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The effects of 30-days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
Open accessAbstract
Polyphenolic compounds, such as resveratrol, have recently received widespread interest because of their ability to mimic effects of calorie restriction. The objective of the present study was to gain more insight into the effects of 30 days resveratrol supplementation on adipose tissue morphology and underlying processes. Eleven healthy obese men were supplemented with placebo and resveratrol for 30 days (150 mg per day), separated by a 4-week washout period in a double-blind randomized crossover design. A postprandial abdominal subcutaneous adipose tissue biopsy was collected to assess adipose tissue morphology and gene expression using microarray analysis. Resveratrol significantly decreased adipocyte size, with a shift toward a reduction in the proportion of large and very-large adipocytes and an increase in small adipocytes. Microarray analysis revealed downregulation of Wnt and Notch signaling pathways and upregulation of pathways involved in cell cycle regulation after resveratrol supplementation, suggesting enhanced adipogenesis. Furthermore, lysosomal/phagosomal pathway and transcription factor EB were upregulated reflecting an alternative pathway of lipid breakdown by autophagy. Further research is necessary to investigate whether resveratrol improves adipose tissue function.
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Metadata
- Authors
- Konings, E., Timmers, S., Boekschoten, M. V., Goossens, G. H., Jocken, J. W., Afman, L. A., Müller, M., Schrauwen, P., Mariman, E. C., & Blaak, E. E.
- Affiliations
- Maastricht University Medical Centre (NL)
- TiFN (NL)
- Corresponding author
- Blaak, E E
- ORCID
- Venue
- International Journal of Obesity
- Published
- 2013-08-20
- Volume
- 38
- Issue
- 3
- Pages
- 470-473
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2113139949
- Semantic Scholar
- 30a0401887408462b85ba740af8254f40ebfe638
- Cited by
- 143
- References
- 21
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 15 · 2017: 14 · 2016: 17 · 2015: 11 · 2014: 6
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- resveratrol, obesity, adipose tissue, adipocyte size, adipose tissue morphology, gene expression, Wnt signaling, Notch signaling, adipogenesis, autophagy, lysosomal pathway, TFEB, polyphenols, subcutaneous adipose tissue
- MeSH terms
- Resveratrol, Adipose Tissue, Adult, Aged, Double-Blind Method, Enzyme Inhibitors, Humans, Male, Middle Aged, Obesity, Stilbenes, Signal Transduction, Treatment Outcome, Adipocytes, Cross-Over Studies, Gene Expression Profiling, Adipogenesis, Receptors, Notch, Wnt Signaling Pathway
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