The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
The role of oxidative stress in the pathophysiology of hypertension
Open accessAbstract
Hypertension is considered to be the most important risk factor in the development of cardiovascular disease. An increasing body of evidence suggests that oxidative stress, which results in an excessive generation of reactive oxygen species (ROS), has a key role in the pathogenesis of hypertension. The modulation of the vasomotor system involves ROS as mediators of vasoconstriction induced by angiotensin II, endothelin-1 and urotensin-II, among others. The bioavailability of nitric oxide (NO), which is a major vasodilator, is highly dependent on the redox status. Under physiological conditions, low concentrations of intracellular ROS have an important role in the normal redox signaling maintaining vascular function and integrity. However, under pathophysiological conditions, increased levels of ROS contribute to vascular dysfunction and remodeling through oxidative damage. In human hypertension, an increase in the production of superoxide anions and hydrogen peroxide, a decrease in NO synthesis and a reduction in antioxidant bioavailability have been observed. In turn, antioxidants are reducing agents that can neutralize these oxidative and otherwise damaging biomolecules. The use of antioxidant vitamins, such as vitamins C and E, has gained considerable interest as protecting agents against vascular endothelial damage. Available data support the role of these vitamins as effective antioxidants that can counteract ROS effects. This review discusses the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of vascular damage in hypertension, and the possible therapeutic strategies that could prevent or treat this disorder.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Oxidative stress may play a role in the development of vascular complications that promote cardiovascular disease by contributing to the pathogenesis of hypertension [143,144] and atherosclerosis [145].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [144]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,694
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
The sympathetic control of blood pressure
Guyenet, P. G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1902 · Cited by 1,863
Landmesser, U., Dikalov, S., Price, S. R., McCann, L., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200314172 · Cited by 1,660
Landmesser, U., Dikalov, S., Price, S. R., McCann, L. A., Fukai, T., Holland, S. M., Mitch, W. E., & Harrison, D. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci14172 · Cited by 1,652
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mazzali, M., Hughes, J., Kim, Y.-G., Jefferson, J. A., Kang, D., GORDON, K. L., Lan, H. Y., Kivlighn, S. D., & Johnson, R. J. (2001) · Hypertension · doi:10.1161/hy1101.092839 · Cited by 1,298
Research works printed but not linked: 5
- Zhou L, Xiang W, Potts J, Floyd M, Sharan C, Yang H, Ross J, Nyanda AM, Guo Z . Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med 2006; 41: 1384–1391. · DOI
- Tanito M, Nakamura H, Kwon YW, Teratani A, Masutani H, Shioji K, Kishimoto C, Ohira A, Horie R, Yodoi J . Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal 2004; 6: 89–97. · DOI
- Duffy SJ, Gokee N, Holbrook M, Huang A, Frei B, Keany JFJ . Treatment of hypertension with ascorbic acid. Lancet 2004; 354: 2048–2049. · DOI
- Mullan B, Young IS, Fee H, McCance DR . Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension 2002; 40: 804–809. · DOI
- Galley HF, Thornton J, Howdle PD, Walker BE, Webster NR . Combination oral antioxidant supplementation reduces blood pressure. Clin Sci 1997; 92: 361–365. · DOI
Cited by
Sorted by citations
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130
Medicinal prospects of antioxidants: A review
Neha, K., Haider, M. R., Pathak, A., & Yar, M. S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.010 · Cited by 748
Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities
Rodrigo, R., Fernández-Gajardo, R., Gutiérrez, R., Matamala, J. M., Carrasco, R. A., Miranda-Merchak, A., & Walter Feuerhake, M. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312050015 · Cited by 649
Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review
Mbikay, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00024 · Cited by 615
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 614
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
Shaito, A. A., Thuan, D. T. B., Hoa, P. T., Nguyen, T. H. D., Hasan, H. A., Halabi, S., Abdelhady, S., Nasrallah, G. K., Eid, A. H., & Pintus, G. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00422 · Cited by 486
Oxidative Stress-Induced Endothelial Dysfunction in Cardiovascular Diseases
Shaito, A. A., Aramouni, K., Assaf, R., Parenti, A., Orekhov, A. N., EL‐Yazbi, A. F., Pintus, G., & Eid, A. H. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2703105 · Cited by 449
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu, S. X., Tyagi, T., Jain, K., Gu, V. W., Lee, S. H., Hwa, J. M., Kwan, J. M., Krause, D. S., Lee, A. I., Halene, S., et al. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00469-1 · Cited by 429
Mechanisms of Coronary Artery Spasm
Lanza, G. A., Careri, G., & Crea, F. (2011) · Circulation · doi:10.1161/circulationaha.111.037283 · Cited by 403
Zhang, Z., Zhao, L. Q., Zhou, X., Meng, X., & Zhou, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1098725 · Cited by 428
Erejuwa, O. O., Sulaiman, S. A., & Wahab, M. S. A. (2012) · Molecules · doi:10.3390/molecules17044400 · Cited by 384
Frąk, W., Wojtasińska, A., Lisińska, W., Młynarska, E., Franczyk, B., & Rysz, J. (2022) · Biomedicines · doi:10.3390/biomedicines10081938 · Cited by 284
Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants.
