The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
Open accessAbstract
Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we focus on two conspicuous but underappreciated regions of these structures that make membrane connections. One is the basal body distal end, which includes transition fibres of largely undefined composition that link to the base of the ciliary membrane. Transition fibres seem to serve as docking sites for intraflagellar transport particles, which move proteins within the ciliary compartment and are required for cilium biogenesis and sustained function. The other is the proximal‐most region of the axoneme, termed the transition zone, which is characterized by Y‐shaped linkers that span from the axoneme to the ciliary necklace on the membrane surface. The transition zone comprises a growing number of ciliopathy proteins that function as modular components of a ciliary gate. This gate, which forms early during ciliogenesis, might function in part by regulating intraflagellar transport. Together with a recently described septin ring diffusion barrier at the ciliary base, the transition fibres and transition zone deserve attention for their varied roles in forming functional ciliary compartments.
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Cites
The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384
Hildebrandt, F., Benzing, T., & Katsanis, N. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1010172 · Cited by 1,331
Ftm is a novel basal body protein of cilia involved in Shh signalling
Vierkotten, J., Dildrop, R., Peters, T., Wang, B., & Rüther, U. (2007) · Development · doi:10.1242/dev.003715 · Cited by 201
Huang, L., Szymanska, K., Jensen, V. L., Janecke, A. R., Innes, A. M., Davis, E. E., Frosk, P., Li, C., Willer, J. R., Chodirker, B. N., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.11.005 · Cited by 194
Self-citationBowen, J. R., Hwang, D., Bai, X., Roy, D., & Spiliotis, E. T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102076 · Cited by 143
Cited by
Genes and molecular pathways underpinning ciliopathies
Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588
Self-citationA Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
Gupta, G. D., Coyaud, É., Gonçalves, J., Mojarad, B. A., Liu, Y., Wu, Q., Gheiratmand, L., Comartin, D., Tkach, J. M., Cheung, S. W. T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.065 · Cited by 538
Signaling through the Primary Cilium
Wheway, G., Nazlamova, L., & Hancock, J. T. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00008 · Cited by 483
Motile and non-motile cilia in human pathology: From function to phenotypes
Mitchison, H. M., & Valente, E. M. (2017) · The Journal of Pathology · doi:10.1002/path.4843 · Cited by 448
The Intraflagellar Transport Machinery
Taschner, M., & Lorentzen, E. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028092 · Cited by 349
Metadata
- Authors
- Reiter, J. F., Blacque, O. E., & Leroux, M. R.
- Venue
- EMBO reports
- Published
- 2012-06
- Volume
- 13
- Issue
- 7
- Pages
- 608-618
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2161870393
- Cited by
- 475
- References
- 6
- FWCI
- 21.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
