Postnatal exposure to household disinfectants, infant gut microbiota and subsequent risk of overweight in children
Open accessAbstract
BACKGROUND: Emerging links between household cleaning products and childhood overweight may involve the gut microbiome. We determined mediating effects of infant gut microbiota on associations between home use of cleaning products and future overweight. METHODS: From the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort, we tested associations between maternal report of cleaning product use and overweight at age 3, and whether associations were mediated by microbial profiles of fecal samples in 3- to 4-month-old infants. RESULTS: Among 757 infants, the abundance of specific gut microbiota was associated with household cleaning with disinfectants and eco-friendly products in a dose-dependent manner. With more frequent use of disinfectants, Lachnospiraceae increasingly became more abundant (highest v. lowest quintile of use: adjusted odds ratio [AOR] 1.93, 95% confidence interval [CI] 1.08 to 3.45) while genus Haemophilus declined in abundance (highest v. lowest quintile of use: AOR 0.36, 95% CI 0.20 to 0.65). Enterobacteriaceae were successively depleted with greater use of eco-friendly products (AOR 0.45, 95% CI 0.27 to 0.74). Lachnospiraceae abundance significantly mediated associations of the top 30th centile of household disinfectant use with higher body mass index (BMI) z score (p = 0.02) and with increased odds of overweight or obesity (p = 0.04) at age 3. Use of eco-friendly products was associated with decreased odds of overweight or obesity independently of Enterobacteriaceae abundance (AOR 0.44, 95% CI 0.22 to 0.86), with no significant mediation (p = 0.2). INTERPRETATION: Exposure to household disinfectants was associated with higher BMI at age 3, mediated by gut microbial composition at age 3–4 months. Although child overweight was less common in households that cleaned with eco-friendly products, the lack of mediation by infant gut microbiota suggests another pathway for this association.
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Self-citationSanitization of Early Life and Microbial Dysbiosis
Jun, S., Drall, K. M., Matenchuk, B. A., McLean, C., Nielsen, C. C., Obiakor, C. V., der Leek, A. V., & Kozyrskyj, A. L. (2018) · Challenges · doi:10.3390/challe9020043 · Cited by 6 · see citing works
Self-citationBehl, A., & Sharma, K. K. (2025) · Letters in Applied Microbiology · doi:10.1093/lambio/ovaf067 · Cited by 6 · see citing works
Early Life Antimicrobial Exposure: Impact on Clostridioides difficile Colonization in Infants
Obiakor, C. V., Parks, J., Takaro, T. K., Tun, H. M., Morales-Lizcano, N. P., Azad, M. B., Mandhane, P. J., Moraes, T. J., Simons, E., Turvey, S. E., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11070981 · Cited by 5 · see citing works
Self-citationField study of the indoor environments for preventing the spread of the SARS‐CoV‐2 in Seoul
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Paediatrician’s perspective of infant gut microbiome research: current status and challenges
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Nuestra Ciencia: Transforming Microbiology for Spanish-Speaking Elementary and College Students
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Household conditions modulate associations between cesarean delivery and childhood growth
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Virucidal activity of household laundry detergents and additives in simulated wash cycles
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Environmentally friendly pediatric gastroenterology: a narrative review
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Ist die Desinfektion öffentlicher Flächen zur Prävention von SARS-CoV-2 – infektionen sinnvoll?
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Are household disinfectants microbially mediated obesogens?
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Antiseptic Stewardship for Surface Disinfectants
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Microbiota, metabolic disorders, and pharmacological opportunities
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Self-citationFunction of Gut Microbiota in Longevity as a Futuristic Approach of Personalised Nutrition
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- Authors
- Tun, M. H., Tun, H. M., Mahoney, J. J., Konya, T. B., Guttman, D. S., Becker, A. B., Mandhane, P. J., Turvey, S. E., Subbarao, P., Sears, M. R., Brook, J. R., Lou, W., Takarao, T. K., Scott, J. A., & Kozyrskyj, A. L.
- Affiliations
- University of British Columbia (CA)
- ORCID
- Venue
- Canadian Medical Association Journal
- Publisher
- CMA Impact Inc.
- Published
- 2018-09-16
- Volume
- 190
- Issue
- 37
- Pages
- E1097-E1107
- ISSN
- 0820-3946 (ISSN-L)
- 1488-2329
- PMC
- PMC6141245
- OpenAlex
- W2892168360
- Cited by
- 68
- References
- 54
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 4
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Medical Association Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- household disinfectants, household cleaning products, infant gut microbiota, childhood overweight, childhood obesity, body mass index, Lachnospiraceae, Enterobacteriaceae, Haemophilus, eco-friendly cleaning products, mediation analysis
- MeSH terms
- Gastrointestinal Microbiome, Canada, Child Development, Child, Preschool, Disinfectants, Environmental Exposure, Feces, Female, Household Work, Humans, Infant, Longitudinal Studies, Male, Odds Ratio, Pediatric Obesity
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