Cited by 436Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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The role of oxidative stress in the pathophysiology of hypertension

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Rodrigo, Ramón, González, Jaime, Paoletto, Fabio·2011·Hypertension Research

DOI 10.1038/hr.2010.264

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Abstract

Hypertension is considered to be the most important risk factor in the development of cardiovascular disease. An increasing body of evidence suggests that oxidative stress, which results in an excessive generation of reactive oxygen species (ROS), has a key role in the pathogenesis of hypertension. The modulation of the vasomotor system involves ROS as mediators of vasoconstriction induced by angiotensin II, endothelin-1 and urotensin-II, among others. The bioavailability of nitric oxide (NO), which is a major vasodilator, is highly dependent on the redox status. Under physiological conditions, low concentrations of intracellular ROS have an important role in the normal redox signaling maintaining vascular function and integrity. However, under pathophysiological conditions, increased levels of ROS contribute to vascular dysfunction and remodeling through oxidative damage. In human hypertension, an increase in the production of superoxide anions and hydrogen peroxide, a decrease in NO synthesis and a reduction in antioxidant bioavailability have been observed. In turn, antioxidants are reducing agents that can neutralize these oxidative and otherwise damaging biomolecules. The use of antioxidant vitamins, such as vitamins C and E, has gained considerable interest as protecting agents against vascular endothelial damage. Available data support the role of these vitamins as effective antioxidants that can counteract ROS effects. This review discusses the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of vascular damage in hypertension, and the possible therapeutic strategies that could prevent or treat this disorder.

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Authors: Rodrigo, R., González, J., & Paoletto, F.
Affiliations: University of Chile (CL)
Corresponding author: Rodrigo, Ramón
ORCID: Rodrigo, Ramón
Venue: Hypertension Research
Publisher: Springer Science and Business Media LLC
Published: 2011-01-13
Volume: 34
Issue: 4
Pages: 431-440
ISSN: 0916-9636 (ISSN-L)
1348-4214
DOI: 10.1038/hr.2010.264
OpenAlex: W2065634680
Cited by: 436
References: 164
Citations by year: 2026: 6 · 2025: 33 · 2024: 35 · 2023: 60 · 2022: 52 · 2021: 47 · 2020: 44 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 19 · 2013: 17 · 2012: 21
FWCI: 2.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Hypertension Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, hypertension, reactive oxygen species, nitric oxide bioavailability, vascular dysfunction, vascular remodeling, antioxidant vitamins, vitamin C, vitamin E, angiotensin II, endothelin-1, urotensin II, superoxide, hydrogen peroxide, antioxidant therapy
MeSH terms: Antioxidants, Blood Pressure, Cardiovascular System, Humans, Hypertension, Reactive Oxygen Species, Oxidative Stress

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