Baradaran, A., Nasri, H., & Rafieian‐Kopaei, M. (2014) · Europe PMC (PubMed Central) · Cited by 294
Arterial stiffness and hypertension
Kim, H. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00258-1 · Cited by 249
Moreno‐Luna, R., Múñoz‐Hernández, R., Miranda, M. L., Costa, A. F., Jiménez-Jiménez, L., Vallejo‐Vaz, A. J., Muriana, F. J. G., Villar, J. R., & Stiefel, P. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.128 · Cited by 243
Healthful aging mediated by inhibition of oxidative stress
Vatner, S. F., Zhang, J., Oydanich, M. K., Berkman, T., Naftalovich, R., & Vatner, D. E. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101194 · Cited by 243
Rodrigo, R., Libuy, M., Feliú, F., & Hasson, D. (2013) · Disease Markers · doi:10.1155/2013/974358 · Cited by 207
Coronary Artery Spasm: Review and Update
Hung, M., Hu, P., & Hung, M. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.9623 · Cited by 207
Phoswa, W. N., & Khaliq, O. P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5581570 · Cited by 218
Oxidative Stress in Hypertension: Role of the Kidney
Araújo, M., & Wilcox, C. S. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5259 · Cited by 189
Elimination of Vitamin D Receptor in Vascular Endothelial Cells Alters Vascular Function
Wei Min, N. I., Watts, S. W., Ng, M., Chen, S., Glenn, D. J., & Gardner, D. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03971 · Cited by 171
Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury
Lillo‐Moya, J., Rojas-Solé, C., Muñoz-Salamanca, D., Panieri, E., Saso, L., & Rodrigo, R. (2021) · Antioxidants · doi:10.3390/antiox10050667 · Cited by 166
Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
Anik, M. I., Mahmud, N., Masud, A. A., Khan, M. I., Islam, M. N., Uddin, S., & Hossain, M. K. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00411 · Cited by 163
Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases
Gianazza, E., Brioschi, M., Fernandez, A. M., Casalnuovo, F., Altomare, A., Aldini, G., & Banfi, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7955 · Cited by 164
Oxidative Stress, Antioxidants and Hypertension
Amponsah-Offeh, M., Diaba‐Nuhoho, P., Speier, S., & Morawietz, H. (2023) · Antioxidants · doi:10.3390/antiox12020281 · Cited by 169
Extra Virgin Olive Oil and Cardiovascular Diseases: Benefits for Human Health
Nocella, C., Cammisotto, V., Fianchini, L., D’Amico, A., Novo, M., Castellani, V., Stefanini, L., Violi, F., & Carnevale, R. (2017) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530317666171114121533 · Cited by 138
Wong, S. K., Chin, K., Suhaimi, F. H., Ahmad, F., & Ima-Nirwana, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00444 · Cited by 132
Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Risk
Vekić, J., Stromsnes, K., Mazzalai, S., Zeljković, A., Rizzo, M., & Gambini, J. (2023) · Biomedicines · doi:10.3390/biomedicines11112897 · Cited by 145
Speisky, H., López‐Alarcón, C., Gómez, M., Fuentes, J., & Sandoval-Acuña, C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205167k · Cited by 130
Oxidative Stress and Cardiac Remodeling: An Updated Edge
