The Intraflagellar Transport Machinery

Taschner, Michael; Lorentzen, Esben

doi:10.1101/cshperspect.a028092

Cited by 349Genetic and Kidney Cyst DiseasesCystic Fibrosis Research AdvancesHereditary Neurological Disorders

The Intraflagellar Transport Machinery

Open access

Taschner, Michael, Lorentzen, Esben·2016·Cold Spring Harbor Perspectives in Biology

DOI 10.1101/cshperspect.a028092PMC PMC5046692

Open this paper in CoChat — free account Open PDF

Abstract

Eukaryotic cilia and flagella are evolutionarily conserved organelles that protrude from the cell surface. The unique location and properties of cilia allow them to function in vital processes such as motility and signaling. Ciliary assembly and maintenance rely on intraflagellar transport (IFT), the bidirectional movement of a multicomponent transport system between the ciliary base and tip. Since its initial discovery more than two decades ago, considerable effort has been invested in dissecting the molecular mechanisms of IFT in a variety of model organisms. Importantly, IFT was shown to be essential for mammalian development, and defects in this process cause a number of human pathologies known as ciliopathies. Here, we review current knowledge of IFT with a particular emphasis on the IFT machinery and specific mechanisms of ciliary cargo recognition and transport.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/cshperspect.a028092

