Resveratrol: Anti-Obesity Mechanisms of Action
Open accessAbstract
Resveratrol is a non-flavonoid polyphenol which belongs to the stilbenes group and is produced naturally in several plants in response to injury or fungal attack. Resveratrol has been recently reported as preventing obesity. The present review aims to compile the evidence concerning the potential mechanisms of action which underlie the anti-obesity effects of resveratrol, obtained either in cultured cells lines and animal models. Published studies demonstrate that resveratrol has an anti-adipogenic effect. A good consensus concerning the involvement of a down-regulation of C/EBPα and PPARγ in this effect has been reached. Also, in vitro studies have demonstrated that resveratrol can increase apoptosis in mature adipocytes. Furthermore, different metabolic pathways involved in triacylglycerol metabolism in white adipose tissue have been shown to be targets for resveratrol. Both the inhibition of de novo lipogenesis and adipose tissue fatty acid uptake mediated by lipoprotein lipase play a role in explaining the reduction in body fat which resveratrol induces. As far as lipolysis is concerned, although this compound per se seems to be unable to induce lipolysis, it increases lipid mobilization stimulated by β-adrenergic agents. The increase in brown adipose tissue thermogenesis, and consequently the associated energy dissipation, can contribute to explaining the body-fat lowering effect of resveratrol. In addition to its effects on adipose tissue, resveratrol can also acts on other organs and tissues. Thus, it increases mitochondriogenesis and consequently fatty acid oxidation in skeletal muscle and liver. This effect can also contribute to the body-fat lowering effect of this molecule.
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Dietary resveratrol supplementation has anti-obesity effects, potentially by mimicking metabolic effects of long-term caloric restriction and improving adipose tissue function and insulin sensitivity in obese models.
“Recent studies have also revealed anti-obesity effects of dietary resveratrol supplementation [82, 83], potentially by mimicking the metabolic effects of long-term caloric restriction [84] and improving adipose tissue function and insulin sensitivity in obese model [85].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [83]
Resveratrol concentrations between 25-50 μM significantly reduce lipid accumulation in pre-adipocytes after 6 days of incubation due to decreased adipogenesis and reduced cell viability.
“Concentrations between 25–50 μM have been shown to significantly reduce the lipid accumulation in pre-adipocytes after 6 days of incubation, due to both decreased adipogenesis and reduced cell viability [27].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [27]
Incubation of pre-adipocytes with resveratrol at concentrations >10 μM down-regulated gene and protein expression of C/EBPα, SREBP-1c, and PPARγ, thereby reducing adipogenesis.
“Some authors found that after incubation of pre-adipocytes with resveratrol at concentrations >10 μM, gene and protein expression of C/EBPα, SREBP-1c, and PPARγ were down-regulated, thereby reducing adipogenesis.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [27]
Some studies reported an increase in adipocyte apoptosis via the SIRT-1/AMPK axis and a lipolytic effect of resveratrol, although the latter effect is still debated.
“Some studies have also reported an increase in adipocyte apoptosis via the SIRT-1/AMPK axis and a lipolytic effect of resveratrol, although the latter effect is still debated [27].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [27]
In the differentiation of adipocytes from stem cells, C/EBPα, SREBP-1c, and PPARγ play a fundamental role in promoting changes from fibroblastic form to spherical cell.
“In the process of differentiation of adipocytes from stem cells, certain proteins such as CCAAT-enhancer-binding protein (C/EBPα), sterol regulatory element-binding protein 1c (SREBP-1c), and PPARγ play a fundamental role in promoting changes from fibroblastic form to spherical cell [27].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [27]
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- Authors
- Aguirre, L., Fernández-Quintela, A., Arias, N., & Portillo, M.
- Affiliations
- University of the Basque Country (ES)
- Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of Basque Country (UPV/EHU) and Lucio Lascaray Research Center, 01006 Vitoria, Spain
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-11-14
- Volume
- 19
- Issue
- 11
- Pages
- 18632-18655
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6271102
- OpenAlex
- W1975120418
- Cited by
- 205
- References
- 84
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 15 · 2023: 18 · 2022: 11 · 2021: 19 · 2020: 18 · 2019: 26 · 2018: 18 · 2017: 23 · 2016: 17 · 2015: 16
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Communities in ADDI (Universidad del Pais Vasco) (submittedVersion, other-oa)
- Communities in ADDI (University of the Basque Country) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Hispana (submittedVersion, cc-by)
- Funders
- Ministerio de Economía y Competitividad (AGL2011-27406-ALI, UFI11/32)
- Euskal Herriko Unibertsitatea ((ELDUNANOTEK UFI11/32, UFI 11/32)
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- resveratrol, anti-obesity, adipogenesis, C/EBPα, PPARγ, adipocyte apoptosis, triglyceride metabolism, de novo lipogenesis, lipoprotein lipase, fatty acid uptake, lipolysis, brown adipose tissue thermogenesis, mitochondrial biogenesis, fatty acid oxidation, skeletal muscle, liver, polyphenols, stilbenes
- MeSH terms
- Resveratrol, Anti-Inflammatory Agents, Non-Steroidal, Fatty Acids, Humans, Liver, Obesity, Stilbenes, Down-Regulation, Apoptosis, Adipocytes, Muscle, Skeletal, CCAAT-Enhancer-Binding Proteins, PPAR gamma, Lipogenesis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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