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Irisin inhibition of growth hormone secretion in cultured tilapia pituitary cells

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Association of Circulating Irisin Levels and the Characteristics and Prognosis of Coronary Artery Disease

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Crosstalk between Irisin Levels, Liver Fibrogenesis and Liver Damage in Non-Obese, Non-Diabetic Individuals with Non-Alcoholic Fatty Liver Disease

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Assessed and Emerging Biomarkers in Stroke and Training-Mediated Stroke Recovery: State of the Art

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Circulating Irisin Levels in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

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Irisin and Energy Metabolism and the Role of Irisin on Metabolic Syndrome

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Endocrine alterations from concentric vs. eccentric muscle actions: A brief review

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Fibronectin type III domain-containing 5 in cardiovascular and metabolic diseases: a promising biomarker and therapeutic target

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Irisin: circulating levels in serum and its relation to gonadal axis

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Effect of Exercise Interventions on Irisin and Interleukin-6 Concentrations and Indicators of Carbohydrate Metabolism in Males with Metabolic Syndrome

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Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity

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Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?

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Central irisin administration suppresses thyroid hormone production but increases energy consumption in rats

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Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism

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Muscle Conditional Medium Reduces Intramuscular Adipocyte Differentiation and Lipid Accumulation through Regulating Insulin Signaling

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Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats

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Association of serum concentrations of irisin and the adipokines adiponectin and leptin with epicardial fat in cardiovascular surgery patients

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Irisin promotes cementoblast differentiation via p38 MAPK pathway

Zhu, J., Wang, Y., Cao, Z., Du, M., Hao, Y., Pan, J., & He, H. (2020) · Oral Diseases · doi:10.1111/odi.13307 · Cited by 24

Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients

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Pathophysiological changes of the liver-muscle axis in end-stage liver disease: what is the right target?

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Adipokines in Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets

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Does iris(in) bring bad news or good news?

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Effects of aerobic training, resistance training, or both on circulating irisin and myostatin in untrained women

Shabani, R., & Izaddoust, F. (2018) · Acta Gymnica · doi:10.5507/ag.2018.007 · Cited by 23

Irisin reverses platelet derived growth factor-BB-induced vascular smooth muscle cells phenotype modulation through STAT3 signaling pathway

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Irisin has no effect on lipolysis in 3T3-L1 adipocytes or fatty acid metabolism in HepG2 hepatocytes

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Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

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Transthyretin Maintains Muscle Homeostasis through the Novel Shuttle Pathway of Thyroid Hormones during Myoblast Differentiation

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Serum Irisin Levels and Clinical Implication in Elderly Patients With Type 2 Diabetes Mellitus

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Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases

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Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration

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Research Progress on the Effect and Mechanism of Exercise Intervention on Sarcopenia Obesity

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Irisin enhances osteogenic differentiation of mouse MC3T3‑E1 cells via upregulating osteogenic genes

Yang, J., Yu, K., Liu, D., Yang, J., Tan, L., & Zhang, D. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10012 · Cited by 20

The role of irisin in kidney diseases

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A brief overview about the physiology of fibronectin type III domain-containing 5

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Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFκB Pathway

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Browning of subcutaneous fat and higher surface temperature in response to phenotype selection for advanced endurance exercise performance in male DUhTP mice

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GLP-1 Induces the Expression of FNDC5 Derivatives That Execute Lipolytic Actions

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Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes

Fu, T., Li, C., Sun, Z., Yan, B., Wu, Y., Huang, Z., & Yin, X. L. (2022) · Obesity Facts · doi:10.1159/000523871 · Cited by 19

Molecular Basis of Irisin Regulating the Effects of Exercise on Insulin Resistance

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Association between irisin and metabolic parameters in nondiabetic, nonobese adults: a meta-analysis

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The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study

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Acute and chronic functional and traditional resistance training improve muscular fitness in young males via the AMPK/PGC-1α/irisin signaling pathway

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Irisin in degenerative musculoskeletal diseases: Functions in system and potential in therapy

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The role of Irisin in multiorgan protection

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Impact of 10‐day bed rest on serum levels of irisin and markers of musculoskeletal metabolism

Oranger, A., Storlino, G., Dicarlo, M., Zerlotin, R., Pignataro, P., Sanesi, L., Narici, M. V., Pišot, R., Šimunič, B., Colaianni, G., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202201005rr · Cited by 16

