Circular RNAs: splicing’s enigma variations

Circular RNAs are a large class of animal RNAs with regulatory potency

Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990

Natural RNA circles function as efficient microRNA sponges

Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985

Circular RNAs are abundant, conserved, and associated with ALU repeats

Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., & Brown, P. O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030733 · Cited by 2,239

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132

Circular transcripts of the testis-determining gene Sry in adult mouse testis

Capel, B., Swain, A., Nicolis, S. K., Hacker, A., Walter, M. A., Koopman, P. A., Goodfellow, P. N., & Lovell-Badge, R. H. (1993) · Cell · doi:10.1016/0092-8674(93)90279-y · Cited by 1,112

miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

Hansen, T. B., Wiklund, E. D., Bramsen, J. B., Villadsen, S. B., Statham, A. L., Clark, S. J., & Kjems, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.359 · Cited by 996

Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

Chen, C.-Y., & Sarnow, P. (1995) · Science · doi:10.1126/science.7536344 · Cited by 766

Emerging Roles for Natural MicroRNA Sponges

Ebert, M. S., & Sharp, P. A. (2010) · Current Biology · doi:10.1016/j.cub.2010.08.052 · Cited by 490

Targeted RNA sequencing reveals the deep complexity of the human transcriptome

Mercer, T. R., Gerhardt, D. J., Dinger, M. E., Crawford, J., Trapnell, C., Jeddeloh, J. A., Mattick, J. S., & Rinn, J. L. (2011) · Nature Biotechnology · doi:10.1038/nbt.2024 · Cited by 490

Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis

Legnini, I., Di Timoteo, G., Rossi, F., Morlando, M., Briganti, F., Sthandier, O., Fatica, A., Santini, T., Andronache, A., Wade, M., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.02.017 · Cited by 2,173

Regulation of circRNA biogenesis

Chen, L.-L., & Yang, L. (2015) · RNA Biology · doi:10.1080/15476286.2015.1020271 · Cited by 1,953

Circular RNA: a new star of noncoding RNAs

Qu, S., Yang, X., Li, X., Wang, J., Gao, Y., Shang, R., Sun, W., Dou, K., & Li, H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.06.003 · Cited by 1,808

CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

Dudekula, D. B., Panda, A. C., Grammatikakis, I., De, S., Abdelmohsen, K., & Gorospe, M. (2015) · RNA Biology · doi:10.1080/15476286.2015.1128065 · Cited by 1,252

Circular RNA circMTO1 acts as the sponge of microRNA‐9 to suppress hepatocellular carcinoma progression

Han, D., Li, J., Wang, H., Su, X., Hou, J., Gu, Y., Qian, C., Lin, Y., Liu, X., Huang, M., et al. (2017) · Hepatology · doi:10.1002/hep.29270 · Cited by 1,215

Circular RNAs: diversity of form and function

Lasda, E. L., & Parker, R. (2014) · RNA · doi:10.1261/rna.047126.114 · Cited by 1,201

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3975 · Cited by 1,149

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

Abdelmohsen, K., Panda, A. C., Munk, R., Grammatikakis, I., Dudekula, D. B., De, S., Kim, J., Noh, J. H., Kim, K. M., Martindale, J. L., et al. (2017) · RNA Biology · doi:10.1080/15476286.2017.1279788 · Cited by 858

Liquid biopsy in cancer: current status, challenges and future prospects

Ma, L., Guo, H., Zhao, Y., Liu, Z., Wang, C., Bu, J., Sun, T., & Wei, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02021-w · Cited by 820

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

Li, P., Chen, S., Chen, H., Mo, X., Li, T., Shao, Y., Xiao, B., & Guo, J. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.02.018 · Cited by 779

Exon Circularization Requires Canonical Splice Signals

Starke, S., Jost, I., Roßbach, O., Schneider, T. P., Schreiner, S., Hung, L.-H., & Bindereif, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.002 · Cited by 774

