CoChat
Sign Up
Cited by 436Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.

The role of oxidative stress in the pathophysiology of hypertension

Open access
Rodrigo, Ramón, González, Jaime, Paoletto, Fabio·2011·Hypertension Research
DOI 10.1038/hr.2010.264
Open this paper in CoChat — free accountOpen PDF

Abstract

Hypertension is considered to be the most important risk factor in the development of cardiovascular disease. An increasing body of evidence suggests that oxidative stress, which results in an excessive generation of reactive oxygen species (ROS), has a key role in the pathogenesis of hypertension. The modulation of the vasomotor system involves ROS as mediators of vasoconstriction induced by angiotensin II, endothelin-1 and urotensin-II, among others. The bioavailability of nitric oxide (NO), which is a major vasodilator, is highly dependent on the redox status. Under physiological conditions, low concentrations of intracellular ROS have an important role in the normal redox signaling maintaining vascular function and integrity. However, under pathophysiological conditions, increased levels of ROS contribute to vascular dysfunction and remodeling through oxidative damage. In human hypertension, an increase in the production of superoxide anions and hydrogen peroxide, a decrease in NO synthesis and a reduction in antioxidant bioavailability have been observed. In turn, antioxidants are reducing agents that can neutralize these oxidative and otherwise damaging biomolecules. The use of antioxidant vitamins, such as vitamins C and E, has gained considerable interest as protecting agents against vascular endothelial damage. Available data support the role of these vitamins as effective antioxidants that can counteract ROS effects. This review discusses the mechanisms involved in ROS generation, the role of oxidative stress in the pathogenesis of vascular damage in hypertension, and the possible therapeutic strategies that could prevent or treat this disorder.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/hr.2010.264

Cites

164 of 164 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 164 references

Research works printed but not linked: 5

  1. Zhou L, Xiang W, Potts J, Floyd M, Sharan C, Yang H, Ross J, Nyanda AM, Guo Z . Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med 2006; 41: 1384–1391. · DOI
  2. Tanito M, Nakamura H, Kwon YW, Teratani A, Masutani H, Shioji K, Kishimoto C, Ohira A, Horie R, Yodoi J . Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats. Antioxid Redox Signal 2004; 6: 89–97. · DOI
  3. Duffy SJ, Gokee N, Holbrook M, Huang A, Frei B, Keany JFJ . Treatment of hypertension with ascorbic acid. Lancet 2004; 354: 2048–2049. · DOI
  4. Mullan B, Young IS, Fee H, McCance DR . Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension 2002; 40: 804–809. · DOI
  5. Galley HF, Thornton J, Howdle PD, Walker BE, Webster NR . Combination oral antioxidant supplementation reduces blood pressure. Clin Sci 1997; 92: 361–365. · DOI

Cited by

Sorted by citations

Items 301–400 of 434

Related

See all

Metadata

Authors
Rodrigo, R., González, J., & Paoletto, F.
Affiliations
University of Chile (CL)
Corresponding author
Rodrigo, Ramón
ORCID
Rodrigo, Ramón
Venue
Hypertension Research
Publisher
Springer Science and Business Media LLC
Published
2011-01-13
Volume
34
Issue
4
Pages
431-440
ISSN
  • 0916-9636 (ISSN-L)
  • 1348-4214
DOI
10.1038/hr.2010.264
OpenAlex
W2065634680
Cited by
436
References
164
Citations by year
2026: 6 · 2025: 33 · 2024: 35 · 2023: 60 · 2022: 52 · 2021: 47 · 2020: 44 · 2019: 26 · 2018: 19 · 2017: 18 · 2016: 15 · 2015: 21 · 2014: 19 · 2013: 17 · 2012: 21
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Hypertension Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
oxidative stress, hypertension, reactive oxygen species, nitric oxide bioavailability, vascular dysfunction, vascular remodeling, antioxidant vitamins, vitamin C, vitamin E, angiotensin II, endothelin-1, urotensin II, superoxide, hydrogen peroxide, antioxidant therapy
MeSH terms
Antioxidants, Blood Pressure, Cardiovascular System, Humans, Hypertension, Reactive Oxygen Species, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review