Cited by 316interferon and immune responsesImmune Response and InflammationMitochondrial Function and Pathology

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

Open access

Castanier, Céline, Garcin, Dominique, Vazquez, Aimé, Arnoult, Damien·2010·The EMBO Reports

DOI 10.1038/embor.2009.258PMC PMC2828750

Open this paper in CoChat — free account Open PDF

Abstract

The intracellular retinoic acid-inducible gene I-like receptors (RLRs) sense viral ribonucleic acid and signal through the mitochondrial protein mitochondrial antiviral signalling (MAVS) to trigger the production of type I interferons and proinflammatory cytokines. In this study, we report that RLR activation promotes elongation of the mitochondrial network. Mimicking this elongation enhances signalling downstream from MAVS and favours the binding of MAVS to stimulator of interferon genes, an endoplasmic reticulum (ER) protein involved in the RLR pathway. By contrast, enforced mitochondrial fragmentation dampens signalling and reduces the association between both proteins. Our finding that MAVS is associated with a pool of mitofusin 1, a protein of the mitochondrial fusion machinery, suggests that MAVS is capable of regulating mitochondrial dynamics to facilitate the mitochondria-ER association required for signal transduction. Importantly, we observed that viral mitochondria-localized inhibitor of apoptosis, a cytomegalovirus (CMV) antiapoptotic protein that promotes mitochondrial fragmentation, inhibits signalling downstream from MAVS, suggesting a possible new immune modulation strategy of the CMV.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/embor.2009.258

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
Chan, D. C. (2006) · Cell · doi:10.1016/j.cell.2006.06.010 · Cited by 1,987
Mitochondria: More Than Just a Powerhouse
McBride, H. M., Neuspiel, M., & Wasiak, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.054 · Cited by 1,985
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Zhong, B., Yang, Y., Li, S., Wang, Y., Li, Y., Diao, F., Lei, C., He, X., Zhang, L., Tien, P., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.003 · Cited by 1,514
RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
Chiu, Y., MacMillan, J. B., & Chen, Z. J. (2009) · Cell · doi:10.1016/j.cell.2009.06.015 · Cited by 1,185