Rababa’h, A. M., Guillory, A. N., Mustafa, R., & Hijjawi, T. B. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x14666180111145207 · Cited by 132
Axelsen, L. N., Calløe, K., Holstein‐Rathlou, N., & Nielsen, M. S. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00130 · Cited by 126
Antioxidant therapy for management of oxidative stress induced hypertension
Ahmad, K. A., Yuan, D. Y., Nawaz, W., Hong, Z., Zhuo, C. X., Talal, B., Taleb, A., Mais, E., & Qi-long, D. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1322205 · Cited by 121
The Antioxidant Therapy: New Insights in the Treatment of Hypertension
Sorriento, D., LUCA, N. D., Trimarco, B., & Iaccarino, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00258 · Cited by 121
Al-Magableh, M., Kemp‐Harper, B. K., & Hart, J. L. (2014) · Hypertension Research · doi:10.1038/hr.2014.125 · Cited by 118
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
Ding, Y., Zhou, Y., Ling, P., Feng, X., Luo, S., Zheng, X., Little, P. J., Xu, S., & Weng, J. (2021) · Theranostics · doi:10.7150/thno.64706 · Cited by 121
Redox signaling in pathophysiology of hypertension
Majzúnová, M., Dovinová, I., Barančı́k, M., & Chan, J. Y. H. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-69 · Cited by 116
Saura, M., Marquez, S. B., Reventún, P., Olea‐Herrero, N., Arenas, M. I., Moreno‐Gómez‐Toledano, R., Gómez‐Parrizas, M., Muñóz‐Moreno, C., Martínez, M. G.-S., Zaragoza, C., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-252460 · Cited by 113
Erejuwa, O. O., Sulaiman, S. A., Wahab, M. S. A., Sirajudeen, K. N. S., Salleh, M. S. M., & Gurtu, S. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/374037 · Cited by 101
Senaphan, K., Kukongviriyapan, U., Sangartit, W., Pakdeechote, P., Pannangpetch, P., Prachaney, P., Greenwald, S. E., & Kukongviriyapan, V. (2015) · Nutrients · doi:10.3390/nu7085283 · Cited by 99
Adherence to the DASH Diet and Risk of Hypertension: A Systematic Review and Meta-Analysis
Theodoridis, X., Chourdakis, M., Chrysoula, L., Chroni, V., Tirodimos, I., Δίπλα, Κ., Gkaliagkousi, Ε., & Triantafyllou, Α. (2023) · Nutrients · doi:10.3390/nu15143261 · Cited by 109
Tinkov, A. A., Bjørklund, G., Skalny, A. V., Holmgren, A., Геннадиевна, С. М., Chirumbolo, S., & Aaseth, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2745-8 · Cited by 94
The Role of PPARγ in Cardiovascular Diseases
Kvandová, M., Majzúnová, M., & Dovinová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933439 · Cited by 95
Quiñones, M., Guerrero, L., Suárez, M., Pons, Z., Aleixandre, A., Arola, L., & Muguerza, B. (2013) · Food Research International · doi:10.1016/j.foodres.2013.01.023 · Cited by 92
Vascular Extracellular Matrix Remodeling and Hypertension
Cai, Z., Gong, Z., Li, Z., Li, L., & Kong, W. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8110 · Cited by 97
Pitter, G., Jeddi, M. Z., Barbieri, G., Gion, M., Fabricio, A. S. C., Daprà, F., Russo, F., Fletcher, T., & Canova, C. (2020) · Environmental Health · doi:10.1186/s12940-020-00656-0 · Cited by 83
Zhu, X., Cheang, I., Tang, Y., Shi, M., Zhu, Q., Gao, R., Liao, S., Yao, W., Zhou, Y., Zhang, H., et al. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.122.027568 · Cited by 82
