Effects of retinoic acid on ischemic brain injury-induced neurogenesis.
Open accessAbstract
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
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Retinoic acid treatment following stroke in rodents reduces neurogenesis, angiogenesis, and gliogenesis in the peri-infarct region.
“retinoic acid treatment following stroke in rodents reduces neurogenesis while also reducing angiogenesis and gliogenesis in the peri-infarct region”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Jung et al., 2007
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- Authors
- Jung, D.-S., Baek, S.-Y., Park, K.-H., Chung, Y.-I., Kim, H.-J., Kim, C.-D., Cho, M.-K., Han, M.-E., Park, K.-P., Kim, B.-S., Kim, J.-B., & Oh, S.-O.
- Affiliations
- Pusan National University (KR)
- ORCID
- Venue
- Experimental & Molecular Medicine
- Published
- 2007-06-01
- Volume
- 39
- Issue
- 3
- Pages
- 304-315
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2079279493
- Cited by
- 10
- References
- 52
- Citations by year
- 2021: 1 · 2020: 1 · 2018: 1 · 2012: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Pusan National University
- Korea Science and Engineering Foundation (R13-2005-009)
- Medical Research Council (R13-2005-009)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- retinoic acid, cerebral ischemia, ischemic brain injury, subventricular zone, subgranular zone, angiogenesis, gliosis, neuronal differentiation, neuroblast proliferation
- MeSH terms
- Animals, Brain, Cell Differentiation, Ischemic Attack, Transient, Male, Neovascularization, Pathologic, Neuroglia, Neurons, Tretinoin, Rats, Sprague-Dawley, Cell Proliferation, Rats
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