Natural immunity: Biodiversity loss and inflammatory diseases are two global megatrends that might be related

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Global Biodiversity: Indicators of Recent Declines

Butchart, S. H. M., Walpole, M., Collen, B., van Strien, A., Scharlemann, J. P. W., Almond, R. E. A., Baillie, J. E. M., Bomhard, B., Brown, C., Bruno, J., et al. (2010) · Science · doi:10.1126/science.1187512 · Cited by 4,892 · see citing works

Epigenetic differences arise during the lifetime of monozygotic twins

Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602 · see citing works

Bacterial Community Variation in Human Body Habitats Across Space and Time

Costello, E. K., Lauber, C. L., Hamady, M., Fierer, N., Gordon, J. I., & Knight, R. (2009) · Science · doi:10.1126/science.1177486 · Cited by 3,231 · see citing works

Topographical and Temporal Diversity of the Human Skin Microbiome

Grice, E. A., Kong, H. H., Conlan, S., Deming, C. B., Davis, J., Young, A. C., Program, N. C. S., Bouffard, G. G., Blakesley, R. W., Murray, P. R., et al. (2009) · Science · doi:10.1126/science.1171700 · Cited by 2,953 · see citing works

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Wen, L., Ley, R. E., Volchkov, P. Y., Stranges, P. B., Avanesyan, L., Stonebraker, A. C., Hu, C., Wong, F. S., Szot, G. L., Bluestone, J. A., et al. (2008) · Nature · doi:10.1038/nature07336 · Cited by 1,921 · see citing works

Disordered Microbial Communities in Asthmatic Airways

Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,825 · see citing works

Morbidity is related to a green living environment

Maas, J., Verheij, R. A., de Vries, S., Spreeuwenberg, P., Schellevis, F. G., & Groenewegen, P. P. (2009) · Journal of Epidemiology and Community Health · doi:10.1136/jech.2008.079038 · Cited by 1,133 · see citing works

The influence of sex, handedness, and washing on the diversity of hand surface bacteria

Fierer, N., Hamady, M., Lauber, C. L., & Knight, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807920105 · Cited by 1,100 · see citing works

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells

Schaub, B., Liu, J., Höppler, S., Schleich, I., Huehn, J., Olek, S., Wieczorek, G., Illi, S., & von Mutius, E. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.01.056 · Cited by 431 · see citing works

Altered early infant gut microbiota in children developing allergy up to 5 years of age

Sjögren, Y. M., Jenmalm, M. C., Böttcher, M. F., Björkstén, B., & Sverremark‐Ekström, E. (2009) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03156.x · Cited by 378 · see citing works

Self-rated health within the Canadian immigrant population: risk and the healthy immigrant effect

Newbold, K. B. (2004) · Social Science & Medicine · doi:10.1016/j.socscimed.2004.06.048 · Cited by 366 · see citing works

Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis

Rook, G. A. W. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.03007.x · Cited by 295 · see citing works

Age- and sex-related prevalence of diabetes mellitus among immigrants to Ontario, Canada

Creatore, M. I., Moineddin, R., Booth, G. L., Manuel, D. G., DesMeules, M., McDermott, S., & Glazier, R. H. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.091551 · Cited by 255 · see citing works

Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population.

Bodansky, H. J., Staines, A. S., Stephenson, C. R., Haigh, D., & Cartwright, R. (1992) · BMJ · doi:10.1136/bmj.304.6833.1020 · Cited by 200 · see citing works

Cancer Incidence in First Generation U.S. Hispanics: Cubans, Mexicans, Puerto Ricans, and New Latinos

Pinheiro, P. S., Sherman, R., Trapido, E. J., Fleming, L. E., Huang, Y., Gómez-Marı́n, O., & Lee, D. J. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0329 · Cited by 191 · see citing works

Trends in prevalence of asthma and allergy in Finnish young men: nationwide study, 1966-2003

Latvala, J., von Hertzen, L., Lindholm, H., & Haahtela, T. (2005) · BMJ · doi:10.1136/bmj.38448.603924.ae · Cited by 132 · see citing works

Microbial exposure, interferon gamma gene demethylation in naïve T‐cells, and the risk of allergic disease

Vuillermin, P., Ponsonby, A., Saffery, R., Tang, M. L. K., Ellis, J. A., Sly, P. D., & Holt, P. G. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.01970.x · Cited by 82 · see citing works