Irisin participates in the beneficial effects of exercise in preventing gestational diabetes mellitus in overweight and obese pregnant women and a mouse model

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Circulating Irisin Is Reduced in Male Patients with Type 1 and Type 2 Myotonic Dystrophies

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Effects of marathon race on selected myokines and sclerostin in middle-aged male amateur runners

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Myokine Response to Blood-Flow Restricted Resistance Exercise in Younger and Older Males in an Untrained and Resistance-Trained State: A Pilot Study

Cordingley, D. M., Anderson, J. E., & Cornish, S. M. (2022) · Journal of Science in Sport and Exercise · doi:10.1007/s42978-022-00164-2 · Cited by 18

Physiological and molecular mechanisms of cold-induced improvements in glucose homeostasis in humans beyond brown adipose tissue

van Beek, S. M. M., Hashim, D., Bengtsson, T., & Hoeks, J. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01270-z · Cited by 16

Crosstalk between bone and muscle in chronic kidney disease

Wong, L., & McMahon, L. P. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1146868 · Cited by 15

Impact of fibronectin type III domain-containing family in the changes in metabolic and hormonal profiles during peripartum period in dairy cows

Daudon, M., Ramé, C., Estienne, A., Price, C. A., & Dupont, J. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.960778 · Cited by 15

Osteosarcopenia: epidemiology, molecular mechanisms, and management

Yi, Y.-T., Zhao, H.-F., Wang, W., & Li, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1577758 · Cited by 18

Research progress of intramuscular fat formation based on co-culture

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Sarcopenia assessed by DXA and hand-grip dynamometer: a potential marker of damage, disability and myokines imbalance in inflammatory myopathies

Giannini, M., Charles, A., Evrard, C., Blaess, J., Bouchard-Marmen, M., Debrut, L., Perniola, S., LAVERNY, G., Javier, R., Charloux, A., et al. (2024) · Lara D. Veeken · doi:10.1093/rheumatology/keae207 · Cited by 14

Gene Location, Expression, and Function of FNDC5 in Meishan Pigs

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The association between sarcopenia and decorin, an exercise‐induced myokine, in patients with liver cirrhosis: a pilot study

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Upregulation of FNDC5 gene expression in C2C12 cells after single and combined treatments of resveratrol and ATRA

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The role of irisin in exercise-induced muscle and metabolic health: a narrative review

Mohammed, S. N., Jasim, M. H., Mahmood, S. H., Saleh, E. N., & Hashemzadeh, A. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04083-1 · Cited by 13

HIF-1α Negatively Regulates Irisin Expression Which Involves in Muscle Atrophy Induced by Hypoxia

Liu, S., Fu, P., Ning, K., Wang, R., Yang, B., Chen, J., & Xu, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020887 · Cited by 14

Roles of Myokines and Muscle-Derived Extracellular Vesicles in Musculoskeletal Deterioration under Disuse Conditions

Zhang, J., Gao, Y., & Yan, J. (2024) · Metabolites · doi:10.3390/metabo14020088 · Cited by 15

Liraglutide promotes UCP1 expression and lipolysis of adipocytes by promoting the secretion of irisin from skeletal muscle cells

Zhang, N., Zhou, H., Xu, Y., Zhang, Y., Yu, F., Gui, L., Zhang, Q., & Lu, Y. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112225 · Cited by 15

Fndc5/irisin is regulated by myogenesis stage, irisin, muscle type and training.

Lavi, G., Horwitz, A., Einstein, O., Zipori, R., Gross, O., & Birk, R. Z. (2022) · PubMed Central · Cited by 13

Maternal serum, placental, and umbilical venous blood irisin levels in intrahepatic cholestasis of pregnancy

Chen, J., Li, Q., & Ma, J. (2019) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2019.1667322 · Cited by 13

Muscles proteome analysis; irisin administration mimics some molecular effects of exercise in quadriceps muscle

Momenzadeh, S., Zamani, S., Tabrizi, Z. P. F., Barreiro, C., & Jami, M. (2021) · Biochimie · doi:10.1016/j.biochi.2021.06.016 · Cited by 14

Irisin attenuates P. gingivalis-suppressed osteogenic/cementogenic differentiation of periodontal ligament cells via p38 signaling pathway

Huang, X., Xiao, J., Wang, X., & Cao, Z. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.06.001 · Cited by 13

Tai chi effects on balance in older adults: the role of sustained attention and myokines

Solianik, R., Brazaitis, M., & ČEKANAUSKAITĖ-KRUŠNAUSKIENĖ, A. (2021) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.21.12990-1 · Cited by 14

The potential role of FNDC5/irisin in various liver diseases: awakening the sleeping beauties

Wang, X., Mao, L., Li, C., Hui, Y., Yu, Z., Sun, M., Li, Y., Guo, G., Yang, W., Cui, B., et al. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.19 · Cited by 12

Maresin 1 Exerts a Tissue-Specific Regulation of Adipo-Hepato-Myokines in Diet-Induced Obese Mice and Modulates Adipokine Expression in Cultured Human Adipocytes in Basal and Inflammatory Conditions

Martínez‐Fernández, L., Burgos, M., Sáinź, N., Laiglesia, L. M., Arbonés-Mainar, J. M., González‐Muniesa, P., & Moreno-Aliaga, M. J. (2023) · Biomolecules · doi:10.3390/biom13060919 · Cited by 11

The Different Shades of Thermogenic Adipose Tissue

Hu, Y., Huang, Y., Jiang, Y., Weng, L., Cai, Z., & He, B. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00559-y · Cited by 11

Differential mitochondrial adaptation and FNDC5 production in brown and white adipose tissue in response to cold and obesity

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Retinoblastoma Protein Knockdown Favors Oxidative Metabolism and Glucose and Fatty Acid Disposal in Muscle Cells

Petrov, P., Ribot, J., López‐Mejía, I. C., Fajas, L., Palou, A., & Bonet, M. L. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25121 · Cited by 11

Irisin mediates beiging of adipose-derived mesenchymal stem cells through binding to TRPC3

Xue, C., Li, X., Ba, L., Shen, Y., Sun, Z., Gu, J., Yang, Y., Han, Q., & Zhao, R. C. (2022) · BMC Biology · doi:10.1186/s12915-022-01287-2 · Cited by 11

Association of serum irisin concentrations with the presence and severity of obstructive sleep apnea syndrome

Li, Y., Li, X., Sun, D., & Cai, S. (2016) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22077 · Cited by 12

Irisin level in type 2 diabetic patients and its relation to glycemic control and diabetic complications

Haddad, H. E. E., Sedrak, H. K., Naguib, M., Yousief, E. M., Ibrahim, D. R., Samie, R. M. A., & Hamdy, A. (2019) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-019-00717-2 · Cited by 11

Alpha lipoic acid protects against dexamethasone-induced metabolic abnormalities via APPL1 and PGC-1 α up regulation

Mohammed, M. A., Mahmoud, M. O., Awaad, A. S., Gamal, G. M., & Abdelfatah, D. (2019) · Steroids · doi:10.1016/j.steroids.2019.01.004 · Cited by 11

Association between plasma irisin and glucose metabolism in pregnant women is modified by dietary n‐3 polyunsaturated fatty acid intake

Cai, L., Wu, W., Lin, L., Chen, Y., Gao, R. C., Shi, B., Ma, B., Chen, Y., & Jin, J. (2020) · Journal of Diabetes Investigation · doi:10.1111/jdi.13249 · Cited by 10

Impacts of rat hindlimb Fndc5/irisin overexpression on muscle and adipose tissue metabolism

Farrash, W. F., Brook, M. S., Crossland, H., Phillips, B. E., Cegielski, J., Wilkinson, D. J., Constantin‐Teodosiu, D., Greenhaff, P. L., Smith, K., Cleasby, M. E., et al. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00034.2020 · Cited by 13

The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs

Tommasini, E., Missaglia, S., Vago, P., Galvani, C., Pecci, C., Rampinini, E., Bosio, A., Morelli, A. M., Bonanomi, A. G., Silvestrini, A., et al. (2024) · European Journal of Translational Myology · doi:10.4081/ejtm.2024.12693 · Cited by 10

Non‐alcoholic fatty liver disease: The importance of physical activity and nutrition education—A randomized controlled study

Us Altay, D., Kaya, Y., Mataraci Değirmenci, D., Kocyiğit, E., Üner, A., & Noyan, T. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16756 · Cited by 10

Correlations of serum myostatin and irisin with sarcopenia and osteoporosis in rheumatoid arthritis patients: a cross-sectional study

Li, W.-J., Yin, R., Xia, X., Xing, Q.-X., & Xu, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-07378-8 · Cited by 10

