H., Wang, Z. P., & Zhu, X. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108188 · Cited by 18

Ferroptosis in head and neck squamous cell carcinoma: from pathogenesis to treatment

Yang, J., & Gu, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1283465 · Cited by 19

circAkap17b acts as a miR-7 family molecular sponge to regulate FSH secretion in rat pituitary cells

Wang, C., Gao, F., Huang, Y., Han, D., Zheng, Y., Wang, W., Jiang, H., Gao, Y., Yuan, B., & Zhang, J. (2020) · Journal of Molecular Endocrinology · doi:10.1530/jme-20-0036 · Cited by 18

CircSFMBT2 facilitates vascular smooth muscle cell proliferation by targeting miR-331-3p/HDAC5

Luo, Y., & Huang, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118691 · Cited by 18

Decrypting the crosstalk of noncoding RNAs in the progression of IPF

Wang, Y., Han, X., Zhao, F., Li, H., Gao, R., Yan, B., Ren, J., & Yang, J. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05368-9 · Cited by 17

Identification of differentially expressed circular RNAs during TGF-β1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells

Chen, Y. (2018) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2018.95142 · Cited by 17

Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma

Wang, Z., Tang, J. P., Wang, Y., Sun, S., Chen, Y., Shen, Y., & Yang, H. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s196618 · Cited by 17

Circular RNAs in gastric cancer: Biomarkers for early diagnosis (Review)

Yang, C., Qiao, G., Song, L., Bao, S., & Ma, L. (2020) · Oncology Letters · doi:10.3892/ol.2020.11623 · Cited by 17

Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis

Yuan, J., Guo, D., Li, X., & Chen, J. (2020) · BMC Cancer · doi:10.1186/s12885-020-06932-z · Cited by 17

Diagnostic Value of CircRNAs as Potential Biomarkers in Oral Squamous Cell Carcinoma: a Meta-Analysis

Wang, M., Zhang, L., Ren, W., Li, S., Zhi, K., Zheng, J., & Gao, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.693284 · Cited by 17

CircPRDM2 Contributes to Doxorubicin Resistance of Osteosarcoma by Elevating EZH2 via Sponging miR-760

Yuan, J., Liu, Y., Zhang, Q., Ren, Z., Li, G., & Tian, R. (2021) · Cancer Management and Research · doi:10.2147/cmar.s295147 · Cited by 17

Evaluation of plasma circ_0006282 as a novel diagnostic biomarker in colorectal cancer

Mohammadi, D., Zafari, Y., Estaki, Z., Mehrabi, M., & Moghbelinejad, S. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24147 · Cited by 17

Discovering the Interactions between Circular RNAs and RNA-binding Proteins from CLIP-seq Data using circScanPreprint

Li, B., Zhang, X., Liu, S., Liu, S., Sun, W., Lin, Q., Luo, Y.-X., Zhou, K., Zhang, C.-M., Tan, Y.-Y., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/115980 · Cited by 17

Circ_0001052 promotes cardiac hypertrophy via elevating Hipk3

Yang, M., Wang, W., Wang, L., & Li, Y. (2023) · Aging · doi:10.18632/aging.204521 · Cited by 16

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

Du, W. W., Rafiq, M., Yuan, H., Li, X., Wang, S., Wu, J., Wei, J., Li, R., Guo, H., & Yang, B. B. (2025) · Advanced Science · doi:10.1002/advs.202411959 · Cited by 16

A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma

Guo, J., Wang, Z., Miao, Y., Shen, Y., Li, M., Gong, L., Wang, H., He, Y., Gao, H., Liu, Q., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6851 · Cited by 16

Hsa_circ_0012563 promotes migration and invasion of esophageal squamous cell carcinoma by regulating XRCC1/EMT pathway

Zhang, Z., Li, X., Xiong, F., Ren, Z., & Han, Y. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23308 · Cited by 16

RNA-binding proteins and long noncoding RNAs in intestinal epithelial autophagy and barrier function

Xiao, L., Rao, J. N., & Wang, J. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.1895648 · Cited by 16

Star Circular RNAs In Human Cancer: Progress And Perspectives

Cheng, Y., Sun, H., Wang, H., Jiang, W., Tang, W., Chen, L., Zhang, W., Chen, Z., & Lv, C. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s215390 · Cited by 15

Comprehensive CircRNA Profiling and Selection of Key CircRNAs Reveal the Potential Regulatory Roles of CircRNAs throughout Ovarian Development and Maturation in Cynoglossus semilaevis