Cultural adaptation is associated with atopy and wheezing among children of Turkish origin living in Germany

Grüber, C., Illi, S., Plieth, A., Sommerfeld, C., & Wahn, U. (2002) · Clinical & Experimental Allergy · doi:10.1046/j.0954-7894.2002.01331.x · Cited by 82 · see citing works

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Psycho‐neuroimmunology and the intestinal microbiota: clinical observations and basic mechanisms

Bienenstock, J., & Collins, S. M. (2010) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2010.04124.x · Cited by 58 · see citing works

Serum IgE levels and allergic spectra in immigrants to Sweden

Kalyoncu, A. F., & Stålenheim, G. (1992) · Allergy · doi:10.1111/j.1398-9995.1992.tb02053.x · Cited by 56 · see citing works

Contrasting Immunological Effects of Two Disparate Dusts – Preliminary Observations

Alenius, H. T., Pakarinen, J., Saris, O., Andersson, M. A., Leino, M. S., Sirola, K., Majuri, M., Niemelä, J. K., Matikainen, S., Wolff, H. J., et al. (2008) · International Archives of Allergy and Immunology · doi:10.1159/000176310 · Cited by 32 · see citing works

Microbial deprivation, inflammation and cancer

von Hertzen, L. C., Joensuu, H., & Haahtela, T. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9284-1 · Cited by 31 · see citing works

Perceived Insomnia, Anxiety, and Depression among Older Russian Immigrants

Casimir, G. J. A., Butler, S., Nunes, J., Jean‐Louis, G., Zizi, F., & Brady, L. (2010) · Psychological Reports · doi:10.2466/pr0.106.2.589-597 · Cited by 16 · see citing works

Environmental biodiversity, human microbiota, and allergy are interrelated

Hanski, I., von Hertzen, L., Fyhrquist, N., Koskinen, K., Torppa, K., Laatikainen, T., Karisola, P., Auvinen, P., Paulin, L., Mäkelä, M. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205624109 · Cited by 1,063 · see citing works

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

Rook, G. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313731110 · Cited by 760 · see citing works

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557 · see citing works

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 554 · see citing works

The biodiversity hypothesis and allergic disease: world allergy organization position statement

Haahtela, T., Holgate, S., Pawankar, R., Akdis, C. A., Benjaponpitak, S., Caraballo, L., Demain, J., Portnoy, J., & von Hertzen, L. (2013) · World Allergy Organization Journal · doi:10.1186/1939-4551-6-3 · Cited by 426 · see citing works

A biodiversity hypothesis

Haahtela, T. (2019) · Allergy · doi:10.1111/all.13763 · Cited by 407 · see citing works

The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems

Flandroy, L., Poutahidis, T., Berg, G., Clarke, G. A., Dao, M. C., Decaestecker, E., Furman, E., Haahtela, T., Massart, S., Plovier, H., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.288 · Cited by 399 · see citing works

Soil and Human Health: Current Status and Future Needs

Brevik, E. C., Slaughter, L. C., Singh, B. R., Steffan, J. J., Collier, D. N., Barnhart, P. R., & Pereira, P. A. D. S. (2020) · Air Soil and Water Research · doi:10.1177/1178622120934441 · Cited by 328 · see citing works

Urban soil and human health: a review

Li, G., Sun, G., Ren, Y., Luo, X., & Zhu, Y. (2018) · European Journal of Soil Science · doi:10.1111/ejss.12518 · Cited by 296 · see citing works

Green areas around homes reduce atopic sensitization in children

Ruokolainen, L., Hertzen, L., Fyhrquist, N., Laatikainen, T., Lehtomäki, J., Auvinen, P., Karvonen, A. M., Hyvärinen, A., Tillmann, V., Niemelä, O., et al. (2015) · Allergy · doi:10.1111/all.12545 · Cited by 273 · see citing works

Toward Improved Public Health Outcomes From Urban Nature

Shanahan, D. F., Lin, B. B., Bush, R. A. B., Gaston, K. J., Dean, J., Barber, E., & Fuller, R. A. (2015) · American Journal of Public Health · doi:10.2105/ajph.2014.302324 · Cited by 268 · see citing works

Diversifying Food Systems in the Pursuit of Sustainable Food Production and Healthy Diets

Dwivedi, S. L., Bueren, E. L. V., Ceccarelli, S., Grando, S., Upadhyaya, H. D., & Ortiz, R. O. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2017.06.011 · Cited by 261 · see citing works

