The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
miR‐29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis
Open accessAbstract
Several microRNAs (miRNAs) have recently been described as crucial regulators of epithelial‐to‐mesenchymal transition (EMT) and metastasis. By comparing the expression profiles of miRNAs, we found upregulation of miR‐29a in mesenchymal, metastatic RasXT cells relative to epithelial EpRas cells. Overexpression of miR‐29a suppressed the expression of tristetraprolin (TTP), a protein involved in the degradation of messenger RNAs with AU‐rich 3′‐untranslated regions, and led to EMT and metastasis in cooperation with oncogenic Ras signalling. We also observed enhanced miR‐29a and reduced TTP levels in breast cancer patient samples, indicating relevance for human disease. Previously, miR‐29 family members were shown to have tumour‐suppressive effects in haematopoietic, cholangiocytic and lung tumours. Therefore, miRNAs can act as either oncogenes or tumour suppressors, depending on the context.
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Metadata
- Authors
- Gebeshuber, C. A., Zatloukal, K., & Martinez, J.
- Venue
- EMBO reports
- Published
- 2009-02-27
- Volume
- 10
- Issue
- 4
- Pages
- 400-405
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2067884710
- Cited by
- 391
- References
- 27
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gebeshuber, C. A., Zatloukal, K., & Martinez, J. (2009). miR‐29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO reports. https://doi.org/10.1038/embor.2009.9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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