CircRNA: a novel type of biomarker for cancer

Zhang, H.-D., Jiang, L., Sun, D., Hou, J., & Ji, Z. (2017) · Breast Cancer · doi:10.1007/s12282-017-0793-9 · Cited by 764

Circular RNAs are miRNA sponges and can be used as a new class of biomarker

Kulcheski, F. R., Christoff, A. P., & Margis, R. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.09.011 · Cited by 741

Efficient backsplicing produces translatable circular mRNAs

Wang, Y., & Wang, Z. (2014) · RNA · doi:10.1261/rna.048272.114 · Cited by 676

Functional interactions among microRNAs and long noncoding RNAs

Yoon, J., Abdelmohsen, K., & Gorospe, M. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.05.015 · Cited by 671

The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function

Zang, J., Lu, D., & Xu, A. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24356 · Cited by 650

Identifying and Characterizing circRNA-Protein Interaction

Du, W. W., Zhang, C., Yang, W., Yong, T., Awan, F. M., & Yang, B. B. (2017) · Theranostics · doi:10.7150/thno.21299 · Cited by 620

Circular RNAs: Identification, biogenesis and function

Ebbesen, K. K., Kjems, J., & Hansen, T. B. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.007 · Cited by 563

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

Xu, H., Guo, S., Li, W., & Yu, P. (2015) · Scientific Reports · doi:10.1038/srep12453 · Cited by 536

The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons

Holt, C. E., & Schuman, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.036 · Cited by 525

The complexity of miRNA-mediated repression

Wilczynska, A., & Bushell, M. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.112 · Cited by 522

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Xu, J., Ji, L., Liang, Y., Wan, Z., Zheng, W., Song, X., Gorshkov, K., Sun, Q., Lin, H. M., Zheng, X., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00375-5 · Cited by 500

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

Beckmann, B. M., Horos, R., Fischer, B., Castelló, A., Eichelbaum, K., Alleaume, A.-M., Schwarzl, T., Curk, T., Föehr, S., Huber, W. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms10127 · Cited by 459

Insights into circular RNA biology

Ebbesen, K. K., Hansen, T. B., & Kjems, J. (2016) · RNA Biology · doi:10.1080/15476286.2016.1271524 · Cited by 458

Rolling Circle Translation of Circular RNA in Living Human Cells

Abe, N., Matsumoto, K., Nishihara, M., Nakano, Y., Shibata, A., Maruyama, H., Shuto, S., Matsuda, A., Yoshida, M., Ito, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep16435 · Cited by 449

A View of Pre-mRNA Splicing from RNase R Resistant RNAs

Suzuki, H., & Tsukahara, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069331 · Cited by 432

Circular RNA participates in the carcinogenesis and the malignant behavior of cancer

Zhao, Z., & Shen, J. (2015) · RNA Biology · doi:10.1080/15476286.2015.1122162 · Cited by 424

Biogenesis, identification, and function of exonic circular RNAs

Chen, I., Chen, C., & Chuang, T. (2015) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1294 · Cited by 402

The bioinformatics toolbox for circRNA discovery and analysis

Chen, L., Wang, C., Sun, H., Wang, J., Liang, Y., Wang, Y., & Wong, G. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa001 · Cited by 402

RNA circularization strategies in vivo and in vitro

Petkovic, S., & Müller, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv045 · Cited by 386

Molecular roles and function of circular RNAs in eukaryotic cells

Holdt, L. M., Kohlmaier, A., & Teupser, D. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2688-5 · Cited by 347

Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies

Wang, S., Zhang, K., Tan, S., Xin, J., Yuan, Q., Xu, H., Xu, X., Qi, L., Christiani, D. C., Wang, M., et al. (2021) · Molecular Cancer · doi:10.1186/s12943-020-01298-z · Cited by 339

Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis

Yang, W., Du, W. W., Li, X., Yee, A., & Yang, B. B. (2015) · Oncogene · doi:10.1038/onc.2015.460 · Cited by 316

Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 ‘Sponge’ in Human Cartilage Degradation

Liu, Q., Zhang, X., Hu, X., Dai, L., Fu, X., Zhang, J., & Ao, Y. (2016) · Scientific Reports · doi:10.1038/srep22572 · Cited by 302

ZKSCAN 1 gene and its related circular RNA (circ ZKSCAN 1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways

Yao, Z., Luo, J., Hu, K., Lin, J., Huang, H., Wang, Q., Zhang, P., Xiong, Z., He, C., Huang, Z., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12045 · Cited by 301

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Xu, J., Wan, Z., Tang, M., Lin, Z., Shi, J., Ji, L., Gorshkov, K., Mao, Q., Xia, S., Cen, D., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01281-8 · Cited by 293

CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts

Tang, C., Zhang, M., Huang, L., Hu, Z.-Q., Zhu, J.-N., Xiao, Z., Zhang, Z., Lin, Q., Zheng, X., Yang, M., et al. (2017) · Scientific Reports · doi:10.1038/srep40342 · Cited by 282

CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene

Shen, S., Wu, Y., Chen, J., Xie, Z., Huang, K., Wang, G., Yang, Y., Ni, W., Chen, Z., Shi, P., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214786 · Cited by 276

Circular RNAs and cancer

He, J., Xie, Q., Xu, H., Li, J., & Li, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.03.027 · Cited by 265

Going circular: history, present, and future of circRNAs in cancer

Pisignano, G., Michael, D. C., Visal, T. H., Pîrlog, R., Ladomery, M., & Călin, G. A. (2023) · Oncogene · doi:10.1038/s41388-023-02780-w · Cited by 272

Circular RNAs as potential biomarkers for cancer diagnosis and therapy.

Wang, F., Nazarali, A. J., & Ji, S. (2016) · PubMed Central · Cited by 254

Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value

Yao, J., Zhao, S., Liu, Q., Lv, M., Zhou, D., Zi-jun, L., & Nan, K. (2017) · Pathology - Research and Practice · doi:10.1016/j.prp.2017.02.011 · Cited by 249

Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.

Wang, X., Zhang, Y., Huang, L., Zhang, J., Pan, F., Li, B., Yan, Y., Jia, B., Liu, H., Li, S., et al. (2015) · PubMed Central · Cited by 210

Metazoan tRNA introns generate stable circular RNAs in vivo

Lu, Z., Filonov, G. S., Noto, J. J., Schmidt, C. A., Hatkevich, T., Wen, Y., Jaffrey, S. R., & Matera, A. G. (2015) · RNA · doi:10.1261/rna.052944.115 · Cited by 209

Circular RNAs in Cardiovascular Disease: An Overview

Fan, X., Weng, X., Zhao, Y., Chen, W., Gan, T., & Xu, D. (2017) · BioMed Research International · doi:10.1155/2017/5135781 · Cited by 196

Circular RNAs as Therapeutic Agents and Targets

Holdt, L. M., Kohlmaier, A., & Teupser, D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01262 · Cited by 189

Circular RNA expression in human hematopoietic cells is widespread and cell-type specific

Nicolet, B. P., Engels, S., Aglialoro, F., van den Akker, E., Lindern, M. V., & Wolkers, M. C. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky721 · Cited by 188

Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation

Dai, X., Chen, C., Yang, Q., Xue, J., Chen, X., Sun, B., Luo, F., Liu, X., Xiao, T., Xu, H., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0485-1 · Cited by 184

Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532–3p / FOXO4 axis

Bian, L., Zhi, X., Ma, L., Zhang, J., Chen, P., Sun, S., Li, J., Sun, Y., & Qin, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.073 · Cited by 183

Circular RNAs in Brain and Other Tissues: A Functional Enigma

Chen, W., & Schuman, E. M. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.06.006 · Cited by 182

Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma

Fu, L., Yao, T. S., Chen, Q., Mo, X., Hu, Y., & Guo, J. (2017) · Oncotarget · doi:10.18632/oncotarget.16881 · Cited by 178

Biological Roles and Mechanisms of Circular RNA in Human Cancers

Tang, Q., & Hann, S. S. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s233672 · Cited by 172

Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance

Bhat, A. A., Younes, S. N., Raza, S. S., Zarif, L., Nisar, S., Ahmed, I., Mir, R., Kumar, S., Sharawat, S. K., Hashem, S., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01175-9 · Cited by 172

Circular RNA circ0005276 promotes the proliferation and migration of prostate cancer cells by interacting with FUS to transcriptionally activate XIAP

Feng, Y., Yang, Y., Zhao, X., Fan, Y., Zhou, L., Rong, J., & Yu, Y. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2028-9 · Cited by 168

Circular RNAs: biogenesis, function, and a role as possible cancer biomarkers

Bolha, L., Ravnik-Glavač, M., & Glavač, D. (2017) · International Journal of Genomics · doi:10.1155/2017/6218353 · Cited by 166

A pathophysiological view of the long non-coding RNA world

Gesualdo, F. D., Capaccioli, S., & Lulli, M. (2014) · Oncotarget · doi:10.18632/oncotarget.2770 · Cited by 169

Emerging function and potential diagnostic value of circular RNAs in cancer

Cui, X., Wang, J., Guo, Z., Li, M., Li, M., Liu, S., Liu, H., Li, W., Yin, X., Tao, J., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0877-y · Cited by 164

Screening Circular RNA Related to Chemotherapeutic Resistance in Breast Cancer

Gao, D., Zhang, X., Liu, B., Meng, D., Fang, K., Guo, Z., & Li, L. (2017) · Epigenomics · doi:10.2217/epi-2017-0055 · Cited by 161

CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs

Schneider, T. P., Hung, L.-H., Schreiner, S., Starke, S., Eckhof, H., Roßbach, O., Reich, S., Medenbach, J., & Bindereif, A. (2016) · Scientific Reports · doi:10.1038/srep31313 · Cited by 161

The circular RNA ci RS ‐7 promotes APP and BACE 1 degradation in an NF ‐κB‐dependent manner

Shi, Z., Chen, T., Yao, Q., Zheng, L., Zhang, Z., Wang, J., Hu, Z., Cui, H., Han, Y., Han, X., et al. (2017) · FEBS Journal · doi:10.1111/febs.14045 · Cited by 160

Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer

Zhang, S., Zeng, X., Ding, T., Guo, L., Li, Y., Ou, S., & Yuan, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-21300-5 · Cited by 158

CircRNAs: a regulator of cellular stress

Fischer, J. W., & Leung, A. K. L. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1276882 · Cited by 156

Mini Review: Circular RNAs as Potential Clinical Biomarkers for Disorders in the Central Nervous System

Lu, D., & Xu, A.-D. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00053 · Cited by 154

Emerging role of non-coding RNA in oral cancer

Momen‐Heravi, F., & Bala, S. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.10.009 · Cited by 153

Insights into the biogenesis and potential functions of exonic circular RNA

Ragan, C., Goodall, G. J., Shirokikh, N. E., & Preiss, T. (2019) · Scientific Reports · doi:10.1038/s41598-018-37037-0 · Cited by 137

Circular RNAs: Novel Regulators of Neuronal Development

van Rossum, D., Verheijen, B. M., & Pasterkamp, R. J. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00074 · Cited by 140

The emerging role of circRNAs and their clinical significance in human cancers

Qian, L., Yu, S., Chen, Z., Meng, Z., Huang, S., & Wang, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.002 · Cited by 136

Circular RNAs in Cancer – Lessons Learned From microRNAs

Dragomir, M. P., & Călin, G. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00179 · Cited by 136

HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein

Li, Y., Chen, B., Zhao, J., Li, Q., Chen, S., Guo, T., Li, Y., Lai, H., Chen, Z., Meng, Z., et al. (2021) · Advanced Science · doi:10.1002/advs.202001701 · Cited by 136

Circular RNAs in monkey muscle: age-dependent changes

Abdelmohsen, K., Panda, A. C., De, S., Grammatikakis, I., Kim, J., Ding, J., Noh, J. H., Kim, K. M., Mattison, J. A., de Cabo, R., et al. (2015) · Aging · doi:10.18632/aging.100834 · Cited by 133

Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer

Wang, S., Zhang, X., Li, Z., Wang, W., Li, B., Huang, X., Sun, G., Xu, J., Li, Q., Xu, Z., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0933-0 · Cited by 131

Hsa_circ_0023404 enhances cervical cancer metastasis and chemoresistance through VEGFA and autophagy signaling by sponging miR-5047

Guo, J., Chen, M., Ai, G., Mao, W., Li, H., & Zhou, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108957 · Cited by 129

circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis

Luan, W., Shi, Y., Zhou, Z., Xia, Y. F., & Wang, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.114 · Cited by 129

MicroRNA Expression Changes during Interferon-Beta Treatment in the Peripheral Blood of Multiple Sclerosis Patients

Hecker, M., Thamilarasan, M., Koczan, D., Schröder, I., Flechtner, K., Freiesleben, S., Füllen, G., Thiesen, H., & Zettl, U. K. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816087 · Cited by 125

NCLscan: accurate identification of non-co-linear transcripts (fusion,trans-splicing and circular RNA) with a good balance between sensitivity and precision

Chuang, T., Wu, C.-S., Chen, C.-Y., Hung, L.-Y., Chiang, T.-W., & Yang, M.-Y. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1013 · Cited by 125

Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis

Liu, Y., Lu, C., Zhou, Y., Zhang, Z., & Li, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.166 · Cited by 122

Roles of Circular RNAs in Neurologic Disease

Shao, Y., & Chen, Y. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00025 · Cited by 123

A comprehensive review of circRNA: from purification and identification to disease marker potential

Xu, S., Zhou, L., Ponnusamy, M., Zhang, L., Dong, Y., Zhang, Y., Wang, Q., Liu, J., & Wang, K. (2018) · PeerJ · doi:10.7717/peerj.5503 · Cited by 121

Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433

Zhu, Y., Pan, W. Q., Yang, T., Meng, X., Jiang, Z., Tao, L., & Wang, L. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00564 · Cited by 119

Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway

Zhang, J., Zhao, X., Zhang, J., Zheng, X.-R., & Li, F. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.006 · Cited by 117

Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression

Sun, H., Xi, P., Sun, Z., Wang, Q., Zhu, B., Zhou, J. P., Jin, H. Z., Zheng, W., Tang, W., Cao, H., et al. (2018) · Cancer Management and Research · doi:10.2147/cmar.s172592 · Cited by 113

Circular RNAs: Isolation, characterization and their potential role in diseases

Liu, L., Wang, J., Khanabdali, R., Kalionis, B., Tai, X., & Xia, S. (2017) · RNA Biology · doi:10.1080/15476286.2017.1367886 · Cited by 112

TGF beta −1, −2 and −3 in the modulation of fibrosis in the cornea and other organs

Wilson, S. E. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108594 · Cited by 113

Downregulation of hsa_circ_0074854 Suppresses the Migration and Invasion in Hepatocellular Carcinoma via Interacting with HuR and via Suppressing Exosomes-Mediated Macrophage M2 Polarization

Wang, Y., Gao, R., Li, J., Tang, S., Li, S., Tong, Q., & Li, S. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s284560 · Cited by 107

The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis

Cardamone, G., Paraboschi, E. M., Rimoldi, V., Duga, S., Soldà, G., & Asselta, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030576 · Cited by 105

A diet high in sugar and fat influences neurotransmitter metabolism and then affects brain function by altering the gut microbiota