Flagged first, then by citations

Show all 17 references

Sorted by citations

Items 101–200 of 316

TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology
Chen, S., Liu, S., Wang, J., Wu, Q., Wang, A., Guan, H., Zhang, Q. Y., Zhang, D., Wang, X., Song, H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.10.018 · Cited by 74
Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species
McGuire, K. A., Barlan, A., Griffin, T., & Wiethoff, C. M. (2011) · Journal of Virology · doi:10.1128/jvi.00675-11 · Cited by 76
Immunometabolism around the Clock
Carroll, R. G., Timmons, G. A., Cervantes‐Silva, M. P., Kennedy, O. D., & Curtis, A. M. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.013 · Cited by 72
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells
Villeret, B., Dieu, A., Straube, M., Solhonne, B., Miklavc, P., Hamadi, S., Borgne, R. L., Mailleux, A., Norel, X., Aerts, J. J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b06934 · Cited by 69
The modified mitochondrial outer membrane carrier MTCH2 links mitochondrial fusion to lipogenesis
Labbè, K., Mookerjee, S. A., Vasseur, M. L., Gibbs, E., Lerner, C. A., & Nunnari, J. M. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202103122 · Cited by 70
Mitochondria: sensors and mediators of innate immune receptor signaling
Cloonan, S. M., & Choi, A. M. K. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.05.005 · Cited by 67
Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease
Yoo, S., Park, J., Kim, S., & Jung, Y. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.274 · Cited by 65
The central role of mitochondrial fitness on antiviral defenses: An advocacy for physical activity during the COVID-19 pandemic
Burtscher, J., Burtscher, M., & Millet, G. P. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101976 · Cited by 67
Mitochondria and the culture of the Borg
Braschi, E., & McBride, H. M. (2010) · BioEssays · doi:10.1002/bies.201000073 · Cited by 65
Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA
Hennig, T., Prusty, A. B., Kaufer, B. B., Whisnant, A. W., Lodha, M., Enders, A., Thomas, J., Kasimir, F., Grothey, A., Klein, T., et al. (2022) · Nature · doi:10.1038/s41586-022-04667-4 · Cited by 62
Mitochondrial hyperfusion: a friend or a foe
Das, R., & Chakrabarti, O. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190987 · Cited by 63
Interferon-Independent Innate Responses to Cytomegalovirus
Ashley, C. L., Abendroth, A., McSharry, B. P., & Slobedman, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02751 · Cited by 65
RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity
Yoshizumi, T., Imamura, H., Taku, T., Kuroki, T., Kawaguchi, A., Ishikawa, K., Nakada, K., & Koshiba, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-05808-w · Cited by 57
Emerging roles of peroxisomes in viral infections
Ferreira, A., Marques, M., Ramos, B., Kagan, J. C., & Ribeiro, D. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.09.010 · Cited by 55
High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells
Chiu, H.-C., Hannemann, H., Heesom, K. J., Matthews, D. A., & Davidson, A. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093305 · Cited by 58
Macrophages and Mitochondria
Tur, J., Vico, T., Lloberas, J., Antonio Zorzano, A., & Celada, A. (2017) · Advances in immunology · doi:10.1016/bs.ai.2016.12.001 · Cited by 61
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens
Campbell, L. K., & Magor, K. E. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00209 · Cited by 55
Zika virus modulates mitochondrial dynamics, mitophagy, and mitochondria-derived vesicles to facilitate viral replication in trophoblast cells
Lee, J. K., & Shin, O. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1203645 · Cited by 56
Mitochondrial hyperfusion promotes NF ‐κB activation via the mitochondrial E3 ligase MULAN
Zemirli, N., Pourcelot, M., Ambroise, G., Hatchi, E. M., Vázquez, A., & Arnoult, D. (2014) · FEBS Journal · doi:10.1111/febs.12846 · Cited by 54
Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response
Magalhães, A. C., Ferreira, A., Gomes, S. R. A. M., Vieira, M., Gouveia, A., Valença, I., Islinger, M., Nascimento, R., Schrader, M., Kagan, J. C., et al. (2016) · Scientific Reports · doi:10.1038/srep26028 · Cited by 54
RNA-seq analysis of early enteromyxosis in turbot (Scophthalmus maximus): new insights into parasite invasion and immune evasion strategies
Ronza, P., Robledo, D., Bermúdez, R., Losada, A. P., Pardo, B. G., Sitjà‐Bobadilla, A., Quiroga, M. I., & Martı́nez, P. (2016) · International Journal for Parasitology · doi:10.1016/j.ijpara.2016.03.007 · Cited by 54
Function of GRIM-19, a Mitochondrial Respiratory Chain Complex I Protein, in Innate Immunity
Chen, Y., Lu, H. K., Liu, Q., Huang, G., Lim, C. P., Zhang, L., Hao, A., & Cao, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.340315 · Cited by 50
ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial Homeostasis
Albert, M., Bécares, M., Falqui, M., Fernandez-Lozano, C., & Guerra, S. (2018) · Viruses · doi:10.3390/v10110629 · Cited by 55
Mitochondrial dynamics and the innate antiviral immune response
Pourcelot, M., & Arnoult, D. (2014) · FEBS Journal · doi:10.1111/febs.12940 · Cited by 50
ER-Mitochondria Communication in Cells of the Innate Immune System
Namgaladze, D., Khodzhaeva, V., & Brüne, B. (2019) · Cells · doi:10.3390/cells8091088 · Cited by 52
Mitochondrially localised MUL1 is a novel modulator of antiviral signaling