Cites

138 of 138 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Subsequent work in protists and metazoans, including Tetrahymena, Trypanosoma, C. elegans, sea urchin, zebrafish, mouse and human, substantiated the evolutionary conservation of IFT and provided insight into its molecular workings and physiological roles.
“Subsequent work in a range of additional organisms, including protists such as Tetrahymena thermophila and Trypanosoma brucei and metazoans like C. elegans, sea urchin, zebrafish, mouse, and human, have substantiated this view, and provided remarkable insight into the molecular workings and physiological roles of IFT 25, 30, 31, 46.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [25]
The paper’s discovery and IFT-A sections describe IFT findings in Tetrahymena, Trypanosoma, C. elegans, zebrafish and mammals, including molecular functions and disease relevance (page unavailable in our copy). Its only sea-urchin mention is a reference to a kinesin purified from sea-urchin eggs; it does not describe sea-urchin work substantiating IFT conservation or clarifying IFT’s roles. (LLM, conf=0.84)
Experimental — accuracy not yet measured
The three-dimensional structures of many IFT-B polypeptides have been solved, and progress has been made in understanding the arrangement and interactions of individual IFT polypeptides within the IFT-A and IFT-B sub-complexes.
“The three dimensional structures of many IFT-B polypeptides have been solved, and progress has been made towards understanding the arrangement and interactions of individual IFT polypeptides within the IFT-A and IFT-B sub-complexes 25.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [25]
Experimental — accuracy not yet measured
The intraflagellar transport system moves along axonemal microtubules to carry specific ciliary cargo proteins into or out of the organelle.
“and the intraflagellar transport (IFT) system that zips up and down axonemal microtubules to mediate the transport of specific ciliary cargo proteins into or out of the organelle 24, 25 (Figure 1).”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [25]
These IFT polypeptides can be subdivided into IFT-A, IFT-B1 and IFT-B2 sub-complexes containing 6, 10 and 6 different IFT particle proteins, respectively.
“We now know these polypeptides can be subdivided into IFT-A, IFT-B1 and IFT-B2 sub-complexes that contain 6, 10 and 6 different IFT particle proteins, respectively 25, 30, 31, 46, 47.”
From Cellular signalling by primary cilia in development, organ function and disease (2019) · cites this paper as [25]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein
Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M. A., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,619 · see citing works
Hedgehog signalling in the mouse requires intraflagellar transport proteins
Huangfu, D., Liu, A., Rakeman, A. S., Murcia, N. S., Niswander, L., & Anderson, K. V. (2003) · Nature · doi:10.1038/nature02061 · Cited by 1,425 · see citing works
When cilia go bad: cilia defects and ciliopathies
Fliegauf, M., Benzing, T., & Omran, H. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2278 · Cited by 1,257 · see citing works
Chlamydomonas IFT 88 and Its Mouse Homologue, Polycystic Kidney Disease Gene Tg 737, Are Required for Assembly of Cilia and Flagella
Pazour, G. J., Dickert, B. L., Vucica, Y., Seeley, E. S., Rosenbaum, J. L., Witman, G. B., & Cole, D. G. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.709 · Cited by 1,147 · see citing works
Proteomic analysis of a eukaryotic cilium
Pazour, G. J., Agrin, N. S., Leszyk, J., & Witman, G. B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504008 · Cited by 1,028 · see citing works
A motility in the eukaryotic flagellum unrelated to flagellar beating.
Kozminski, K. G., Johnson, K. A., Forscher, P., & Rosenbaum, J. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5519 · Cited by 1,007 · see citing works
Chlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons
Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898 · see citing works
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
Janke, C., & Bulinski, J. C. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3227 · Cited by 838 · see citing works
FLAGELLAR ELONGATION AND SHORTENING IN CHLAMYDOMONAS
Rosenbaum, J. L., Moulder, J. E., & Ringo, D. L. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.41.2.600 · Cited by 624 · see citing works
The Conserved Bardet-Biedl Syndrome Proteins Assemble a Coat that Traffics Membrane Proteins to Cilia
Jin, H., White, S. R., Shida, T., Schulz, S., Aguiar, M., Gygi, S. P., Bazán, J. F., & Nachury, M. V. (2010) · Cell · doi:10.1016/j.cell.2010.05.015 · Cited by 594 · see citing works
The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane.
Kozminski, K. G., Beech, P. L., & Rosenbaum, J. L. (1995) · The Journal of cell biology · doi:10.1083/jcb.131.6.1517 · Cited by 586 · see citing works
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
Marszalek, J. R., Ruiz‐Lozano, P., Roberts, E. A., Chien, K. R., & Goldstein, L. S. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5043 · Cited by 530 · see citing works
Implications for Kinetochore-Microtubule Attachment from the Structure of an Engineered Ndc80 Complex
Ciferri, C., Pasqualato, S., Screpanti, E., Varetti, G., Santaguida, S., Reis, G. D., Maiolica, A., Polka, J., DeLuca, J. G., Wulf, P. D., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.020 · Cited by 529 · see citing works
The Intraflagellar Transport Protein IFT20 Is Associated with the Golgi Complex and Is Required for Cilia Assembly
Follit, J. A., Tuft, R. A., Fogarty, K. E., & Pazour, G. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0133 · Cited by 499 · see citing works
The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling
Mukhopadhyay, S., Wen, X., Ratti, N., Loktev, A., Rangell, L., Scales, S. J., & Jackson, P. K. (2013) · Cell · doi:10.1016/j.cell.2012.12.026 · Cited by 486 · see citing works
The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization
Reiter, J. F., Blacque, O. E., & Leroux, M. R. (2012) · EMBO Reports · doi:10.1038/embor.2012.73 · Cited by 476 · see citing works
A Proteomic Analysis of Human Cilia
Ostrowski, L. E., Blackburn, K., Radde, K. M., Moyer, M. B., Schlatzer, D., Moseley, M. A., & Boucher, R. C. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200037-mcp200 · Cited by 441 · see citing works
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
Mukhopadhyay, S., Wen, X., Chih, B., Nelson, C. D., Lane, W. S., Scales, S. J., & Jackson, P. K. (2010) · Genes & Development · doi:10.1101/gad.1966210 · Cited by 435 · see citing works
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
May, S., Ashique, A. M., Karlén, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J. F., Ericson, J., & Peterson, A. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.08.050 · Cited by 428 · see citing works
A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT)
Pazour, G. J., Wilkerson, C. G., & Witman, G. B. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.979 · Cited by 425 · see citing works
Functional coordination of intraflagellar transport motors
Ou, G., E. Blacque, O., Snow, J. J., Leroux, M. R., & Scholey, J. M. (2005) · Nature · doi:10.1038/nature03818 · Cited by 411 · see citing works
Proteomics of Primary Cilia by Proximity Labeling
Mick, D. U., Rodrigues, R. B., Leib, R. D., Adams, C. M., Chien, A. S., Gygi, S. P., & Nachury, M. V. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.10.015 · Cited by 409 · see citing works
Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons
Snow, J. J., Ou, G., Gunnarson, A. L., Walker, M. R. S., Zhou, H. M., Brust-Mascher, I., & Scholey, J. M. (2004) · Nature Cell Biology · doi:10.1038/ncb1186 · Cited by 404 · see citing works
Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles
Deane, J. A., Cole, D. G., Seeley, E. S., Diener, D. R., & Rosenbaum, J. L. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00484-5 · Cited by 391 · see citing works
The proteome of the mouse photoreceptor sensory cilium complex
Liu, Q., Tan, G., Levenkova, N., Li, T., Pugh, E. N., Rux, J. J., Speicher, D. W., & Pierce, E. A. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700054-mcp200 · Cited by 359 · see citing works
The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
Lechtreck, K.-F., Johnson, E. C., Sakai, T., Cochran, D., Ballif, B. A., Rush, J., Pazour, G. J., Ikebe, M., & Witman, G. B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200909183 · Cited by 347 · see citing works
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment
Wei, R. R., Al‐Bassam, J., & Harrison, S. C. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1186 · Cited by 345 · see citing works
Intraflagellar transport (IFT) cargo