Guo, Y., Zhu, X., Zeng, M., Qi, L., Tang, X., Wang, D., Zhang, M., Xie, Y., Li, H., Yang, X., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01443-2 · Cited by 105

CircRNAs and their regulatory roles in cancers

Tao, M., Zheng, M., Xu, Y., Ma, S., Zhang, W., & Ju, S. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00359-3 · Cited by 102

Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis

Liu, Q., Zhang, X., Hu, X., Yuan, L., Cheng, J., Jiang, Y., & Ao, Y. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.04.004 · Cited by 99

Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells

Sun, H.-D., Xu, Z., Sun, Z., Zhu, B., Wang, Q., Zhou, J. P., Jin, H. Z., Zhao, A., Tang, W., & Cao, X. (2018) · Scientific Reports · doi:10.1038/s41598-018-27837-9 · Cited by 96

CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation

Chen, T., Wang, X., Li, C., Zhang, H., Liu, Y., Han, D., Li, Y., Zheng, L., Luo, D., Zhang, N., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01739-z · Cited by 96

Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function

Xiao, L., Ma, X., Luo, J., Chung, H. K., Kwon, M. S., Yu, T., Rao, J. N., Kozar, R. A., Gorospe, M., & Wang, J. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.05.060 · Cited by 96

Circular RNAs and RNA Splice Variants as Biomarkers for Prognosis and Therapeutic Response in the Liquid Biopsies of Lung Cancer Patients

de Fraipont, F., Gazzéri, S., Cho, W. C. S., & Eymin, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00390 · Cited by 93

Non-coding RNA in endothelial-to-mesenchymal transition

Hulshoff, M. S., del Monte‐Nieto, G., Kovacic, J. C., & Krenning, G. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz211 · Cited by 93

circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893

Chen, M., Ai, G., Zhou, J., Mao, W., Li, H., & Guo, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109064 · Cited by 92

Circular RNA TTN Acts As a miR-432 Sponge to Facilitate Proliferation and Differentiation of Myoblasts via the IGF2/PI3K/AKT Signaling Pathway

Wang, X., Cao, X., Dong, D., Shen, X., Cheng, J., Jiang, R., Yang, Z., Peng, S., Huang, Y., Lan, X., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.10.019 · Cited by 92

A Neuroligin Isoform Translated by circNlgn Contributes to Cardiac Remodeling

Du, W. W., Xu, J., Yang, W., Wu, N., Li, F., Zhou, L., Wang, S., Li, X., He, A. T., Du, K. Y., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318364 · Cited by 92

Acfs: accurate circRNA identification and quantification from RNA-Seq data

You, X. A., & Conrad, T. (2016) · Scientific Reports · doi:10.1038/srep38820 · Cited by 94

Circular logic: understanding RNA’s strangest form yet

Dance, A. (2024) · Nature · doi:10.1038/d41586-024-03683-w · Cited by 20

Visualization of circular RNAs and their internal splicing events from transcriptomic data

Zheng, Y., & Zhao, F. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa033 · Cited by 18

Methods for Annotation and Validation of Circular RNAs from RNAseq Data

Sharma, D., Sehgal, P., Hariprakash, J. M., Sivasubbu, S., & Scaria, V. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-8982-9_3 · Cited by 12

Circular RNAs as a New Field in Gene Regulation and their Implications in Translational Research

Vidal, A. F., Sandoval, G. T., de Magalhães, L. L., Santos, S. E., & Ribeiro‐dos‐Santos, Â. (2016) · Epigenomics · doi:10.2217/epi.16.3 · Cited by 41

A guide to naming eukaryotic circular RNAs

Chen, L., Bindereif, A., Bozzoni, I., Chang, H. Y., Matera, A. G., Gorospe, M., Hansen, T. B., Kjems, J., Ma, X.-K., Pek, J. W., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-022-01066-9 · Cited by 121