High-Dose Resveratrol Supplementation in Obese Men
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Obesity, diabetes, hypertension, and hyperlipidemia constitute risk factors for morbidity and premature mortality. Based on animal and in vitro studies, resveratrol reverts these risk factors via stimulation of silent mating type information regulation 2 homolog 1 (SIRT1), but data in human subjects are scarce. The objective of this study was to examine the metabolic effects of high-dose resveratrol in obese human subjects. In a randomized, placebo-controlled, double-blinded, and parallel-group design, 24 obese but otherwise healthy men were randomly assigned to 4 weeks of resveratrol or placebo treatment. Extensive metabolic examinations including assessment of glucose turnover and insulin sensitivity (hyperinsulinemic euglycemic clamp) were performed before and after the treatment. Insulin sensitivity, the primary outcome measure, deteriorated insignificantly in both groups. Endogenous glucose production and the turnover and oxidation rates of glucose remained unchanged. Resveratrol supplementation also had no effect on blood pressure; resting energy expenditure; oxidation rates of lipid; ectopic or visceral fat content; or inflammatory and metabolic biomarkers. The lack of effect disagrees with persuasive data obtained from rodent models and raises doubt about the justification of resveratrol as a human nutritional supplement in metabolic disorders.
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In Poulsen et al.'s trial, resveratrol 500 mg three times daily for 4 weeks in obese men with moderate insulin resistance had no effect on glucose homeostasis, HbA1c, insulin sensitivity, lipid profile, blood pressure, total body fat mass, resting energy expenditure, or glucose/lipid oxidation rate.
“At the end of the study, the authors found no effects on glucose homeostasis, glycosylated hemoglobin (HbA1c), insulin sensitivity, lipid profile, blood pressure, total body fat mass, resting energy expenditure, glucose or lipid oxidation rate.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [36]
Poulsen et al. concluded that resveratrol has no effects in obese patients with moderate insulin-resistance.
“Based on these results, they concluded that resveratrol has no effects in obese patients with moderate insulin-resistance [36].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [36]
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- Authors
- Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L.
- Affiliations
- Aarhus University Hospital (DK)
- University of Southern Denmark (DK)
- Magnetic Resonance Research Centre, Aarhus University Hospital, Aarhus, Denmark
- Corresponding author
- Poulsen, Morten M.
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2013-03-14
- Volume
- 62
- Issue
- 4
- Pages
- 1186-1195
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3609591
- OpenAlex
- W2144770293
- Cited by
- 455
- References
- 54
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 20 · 2023: 23 · 2022: 27 · 2021: 33 · 2020: 31 · 2019: 21 · 2018: 33 · 2017: 41 · 2016: 43 · 2015: 49 · 2014: 49 · 2013: 54
- FWCI
- 23.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, other-oa)
- Funders
- Strategiske Forskningsråd (10‐093499)
- Aarhus Universitet
- Aarhus Universitetshospital
- Novo Nordisk
- Riisfort Fonden
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- resveratrol, obesity, SIRT1, insulin sensitivity, glucose turnover, endogenous glucose production, glucose oxidation, blood pressure, energy expenditure, lipid oxidation, visceral fat, inflammation, dietary supplementation, metabolic disorders
- MeSH terms
- Resveratrol, Adolescent, Adult, Aged, Antioxidants, Body Composition, Dose-Response Relationship, Drug, Double-Blind Method, Energy Metabolism, Gene Expression Regulation, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Pilot Projects, Stilbenes, Dietary Supplements, Young Adult
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