Qin, H., Diener, D. R., Geimer, S., Cole, D. G., & Rosenbaum, J. L. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200308132 · Cited by 342 · see citing works
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
Tran, P. V., Haycraft, C. J., Besschetnova, T. Y., Turbé-Doan, A., Stottmann, R. W., Herron, B. J., Chesebro, A. L., Qiu, H., Scherz, P., Shah, J. V., et al. (2008) · Nature Genetics · doi:10.1038/ng.105 · Cited by 337 · see citing works
Cytoplasmic Dynein Heavy Chain 1b Is Required for Flagellar Assembly inChlamydomonas
Porter, M. E., Bower, R., Knott, J. A., Byrd, P., & Dentler, W. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.3.693 · Cited by 333 · see citing works
Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
Bhogaraju, S., Cajanek, L., Fort, C., Blisnick, T., Weber, K., Taschner, M., Mizuno, N., Lamla, S., Bastin, P., Nigg, E. A., et al. (2013) · Science · doi:10.1126/science.1240985 · Cited by 317 · see citing works
Self-citation
A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation
Loktev, A. V., Zhang, Q., Beck, J. S., Searby, C. C., Scheetz, T. E., Bazán, J. F., Slusarski, D. C., Sheffield, V. C., Jackson, P. K., & Nachury, M. V. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.11.001 · Cited by 311 · see citing works
Flagellar and ciliary beating: the proven and the possible
Lindemann, C. B., & Lesich, K. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.051326 · Cited by 306 · see citing works
Role of a Class Dhc1b Dynein in Retrograde Transport of Ift Motors and Ift Raft Particles along Cilia, but Not Dendrites, in Chemosensory Neurons of Living Caenorhabditis elegans
Signor, D., Wedaman, K. P., Orozco, J. T., Dwyer, N. D., Bargmann, C. I., Rose, L. S., & Scholey, J. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.519 · Cited by 301 · see citing works
FLAGELLAR REGENERATION IN PROTOZOAN FLAGELLATES
Rosenbaum, J. L., & Child, F. M. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.345 · Cited by 296 · see citing works
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease
Jonassen, J. A., Agustin, J. T. S., Follit, J. A., & Pazour, G. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200808137 · Cited by 278 · see citing works
Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella
Piperno, G., & Mead, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4457 · Cited by 275 · see citing works
Novel heterotrimeric kinesin-related protein purified from sea urchin eggs
Cole, D. G., Chinn, S. W., Wedaman, K. P., Hall, K., Vuong, T., & Scholey, J. M. (1993) · Nature · doi:10.1038/366268a0 · Cited by 269 · see citing works
IFT27 Links the BBSome to IFT for Maintenance of the Ciliary Signaling Compartment
Eguether, T., San Agustin, J. T., Keady, B. T., Jonassen, J. A., Liang, Y., Francis, R., Tobita, K., Johnson, C. A., Abdelhamed, Z. A., Lo, C. W., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.011 · Cited by 260 · see citing works
Polarity of flagellar assembly in Chlamydomonas.
Johnson, K. A., & Rosenbaum, J. L. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.6.1605 · Cited by 255 · see citing works
Microtubule doublets are double-track railways for intraflagellar transport trains
S̆tĕpánek, L., & Pigino, G. (2016) · Science · doi:10.1126/science.aaf4594 · Cited by 252 · see citing works
Protein Particles inChlamydomonasFlagella Undergo a Transport Cycle Consisting of Four Phases
Iomini, C., Babaev-Khaimov, V., Sassaroli, M., & Piperno, G. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.1.13 · Cited by 241 · see citing works
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
Boldt, K., van Reeuwijk, J., Lu, Q., Koutroumpas, K., Nguyen, T.-M. T., Texier, Y., van Beersum, S. E. C., Horn, N., Willer, J. R., Mans, D. A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11491 · Cited by 240 · see citing works
Ciliopathies with Skeletal Anomalies and Renal Insufficiency due to Mutations in the IFT-A Gene WDR19
Bredrup, C., Saunier, S., Oud, M. M., Fiskerstrand, T., Hoischen, A., Brackman, D., Leh, S. M., Midtbø, M., Filhol-Blin, E., Bôle‐Feysot, C., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.10.001 · Cited by 235 · see citing works
The Chlamydomonas FLA10 gene encodes a novel kinesin-homologous protein.
Walther, Z., Vashishtha, M., & Hall, J. L. (1994) · The Journal of cell biology · doi:10.1083/jcb.126.1.175 · Cited by 226 · see citing works
Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella
Hou, Y., Qin, H., Follit, J. A., Pazour, G. J., Rosenbaum, J. L., & Witman, G. B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608041 · Cited by 226 · see citing works
Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium
Jékely, G., & Arendt, D. (2006) · BioEssays · doi:10.1002/bies.20369 · Cited by 221 · see citing works
elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8
Omori, Y., Zhao, C., Saras, A., Mukhopadhyay, S., Kim, W., Furukawa, T., Sengupta, P., Veraksa, A. N., & Malicki, J. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1706 · Cited by 218 · see citing works
IFT25 Links the Signal-Dependent Movement of Hedgehog Components to Intraflagellar Transport
Keady, B. T., Samtani, R., Tobita, K., Tsuchya, M., San Agustin, J. T., Follit, J. A., Jonassen, J. A., Subramanian, R., Lo, C. W., & Pazour, G. J. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.04.009 · Cited by 216 · see citing works
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
Liem, K. F., Ashe, A., He, M., Satir, P., Moran, J., Beier, D., Wicking, C., & Anderson, K. V. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201110049 · Cited by 214 · see citing works
The sensory cilia of Caenorhabditis elegans_Revised
Scholey, J. M. (2007) · WormBook · doi:10.1895/wormbook.1.126.2 · Cited by 209 · see citing works
Complex interactions between genes controlling trafficking in primary cilia
Ocbina, P. J. R., Eggenschwiler, J. T., Moskowitz, I., & Anderson, K. V. (2011) · Nature Genetics · doi:10.1038/ng.832 · Cited by 208 · see citing works
The BBSome controls IFT assembly and turnaround in cilia
Wei, Q., Zhang, Y., Li, Y., Zhang, Q., Ling, K., & Hu, J. (2012) · Nature Cell Biology · doi:10.1038/ncb2560 · Cited by 208 · see citing works
A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened
Seo, S., Zhang, Q., Bugge, K., Breslow, D. K., Searby, C. C., Nachury, M. V., & Sheffield, V. C. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002358 · Cited by 205 · see citing works
Electron-tomographic analysis of intraflagellar transport particle trains in situ
Pigino, G., Geimer, S., Lanzavecchia, S., Paccagnini, E., Cantele, F., Diener, D. R., Rosenbaum, J. L., & Lupetti, P. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200905103 · Cited by 204 · see citing works
Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model
Engel, B. D., Ludington, W. B., & Marshall, W. F. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200812084 · Cited by 203 · see citing works
Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism
Weghe, J. C. V. D., Harris, J. A., Hyman, S., Kner, P., & Lechtreck, K. F. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409036 · Cited by 197 · see citing works
The Golgin GMAP210/TRIP11 Anchors IFT20 to the Golgi Complex
Follit, J. A., Agustin, J. T. S., Xu, F., Jonassen, J. A., Samtani, R. R., Lo, C. W., & Pazour, G. J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000315 · Cited by 194 · see citing works
Distinct Mutants of Retrograde Intraflagellar Transport (IFT) Share Similar Morphological and Molecular Defects
Piperno, G., Siuda, E. R., Henderson, S. C., Segil, M., Väänänen, H., & Sassaroli, M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1591 · Cited by 194 · see citing works
The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3
Liew, G. M., Ye, F., Nager, A. R., Murphy, J. P., Lee, J. S., Aguiar, M., Breslow, D. K., Gygi, S. P., & Nachury, M. V. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.09.004 · Cited by 193 · see citing works
Architecture and function of IFT complex proteins in ciliogenesis
Taschner, M. J., Bhogaraju, S., & Lorentzen, E. (2011) · Differentiation · doi:10.1016/j.diff.2011.11.001 · Cited by 190 · see citing works
Self-citation
Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments
Hao, L., Thein, M. C., Brust‐Mascher, I., Civelekoglu‐Scholey, G., Lu, Y., Açar, Ş., Prevo, B., Shaham, S., & Scholey, J. M. (2011) · Nature Cell Biology · doi:10.1038/ncb2268 · Cited by 188 · see citing works
Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport
Blacque, O. E., & Leroux, M. R. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6180-x · Cited by 186 · see citing works
Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin‐binding IFT‐B2 complex
Taschner, M. J., Weber, K., Mourão, A., Vetter, M., Awasthi, M., Stiegler, M., Bhogaraju, S., & Lorentzen, E. (2016) · The EMBO Journal · doi:10.15252/embj.201593164 · Cited by 186 · see citing works
Self-citation
Characterization of the Intraflagellar Transport Complex B Core
