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Cited by 13Retinal Development and DisordersRetinal Diseases and TreatmentsVisual perception and processing mechanisms

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Photopsias are related in part to perceived stress and positive mood in retinitis pigmentosa

Open access
Bittner, A K, Haythornthwaite, J A, Diener-West, M, Dagnelie, G·2012·Eye
DOI 10.1038/eye.2011.247PMC PMC3259584
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Abstract

Purpose We measured the relationship between the occurrence of photopsias (spontaneous phosphenes), and retinitis pigmentosa (RP) subjects' level of vision, light exposure, and psychosocial factors to attempt to confirm RP patients' previous reports of these associations.Methods A total of 36 RP subjects self-administered PC-based binocular visual acuity, contrast sensitivity, and visual field tests at home twice a week, for 16 sessions in 2-3 months. After each session, subjects reported photopsias during the vision tests and completed questionnaires: Epworth Sleepiness Scale, Stanford Sleepiness Scale, Perceived Stress Scale, and Positive and Negative Affect Schedules.Results Across all subjects, photopsias occurred during 47% of sessions. Five (14%) subjects never noted photopsias, while five others noted photopsias at every session. Two-thirds of subjects experienced photopsias frequently (>20% of sessions). On average, the odds of noticing photopsias increased by 57% for every 1-point increase in mean perceived stress (OR = 1.57; 95% CI: 1.04, 2.4; P = 0.03) or reduced by 38% for every 1-point increase in positive mood (OR=0.62; 95% CI: 0.39, 0.98; P = 0.04), after adjusting for age, gender, and vision. Similarly, the odds of experiencing photopsias during a session increased by 16% for every 3-point increase in perceived stress and decreased by 17% for every 3-point increase in positive mood, after adjusting for age and gender (OR = 1.16; 95% CI: 1.01, 1.33; P = 0.048)(OR = 0.83; 95% CI: 0.73, 0.94; P = 0.004), respectively. Frequency of photopsias was not statistically significantly related to other factors measured.Conclusions Increased photopsias appear to be related to times when subjects report increased perceived stress and/or decreased positive mood, rather than RP patients' age, level of vision, reported light exposure, or sleepiness.

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  • Spontaneous phosphenes are common in many blind persons.

    “as is common in many blind persons (17-19)”

    From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [18]

    The Introduction describes phosphenes or photopsias as spontaneous visual phenomena, and the Results report frequent photopsias in 24 of 36 participants. But the Subjects section identifies the participants as people with retinitis pigmentosa who retained enough vision to read large text; the paper does not establish that phosphenes are common among blind people generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Individuals with profound blindness generally do not live in total blackness but experience a variety of spontaneous phosphenes.

    “Individuals with profound blindness generally do not live in a world of total blackness but experience a variety of spontaneous phosphenes (18, 19)”

    From Visual percepts evoked with an intracortical 96-channel microelectrode array inserted in human occipital cortex (2021) · cites this paper as [18]

    The Results report several types of spontaneous photopsias in people with retinitis pigmentosa, including flashes, dots or shapes, glare, and background glow. But the study concerns people with retinitis pigmentosa who underwent vision testing; it does not establish that individuals with profound blindness generally have these experiences or do not perceive total blackness (Results and Data collection; page not available). (LLM, conf=0.87)

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Metadata

Authors
Bittner, A. K., Haythornthwaite, J. A., Diener-West, M., & Dagnelie, G.
Affiliations
Johns Hopkins University (US)
Corresponding author
Bittner, A K
ORCID
Venue
Eye
Publisher
Springer Science and Business Media LLC
Published
2011-10-14
Volume
26
Issue
1
Pages
101-108
ISSN
  • 0078-5334 (ISSN-L)
  • 0950-222X
  • 1476-5454
DOI
10.1038/eye.2011.247
PMC
PMC3259584
OpenAlex
W1987080606
Cited by
13
References
23
Citations by year
2024: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2014: 2 · 2013: 1
FWCI
0.39
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Eye (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Johns Hopkins University
  • Johns Hopkins Center for Mind-Body Research
  • National Institutes of Health
  • National Eye Institute (K23EY018356)
  • National Center for Complementary and Integrative Health (R24AT004641)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords
photopsia, retinitis pigmentosa, perceived stress, positive mood, phosphenes, psychosocial factors, visual impairment, sleepiness, visual acuity, contrast sensitivity, visual field
MeSH terms
Adult, Female, Hallucinations, Happiness, Humans, Male, Middle Aged, Phosphenes, Surveys and Questionnaires, Retinitis Pigmentosa, Stress, Psychological, Visual Acuity, Contrast Sensitivity

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