Microbial ‘Old Friends’, immunoregulation and stress resilience

Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2013) · Evolution Medicine and Public Health · doi:10.1093/emph/eot004 · Cited by 245 · see citing works

Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation

Fyhrquist, N., Ruokolainen, L., Suomalainen, A., Lehtimäki, S., Veckman, V., Vendelin, J., Karisola, P., Lehto, M., Savinko, T., Jarva, H., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.059 · Cited by 205 · see citing works

Bacterial microbiota of the upper respiratory tract and childhood asthma

Depner, M., Ege, M. J., Cox, M. J., Dwyer, S., Walker, A. W., Birzele, L. T., Genuneit, J., Horak, E., Braun‐Fahrländer, C., Danielewicz, H., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.050 · Cited by 198 · see citing works

Microbiome and skin diseases

Zeeuwen, P. L. J. M., Kleerebezem, M., Timmerman, H. M., & Schalkwijk, J. (2013) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328364ebeb · Cited by 199 · see citing works

Does Soil Contribute to the Human Gut Microbiome?

Blum, W. E. H., Zechmeister‐Boltenstern, S., & Keiblinger, K. M. (2019) · Microorganisms · doi:10.3390/microorganisms7090287 · Cited by 189 · see citing works

Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development

Dannemiller, K. C., Mendell, M. J., Macher, J. M., Kumagai, K., Bradman, A., Holland, N., Harley, K. G., Eskenazi, B., & Peccia, J. (2013) · Indoor Air · doi:10.1111/ina.12072 · Cited by 183 · see citing works

Linking the Gut Microbial Ecosystem with the Environment: Does Gut Health Depend on Where We Live?

Tasnim, N., Abulizi, N., Pither, J., Hart, M. M., & Gibson, D. L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01935 · Cited by 181 · see citing works

Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model

Ottman, N., Ruokolainen, L., Suomalainen, A., Sinkko, H., Karisola, P., Lehtimäki, J., Lehto, M., Hanski, I., Alenius, H. T., & Fyhrquist, N. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.06.024 · Cited by 177 · see citing works

Transfer of environmental microbes to the skin and respiratory tract of humans after urban green space exposure

Selway, C. A., Mills, J. G., Weinstein, P., Skelly, C., Yadav, S., Lowe, A. J., Breed, M. F., & Weyrich, L. S. (2020) · Environment International · doi:10.1016/j.envint.2020.106084 · Cited by 173 · see citing works

Urban habitat restoration provides a human health benefit through microbiome rewilding: the Microbiome Rewilding Hypothesis

Mills, J. G., Weinstein, P., Gellie, N. J. C., Weyrich, L. S., Lowe, A. J., & Breed, M. F. (2017) · Restoration Ecology · doi:10.1111/rec.12610 · Cited by 172 · see citing works

Hunt for the origin of allergy – comparing the Finnish and Russian Karelia

Haahtela, T., Laatikainen, T. K., Alenius, H. T., Auvinen, P., Fyhrquist, N., Hanski, I., von Hertzen, L., Jousilahti, P., Kosunen, T. U., Markelova, O., et al. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12527 · Cited by 158 · see citing works

Naturally-diverse airborne environmental microbial exposures modulate the gut microbiome and may provide anxiolytic benefits in mice

Liddicoat, C., Sydnor, H., Cando-Dumancela, C., Dresken, R., Liu, J., Gellie, N. J. C., Mills, J. G., Young, J. M., Weyrich, L. S., Hutchinson, M. R., et al. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134684 · Cited by 140 · see citing works

Urban-associated diseases: Candidate diseases, environmental risk factors, and a path forward

Flies, E. J., Mavoa, S., Zosky, G. R., Mantzioris, E., Williams, C. R., Eri, R. D., Brook, B. W., & Buettel, J. C. (2019) · Environment International · doi:10.1016/j.envint.2019.105187 · Cited by 154 · see citing works

Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts

Fuertes, E., Markevych, I., Bowatte, G., Gruzieva, O., Gehring, U., Becker, A., Berdel, D., von Berg, A., Bergström, A., Brauer, M., et al. (2016) · Allergy · doi:10.1111/all.12915 · Cited by 149 · see citing works

Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review

Andersen, L., Corazon, S. S., & Stigsdotter, U. K. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041416 · Cited by 153 · see citing works

Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry

Kamrath, C., Rosenbauer, J., Eckert, A. J., Siedler, K., Bartelt, H., Klose, D., Sindichakis, M., Herrlinger, S., Lahn, V., & Holl, R. W. (2022) · Diabetes Care · doi:10.2337/dc21-0969 · Cited by 134 · see citing works

Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia

Ruokolainen, L., Paalanen, L., Karkman, A., Laatikainen, T. K., von Hertzen, L., Vlasoff, T., Markelova, O., Masyuk, V., Auvinen, P., Paulin, L. G., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12895 · Cited by 132 · see citing works

Patterns in the skin microbiota differ in children and teenagers between rural and urban environments

Lehtimäki, J., Karkman, A., Laatikainen, T., Paalanen, L., von Hertzen, L., Haahtela, T., Hanski, I., & Ruokolainen, L. (2017) · Scientific Reports · doi:10.1038/srep45651 · Cited by 131 · see citing works

The Hygiene Hypothesis in the Age of the Microbiome

Ege, M. J. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201702-139aw · Cited by 128 · see citing works

Higher levels of greenness and biodiversity associate with greater subjective wellbeing in adults living in Melbourne, Australia

Mavoa, S., Davern, M. T., Breed, M. F., & Hahs, A. K. (2019) · Health & Place · doi:10.1016/j.healthplace.2019.05.006 · Cited by 124 · see citing works

The maternal gut microbiome during pregnancy and offspring allergy and asthma

Gao, Y., Nanan, R. K. H., Macia, L., Tan, J., Sominsky, L., Quinn, T. P., O’Hely, M., Ponsonby, A., Tang, M. L. K., Collier, F., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.07.011 · Cited by 121 · see citing works

Microbiota, immunoregulatory old friends and psychiatric disorders

Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117 · see citing works

Greenness and allergies: evidence of differential associations in two areas in Germany

Fuertes, E., Markevych, I., Berg, A. V., Bauer, C., Berdel, D., Koletzko, S., Sugiri, D., & Heinrich, J. (2014) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2014-203903 · Cited by 117 · see citing works

The ecology of human microbiota: dynamics and diversity in health and disease

Karkman, A., Lehtimäki, J., & Ruokolainen, L. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13326 · Cited by 116 · see citing works

Urbanized microbiota in infants, immune constitution, and later risk of atopic diseases

Lehtimäki, J., Thorsen, J., Rasmussen, M. A., Hjelmsø, M., Shah, S., Mortensen, M. S., Trivedi, U., Vestergaard, G., Bønnelykke, K., Chawes, B. L., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.12.621 · Cited by 116 · see citing works

Hygiene and other early childhood influences on the subsequent function of the immune system

Rook, G. A. W., Lowry, C. A., & Raison, C. L. (2015) · Brain Research · doi:10.1016/j.brainres.2014.04.004 · Cited by 109 · see citing works

Helsinki alert of biodiversity and health

von Hertzen, L., Beutler, B., Bienenstock, J., Blaser, M. J., Cani, P. D., Eriksson, J. G., Färkkilä, M. A., Haahtela, T., Hanski, I., Jenmalm, M. C., et al. (2015) · Annals of Medicine · doi:10.3109/07853890.2015.1010226 · Cited by 108 · see citing works

Indoor Emissions as a Primary Source of Airborne Allergenic Fungal Particles in Classrooms

Yamamoto, N., Hospodsky, D., Dannemiller, K. C., Nazaroff, W. W., & Peccia, J. (2015) · Environmental Science & Technology · doi:10.1021/es506165z · Cited by 107 · see citing works

Role of soil in the regulation of human and plant pathogens: soils' contributions to people

Samaddar, S., Karp, D. S., Schmidt, R., Devarajan, N., McGarvey, J. A., Pires, A. F. A., & Scow, K. M. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0179 · Cited by 105 · see citing works

Outdoor learning in early childhood education: exploring benefits and challenges

Kiviranta, L., Lindfors, E., Rönkkö, M., & Luukka, E. (2023) · Educational Research · doi:10.1080/00131881.2023.2285762 · Cited by 160 · see citing works

Biodiverse green spaces: a prescription for global urban health

Flies, E. J., Skelly, C., Negi, S., Prabhakaran, P., Liu, Q., Liu, K., Goldizen, F. C., Lease, C., & Weinstein, P. (2017) · Frontiers in Ecology and the Environment · doi:10.1002/fee.1630 · Cited by 104 · see citing works

