Cited by 316interferon and immune responsesImmune Response and InflammationMitochondrial Function and Pathology

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Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

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Castanier, Céline, Garcin, Dominique, Vazquez, Aimé, Arnoult, Damien·2010·The EMBO Reports

DOI 10.1038/embor.2009.258PMC PMC2828750

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Abstract

The intracellular retinoic acid-inducible gene I-like receptors (RLRs) sense viral ribonucleic acid and signal through the mitochondrial protein mitochondrial antiviral signalling (MAVS) to trigger the production of type I interferons and proinflammatory cytokines. In this study, we report that RLR activation promotes elongation of the mitochondrial network. Mimicking this elongation enhances signalling downstream from MAVS and favours the binding of MAVS to stimulator of interferon genes, an endoplasmic reticulum (ER) protein involved in the RLR pathway. By contrast, enforced mitochondrial fragmentation dampens signalling and reduces the association between both proteins. Our finding that MAVS is associated with a pool of mitofusin 1, a protein of the mitochondrial fusion machinery, suggests that MAVS is capable of regulating mitochondrial dynamics to facilitate the mitochondria-ER association required for signal transduction. Importantly, we observed that viral mitochondria-localized inhibitor of apoptosis, a cytomegalovirus (CMV) antiapoptotic protein that promotes mitochondrial fragmentation, inhibits signalling downstream from MAVS, suggesting a possible new immune modulation strategy of the CMV.

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Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270
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Tait, S. W. G., & Green, D. R. (2012) · Journal of Cell Science · doi:10.1242/jcs.099234 · Cited by 453
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Authors: Castanier, C., Garcin, D., Vazquez, A., & Arnoult, D.
Affiliations: Université Paris-Sud (FR)
University of Geneva (CH)
Corresponding author: Arnoult, Damien
ORCID: Garcin, Dominique
Arnoult, Damien
Venue: The EMBO Reports
Publisher: Springer Science and Business Media LLC
Published: 2009-12-18
Volume: 11
Issue: 2
Pages: 133-138
ISSN: 1469-221X (ISSN-L)
1469-3178
DOI: 10.1038/embor.2009.258
PMC: PMC2828750
OpenAlex: W1993205112
Cited by: 316
References: 17
Citations by year: 2026: 10 · 2025: 18 · 2024: 14 · 2023: 20 · 2022: 19 · 2021: 26 · 2020: 27 · 2019: 23 · 2018: 19 · 2017: 20 · 2016: 16 · 2015: 17 · 2014: 22 · 2013: 11 · 2012: 20
FWCI: 7.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Reports (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondrial dynamics, RIG-I-like receptors, MAVS, mitochondrial fusion, mitofusin 1, mitochondrial fragmentation, STING, type I interferon signaling, viral RNA sensing, cytomegalovirus, immune evasion, antiviral innate immunity
MeSH terms: STING Protein, Antiviral Agents, Cells, Cultured, HeLa Cells, Humans, Immunity, Innate, Membrane Proteins, Mitochondria, Protein Binding, Virus Diseases, Signal Transduction, Receptors, Retinoic Acid, Mitochondrial Proteins, Organelle Shape, Organelle Size

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Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

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