Jenkins, K. A., Khoo, J. J., Sadler, A. J., Piganis, R., Wang, D., Borg, N. A., Hjerrild, K., Gould, J. A., Thomas, B. J., Nagley, P., et al. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.7 · Cited by 51
Mitochondria: Metabolic regulators of innate immune responses to pathogens and cell stress
Lartigue, L., & Faustin, B. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.014 · Cited by 52
Mitochondrial Dynamics Imbalance: A Strategy for Promoting Viral Infection
Ren, Z., Zhang, X., Ding, T., Zhong, Z., Hu, H., Xu, Z., & Deng, J. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01992 · Cited by 50
Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy
Pila‐Castellanos, I., Molino, D., McKellar, J., Linès, L., Graça, J. D., Tauziet, M., Chanteloup, L., Mikaélian, I., Meyniel‐Schicklin, L., Codogno, P., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009340 · Cited by 50
Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection
Zhang, S., Carrière, J., Lin, X., Xie, N., & Feng, P. (2018) · Viruses · doi:10.3390/v10100521 · Cited by 53
Long COVID-19 and the Heart: Is Cardiac Mitochondria the Missing Link?
Chang, X., Ismail, N. I., Rahman, A., Xu, D., Chan, R. W. Y., Ong, S., & Ong, S. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0126 · Cited by 53
Regulation of Mitochondrial Antiviral Signaling (MAVS) Expression and Signaling by the Mitochondria-associated Endoplasmic Reticulum Membrane (MAM) Protein Gp78
Jacobs, J. L., Zhu, J., Sarkar, S. N., & Coyne, C. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520254 · Cited by 46
Mitochondria-associated membranes (MAMs): An emerging platform connecting energy and immune sensing to metabolic flexibility
Rieusset, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.06.097 · Cited by 47
Mitochondrial localization of viral proteins as a means to subvert host defense
Castanier, C., & Arnoult, D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.08.009 · Cited by 47
Peroxisomes and Innate Immunity: Antiviral Response and Beyond
Ferreira, A., Marques, M., & Ribeiro, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153795 · Cited by 46
Antiviral Effects of Menthol on Coxsackievirus B
Taylor, D. J. R., Hamid, S. M., Andres, A. M., Saadaeijahromi, H., Piplani, H., Germano, J. D. F., Song, Y., Sawaged, S., Feuer, R., Pandol, S. J., et al. (2020) · Viruses · doi:10.3390/v12040373 · Cited by 46
The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon Response by Inhibiting MAVS Signaling
Vera‐Otarola, J., Solís, L., Lowy, F., Olguín, V., Angulo, J., Pino, K., Tischler, N. D., Carola Otth, L., Padula, P., & López‐Lastra, M. (2020) · Journal of Virology · doi:10.1128/jvi.00454-20 · Cited by 47
MIP-T3 Is a Negative Regulator of Innate Type I IFN Response
Ng, M.-H. J., Ho, T., Kok, K., Siu, K., Li, J., & Jin, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100719 · Cited by 44
Autophagy and selective deployment of Atg proteins in antiviral defense
Yordy, B., Tal, M. C., Hayashi, K., Arojo, O., & Iwasaki, A. (2012) · International Immunology · doi:10.1093/intimm/dxs101 · Cited by 45
The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity
Yasukawa, K., Kinoshita, D., Yaku, K., Nakagawa, T., & Koshiba, T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010511 · Cited by 43
SOD2 Facilitates the Antiviral Innate Immune Response by Scavenging Reactive Oxygen Species
Wang, W., Jin, Y., Zeng, N., Ruan, Q., & Qian, F. (2017) · Viral Immunology · doi:10.1089/vim.2017.0043 · Cited by 41
Emerging Mechanisms of Innate Immunity and Their Translational Potential in Inflammatory Bowel Disease
Corridoni, D., Chapman, T., Ambrose, T., & Simmons, A. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00032 · Cited by 45
Mitochondrial dynamics in macrophages: divide to conquer or unite to survive?
Afroz, S. F., Raven, K. D., Lawrence, G. M. E. P., Kapétanovic, R., Schroder, K., & Sweet, M. J. (2023) · Biochemical Society Transactions · doi:10.1042/bst20220014 · Cited by 44
Hepatitis C Virus: Strategies to Evade Antiviral Responses
Gokhale, N. S., Vazquez, C., & Horner, S. M. (2014) · Future Virology · doi:10.2217/fvl.14.89 · Cited by 41
Inhibition of Drp1 attenuates mitochondrial damage and myocardial injury in Coxsackievirus B3 induced myocarditis
Lin, L., Zhang, M., Yan, R., Hu, S., Diao, J., & Wei, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.01.116 · Cited by 41
The mitochondrial respiratory chain: A metabolic rheostat of innate immune cell-mediated antibacterial responses
Sander, L. E., & Garaude, J. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.10.008 · Cited by 41
The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek
Tremblay, N., Freppel, W., Sow, A. A., & Chatel‐Chaix, L. (2019) · Vaccines · doi:10.3390/vaccines7040145 · Cited by 44
DDAH2 suppresses RLR-MAVS–mediated innate antiviral immunity by stimulating nitric oxide–activated, Drp1-induced mitochondrial fission
Huang, S., Li, Z., Wu, Z., Liu, C., Yu, M., Wen, M., Zhang, L., & Wang, X. (2021) · Science Signaling · doi:10.1126/scisignal.abc7931 · Cited by 40
Mitoxosome: a mitochondrial platform for cross‐talk between cellular stress and antiviral signaling
Tal, M. C., & Iwasaki, A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01038.x · Cited by 38
The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-α
Gao, F., Reynolds, M. B., Passalacqua, K. D., Sexton, J. Z., Abuaita, B. H., & O’Riordan, M. X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.593805 · Cited by 38