Multispecies sustainability

Rupprecht, C. D. D., Vervoort, J., Berthelsen, C., Mangnus, A., Osborne, N., Thompson, K. A., Urushima, A. Y. F., Kóvskaya, M., Spiegelberg, M., Cristiano, S., et al. (2020) · Global Sustainability · doi:10.1017/sus.2020.28 · Cited by 101 · see citing works

Short‐term direct contact with soil and plant materials leads to an immediate increase in diversity of skin microbiota

Grönroos, M., Parajuli, A., Laitinen, O. H., Roslund, M. I., Vari, H. K., Hyöty, H., Puhakka, R., & Sinkkonen, A. (2018) · MicrobiologyOpen · doi:10.1002/mbo3.645 · Cited by 101 · see citing works

Antibiotics as Instigators of Microbial Dysbiosis: Implications for Asthma and Allergy

Wypych, T. P., & Marsland, B. J. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.02.008 · Cited by 94 · see citing works

Relating Urban Biodiversity to Human Health With the ‘Holobiont’ Concept

Mills, J. G., Brookes, J. D., Gellie, N. J. C., Liddicoat, C., Lowe, A. J., Sydnor, H. R., Thomas, T., Weinstein, P., Weyrich, L. S., & Breed, M. F. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00550 · Cited by 97 · see citing works

Revegetation of urban green space rewilds soil microbiotas with implications for human health and urban design

Mills, J. G., Bissett, A., Gellie, N. J. C., Lowe, A. J., Selway, C. A., Thomas, T., Weinstein, P., Weyrich, L. S., & Breed, M. F. (2020) · Restoration Ecology · doi:10.1111/rec.13175 · Cited by 90 · see citing works

The old friends hypothesis: evolution, immunoregulation and essential microbial inputs

Rook, G. A. W. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2023.1220481 · Cited by 93 · see citing works

Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study

House, J. S., Wyss, A. B., Hoppin, J. A., Richards, M., Long, S., Umbach, D. M., Henneberger, P. K., Beane Freeman, L. E., Sandler, D. P., Long O'Connell, E., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.036 · Cited by 83 · see citing works

Skin microbiota and allergic symptoms associate with exposure to environmental microbes

Lehtimäki, J., Sinkko, H., Hielm-Björkman, A. K., Salmela, E., Tiira, K., Laatikainen, T. K., Mäkeläinen, S., Kaukonen, M. K., Uusitalo, L., Hanski, I., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719785115 · Cited by 81 · see citing works

Defining the Human Envirome

Riggs, D. W., Yeager, R. A., & Bhatnagar, A. (2018) · Circulation Research · doi:10.1161/circresaha.117.311230 · Cited by 82 · see citing works

Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish

Peuß, R., Box, A., Chen, S., Wang, Y., Tsuchiya, D., Persons, J. L., Kenzior, A., Maldonado, E., Krishnan, J., Scharsack, J. P., et al. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1234-2 · Cited by 79 · see citing works

Increased plant species richness associates with greater soil bacterial diversity in urban green spaces

Baruch, Z., Liddicoat, C., Cando‐Dumancela, C., Laws, M., Morelli, H., Weinstein, P., Young, J. M., & Breed, M. F. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110425 · Cited by 76 · see citing works

Urbanisation reduces the abundance and diversity of airborne microbes - but what does that mean for our health? A systematic review

Flies, E. J., Clarke, L. J., Brook, B. W., & Jones, P. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.140337 · Cited by 74 · see citing works

Atopic dermatitis: Pathophysiology, microbiota, and metabolome – A comprehensive review

Mohammad, S., Karim, M. R., Iqbal, S., Lee, J. H., Mathiyalagan, R., Kim, Y. J., Yang, D. U., & Yang, D. (2024) · Microbiological Research · doi:10.1016/j.micres.2023.127595 · Cited by 78 · see citing works

Evolutionary biology and anthropology suggest biome reconstitution as a necessary approach toward dealing with immune disorders

Parker, W., & Ollerton, J. (2013) · Evolution Medicine and Public Health · doi:10.1093/emph/eot008 · Cited by 73 · see citing works

GM Crops, Organic Agriculture and Breeding for Sustainability

Ceccarelli, S. (2014) · Sustainability · doi:10.3390/su6074273 · Cited by 71 · see citing works