Redox-inflammatory synergy in the metabolic syndrome
Bryan, S., Baregzay, B., Spicer, D., Singal, P. K., & Khaper, N. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0295 · Cited by 82
Antihypertensive Role of Polyphenols
Rodrigo, R., Gil, D., Miranda-Merchak, A., & Kalantzidis, G. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394383-5.00014-x · Cited by 78
Isometric Exercise Training and Arterial Hypertension: An Updated Review
Edwards, J. J., Coleman, D. A., Ritti‐Dias, R. M., Farah, B. Q., Stensel, D. J., Lucas, S. J. E., Millar, P. J., Gordon, B. D., Cornelissen, V., Smart, N. A., et al. (2024) · Sports Medicine · doi:10.1007/s40279-024-02036-x · Cited by 98
Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lü, Q., Groß, C., Rafikova, O., Lee, S. G., Dasarathi, S., Hou, Y., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0187oc · Cited by 77
Li, M., Fan, W., & Xu, Y. (2021) · LWT · doi:10.1016/j.lwt.2021.112221 · Cited by 69
Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement
Fernández-Gajardo, R., Matamala, J. M., Carrasco, R. A., Gutiérrez, R., Melo, R., & Rodrigo, R. (2014) · CNS Drugs · doi:10.1007/s40263-013-0138-y · Cited by 69
Higashino, S., Sasaki, Y., Giddings, J. C., Hyodo, K., Sakata, S. F., Matsuda, K., Horikawa, Y., & Yamamoto, J. (2014) · Phytotherapy Research · doi:10.1002/ptr.5130 · Cited by 68
Wu, P.-T., Fitschen, P. J., Kistler, B. M., Jeong, J., Chung, H. R., Aviram, M., Phillips, S. A., Fernhall, B., & Wilund, K. R. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.0103 · Cited by 66
Deo, S. H., Fisher, J. P., Vianna, L. C., Kim, A., Chockalingam, A., Zimmerman, M. C., Zucker, I. H., & Fadel, P. J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00289.2012 · Cited by 66
Serum bilirubin and the risk of hypertension
Wang, L., & Bautista, L. E. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu242 · Cited by 63
Francisqueti‐Ferron, F. V., Ferron, A. J. T., Garcia, J. L., Silva, C. C. V. D. A., Costa, M. R., Gregolin, C. S., Moreto, F., Ferreira, A. L. A., Minatel, I. O., & Corrêa, C. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133208 · Cited by 62
Kim, J. Y., Lee, J.-S., Han, Y.-S., Lee, J. H., Bae, I., Yoon, Y. M., Kwon, S. M., & Lee, S. H. (2015) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2015.085 · Cited by 59
Rao, K. N. S., Shen, X., Pardue, S., & Krzywanski, D. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101650 · Cited by 64
Antihypertensive effect of spent brewer yeast peptide
Amorim, M., Marques, C., Pereira, J. O., Guardão, L., Martins, M. J., Osório, H., Moura, D., Calhau, C., Pinheiro, H., & Pintado, M. (2018) · Process Biochemistry · doi:10.1016/j.procbio.2018.10.004 · Cited by 61
Deo, S. H., Jenkins, N. T., Padilla, J., Parrish, A. R., & Fadel, P. J. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00347.2013 · Cited by 60
Cellular Stress and General Pathological Processes
Gusev, E. Y., & Zotova, N. V. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190319114641 · Cited by 64
Role of oxidative stress on chronic kidney disease progression.