Cytomegalovirus immune evasion of myeloid lineage cells
Brinkmann, M. M., Dağ, F., Hengel, H., Messerle, M., Kalinke, U., & Čičin‐Šain, L. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0403-4 · Cited by 38
Modulation of Innate Immune Signaling Pathways by Herpesviruses
Liu, Q., Rao, Y., Tian, M., Zhang, S. J., & Feng, P. (2019) · Viruses · doi:10.3390/v11060572 · Cited by 37
Influenza A virus PB1-F2 protein: An ambivalent innate immune modulator and virulence factor
Cheung, P. H., Lee, T.-W. T., Chan, C., & Jin, D. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0320-206r · Cited by 35
Influenza Virus RNA Synthesis and the Innate Immune Response
Weis, S., & Velthuis, A. J. W. T. (2021) · Viruses · doi:10.3390/v13050780 · Cited by 34
Viperin interaction with mitochondrial antiviral signaling protein (MAVS) limits viperin-mediated inhibition of the interferon response in macrophages
Hee, J. S., & Cresswell, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172236 · Cited by 34
Cytosolic Nucleic Acid Sensors in Inflammatory and Autoimmune Disorders
Khan, S., Godfrey, V., & Zaki, H. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.10.002 · Cited by 34
Differential remodeling of the electron transport chain is required to support TLR3 and TLR4 signaling and cytokine production in macrophages
Ahmed, D., Roy, D., Jaworski, A. F., Edwards, A., Abizaid, A. B., Kumar, A., Golshani, A., & Cassol, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-55295-4 · Cited by 35
A fluorescent reporter system enables spatiotemporal analysis of host cell modification during herpes simplex virus-1 replication
Scherer, K. M., Manton, J. D., Soh, T. K., Mascheroni, L., Connor, V., Crump, C. M., & Kaminski, C. F. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016571 · Cited by 35
Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19
Singh, S. P., Amar, S., Gehlot, P., Patra, S. K., Kanwar, N., & Kanwal, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158180 · Cited by 35
MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer
Wang, C., Yang, K., Liu, X., Wang, S., Song, M., Belmonte, J. C. I., Qu, J. T., Liu, G., & Zhang, W. (2023) · Research · doi:10.34133/research.0192 · Cited by 32
MicroRNA-33/33* inhibit the activation of MAVS through AMPK in antiviral innate immunity
Liu, D., Tan, Q., Zhu, J., Zhang, Y., Xue, Y., Song, Y., Liu, Y., Wang, Q., & Lai, L. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0326-x · Cited by 32
Mitochondria–Endoplasmic Reticulum Contact Sites Mediate Innate Immune Responses
Misawa, T., Takahama, M., & Saitoh, T. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4567-7_14 · Cited by 32
Doxycycline Induces Mitophagy and Suppresses Production of Interferon-β in IPEC-J2 Cells
Yang, X., Zhu, L., Lin, J., Qinghua, Y., & Yang, Q. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00021 · Cited by 30
The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription
Chan, B., Magalhães, V. G., Lemmermann, N. A. W., Lisnić, V. J., Stempel, M., Bussey, K. A., Reimer, E., Podlech, J., Lienenklaus, S., Reddehase, M. J., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006382 · Cited by 29
Type I Interferon Production Induced by RIG-I-Like Receptors
Onomoto, K., Onoguchi, K., Takahasi, K., & Fujita, T. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0117 · Cited by 30
Superresolution Imaging of Human Cytomegalovirus vMIA Localization in Sub-Mitochondrial Compartments
Bhuvanendran, S., Salka, K., Rainey, K. H., Sreetama, S. C., Williams, E. D., Leeker, M., Prasad, V., Boyd, J., Patterson, G. H., Jaiswal, J. K., et al. (2014) · Viruses · doi:10.3390/v6041612 · Cited by 30
Viral Product Trafficking to Mitochondria, Mechanisms and Roles in Pathogenesis
Williamson, C. D., DeBiasi, R. L., & Colberg‐Poley, A. M. (2012) · Infectious Disorders - Drug Targets · doi:10.2174/187152612798994948 · Cited by 30
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity
Doiron, K., Goyon, V., Coyaud, É., Rajapakse, S., Raught, B., & McBride, H. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-00151-6 · Cited by 30
Mitochondrial anti-viral immunity
Zemirli, N., & Arnoult, D. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.05.018 · Cited by 29
Mitofusin 2-Deficiency Suppresses Mycobacterium tuberculosis Survival in Macrophages
Lee, J., Choi, J., Cho, S., Son, S., & Song, C. (2019) · Cells · doi:10.3390/cells8111355 · Cited by 29
Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity
Kim, I. S., Silwal, P., & Jo, E. (2021) · Virulence · doi:10.1080/21505594.2021.1965829 · Cited by 29
Host mitochondria: more than an organelle in SARS-CoV-2 infection
Shoraka, S., Samarasinghe, A. E., Ghaemi, A., & Mohebbi, S. R. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1228275 · Cited by 29
The expression of IFN-β is suppressed by the viral 3D polymerase via its impact on PGAM5 expression during enterovirus D68 infection
Yang, Z., Zheng, H., Li, H., Chen, Y., Hou, D., Fan, Q., Song, J., Guo, L., & Liu, L. (2021) · Virus Research · doi:10.1016/j.virusres.2021.198549 · Cited by 27
Mitochondria and antiviral innate immunity.
Koshiba, T., Bashiruddin, N. K., & Kawabata, S. (2011) · Europe PMC (PubMed Central) · Cited by 26
Mitochondrion: an emerging platform critical for host antiviral signaling
Wang, C., Liu, X., & Wei, B. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.561321 · Cited by 27
The Interplay between Human Cytomegalovirus and Pathogen Recognition Receptor Signaling