Li, J., Shi, B., Wang, C., Shao, C., Liu, X., & Zhang, D. (2021) · Biology · doi:10.3390/biology10090830 · Cited by 15

Circular RNAs exhibit limited evidence for translation, or translation regulation of the mRNA counterpart in terminal hematopoiesis

Nicolet, B. P., Jansen, S. B. G., Heideveld, E., Ouwehand, W. H., van den Akker, E., Lindern, M. V., & Wolkers, M. C. (2021) · RNA · doi:10.1261/rna.078754.121 · Cited by 17

Comprehensive analysis of the expression profile of circRNAs and their predicted protein-coding ability in the muscle of mdx mice

Song, Z., Liu, Y., Fang, X., Xie, M., Ma, Z., Zhong, Z., Feng, X., & Zhang, W. (2019) · Functional & Integrative Genomics · doi:10.1007/s10142-019-00724-w · Cited by 15

Exosome-Mediated Transfer of circ- GLIS3 Enhances Temozolomide Resistance in Glioma Cells Through the miR-548m/MED31 Axis

Li, G., & Lan, Q. (2021) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2021.0299 · Cited by 15

Circular RNA: From non-coding regulators to functional protein encoders

Zhang, X., Wu, H., Hong, X., Xiao, Y., & Zeng, X. (2025) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2025.100085 · Cited by 14

Overview of CircRNAs Roles and Mechanisms in Liver Fibrosis

Wang, G., Tong, J., Li, Y.-C., Qiu, X., Chen, A., Chang, C., & Yu, G. (2023) · Biomolecules · doi:10.3390/biom13060940 · Cited by 14

Transcriptional information revealed differentially expressed circular RNAs in facet joint osteoarthritis

Chu, C., Wu, C., Jiajia, C., Jinlong, Z., Xue, P., Jia-wei, J., & Cui, Z. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.02.157 · Cited by 14

Silencing circular RNA hsa_circ_009755 promotes growth and metastasis of oral squamous cell carcinoma

Zhang, B., Wang, Z., Shen, Y., & Yang, H. (2020) · Genomics · doi:10.1016/j.ygeno.2020.09.035 · Cited by 14

The profile analysis of circular RNAs in cervical cancer

Huang, J., Chen, J., & Huang, Q. (2021) · Medicine · doi:10.1097/md.0000000000027404 · Cited by 14

Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene

Huang, G., Ma, J., & Zhang, L. (2020) · Medical Science Monitor · doi:10.12659/msm.920623 · Cited by 14

FcircSEC: An R Package for Full Length circRNA Sequence Extraction and Classification

Hossain, M. T., Peng, Y., Feng, S., & Wei, Y. (2020) · International Journal of Genomics · doi:10.1155/2020/9084901 · Cited by 14

Hsa_circ_101882 promotes migration and invasion of gastric cancer cells by regulating EMT

Yin, G., Gao, F., Tian, J., & Zhang, W. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23002 · Cited by 14

SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells

Duan, J., Cai, H., Huang, Y., & Shi, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.689916 · Cited by 13

Molecular and Therapeutic Roles of Non-Coding RNAs in Oral Cancer—A Review

Umapathy, V. R., Natarajan, P. M., & Swamikannu, B. (2024) · Molecules · doi:10.3390/molecules29102402 · Cited by 13

Diagnostic value of circular RNAs as effective biomarkers for cancer: a systematic review and meta-analysis

Tan, H., Gan, L., Fan, X., Liu, L., & Liu, S. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s197537 · Cited by 13

Circular logic: understanding RNA’s strangest form yet

Dance, A. (2024) · Nature · doi:10.1038/d41586-024-03683-w · Cited by 20

Visualization of circular RNAs and their internal splicing events from transcriptomic data

Zheng, Y., & Zhao, F. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa033 · Cited by 18

Methods for Annotation and Validation of Circular RNAs from RNAseq Data

Sharma, D., Sehgal, P., Hariprakash, J. M., Sivasubbu, S., & Scaria, V. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-8982-9_3 · Cited by 12

Circular RNAs as a New Field in Gene Regulation and their Implications in Translational Research

Vidal, A. F., Sandoval, G. T., de Magalhães, L. L., Santos, S. E., & Ribeiro‐dos‐Santos, Â. (2016) · Epigenomics · doi:10.2217/epi.16.3 · Cited by 41

A guide to naming eukaryotic circular RNAs

Chen, L., Bindereif, A., Bozzoni, I., Chang, H. Y., Matera, A. G., Gorospe, M., Hansen, T. B., Kjems, J., Ma, X.-K., Pek, J. W., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-022-01066-9 · Cited by 121