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Cited by 154Hormonal and reproductive studiesHypothalamic control of reproductive hormonesSperm and Testicular Function

Obesity and late-onset hypogonadism

Corona, G., Vignozzi, L., Sforza, A., Mannucci, E., Maggi, M.·2015·Molecular and Cellular Endocrinology
DOI 10.1016/j.mce.2015.06.031
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Abstract

Obesity and male hypogonadism (HG) are often associated, as demonstrated in all cross-sectional studies. Prospective studies have indicated that i) having HG at baseline increases the risk of visceral obesity (and metabolic syndrome) and that ii) obesity induces incident HG. Hence, there is a bidirectional relationship between the two conditions. This is the main topic of this review, along with some pathogenic considerations. Meta-analysis of intervention studies indicates that treating obesity is a very efficient treatment for obesity-induced HG. The mechanism by which obesity induces HG has not yet been completely understood, but dietary-induced hypothalamic inflammation, along with a decreased GnRH release, is plausible. Among patients seeking medical care for obesity, the proportion of HG is relatively high. The prevalence of obesity among patients referring for sexual dysfunction is also elevated. Hence, in symptomatic, obese, hypogonadal subjects, testosterone supplementation (TS) can be considered. Whereas long-term uncontrolled register studies suggest that TS could decrease weight, analysis of controlled studies only support a parallel increase in lean mass and decrease in fat mass, with a resulting null effect on weight. Considering that T induces an increase in muscle mass, it is conceivable that the amount of activity obese people can undertake after TS will increase, allowing a closer adherence to physical exercise programs. Some studies, here meta-analyzed, support this concept.

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Crossref · 10.1016/j.mce.2015.06.031

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  • Total estradiol was significantly decreased after bariatric surgery, with a mean reduction of about 20 pmol/L as documented by most meta-analyses, except the earliest one which found a decline of around a half.

    “Total estradiol was significantly decreased after bariatric surgery, with a mean reduction of about 20 pmol/L, as documented by most meta-analyses, except for the earliest one [11] which found a decline of around a half (Fig. 2F).”

    From Treatment of Functional Hypogonadism Besides Pharmacological Substitution (2020) · cites this paper as [11]

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Authors
Corona, G., Vignozzi, L., Sforza, A., Mannucci, E., & Maggi, M.
Affiliations
  • Azienda USL di Bologna (IT)
  • University of Florence (IT)
  • Azienda Ospedaliero-Universitaria Careggi (IT)
Corresponding author
Maggi, M.
ORCID
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
2015-12
Volume
418
Pages
120-133
ISSN
0303-7207 (ISSN-L)
DOI
10.1016/j.mce.2015.06.031
OpenAlex
W791798302
Semantic Scholar
aa5f051f9d693bee3245fafce9350033772e50c2
Cited by
154
References
113
Citations by year
2026: 8 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 12 · 2020: 8 · 2019: 17 · 2018: 24 · 2017: 21 · 2016: 19 · 2015: 8
FWCI
20.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Florence Research (University of Florence) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords
obesity, andropause, male hypogonadism, visceral obesity, metabolic syndrome, testosterone supplementation, hypothalamic inflammation, GnRH release, sexual dysfunction, weight loss, lean body mass, exercise adherence, bidirectional relationship
MeSH terms
Animals, Body Weight, Eunuchism, Humans, Male, Obesity, Testosterone, Meta-Analysis as Topic, Exercise, Age of Onset, Muscle, Skeletal

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