Lucker, B. F., Behal, R. H., Qin, H., Siron, L. C., Taggart, W. D., Rosenbaum, J. L., & Cole, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505062200 · Cited by 184 · see citing works
Vesicle coats: structure, function, and general principles of assembly
Faini, M., Beck, R., Wieland, F., & Briggs, J. A. G. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.01.005 · Cited by 179 · see citing works
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components
Qin, J., Lin, Y., Norman, R. X., Ko, H. W., & Eggenschwiler, J. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011410108 · Cited by 176 · see citing works
Dissecting the Molecular Mechanisms of Intraflagellar Transport in Chlamydomonas
Pedersen, L. B., Geimer, S., & Rosenbaum, J. L. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.020 · Cited by 174 · see citing works
Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia
Williams, C. L., McIntyre, J. C., Norris, S. R., Jenkins, P. M., Zhang, L., Pei, Q., Verhey, K. J., & Martens, J. R. (2014) · Nature Communications · doi:10.1038/ncomms6813 · Cited by 171 · see citing works
Drosophila KAP Interacts with the Kinesin II Motor Subunit KLP64D to Assemble Chordotonal Sensory Cilia, but Not Sperm Tails
Sarpal, R., Todi, S. V., Sivan‐Loukianova, E., Shirolikar, S. M., Subramanian, N., Raff, E. C., Erickson, J. W., Ray, K., & Eberl, D. F. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.025 · Cited by 168 · see citing works
Chlamydomonas IFT172 Is Encoded by FLA11, Interacts with CrEB1, and Regulates IFT at the Flagellar Tip
Pedersen, L. B., Miller, M. S., Geimer, S., Leitch, J. M., Rosenbaum, J. L., & Cole, D. G. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.037 · Cited by 164 · see citing works
ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery
Ahmed, N. T., Gao, C., Lucker, B. F., Cole, D. G., & Mitchell, D. R. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200802025 · Cited by 164 · see citing works
Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia
Prevo, B., Mangeol, P., Oswald, F., Scholey, J. M., & Peterman, E. J. G. (2015) · Nature Cell Biology · doi:10.1038/ncb3263 · Cited by 163 · see citing works
Intraflagellar Transport Particles Participate Directly in Cilium-Generated Signaling in Chlamydomonas
Wang, Q., Pan, J., & Snell, W. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.044 · Cited by 154 · see citing works
Evolution of modular intraflagellar transport from a coatomer-like progenitor
van Dam, T. J. P., Townsend, M. J., Turk, M., Schlessinger, A., Šali, A., Field, M. C., & Huynen, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221011110 · Cited by 152 · see citing works
Temperature-sensitive mutations affecting flagellar assembly and function in Chlamydomonas reinhardtii.
Huang, B.-W., Rifkin, M. R., & Luck, D. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.72.1.67 · Cited by 150 · see citing works
Characterization of mouse IFT complex B
Follit, J. A., Xu, F., Keady, B. T., & Pazour, G. J. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20346 · Cited by 147 · see citing works
The tubby family proteins
Mukhopadhyay, S., & Jackson, P. K. (2011) · Genome biology · doi:10.1186/gb-2011-12-6-225 · Cited by 146 · see citing works
IFT20 Links Kinesin II with a Mammalian Intraflagellar Transport Complex That Is Conserved in Motile Flagella and Sensory Cilia
Baker, S. A., Freeman, K. C., Luby‐Phelps, K., Pazour, G. J., & Besharse, J. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300156200 · Cited by 144 · see citing works
IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome
Aldahmesh, M. A., Li, Y., Alhashem, A. M., Anazi, S., Alkuraya, H., Hashem, M., Awaji, A., Sogaty, S., Al-Kharashi, A. S., Alzahrani, S. S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu044 · Cited by 143 · see citing works
Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(FLA10) to reach the distal part of flagella in Chlamydomonas.
Piperno, G., Mead, K., & Henderson, S. C. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.2.371 · Cited by 131 · see citing works
A Novel Dynein Light Intermediate Chain Colocalizes with the Retrograde Motor for Intraflagellar Transport at Sites of Axoneme Assembly inChlamydomonasand Mammalian Cells
Perrone, C. A., Tritschler, D., Taulman, P. D., Bower, R., Yoder, B. K., & Porter, M. E. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-10-0682 · Cited by 130 · see citing works
The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly
Brazelton, W. J., Amundsen, C. D., Silflow, C. D., & Lefebvre, P. A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00485-7 · Cited by 128 · see citing works
The Microtubule Plus End-Tracking Protein EB1 Is Localized to the Flagellar Tip and Basal Bodies in Chlamydomonas reinhardtii
Pedersen, L. B., Geimer, S., Sloboda, R. D., & Rosenbaum, J. L. (2003) · Current Biology · doi:10.1016/j.cub.2003.10.058 · Cited by 126 · see citing works
Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
Cortellino, S., Wang, C., Wang, B., Bassi, M. R., Caretti, E., Champeval, D., Calmont, A., Jarník, M., Burch, J. B. E., Zaret, K. S., et al. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.020 · Cited by 125 · see citing works
Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly
Taschner, M. J., Kotsis, F., Bräuer, P., Kuehn, E. W., & Lorentzen, E. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201408002 · Cited by 120 · see citing works
Self-citation
A Dynein Light Intermediate Chain, D1bLIC, Is Required for Retrograde Intraflagellar Transport
Hou, Y., Pazour, G. J., & Witman, G. B. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0377 · Cited by 120 · see citing works
Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex
Katoh, Y., Terada, M., Nishijima, Y., Takei, R., Nozaki, S., Hamada, H., & Nakayama, K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.713883 · Cited by 120 · see citing works
Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins
Behal, R. H., Miller, M. S., Qin, H., Lucker, B. F., Jones, A., & Cole, D. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.287102 · Cited by 119 · see citing works
Retrograde Intraflagellar Transport Mutants Identify Complex A Proteins With Multiple Genetic Interactions inChlamydomonas reinhardtii
Iomini, C., Li, L., Esparza, J. M., & Dutcher, S. K. (2009) · Genetics · doi:10.1534/genetics.109.101915 · Cited by 117 · see citing works
FLA8/KIF3B Phosphorylation Regulates Kinesin-II Interaction with IFT-B to Control IFT Entry and Turnaround
Liang, Y., Pang, Y., Wu, Q., Hu, Z., Han, X., Xu, Y., Deng, H., & Pan, J. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.07.019 · Cited by 116 · see citing works
The role of retrograde intraflagellar transport in flagellar assembly, maintenance, and function
Engel, B. D., Ishikawa, H., Wemmer, K. A., Geimer, S., Wakabayashi, K., Hirono, M., Craige, B., Pazour, G. J., Witman, G. B., Kamiya, R., et al. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201206068 · Cited by 111 · see citing works
An IFT-A Protein Is Required to Delimit Functionally Distinct Zones in Mechanosensory Cilia
Lee, E., Sivan‐Loukianova, E., Eberl, D. F., & Kernan, M. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.11.020 · Cited by 106 · see citing works
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization
Bizet, A. A., Becker-Heck, A., Ryan, R., Weber, K., Filhol-Blin, E., Krug, P., Halbritter, J., Delous, M., Lasbennes, M.-C., Linghu, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms9666 · Cited by 106 · see citing works
Self-citation
Crystal structure of the intraflagellar transport complex 25/27
Bhogaraju, S., Taschner, M. J., Morawetz, M., Minard‐Basquin, C., & Lorentzen, E. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.110 · Cited by 104 · see citing works
Self-citation
The WD Repeat-containing Protein IFTA-1 Is Required for Retrograde Intraflagellar Transport
Blacque, O. E., Li, C., Inglis, P. N., Esmail, M. A., Ou, G., Mah, A. K., Baillie, D. L., Scholey, J. M., & Leroux, M. R. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0571 · Cited by 103 · see citing works
Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin
Kubo, T., Brown, J., Bellve, K. D., Craige, B., Weghe, J. C. V. D., Fogarty, K. E., Lechtreck, K. F., & Witman, G. B. (2016) · Journal of Cell Science · doi:10.1242/jcs.187120 · Cited by 103 · see citing works
Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas
Wang, Z., Fan, Z., Williamson, S. M., & Qin, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005384 · Cited by 101 · see citing works
Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos
Zhao, C., & Malicki, J. J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.165 · Cited by 97 · see citing works
TEMPERATURE-SENSITIVE, ASSEMBLY-DEFECTIVE FLAGELLA MUTANTS OF CHLAMYDOMONAS REINHARDTII