Climate Change and Human Health: A Review of Allergies, Autoimmunity and the Microbiome

Ray, C., & Ming, X. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17134814 · Cited by 72 · see citing works

Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers

Soininen, L., Roslund, M. I., Nurminen, N., Puhakka, R., Laitinen, O. H., Hyöty, H., Sinkkonen, A., Cerrone, D., Grönroos, M., Hui, N., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10432-4 · Cited by 70 · see citing works

A perspective on green, blue, and grey spaces, biodiversity, microbiota, and human health

Potter, J. D., Brooks, C., Donovan, G. H., Cunningham, C. W., & Douwes, J. E. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164772 · Cited by 71 · see citing works

Natural environments, ancestral diets, and microbial ecology: is there a modern “paleo-deficit disorder”? Part I

Logan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-015-0041-y · Cited by 69 · see citing works

Microbiome applications for pathology: challenges of low microbial biomass samples during diagnostic testing

Selway, C. A., Eisenhofer, R., & Weyrich, L. S. (2020) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.151 · Cited by 67 · see citing works

Can bacterial indicators of a grassy woodland restoration inform ecosystem assessment and microbiota-mediated human health?

Liddicoat, C., Weinstein, P., Bissett, A., Gellie, N., Mills, J. G., Waycott, M., & Breed, M. F. (2019) · Environment International · doi:10.1016/j.envint.2019.05.011 · Cited by 53 · see citing works

Yard vegetation is associated with gut microbiota composition

Parajuli, A., Hui, N., Puhakka, R., Oikarinen, S., Grönroos, M., Selonen, V. A. O., Siter, N., Kramná, L., Roslund, M. I., Vari, H. K., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.136707 · Cited by 62 · see citing works

Microbial influence on tolerance and opportunities for intervention with prebiotics/probiotics and bacterial lysates

Pfefferle, P. I., Prescott, S. L., & Kopp, M. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.03.020 · Cited by 63 · see citing works

Associations of urban greenness with asthma and respiratory symptoms in Mexican American children

Eldeirawi, K. M., Kunzweiler, C. P., Zenk, S. N., Finn, P. W., Nyenhuis, S. M., Rosenberg, N., & Persky, V. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.12.009 · Cited by 59 · see citing works

Landscape biodiversity correlates with respiratory health in Australia

Liddicoat, C., Bi, P., Waycott, M., Glover, J. D., Lowe, A. J., & Weinstein, P. (2017) · Journal of Environmental Management · doi:10.1016/j.jenvman.2017.10.007 · Cited by 61 · see citing works

Hygiene and Other Early Childhood Influences on the Subsequent Function of the Immune System

Rook, G. A. W. (2011) · Digestive Diseases · doi:10.1159/000323877 · Cited by 59 · see citing works

Helsinki by nature: The Nature Step to Respiratory Health

Haahtela, T., von Hertzen, L., Antó, J. M., Bai, C., Baigenzhin, A. K., Bateman, E., Behera, D., Bennoor, K. S., Camargos, P. A. M., Chavannes, N. H., et al. (2019) · Clinical and Translational Allergy · doi:10.1186/s13601-019-0295-2 · Cited by 58 · see citing works

Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases

Losol, P., Sokołowska, M., Hwang, Y.-K., Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Radzikowska, U., Ardıçlı, S., Yoon, J.-E., et al. (2023) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2023.15.6.705 · Cited by 54 · see citing works

Urban forests as a strategy for transforming towards healthy cities

Yin, S., Chen, W. Y., & Liu, C. (2023) · Urban forestry & urban greening · doi:10.1016/j.ufug.2023.127871 · Cited by 52 · see citing works

Urban environment predisposes dogs and their owners to allergic symptoms

Hakanen, E., Lehtimäki, J., Salmela, E., Tiira, K., Anturaniemi, J., Hielm-Björkman, A. K., Ruokolainen, L., & Lohi, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-19953-3 · Cited by 52 · see citing works

Association between Residential Greenness and Human Microbiota: Evidence from Multiple Countries

Zhang, Y., Fan, S., Zhang, Z., Li, J., Liu, X.-X., Hu, L.-X., Knibbs, L. D., Dadvand, P., Jalaludin, B. B., Browning, M. H. E. M., et al. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12186 · Cited by 50 · see citing works