Marques, M., Ferreira, A., & Ribeiro, D. (2018) · Viruses · doi:10.3390/v10100514 · Cited by 28
Mitochondria and Peroxisome Remodeling across Cytomegalovirus Infection Time Viewed through the Lens of Inter-ViSTA
Federspiel, J. D., Cook, K. C., Kennedy, M. A., Venkatesh, S. S., Otter, C. J., Hofstadter, W. A., Beltran, P. M. J., & Cristea, I. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107943 · Cited by 24
Mitophagy in Antiviral Immunity
Wang, H., Zheng, Y., Huang, J., & Li, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.723108 · Cited by 26
Crosstalk between mitophagy and innate immunity in viral infection
Fu, C., Cao, N., Liu, W., Zhang, Z., Yang, Z., Zhu, W., & Fan, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1064045 · Cited by 26
Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics
Molino, D., Pila‐Castellanos, I., Marjault, H., Amoêdo, N. D., Kopp, K., Rochin, L., Karmi, O., Sohn, Y., Linès, L., Hamaï, A., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949019 · Cited by 27
Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model
Tanaka, M., Yamaguchi, S., Yamazaki, Y., Kinoshita, H., Kuwahara, K., Nakao, K., Jay, P. Y., Noda, T., & Nakamura, T. (2015) · Scientific Reports · doi:10.1038/srep07826 · Cited by 28
Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections
Qu, C., Zhang, S., Li, Y., Wang, Y., Peppelenbosch, M. P., & Pan, Q. (2019) · Reviews in Medical Virology · doi:10.1002/rmv.2075 · Cited by 25
The Essential Role of Mitochondrial Dynamics in Viral Infections
Duan, X., Liu, R., Lan, W., & Liu, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26051955 · Cited by 24
Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis
Song, X., Wang, Y., Zou, W., Wang, Z., Cao, W., Liang, M., Li, F., Zeng, Q., Ren, Z., Wang, Y., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.08.003 · Cited by 24
Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?
Кутихин, А. Г., & Yuzhalin, A. E. (2012) · Cancer Management and Research · doi:10.2147/cmar.s28688 · Cited by 23
Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein
Glon, D., Vilmen, G., Perdiz, D., Hernández, E., Beauclair, G., Quignon, F., Berlioz‐Torrent, C., Maréchal, V., Poüs, C., Lussignol, M., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010371 · Cited by 25
HIV-1 Infection and First Line ART Induced Differential Responses in Mitochondria from Blood Lymphocytes and Monocytes: The ANRS EP45 “Aging” Study
Perrin, S., Cremer, J., Roll, P., Zaegel‐Faucher, O., Menard, A., Reynes, J., Dellamonica, P., Naqvi, A., Micallef, J., Jouve, É., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041129 · Cited by 22
Recognition of viruses in the cytoplasm by RLRs and other helicases—how conformational changes, mitochondrial dynamics and ubiquitination control innate immune responses
Ng, C. S., Kato, H., & Fujita, T. (2012) · International Immunology · doi:10.1093/intimm/dxs099 · Cited by 23
Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop
Cheng, J., Liao, Y., Zhou, L., Peng, S., Chen, H., & Yuan, Z. (2016) · Scientific Reports · doi:10.1038/srep20158 · Cited by 23
Exploiting Connections for Viral Replication
Wong, L. H., Edgar, J. R., Martello, A., Ferguson, B. J., & Eden, E. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.640456 · Cited by 23
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells
Lietzén, N., Hirvonen, M. K., Honkimaa, A., Buchacher, T., Laiho, J. E., Oikarinen, S., Mazur, M. A., Flodström‐Tullberg, M., Dufour, É., Sioofy‐Khojine, A., et al. (2019) · iScience · doi:10.1016/j.isci.2019.07.040 · Cited by 23
Innate Immune Responses to Herpesvirus Infection
O’Connor, C. M., & Sen, G. C. (2021) · Cells · doi:10.3390/cells10082122 · Cited by 24
Listeria infection modulates mitochondrial dynamics
Stavru, F., & Cossart, P. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.4.3.15506 · Cited by 28
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells
Cheng, J., Wang, Y., Yin, L., Liang, W., Zhang, J., Ma, C., Zhang, Y., Liu, B., Wang, J., Zhao, W., et al. (2023) · mBio · doi:10.1128/mbio.01480-23 · Cited by 23
Mitochondrial hyperactivity and reactive oxygen species drive innate immunity to the yellow fever virus-17D live-attenuated vaccine
Muccilli, S. G., Schwarz, B. H., Shue, B., Jessop, F., Shannon, J. G., Larson, C. L., Hage, A., Hong, S.-H., Bohrnsen, E., Hsu, T., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1012561 · Cited by 21
Listeria infection modulates mitochondrial dynamics.
Stavru, F., & Cossart, P. (2011) · Europe PMC (PubMed Central) · doi:10.4161/cib.4.2.15506 · Cited by 21
Subversion of cellular autophagy during virus infection: Insights from hepatitis B and hepatitis C viruses
Khan, M. A., Imam, H., & Siddiqui, A. (2018) · Liver Research · doi:10.1016/j.livres.2018.09.002 · Cited by 21
A Levee to the Flood: Pre-injury Neuroinflammation and Immune Stress Influence Traumatic Brain Injury Outcome
Houle, S., & Kokiko‐Cochran, O. N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.788055 · Cited by 22
Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes
Rivera-Serrano, E. E., DeAngelis, N., & Sherry, B. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.08.008 · Cited by 19
Target verification of artesunate-related antiviral drugs: Assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling
Hahn, F., Niesar, A., Wangen, C., Wild, M. R., Grau, B. W., Herrmann, L., Çapcı, A., Adrait, A., Couté, Y., Tsogoeva, S. B., et al. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104861 · Cited by 22

