Infant antibiotic exposure and the development of childhood overweight and central adiposity
Abstract
Background Obesity has been associated with disruption of the gut microbiota, which is established during infancy and vulnerable to disruption by antibiotics. Objectives To investigate the association between early-life antibiotic exposure and subsequent development of overweight and central adiposity. Methods Provincial health-care records were linked to clinical and survey data from a Canadian longitudinal birth cohort study. Antibiotic exposure during the first year of life was documented from prescription records. Overweight and central adiposity were determined from anthropometric measurements at ages 9 (n=616) and 12 (n=431). Associations were determined by multiple logistic regression. Results Infants receiving antibiotics in the first year of life were more likely to be overweight later in childhood compared with those who were unexposed (32.4 versus 18.2% at age 12, P=0.002). Following adjustment for birth weight, breastfeeding, maternal overweight and other potential confounders, this association persisted in boys (aOR 5.35, 95% confidence interval (CI) 1.94-14.72) but not in girls (aOR 1.13, CI 0.46-2.81). Similar gender-specific associations were found for overweight at age 9 (aOR 2.19, CI 1.06-4.54 for boys; aOR 1.20, CI 0.53-2.70 for girls) and for high central adiposity at age 12 (aOR 2.85, CI 1.24-6.51 for boys; aOR 1.59, CI 0.68-3.68 for girls). Conclusions Among boys, antibiotic exposure during the first year of life was associated with an increased risk of…
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The evidence supports a link between early-life microbiota composition or antibiotic use and later metabolic and immune function, specifically overweight/obesity and asthma/allergy.
“The evidence supports a link between early-life microbiota composition, or antibiotic use, and later metabolic and immune function (specifically overweight/obesity and asthma/allergy; Abrahamsson et al., 2014;Azad et al., 2014;Penders et al., 2007;Sjogren et al., 2009;Stanislawski et al., 2018a;Sugino et al., 2019).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Azad et al., 2014
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- Authors
- Azad, M. B., Bridgman, S. L., Becker, A. B., & Kozyrskyj, A. L.
- Affiliations
- University of Alberta (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- Corresponding author
- Kozyrskyj, A L
- Venue
- International Journal of Obesity
- Published
- 2014-07-11
- Volume
- 38
- Issue
- 10
- Pages
- 1290-1298
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2033001504
- Cited by
- 331
- References
- 2
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 18 · 2023: 18 · 2022: 26 · 2021: 22 · 2020: 36 · 2019: 30 · 2018: 41 · 2017: 42 · 2016: 39 · 2015: 27 · 2014: 4
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research Manitoba
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- childhood overweight, abdominal obesity, childhood obesity, gut microbiota, antibiotic stewardship, sex differences, late childhood, birth cohort
- MeSH terms
- Anti-Bacterial Agents, Canada, Child, Child, Preschool, Environmental Exposure, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Male, Risk Factors, Sex Factors, Cohort Studies, Weight Gain, Body Mass Index, Prevalence, Age of Onset, Obesity, Abdominal, Microbiota
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