Engineering microbial technologies for environmental sustainability: choices to make

Verstraete, W., Yanuka‐Golub, K., Driesen, N., & Vrieze, J. D. (2021) · Microbial Biotechnology · doi:10.1111/1751-7915.13986 · Cited by 49 · see citing works

Participatory tomato breeding for organic conditions in Italy

Campanelli, G., Acciarri, N., Campion, B., Delvecchio, S., Leteo, F., Fusari, F., Angelini, P., & Ceccarelli, S. (2015) · Euphytica · doi:10.1007/s10681-015-1362-y · Cited by 48 · see citing works

Derived habitats of indoor microbes are associated with asthma symptoms in Chinese university dormitories

Fu, X., Li, Y., Meng, Y., Yuan, Q., Zhang, Z., Wen, H., Deng, Y., Norbäck, D., Hu, Q., Zhang, X., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110501 · Cited by 48 · see citing works

Assessing ecosystem impacts on health: A tool review

Oosterbroek, B., de Kraker, J., Huynen, M. M. T. E., & Martens, P. (2016) · Ecosystem Services · doi:10.1016/j.ecoser.2015.12.008 · Cited by 46 · see citing works

Holistic View on Health: Two Protective Layers of Biodiversity

Ruokolainen, L., Lehtimäki, J., Karkman, A., Haahtela, T., von Hertzen, L., & Fyhrquist, N. (2017) · Annales Zoologici Fennici · doi:10.5735/086.054.0106 · Cited by 46 · see citing works

Gluten-degrading bacteria: availability and applications

Köiv, V., & Tenson, T. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11263-5 · Cited by 46 · see citing works

Biodiversity: the overlooked source of human health.

Linhares, Y., Kaganski, A., Agyare, C., Kurnaz, I., Neergheen, V., Kolodziejczyk, B., Kędra, M., Wahajuddin, M., El-Youssf, L., Cruz, T. E. D. D., et al. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.12.002 · Cited by 35 · see citing works

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation

Garn, H., Bahn, S., Baune, B. T., Binder, E. B., Bisgaard, H. F., Chatila, T. A., Chavakis, T., Culmsee, C., Dannlowski, U., Gay, S., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.046 · Cited by 46 · see citing works

Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1)

Shimizu, C., Wakita, Y., Inoue, T., Hiramitsu, M., Okada, M., Mitani, Y., Segawa, S., Tsuchiya, Y., & Nabeshima, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-40253-x · Cited by 46 · see citing works

The regenerative compatibility: A synergy between healthy ecosystems, environmental attitudes, and restorative experiences

Giusti, M., & Samuelsson, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227311 · Cited by 48 · see citing works

The rich and the poor: environmental biodiversity protecting from allergy

Ruokolainen, L., Fyhrquist, N., & Haahtela, T. (2016) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000304 · Cited by 45 · see citing works

Neighbourhood green and blue spaces and allergic sensitization in children: A longitudinal study based on repeated measures from the Generation XXI cohort

Paciência, I., Moreira, A., Moreira, C., Cavaleiro Rufo, J., Sokhatska, O., Rama, T., Hoffimann, E., Santos, A. C., Barros, H., & Ribeiro, A. I. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.145394 · Cited by 44 · see citing works

Morphology and quantification of fungal growth in residential dust and carpets

Nastasi, N., Haines, S. R., Xu, L., Silva, H. D., Divjan, A., Barnes, M. A., Rappleye, C. A., Perzanowski, M. S., Green, B. J., & Dannemiller, K. C. (2020) · Building and Environment · doi:10.1016/j.buildenv.2020.106774 · Cited by 44 · see citing works

Science–policy challenges for biodiversity, public health and urbanization: examples from Belgium

Keune, H., Kretsch, C., Blust, G. D., Gilbert, M., Flandroy, L., Berge, K. V. D., Versteirt, V., Hartig, T., Keersmaecker, L. D., Eggermont, H., et al. (2013) · Environmental Research Letters · doi:10.1088/1748-9326/8/2/025015 · Cited by 43 · see citing works

Natural environments, ancestral diets, and microbial ecology: is there a modern “paleo-deficit disorder”? Part II

Logan, A. C., Katzman, M. A., & Balanzá‐Martínez, V. (2015) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-014-0040-4 · Cited by 42 · see citing works

Managing the allergy and asthma epidemic in 2020s—Lessons from the Finnish experience