Authors: Castanier, C., Garcin, D., Vazquez, A., & Arnoult, D.
Affiliations: Université Paris-Sud (FR)
University of Geneva (CH)
Corresponding author: Arnoult, Damien
ORCID: Garcin, Dominique
Arnoult, Damien
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2009-12-18
Volume: 11
Issue: 2
Pages: 133-138
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1038/embor.2009.258
PMC: PMC2828750
OpenAlex: W1993205112
Cited by: 316
References: 17
Citations by year: 2026: 10 · 2025: 18 · 2024: 14 · 2023: 20 · 2022: 19 · 2021: 26 · 2020: 27 · 2019: 23 · 2018: 19 · 2017: 20 · 2016: 16 · 2015: 17 · 2014: 22 · 2013: 11 · 2012: 20
FWCI: 7.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondrial dynamics, RIG-I-like receptors, MAVS, mitochondrial fusion, mitofusin 1, mitochondrial fragmentation, STING, type I interferon signaling, viral RNA sensing, cytomegalovirus, immune evasion, antiviral innate immunity
MeSH terms: STING Protein, Antiviral Agents, Cells, Cultured, HeLa Cells, Humans, Immunity, Innate, Membrane Proteins, Mitochondria, Protein Binding, Virus Diseases, Signal Transduction, Receptors, Retinoic Acid, Mitochondrial Proteins, Organelle Shape, Organelle Size

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks