Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics
Abstract
Objective To investigate whether delivery mode (vaginal versus by caesarean section), maternal pre-pregnancy body mass index (BMI) and early exposure to antibiotics (<6 months of age) influence child's risk of overweight at age 7 years, hence supporting the hypotheses that environmental factors influencing the establishment and diversity of the gut microbiota are associated with later risk of overweight.Design Longitudinal, prospective study with measure of exposures in infancy and follow-up at age 7 years.Methods A total of 28 354 mother-child dyads from the Danish National Birth Cohort, with information on maternal pre-pregnancy BMI, delivery mode and antibiotic administration in infancy, were assessed. Logistic regression analyses were performed with childhood height and weight at the 7-year follow-up as outcome measures.Results Delivery mode was not significantly associated with childhood overweight (odds ratio (OR):1.18, 95% confidence interval (CI): 0.95-1.47). Antibiotics during the first 6 months of life led to increased risk of overweight among children of normal weight mothers (OR: 1.54, 95% CI: 1.09-2.17) and a decreased risk of overweight among children of overweight mothers (OR: 0.54, 95% CI: 0.30-0.98). The same tendency was observed among children of obese mothers (OR: 0.85, 95% CI: 0.41-1.76).Conclusion The present cohort study revealed that a combination of early exposures, including delivery mode, maternal pre-pregnancy BMI and antibiotics in infancy, influences the risk of overweight in later childhood. This effect may potentially be explained by an impact on establishment and diversity of the microbiota.
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Antibiotic exposure early in life correlates with obesity in people and in mice.
“The use of antibiotics in early life is associated with obesity in both people and mice”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [122]
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- Authors
- Ajslev, T. A., Andersen, C. S., Gamborg, M., Sørensen, T. I. A., & Jess, T.
- Affiliations
- Copenhagen University Hospital (DK)
- Corresponding author
- Ajslev, T A
- Venue
- International Journal of Obesity
- Published
- 2011-03-08
- Volume
- 35
- Issue
- 4
- Pages
- 522-529
- ISSN
- 0307-0565 (ISSN-L)
- 1476-5497
- OpenAlex
- W2003202328
- Cited by
- 534
- References
- 36
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 17 · 2023: 20 · 2022: 27 · 2021: 36 · 2020: 51 · 2019: 54 · 2018: 51 · 2017: 51 · 2016: 54 · 2015: 59 · 2014: 32 · 2013: 33 · 2012: 21
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Obesity (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- childhood overweight, gut microbiota, mode of delivery, cesarean section, vaginal delivery, maternal pre-pregnancy BMI, maternal obesity, early antibiotic exposure, infancy, environmental risk factors
- MeSH terms
- Adolescent, Adult, Anti-Bacterial Agents, Cesarean Section, Child, Female, Humans, Infant, Newborn, Longitudinal Studies, Male, Mothers, Obesity, Pregnancy, Prospective Studies, Surveys and Questionnaires, Risk Factors, Body Mass Index, Delivery, Obstetric, Gastrointestinal Tract, Metagenome, Young Adult
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