Haahtela, T., Jantunen, J., Saarinen, K., Tommila, E., Valovirta, E. J., Vasankari, T., & Mäkelä, M. J. (2022) · Allergy · doi:10.1111/all.15266 · Cited by 42 · see citing works

Environmental quality in primary schools and related health effects in children. An overview of assessments conducted in the Northern Portugal

Gabriel, M. F., Paciência, I., Felgueiras, F., Rufo, J. C., Mendes, F. C., Farraia, M., Mourão, Z. S., Moreira, A. M., & Fernandes, E. D. O. (2021) · Energy and Buildings · doi:10.1016/j.enbuild.2021.111305 · Cited by 41 · see citing works

Twenty Important Research Questions in Microbial Exposure and Social Equity

Robinson, J. M., Redvers, N., Camargo, A., Bosch, C. A., Breed, M. F., Brenner, L. A., Carney, M. A., Chauhan, A., Dasari, M. R., Dietz, L. G., et al. (2022) · mSystems · doi:10.1128/msystems.01240-21 · Cited by 42 · see citing works

The integration of biodiversity into One Health

Romanelli, C., Cooper, H. D., & B.F., B. F. D. S. D. (2014) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.33.2.2291 · Cited by 40 · see citing works

Ambient soil cation exchange capacity inversely associates with infectious and parasitic disease risk in regional Australia

Liddicoat, C., Bi, P., Waycott, M., Glover, J. D., Breed, M. F., & Weinstein, P. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.077 · Cited by 39 · see citing works

Characterising the soil fungal microbiome in metropolitan green spaces across a vegetation biodiversity gradient

Baruch, Z., Liddicoat, C., Laws, M., Marker, L. K., Morelli, H., Yan, D., Young, J. M., & Breed, M. F. (2020) · Fungal ecology · doi:10.1016/j.funeco.2020.100939 · Cited by 40 · see citing works

Interplay between natural environment, human microbiota and immune system: A scoping review of interventions and future perspectives towards allergy prevention

Tischer, C., Kirjavainen, P. V., Matterne, U., Tempes, J., Willeke, K., Keil, T. O. P., Apfelbacher, C., & Täubel, M. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153422 · Cited by 42 · see citing works

Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry

Bächle, C., Eckert, A. J., Kamrath, C., Neu, A., Manuwald, U., Thiele‐Schmitz, S., Weidler, O., Knauer-Fischer, S., Rosenbauer, J., & Holl, R. W. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110559 · Cited by 39 · see citing works

Expansion of the built-up areas in Finnish city regions – The approach of travel-related urban zones

Tiitu, M. (2018) · Applied Geography · doi:10.1016/j.apgeog.2018.10.001 · Cited by 38 · see citing works

It’s time to take a sustainable approach to health care in the face of the challenges of the 21st century

Laprise, C. (2023) · One Health · doi:10.1016/j.onehlt.2023.100510 · Cited by 37 · see citing works

The soil-plant-human gut microbiome axis into perspective

Ma, H., Cornadó, D., & Raaijmakers, J. M. (2025) · Nature Communications · doi:10.1038/s41467-025-62989-z · Cited by 38 · see citing works

Biodiversity Loss and the Rise of Emerging Infectious Diseases: An Ecological Analysis

Sahu, M. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.20363283

COVID-19: Why Declining Biodiversity Puts Us at Greater Risk for Emerging Infectious Diseases, and What We Can Do

Khetan, A. K. (2020) · Journal of General Internal Medicine · doi:10.1007/s11606-020-05977-x · Cited by 22 · see citing works

Holistic View on Health: Two Protective Layers of Biodiversity

Ruokolainen, L., Lehtimäki, J., Karkman, A., Haahtela, T., von Hertzen, L., & Fyhrquist, N. (2017) · Annales Zoologici Fennici · doi:10.5735/086.054.0106 · Cited by 46 · see citing works

Ecología de las enfermedades: pasado y presente para un futuro mejor

Galeano, S. P. O., & Flechas, S. V. (2019) · instname:Instituto de Investigación de Recursos Biológicos Alexander von Humboldt · doi:10.1643/ch-18-053.short

The Natural Relation between Biodiversity and Public Health

Keune, H., Martens, P., Kretsch, C., & Prieur‐Richard, A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-419964-4.00016-0 · Cited by 4 · see citing works