Putri, A. Y., & Thaha, M. (2014) · Acta medica Indonesiana · Cited by 58
Tain, Y., & Hsu, C. (2022) · Antioxidants · doi:10.3390/antiox11030511 · Cited by 58
Su, Q., Liu, J., Cui, W., Shi, X., Guo, J., Li, H., Huo, C.-J., Miao, Y.-W., Zhang, M., Yang, Q., et al. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.019 · Cited by 56
Maciejczyk, M., Taranta‐Janusz, K., Wasilewska, A. M., Kossakowska, A., & Zalewska, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030837 · Cited by 53
Al-Waili, N., Salom, K., Al-Ghamdi, A., Ansari, M. J., Al-Waili, A. N., & Al-Waili, T. N. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0285 · Cited by 54
Bornhoeft, J., Castaneda, D., Nemoseck, T., Wang, P., Henning, S. M., & Hong, M. Y. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0258 · Cited by 52
Cao, Y., Zhang, Y., Wang, N., & He, L. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.04.006 · Cited by 53
Rodrigo, R., Retamal, C., Schupper, D., Vergara-Hernández, D., Saha, S., Profumo, E., Buttari, B., & Saso, L. (2022) · Molecules · doi:10.3390/molecules27082564 · Cited by 57
Barghchi, H., Dehnavi, Z., Nattagh‐Eshtivani, E., Alwaily, E. R., Almulla, A. F., Kareem, A. K., Barati, M., Ranjbar, G., Mohammadzadeh, A., Rahimi, P., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114624 · Cited by 55
Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes
Arabshomali, A., Bazzazzadehgan, S., Mahdi, F., & Shariat‐Madar, Z. (2023) · Molecules · doi:10.3390/molecules28207209 · Cited by 56
Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats
Sasaki, Y., Kobara, N., Higashino, S., Giddings, J. C., & Yamamoto, J. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.010 · Cited by 50
Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice
Farooqui, Z., Mohammad, R. S., Lokhandwala, M. F., & Banday, A. A. (2020) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2020.1836191 · Cited by 49
Hypotension as a marker or mediator of perioperative organ injury: a narrative review
Ackland, G. L., & Abbott, T. E. F. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.01.012 · Cited by 53
BioAge: Toward a multi-determined, mechanistic account of cognitive aging
DeCarlo, C. A., Tuokko, H. A., Williams, D., Dixon, R. A., & MacDonald, S. W. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.09.003 · Cited by 50
Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke
Jia, G., Tan, B., Ma, J., Zhang, L., Jin, X., & Li, C. (2017) · BioMed Research International · doi:10.1155/2017/6597401 · Cited by 45
Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension
Noh, M. R., Kong, M. J., Han, S. J., Kim, J. I., & Park, K. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101548 · Cited by 45
Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension
Yang, J., Villar, V. A. M., José, P. A., & Zeng, C. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8106 · Cited by 47
Hypertension-related risk for dementia: A summary review with future directions
Daugherty, A. M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.03.002 · Cited by 49
Martineau-Côté, D., Achouri, A., Karboune, S., & L’Hocine, L. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00829 · Cited by 44
Liang, D., Liu, L., Ye, C.-G., Zhao, L., Yu, F., Gao, D., Wang, Y., Yang, Z., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064895 · Cited by 43
Mendes-Júnior, L. G., Monteiro, M. M. D. O., Carvalho, A. D. S., de Queiroz, T. M., & Braga, V. A. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0091 · Cited by 43
Li, J., Li, J., Li, Q., & Zhou, B. (2014) · Molecules · doi:10.3390/molecules190913587 · Cited by 42
Johnston, E. K., & Abbott, R. D. (2023) · Cells · doi:10.3390/cells12030407 · Cited by 44
Beňová, T. E., Bačová, B. S., Viczenczová, C., Diez, E. R., Barančı́k, M., & Tribulová, N. (2016) · Physiological Research · doi:10.33549/physiolres.933391 · Cited by 41
Lin, P. D., Cárdenas, A., Hauser, R. B., Gold, D. R., Kleinman, K., Hivert, M., Calafat, A. M., Webster, T. F., Horton, E. S., & Oken, E. (2020) · Environment International · doi:10.1016/j.envint.2020.105573 · Cited by 44
Rattanavipanon, W., Nithiphongwarakul, C., Sirisuwansith, P., Chaiyasothi, T., Thakkinstian, A., Nathisuwan, S., & Pathomwichaiwat, T. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153512 · Cited by 43
Ramli, I., Posadino, A. M., Giordo, R., Fenu, G., Fardoun, M., Iratni, R., Eid, A. H., Zayed, H., & Pintus, G. (2023) · Antioxidants · doi:10.3390/antiox12020341 · Cited by 39
Ozone and hypertensive disorders of pregnancy in Florida: Identifying critical windows of exposure
Hu, H. Z., Ha, S., & Xu, X. (2016) · Environmental Research · doi:10.1016/j.envres.2016.12.002 · Cited by 40
Current insights and future perspectives of flavonoids: A promising antihypertensive approach
Harahap, U., Syahputra, R. A., Ahmed, A., Nasution, A., Wisely, W., Sirait, M. L., Dalimunthe, A., Zainalabidin, S., Taslim, N. A., Nurkolis, F., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8199 · Cited by 45
Oxidative stress in patients with essential hypertension: A comparison of dippers and non-dippers
Gönenç, A., Hacışevki, A., Tavıl, Y., Çengel, A., & Torun, M. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.08.016 · Cited by 38
Aremu, O. O., Oyedeji, A. O., Oyedeji, O. O., Nkeh-Chungag, B. N., & Sewani-Rusike, C. R. (2019) · Antioxidants · doi:10.3390/antiox8080309 · Cited by 38
Andrés, C. M. C., de la Lastra, J. M. P., Andrés, C., Plou, F. J., & Pérez‐Lebeña, E. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23455 · Cited by 44
Maideen, N. M. P., Balasubramanian, R., & Ramanathan, S. (2020) · Current Cardiology Reviews · doi:10.2174/1573403x16666201110125906 · Cited by 35
Kobi, J. B. B. S., Matias, A. M., Gasparini, P. V. F., Sales, S. T., Madureira, A. R., da Silva, D. S., Corrêa, C. R., Garcia, J. L., Haese, D., Nogueira, B. V., et al. (2023) · Physiological Reports · doi:10.14814/phy2.15635 · Cited by 35
Diosmin Protects Rat Retina from Ischemia/Reperfusion Injury
Tong, N., Zhang, Z., Gong, Y., Yin, L., & Wu, X. (2012) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2011.0218 · Cited by 35
Emergency Management of Hypertension in Children
Singh, D., Akingbola, O., Yosypiv, I. V., & El-Dahr, S. S. (2012) · International Journal of Nephrology · doi:10.1155/2012/420247 · Cited by 35
Kunutsor, S. K., Kieneker, L. M., Burgess, S., Bakker, S. J. L., & Dullaart, R. P. F. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006503 · Cited by 37
Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial
Samaha, A., Fawaz, M. A., Salami, A., Baydoun, S. A., & Eid, A. H. (2019) · Biomolecules · doi:10.3390/biom9070292 · Cited by 34
Metadata
- Authors
- Rodrigo, R., González, J., & Paoletto, F.
- Affiliations
- University of Chile (CL)
- Corresponding author
- Rodrigo, Ramón
- ORCID
- Rodrigo, Ramón
- Venue
- Hypertension Research
- Published
- 2011-01-13
- Volume
- 34
- Issue
- 4
- Pages
- 431-440
- ISSN
- 0916-9636 (ISSN-L)
- 1348-4214
- OpenAlex
- W2065634680
- Cited by
- 436
- References
- 164
- Citations by year
- 2026: 6 · 2025: 33 · 2024: 35 · 2023: 60 · 2022: 52 · 2021: 47 · 2020: 44 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 19 · 2013: 17 · 2012: 21
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Hypertension Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, hypertension, reactive oxygen species, nitric oxide bioavailability, vascular dysfunction, vascular remodeling, antioxidant vitamins, vitamin C, vitamin E, angiotensin II, endothelin-1, urotensin II, superoxide, hydrogen peroxide, antioxidant therapy
- MeSH terms
- Antioxidants, Blood Pressure, Cardiovascular System, Humans, Hypertension, Reactive Oxygen Species, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