Adams, G. M. W., Huang, B., & Luck, D. (1982) · Genetics · doi:10.1093/genetics/100.4.579 · Cited by 94 · see citing works
An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia
Rix, S., Calmont, A., Scambler, P. J., & Beales, P. L. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr013 · Cited by 93 · see citing works
Kinesin-2 family in vertebrate ciliogenesis
Zhao, C., Omori, Y., Brodowska, K., Kovach, P., & Malicki, J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116035109 · Cited by 91 · see citing works
Structural basis for membrane targeting of the BBSome by ARL6
Mourão, A., Nager, A. R., Nachury, M. V., & Lorentzen, E. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2920 · Cited by 86 · see citing works
Self-citation
Biochemical Mapping of Interactions within the Intraflagellar Transport (IFT) B Core Complex
Taschner, M. J., Bhogaraju, S., Vetter, M., Morawetz, M., & Lorentzen, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254920 · Cited by 84 · see citing works
Self-citation
Direct Interactions of Intraflagellar Transport Complex B Proteins IFT88, IFT52, and IFT46
Lucker, B. F., Miller, M. S., Dziedzic, S. A., Blackmarr, P. T., & Cole, D. G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.106997 · Cited by 83 · see citing works
Assembly of IFT Trains at the Ciliary Base Depends on IFT74
Brown, J., Cochran, D. A., Craige, B., Kubo, T., & Witman, G. B. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.060 · Cited by 82 · see citing works
Caenorhabditis elegansDYF-2, an Orthologue of Human WDR19, Is a Component of the Intraflagellar Transport Machinery in Sensory Cilia
Efimenko, E., Blacque, O. E., Ou, G., Haycraft, C. J., Yoder, B. K., Scholey, J. M., Leroux, M. R., & Swoboda, P. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-04-0260 · Cited by 72 · see citing works
TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella
Ishikawa, H., Ide, T., Yagi, T., Jiang, X., Hirono, M., Sasaki, H., Yanagisawa, H., Wemmer, K. A., Stainier, D. Y. R., Qin, H., et al. (2014) · eLife · doi:10.7554/elife.01566 · Cited by 71 · see citing works
The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport
Huet, D., Blisnick, T., Perrot, S., & Bastin, P. (2014) · eLife · doi:10.7554/elife.02419 · Cited by 71 · see citing works
ChlamydomonasIFT70/CrDYF-1 Is a Core Component of IFT Particle Complex B and Is Required for Flagellar Assembly
Fan, Z., Behal, R. H., Geimer, S., Wang, Z., Williamson, S. M., Zhang, H., Cole, D. G., & Qin, H. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0191 · Cited by 70 · see citing works
HA‐tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B
Lechtreck, K. F., Luro, S., Awata, J., & Witman, G. B. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20369 · Cited by 67 · see citing works
MIP-T3, a Novel Protein Linking Tumor Necrosis Factor Receptor-associated Factor 3 to the Microtubule Network
Lei, L., & Goeddel, D. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001095200 · Cited by 65 · see citing works
A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum
Adhiambo, C., Blisnick, T., Toutirais, G., Delannoy, E., & Bastin, P. (2009) · Journal of Cell Science · doi:10.1242/jcs.040444 · Cited by 65 · see citing works
Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation
Berbari, N. F., Kin, N. W., Sharma, N., Michaud, E. J., Kesterson, R. A., & Yoder, B. K. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.09.001 · Cited by 63 · see citing works
SnapShot: Intraflagellar Transport
Cole, D. G., & Snell, W. J. (2009) · Cell · doi:10.1016/j.cell.2009.04.053 · Cited by 62 · see citing works
Single-particle imaging reveals intraflagellar transport–independent transport and accumulation of EB1 inChlamydomonasflagella
Harris, J. A., Liu, Y., Yang, P., Kner, P., & Lechtreck, K. F. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0608 · Cited by 60 · see citing works
Different Effects ofTetrahymena IFT172Domains on Anterograde and Retrograde Intraflagellar Transport
Tsao, C.-C., & Gorovsky, M. A. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0403 · Cited by 59 · see citing works
Tetrahymena IFT122A is not essential for cilia assembly but plays a role in returning IFT proteins from the ciliary tip to the cell body
Tsao, C.-C., & Gorovsky, M. A. (2008) · Journal of Cell Science · doi:10.1242/jcs.015826 · Cited by 57 · see citing works
Different roles for KIF17 and kinesin II in photoreceptor development and maintenance
Insinna, C., Humby, M. S., Sedmak, T., Wolfrum, U., & Besharse, J. C. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21956 · Cited by 57 · see citing works
Dissecting the Sequential Assembly and Localization of Intraflagellar Transport Particle Complex B in Chlamydomonas
Richey, E. A., & Qin, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043118 · Cited by 57 · see citing works
The PKD protein qilin undergoes intraflagellar transport
Ou, G., Qin, H., Rosenbaum, J. L., & Scholey, J. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.044 · Cited by 48 · see citing works
Total Internal Reflection Fluorescence (TIRF) Microscopy of Chlamydomonas Flagella
Engel, B. D., Lechtreck, K. F., Sakai, T., Ikebe, M., Witman, G. B., & Marshall, W. F. (2009) · Methods in cell biology · doi:10.1016/s0091-679x(08)93009-0 · Cited by 47 · see citing works
Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella
Vannuccini, E., Paccagnini, E., Cantele, F., Gentile, M., Dini, D., Fino, F., Diener, D. R., Mencarelli, C., & Lupetti, P. (2016) · Journal of Cell Science · doi:10.1242/jcs.183244 · Cited by 47 · see citing works
Caenorhabditis elegans DYF‐11, an orthologue of mammalian Traf3ip1/MIP‐T3, is required for sensory cilia formation
Kunitomo, H., & Iino, Y. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01147.x · Cited by 46 · see citing works
IFT46 plays an essential role in cilia development
Lee, M., Hwang, K.-S., Oh, H.-W., Ji-Ae, K., Kim, H.-T., Cho, H., Lee, J.-J., Ko, J. Y., Choi, J.-H., Jeong, Y.-M., et al. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.02.009 · Cited by 43 · see citing works
Getting tubulin to the tip of the cilium: One IFT train, many different tubulin cargo‐binding sites?
Bhogaraju, S., Weber, K., Engel, B. D., Lechtreck, K. F., & Lorentzen, E. (2014) · BioEssays · doi:10.1002/bies.201400007 · Cited by 42 · see citing works
Self-citation
A divergent calponin homology (NN–CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins
Schou, K. B., Andersen, J., & Pedersen, L. B. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt661 · Cited by 42 · see citing works
Manipulating Ciliary Protein-Encoding Genes in Tetrahymena thermophila
Dave, D., Włoga, D., & Gaertig, J. (2009) · Methods in cell biology · doi:10.1016/s0091-679x(08)93001-6 · Cited by 40 · see citing works
Probing the role of IFT particle complex A and B in flagellar entry and exit of IFT-dynein in Chlamydomonas
Williamson, S. M., Silva, D. A., Richey, E., & Qin, H. (2011) · PROTOPLASMA · doi:10.1007/s00709-011-0311-4 · Cited by 33 · see citing works
Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis
Pasek, R. C., Berbari, N. F., Lewis, W., Kesterson, R. A., & Yoder, B. K. (2012) · Cilia · doi:10.1186/2046-2530-1-20 · Cited by 32 · see citing works
A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling
Swiderski, R. E., Nakano, Y., Mullins, R. F., Seo, S., & Bánfi, B. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004689 · Cited by 31 · see citing works
IFT‐81 and IFT‐74 are required for intraflagellar transport in C. elegans
Kobayashi, T., Gengyo‐Ando, K., Ishihara, T., Katsura, I., & Mitani, S. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01076.x · Cited by 28 · see citing works
Total internal reflection fluorescence microscopy of intraflagellar transport in Tetrahymena thermophila
Jiang, Y., Lechtreck, K. F., & Gaertig, J. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.01.001 · Cited by 22 · see citing works
Efficient live fluorescence imaging of intraflagellar transport in mammalian primary cilia
Ishikawa, H., & Marshall, W. F. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.01.002 · Cited by 19 · see citing works
Abnormal cilia in a male-sterile mutant mouse
Bryan, J. H. D. (1983) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00627011 · Cited by 18 · see citing works
Analysis of Intraflagellar Transport in C. elegans Sensory Cilia
Hao, L., Açar, Ş., Evans, J. E., Ou, G., & Scholey, J. M. (2009) · Methods in cell biology · doi:10.1016/s0091-679x(08)93013-2 · Cited by 17 · see citing works
Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17
Howard, P. W., Jue, S. F., & Maurer, R. A. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.06.010 · Cited by 14 · see citing works
Imaging intraflagellar transport in trypanosomes
Santi‐Rocca, J., Chenouard, N., Fort, C., Lagache, T., Olivo‐Marín, J., & Bastin, P. (2015) · Methods in cell biology · doi:10.1016/bs.mcb.2015.01.005 · Cited by 7 · see citing works

Flagged first, then by citations

Sorted by citations

Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Z., Mykytyn, K., Mukhopadhyay, S., Pedersen, L. B., & Christensen, S. T. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0116-9 · Cited by 845 · see citing works
Motile and non-motile cilia in human pathology: From function to phenotypes
Mitchison, H. M., & Valente, E. M. (2017) · The Journal of Pathology · doi:10.1002/path.4843 · Cited by 448 · see citing works
Primary cilia as dynamic and diverse signalling hubs in development and disease
Mill, P., Christensen, S. T., & Pedersen, L. B. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00587-9 · Cited by 417 · see citing works
Mechanism and Regulation of Centriole and Cilium Biogenesis
Breslow, D. K., & Holland, A. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111153 · Cited by 284 · see citing works
The cryo-EM structure of intraflagellar transport trains reveals how dynein is inactivated to ensure unidirectional anterograde movement in cilia
Jordan, M. A., Diener, D. R., Stepanek, L., & Pigino, G. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0213-1 · Cited by 186 · see citing works
Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery
Prevo, B., Scholey, J. M., & Peterman, E. J. G. (2017) · The FEBS Journal · doi:10.1111/febs.14068 · Cited by 203 · see citing works
Integration of over 9,000 mass spectrometry experiments builds a global map of human protein complexes
Drew, K., Lee, C., Huizar, R. L., Tu, F., Borgeson, B., McWhite, C. D., Ma, Y., Wallingford, J. B., & Marcotte, E. M. (2017) · Molecular Systems Biology · doi:10.15252/msb.20167490 · Cited by 191 · see citing works
Primary Cilia in Brain Development and Diseases
Youn, Y. H., & Han, Y.-G. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.08.031 · Cited by 173 · see citing works
The cytoskeleton in spermatogenesis
Dunleavy, J. E. M., O’Bryan, M. K., Stanton, P. G., & O’Donnell, L. (2018) · Reproduction · doi:10.1530/rep-18-0457 · Cited by 164 · see citing works
Trafficking of ciliary membrane proteins by the intraflagellar transport/BBSome machinery
Wingfield, J. L., Lechtreck, K.-F., & Lorentzen, E. (2018) · Essays in Biochemistry · doi:10.1042/ebc20180030 · Cited by 157 · see citing works
Self-citation
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations
Shimada, H., Lü, Q., Insinna-Kettenhofen, C., Nagashima, K., English, M. A., Semler, E. M., Mahgerefteh, J., Cideciyan, A. V., Li, T., Brooks, B. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.045 · Cited by 148 · see citing works
Structural Biology of Cilia and Intraflagellar Transport
Klena, N., & Pigino, G. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120219-034238 · Cited by 138 · see citing works
Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors
Nakayama, K., & Katoh, Y. (2017) · The Journal of Biochemistry · doi:10.1093/jb/mvx087 · Cited by 130 · see citing works
Structure of the dynein-2 complex and its assembly with intraflagellar transport trains
Toropova, K., Zalyte, R., Mukhopadhyay, A. G., Mladenov, M., Carter, A. P., & Roberts, A. J. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0286-y · Cited by 122 · see citing works
Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice
Tu, C., Cong, J., Zhang, Q., He, X., Zheng, R., Yang, X., Gao, Y., Wu, H., Lv, M., Gu, Y., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.06.010 · Cited by 116 · see citing works
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Lacey, S. E., Foster, H. E., & Pigino, G. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00905-5 · Cited by 110 · see citing works
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base
Kanie, T., Abbott, K. L., Mooney, N. A., Plowey, E. D., Demeter, J., & Jackson, P. K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.05.016 · Cited by 109 · see citing works
Assembly, Functions and Evolution of Archaella, Flagella and Cilia
Khan, S., & Scholey, J. M. (2018) · Current Biology · doi:10.1016/j.cub.2018.01.085 · Cited by 96 · see citing works
Developmental toxicity of the novel PFOS alternative OBS in developing zebrafish: An emphasis on cilia disruption
Huang, J., Sun, L., Mennigen, J. A., Liu, Y., Liu, S., Zhang, M., Wang, Q., & Tu, W. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124491 · Cited by 98 · see citing works
Primary cilia proteins: ciliary and extraciliary sites and functions
Hua, K., & Ferland, R. J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2740-5 · Cited by 91 · see citing works
Ciliogenesis membrane dynamics and organization
Zhao, H., Khan, Z., & Westlake, C. J. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.021 · Cited by 89 · see citing works
Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system
Katoh, Y., Michisaka, S., Nozaki, S., Funabashi, T., Hirano, T., Takei, R., & Nakayama, K. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-01-0051 · Cited by 88 · see citing works
RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly
Nishijima, Y., Hagiya, Y., Kubo, T., Takei, R., Katoh, Y., & Nakayama, K. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-01-0017 · Cited by 87 · see citing works
Mucociliary Respiratory Epithelium Integrity in Molecular Defense and Susceptibility to Pulmonary Viral Infections
Adivitiya, Kaushik, M. S., Chakraborty, S., Veleri, S., & Kateriya, S. (2021) · Biology · doi:10.3390/biology10020095 · Cited by 90 · see citing works
Gates for soluble and membrane proteins, and two trafficking systems (IFT and LIFT), establish a dynamic ciliary signaling compartment
Jensen, V. L., & Leroux, M. R. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.03.012 · Cited by 84 · see citing works
Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements
Toropova, K., Mladenov, M., & Roberts, A. J. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3391 · Cited by 85 · see citing works
IFT-A structure reveals carriages for membrane protein transport into cilia
Hesketh, S. J., Mukhopadhyay, A. G., Nakamura, D., Toropova, K., & Roberts, A. J. (2022) · Cell · doi:10.1016/j.cell.2022.11.010 · Cited by 83 · see citing works
Cell-Specific α-Tubulin Isotype Regulates Ciliary Microtubule Ultrastructure, Intraflagellar Transport, and Extracellular Vesicle Biology
Silva, M., Morsci, N. S., Nguyen, K. C. Q., Rizvi, A., Rongo, C., Hall, D. H., & Barr, M. M. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.039 · Cited by 80 · see citing works
Rab GTPases in cilium formation and function
Blacque, O. E., Scheidel, N., & Kuhns, S. (2017) · Small GTPases · doi:10.1080/21541248.2017.1353847 · Cited by 78 · see citing works
Emerging principles of primary cilia dynamics in controlling tissue organization and function
Gopalakrishnan, J., Feistel, K., Friedrich, B. M., Grapin‐Botton, A., Jurisch‐Yaksi, N., Mass, E., Mick, D. U., Müller, R., May‐Simera, H., Schermer, B., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023113891 · Cited by 79 · see citing works
Primary ciliary signaling: links with the cell cycle
Kasahara, K., & Inagaki, M. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.07.009 · Cited by 81 · see citing works
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium
Mönnich, M., Borgeskov, L., Breslin, L., Jakobsen, L., Rogowski, M., Doğanlı, C., Schrøder, J. M., Mogensen, J. B., Blinkenkjær, L., Harder, L. M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.043 · Cited by 79 · see citing works
Routes and machinery of primary cilium biogenesis
Bernabé‐Rubio, M., & Alonso, M. A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2570-5 · Cited by 72 · see citing works
Microtubule Motors Drive Hedgehog Signaling in Primary Cilia
He, M., Agbu, S. O., & Anderson, K. V. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.09.010 · Cited by 69 · see citing works
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling
Schou, K. B., Mogensen, J. B., Morthorst, S. K., Nielsen, B. S., Aleliunaite, A., Serra-Marques, A., Fürstenberg, N., Saunier, S., Bizet, A. A., Veland, I. R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14177 · Cited by 72 · see citing works
Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects
Bonnefoy, S., Watson, C. M., Kernohan, K. D., Lemos, M., Hutchinson, S., Poulter, J. A., Crinnion, L. A., Berry, I. R., Simmonds, J., Vasudevan, P. C., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.003 · Cited by 69 · see citing works
Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis
Zhu, B., Zhu, X., Wang, L., Liang, Y., Feng, Q., & Pan, J. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006627 · Cited by 70 · see citing works
Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis
Takahara, M., Katoh, Y., Nakamura, K., Hirano, T., Sugawa, M., Tsurumi, Y., & Nakayama, K. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddx421 · Cited by 62 · see citing works
Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking
Hamada, Y., Tsurumi, Y., Nozaki, S., Katoh, Y., & Nakayama, K. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-03-0173 · Cited by 69 · see citing works
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases
Schmid, F. M., Schou, K. B., Vilhelm, M. J., Holm, M. S., Breslin, L., Farinelli, P., Larsen, L. A., Andersen, J., Pedersen, L. B., & Christensen, S. T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611050 · Cited by 67 · see citing works
Intraflagellar transport trains and motors: Insights from structure
Webb, S., Mukhopadhyay, A. G., & Roberts, A. J. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.021 · Cited by 66 · see citing works
SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation
Lehti, M. S., Zhang, F., Kotaja, N., & Sironen, A. I. (2017) · Development · doi:10.1242/dev.152108 · Cited by 67 · see citing works
BBS1 is involved in retrograde trafficking of ciliary GPCRs in the context of the BBSome complex
Nozaki, S., Katoh, Y., Kobayashi, T., & Nakayama, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195005 · Cited by 66 · see citing works
Interaction of heterotrimeric kinesin-II with IFT-B–connecting tetramer is crucial for ciliogenesis
Funabashi, T., Katoh, Y., Okazaki, M., Sugawa, M., & Nakayama, K. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201801039 · Cited by 65 · see citing works
Emerging mechanisms of dynein transport in the cytoplasm versus the cilium
Roberts, A. J. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170568 · Cited by 62 · see citing works
Intraflagellar transporter protein 140 (IFT140), a component of IFT‐A complex, is essential for male fertility and spermiogenesis in mice
Zhang, Y., Liu, H., Li, W., Zhang, Z., Zhang, S., Teves, M. E., Stevens, C. M., Foster, J. A., Campbell, G. E., Windle, J. J., et al. (2017) · Cytoskeleton · doi:10.1002/cm.21427 · Cited by 61 · see citing works
IFT25, an intraflagellar transporter protein dispensable for ciliogenesis in somatic cells, is essential for sperm flagella formation†
Liu, H., Li, W., Zhang, Y., Zhang, Z., Zhang, L., Zhang, S., Zhang, S., Li, Y., Somoza, A. V., Delpi, B., et al. (2017) · Biology of Reproduction · doi:10.1093/biolre/iox029 · Cited by 61 · see citing works
Intraflagellar transport
Pigino, G. (2021) · Current Biology · doi:10.1016/j.cub.2021.03.081 · Cited by 55 · see citing works
The intraflagellar transport cycle
Lacey, S. E., & Pigino, G. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00797-x · Cited by 64 · see citing works
Maintaining centrosomes and cilia
Werner, S., Pimenta-Marques, A., & Bettencourt‐Dias, M. (2017) · Journal of Cell Science · doi:10.1242/jcs.203505 · Cited by 59 · see citing works
Enriched expression of genes associated with autism spectrum disorders in human inhibitory neurons
Wang, P., Zhao, D., Lachman, H. M., & Zheng, D. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0058-6 · Cited by 58 · see citing works
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import
Kobayashi, T., Ishida, Y., Hirano, T., Katoh, Y., & Nakayama, K. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e20-08-0556 · Cited by 60 · see citing works
Progress in ciliary ion channel physiology
Pablo, J. L., DeCaen, P. G., & Clapham, D. E. (2016) · The Journal of General Physiology · doi:10.1085/jgp.201611696 · Cited by 57 · see citing works
Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly
Wachter, S., Jung, J., Shafiq, S., Basquin, J., Fort, C., Bastin, P., & Lorentzen, E. (2019) · The EMBO Journal · doi:10.15252/embj.2018101251 · Cited by 52 · see citing works
Self-citation
Diffusion as a Ruler: Modeling Kinesin Diffusion as a Length Sensor for Intraflagellar Transport
Hendel, N. L., Thomson, M., & Marshall, W. F. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2017.11.3784 · Cited by 56 · see citing works
ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments
Dilan, T. L., Moye, A. R., Salido, E. M., Saravanan, T., Kolandaivelu, S., Goldberg, A. F. X., & Ramamurthy, V. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1761-18.2018 · Cited by 55 · see citing works
CCDC38 is required for sperm flagellum biogenesis and male fertility in mice
Zhang, R., Wu, B., Liu, C., Zhang, Z., Wang, X., Wang, L., Xiao, S. J., Chen, Y., Wei, H., Jiang, H., et al. (2022) · Development · doi:10.1242/dev.200516 · Cited by 54 · see citing works
Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia
Yi, P., Li, W.-J., Dong, M., & Ou, G. (2017) · Current Biology · doi:10.1016/j.cub.2017.04.015 · Cited by 53 · see citing works
Bidirectional intraflagellar transport is restricted to two sets of microtubule doublets in the trypanosome flagellum
Bertiaux, E., Mallet, A., Fort, C., Blisnick, T., Bonnefoy, S., Jung, J., Lemos, M., Marco, S., Vaughan, S., Trépout, S., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201805030 · Cited by 52 · see citing works
Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia
Nozaki, S., Araya, R. F. C., Katoh, Y., & Nakayama, K. (2019) · Biology Open · doi:10.1242/bio.043786 · Cited by 53 · see citing works
Protein transport in growing and steady‐state cilia
Lechtreck, K. F., Weghe, J. C. V. D., Harris, J. A., & Liu, P. (2017) · Traffic · doi:10.1111/tra.12474 · Cited by 50 · see citing works
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
Frikstad, K.-A. M., Molinari, E., Thoresen, M., Ramsbottom, S. A., Hughes, F. E. P., Letteboer, S. J. F., Gilani, S., Schink, K. O., Stokke, T., Geimer, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.025 · Cited by 49 · see citing works
Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice
Tan, C., Meng, L., Lv, M., He, X., Sha, Y., Tang, D., Tan, Y., He, W., He, W., Tu, C., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.022 · Cited by 50 · see citing works
Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46
Taschner, M. J., Mourão, A., Awasthi, M., Basquin, J., & Lorentzen, E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780155 · Cited by 50 · see citing works
Self-citation
Intraflagellar Transport Complex A Genes Differentially Regulate Cilium Formation and Transition Zone Gating
Scheidel, N., & Blacque, O. E. (2018) · Current Biology · doi:10.1016/j.cub.2018.08.017 · Cited by 50 · see citing works
Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, S. K., Christensen, S. T., & Pedersen, L. B. (2018) · The FEBS Journal · doi:10.1111/febs.14583 · Cited by 49 · see citing works
Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B
Petriman, N.-A., Loureiro, M., Taschner, M., Zacharia, N. K., Georgieva, M. M., Boegholm, N., Wang, J., Mourão, A., Russell, R. B., Andersen, J., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022112440 · Cited by 51 · see citing works
Self-citation
The structural basis of intraflagellar transport at a glance
Jordan, M. A., & Pigino, G. (2021) · Journal of Cell Science · doi:10.1242/jcs.247163 · Cited by 48 · see citing works
Mechanism of IFT-A polymerization into trains for ciliary transport
Meleppattu, S., Zhou, H., Dai, J., Gui, M., & Brown, A. (2022) · Cell · doi:10.1016/j.cell.2022.11.033 · Cited by 44 · see citing works
Molecular basis of the morphogenesis of sperm head and tail in mice
Yogo, K. (2022) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12466 · Cited by 47 · see citing works