Effects of partial vascular occlusion on irisin responses to loaded muscle contractions

Kraemer, R. R., Goldfarb, A. H., Reeves, G. V., Meachum, W. A., & Castracane, V. D. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0464 · Cited by 10

Effects of 2-week HMB-FA supplementation with or without eccentric resistance exercise on expression of some genes related to muscle protein turnover and serum irisin and IGF-1 concentrations

Shirvani, H., Rahmati-Ahmadabad, S., Kowsari, E., Fry, H. L., Kazemi, M., & Kaviani, M. (2020) · Gene · doi:10.1016/j.gene.2020.145018 · Cited by 10

Dietary Intervention, When Not Associated With Exercise, Upregulates Irisin/FNDC5 While Reducing Visceral Adiposity Markers in Obese Rats

Furino, V. D. O., Alves, J. M., Marine, D. A., Sene‐Fiorese, M., Rodrigues, C. N. D. S., Arrais-Lima, C., Mattiello, S. M., de Castro, C. A., Borra, R. C., Rocha, M. C., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.564963 · Cited by 10

Irisin: A Possible Marker of Adipose Tissue Dysfunction in Obesity

Tomasello, L., Pitrone, M., Guarnotta, V., Giordano, C. S. D. S., & Pizzolanti, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512082 · Cited by 11

Therapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.

Das, S., Preethi, B., Kushwaha, S., & Shrivastava, R. (2024) · PubMed · doi:10.14670/hh-18-730 · Cited by 13

The kidney–skeletal muscle–heart axis in chronic kidney disease: implications for myokines

Quiroga, B., & Dı́ez, J. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae193 · Cited by 9

Irisin in Reproduction: Its Roles and Therapeutic Potential in Male and Female Fertility Disorders

Khan, M. I., Khan, M. I., & Wahab, F. (2024) · Biomolecules · doi:10.3390/biom14101222 · Cited by 12

Unraveling the metabolic pathways between atherosclerosis and sarcopenia

Yu, M., Ge, L., Fu, C., & Zhao, R. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1762825 · Cited by 9

Whole-body repeated hyperthermia increases irisin and brain-derived neurotrophic factor: A randomized controlled trial

Glazachev, O. S., Zapara, M. A., Kryzhanovskaya, S. Y., Dudnik, E. N., Yumatov, E., & Susta, D. (2021) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2021.103067 · Cited by 8

Body composition and myokines in a cohort of patients with Becker muscular dystrophy

Barp, A., Carraro, E., Goggi, G., Lizio, A., Zanolini, A., Messina, C., Perego, S., Verdelli, C., Lombardi, G., Sansone, V., et al. (2022) · Muscle & Nerve · doi:10.1002/mus.27565 · Cited by 8

Pathophysiology of Physical Exercise in Kidney Patients: Unveiling New Players – The Role of Myokines

Picciotto, D., Macciò, L., Verzola, D., Baciga, F., Momentè, C., Russo, E., Viazzi, F. C., Battaglia, Y., & Esposito, P. B. (2024) · Kidney & Blood Pressure Research · doi:10.1159/000539489 · Cited by 9

Irisin levels in LMNA-associated partial lipodystrophies

Bensmaine, F., Benomar, K., Espiard, S., Vahé, C., Mapihan, K. L., Lion, G., Lemdani, M., Chazard, E., Ernst, O., Vigouroux, C., et al. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.08.003 · Cited by 8

Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism

Yan, L.-J., & Guo, L. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31056 · Cited by 9

Irisin Is Target of Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor-Mediated Signaling in Skeletal Muscle Cells

Pierucci, F., Chirco, A., & Meacci, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310548 · Cited by 8

Irisin physiology, oxidative stress, and thyroid dysfunction: What next?

Huh, J. Y., & Mantzoros, C. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.02.009 · Cited by 30

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis

Pérez-Sotelo, D., Roca-Rivada, A., de la Torre, I. B., Baltar, J., Castro, A. I., Domínguez, E., Collado, M., Casanueva, F. F., & Pardo, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-16602-z · Cited by 59

Evidence against a beneficial effect of irisin in humans

Raschke, S., Elsen, M., Romacho, T., Eckardt, K., & Eckel, J. (2013) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0033-1336630 · Cited by 13

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Ma, E. B., Sahar, N.-E., Jeong, M., & Huh, J. Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01085 · Cited by 69