Human IFT-A complex structures provide molecular insights into ciliary transport
Jiang, M., Palicharla, V. R., Miller, D. J., Hwang, S., Zhu, H., Hixson, P. M., Mukhopadhyay, S., & Sun, J. (2023) · Cell Research · doi:10.1038/s41422-023-00778-3 · Cited by 48 · see citing works
Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking
Tsurumi, Y., Hamada, Y., Katoh, Y., & Nakayama, K. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-10-0678 · Cited by 46 · see citing works
Length-dependent flagellar growth of Vibrio alginolyticus revealed by real time fluorescent imaging
Chen, M., Zhao, Z., Yang, J., Peng, K., Baker, M. A. B., Bai, F., & Lo, C. (2017) · eLife · doi:10.7554/elife.22140 · Cited by 48 · see citing works
Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis
Takei, R., Katoh, Y., & Nakayama, K. (2018) · Biology Open · doi:10.1242/bio.033241 · Cited by 44 · see citing works
Retinal disease in ciliopathies: Recent advances with a focus on stem cell-based therapies
Chen, H. Y., Welby, E., Li, T., & Swaroop, A. (2019) · Translational Science of Rare Diseases · doi:10.3233/trd-190038 · Cited by 44 · see citing works
Single-Molecule Turnarounds of Intraflagellar Transport at the C. elegans Ciliary Tip
Mijalkovic, J., van Krugten, J., Oswald, F., Açar, Ş., & Peterman, E. J. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.050 · Cited by 43 · see citing works
A CCRK and a MAK Kinase Modulate Cilia Branching and Length via Regulation of Axonemal Microtubule Dynamics in Caenorhabditis elegans
Maurya, A. K., Rogers, T., & Sengupta, P. (2019) · Current Biology · doi:10.1016/j.cub.2019.02.062 · Cited by 41 · see citing works
Recent advances in understanding assembly of the primary cilium membrane
Shakya, S., & Westlake, C. J. (2021) · Faculty Reviews · doi:10.12703/r/10-16 · Cited by 41 · see citing works
IFT54 regulates IFT20 stability but is not essential for tubulin transport during ciliogenesis
Zhu, X., Liang, Y., Gao, F., & Pan, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2525-x · Cited by 42 · see citing works
Role for intraflagellar transport in building a functional transition zone
Jensen, V. L., Lambacher, N. J., Li, C., Mohan, S., Williams, C. L., Inglis, P. N., Yoder, B. K., Blacque, O. E., & Leroux, M. R. (2018) · EMBO Reports · doi:10.15252/embr.201845862 · Cited by 40 · see citing works
Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes
Osinka, A., Poprzeczko, M., Zielińska, M., Fabczak, H., Joachimiak, E., & Włoga, D. (2019) · Cells · doi:10.3390/cells8070730 · Cited by 42 · see citing works
Transport and barrier mechanisms that regulate ciliary compartmentalization and ciliopathies
Moran, A. L., Louzao-Martinez, L., Norris, D. P., Peters, D. J. M., & Blacque, O. E. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00773-2 · Cited by 39 · see citing works
Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella
Lv, B., Wan, L., Taschner, M., Cheng, X., Lorentzen, E., & Huang, K. (2017) · Journal of Cell Science · doi:10.1242/jcs.200758 · Cited by 41 · see citing works
Self-citation
The N-terminus of IFT46 mediates intraflagellar transport of outer arm dynein and its cargo-adaptor ODA16
Hou, Y., & Witman, G. B. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-03-0172 · Cited by 39 · see citing works
The kinases male germ cell‐associated kinase and cell cycle‐related kinase regulate kinesin‐2 motility in Caenorhabditis elegans neuronal cilia
Yi, P., Xie, C., & Ou, G. (2018) · Traffic · doi:10.1111/tra.12572 · Cited by 41 · see citing works
Intraflagellar transport protein 74 is essential for spermatogenesis and male fertility in mice†
Shi, L., Zhou, T., Huang, Q., Zhang, S., Li, W., Zhang, L., Hess, R. A., Pazour, G. J., & Zhang, Z. (2019) · Biology of Reproduction · doi:10.1093/biolre/ioz071 · Cited by 41 · see citing works
Cilia as Wnt signaling organelles
Niehrs, C., Silva, F. D., & Seidl, C. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.04.001 · Cited by 38 · see citing works
The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length
Hunter, E. L., Lechtreck, K. F., Fu, G., Hwang, J., Lin, H., Gokhale, A., Alford, L. M., Lewis, B. L., Yamamoto, R., Kamiya, R., et al. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-12-0729 · Cited by 40 · see citing works
IFT54 directly interacts with kinesin‐II and IFT dynein to regulate anterograde intraflagellar transport
Zhu, X., Wang, J., Li, S., Lechtreck, K. F., & Pan, J. (2020) · The EMBO Journal · doi:10.15252/embj.2020105781 · Cited by 37 · see citing works
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex
McCafferty, C. L., Papoulas, O., Jordan, M. A., Hoogerbrugge, G., Nichols, C., Pigino, G., Taylor, D. W., Wallingford, J. B., & Marcotte, E. M. (2022) · eLife · doi:10.7554/elife.81977 · Cited by 40 · see citing works
Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse
Portal, C., Lwigale, P. Y., Rompolas, P., & Iomini, C. (2019) · eLife · doi:10.7554/elife.52423 · Cited by 37 · see citing works
CDKL kinase regulates the length of the ciliary proximal segment
Park, K., Li, C., Tsiropoulou, S., Gonçalves, J., Kondratev, C., Pelletier, L., Blacque, O. E., & Leroux, M. R. (2021) · Current Biology · doi:10.1016/j.cub.2021.03.068 · Cited by 38 · see citing works
Reconstitution reveals motor activation for intraflagellar transport
Mohamed, M. A. A., Stepp, W. L., & Ökten, Z. (2018) · Nature · doi:10.1038/s41586-018-0105-3 · Cited by 38 · see citing works
Anterograde trafficking of ciliary MAP kinase–like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking
Nakamura, K., Noguchi, T., Takahara, M., Omori, Y., Furukawa, T., Katoh, Y., & Nakayama, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014142 · Cited by 37 · see citing works
Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice
Cong, J., Wang, X., Amiri‐Yekta, A., Wang, L., Kherraf, Z., Liu, C., Cazin, C., Tang, S., Hosseini, S., Tian, S., et al. (2021) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2021-107919 · Cited by 38 · see citing works
Chlamydomonas Basal Bodies as Flagella Organizing Centers
Wingfield, J. L., & Lechtreck, K. F. (2018) · Cells · doi:10.3390/cells7070079 · Cited by 34 · see citing works
Cytoplasmic dynein-2 at a glance
Vuolo, L., Stevenson, N. L., Mukhopadhyay, A. G., Roberts, A. J., & Stephens, D. J. (2020) · Journal of Cell Science · doi:10.1242/jcs.240614 · Cited by 36 · see citing works
Morphological and Molecular Bases of Male Infertility: A Closer Look at Sperm Flagellum
Pereira, R., & Sousa, M. (2023) · Genes · doi:10.3390/genes14020383 · Cited by 37 · see citing works
Identification and Characterization of Known Biallelic Mutations in the IFT27 (BBS19) Gene in a Novel Family With Bardet-Biedl Syndrome
Schaefer, É., Delvallée, C., Mary, L., Stoetzel, C., Geoffroy, V., Marks, C., Holder‐Espinasse, M., Ghoumid, J., Dollfus, H., & Muller, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00021 · Cited by 36 · see citing works
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons
Toro-Tapia, G., & Das, R. M. (2020) · Science Advances · doi:10.1126/sciadv.abb0601 · Cited by 36 · see citing works

Authors: Taschner, M., & Lorentzen, E.
Affiliations: Max Planck Institute of Biochemistry (DE)
ORCID: Taschner, Michael
Lorentzen, Esben
Venue: Cold Spring Harbor Perspectives in Biology
Publisher: Cold Spring Harbor Laboratory
Published: 2016-06-28
Volume: 8
Issue: 10
Pages: a028092
ISSN: 1943-0264 (ISSN-L)
DOI: 10.1101/cshperspect.a028092
PMC: PMC5046692
OpenAlex: W2466500085
Cited by: 349
References: 138
Citations by year: 2026: 10 · 2025: 39 · 2024: 26 · 2023: 38 · 2022: 46 · 2021: 33 · 2020: 42 · 2019: 30 · 2018: 37 · 2017: 43 · 2016: 4
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Keywords: intraflagellar transport, cilia, flagella, ciliary assembly, ciliopathies, ciliary motility, ciliary signaling, mammalian development
MeSH terms: Animals, Biological Transport, Cilia, Flagella, Humans, Protein Binding, Proteins, Protein Stability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Intraflagellar Transport Machinery

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks