Association of Circulating Irisin Levels and the Characteristics and Prognosis of Coronary Artery Disease
Abstract
Background Irisin is a new muscle factor discovered in recent years that shows a strong association with metabolic diseases. However, its role in coronary artery disease (CAD) is still controversial. We performed this study to determine the relationship of serum irisin with the characteristics and prognosis of CAD. Materials and methods Patients with acute coronary syndrome (ACS) (n = 355), stable coronary artery disease (SCAD) (n = 162), nonobstructive coronary artery disease (NO-CAD) (n = 126) and normal coronary arteries (n = 109) were enrolled. An enzyme-linked immunosorbent assay kit was used to measure serum irisin concentrations. Major adverse cardiovascular events (MACEs) of patients with SCAD (n = 132) and ACS (n = 331) after percutaneous coronary intervention (PCI) were recorded during a 12-month follow-up. Receiver-operator characteristic (ROC) curve analysis was used to explore predictors of CAD. Kaplan-Meier survival analysis and the Cox proportional hazards regression model were used to explore the association between serum irisin levels and MACEs. Results Serum irisin levels in patients with ACS, SCAD, NO-CAD and normal coronary arteries were 196.62±72.05 ng/ml, 216.81±79.69 ng/ml, 245.26±77.92 ng/ml and 300.17±76.74 ng/ml, respectively (p Conclusions Serum irisin levels were significantly decreased in patients with CAD. Patients with ACS exhibited the lowest serum irisin levels. Furthermore, serum irisin levels were interrelated with prognosis in patients with…
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Clinical evidence shows negative correlations between irisin levels and coronary artery disease severity, with higher irisin associated with improved prognosis.
“clinical evidence shows negative correlations between irisin levels and coronary artery disease severity, with higher irisin associated with improved prognosis [48].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [48]
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Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process
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“Regarding cardiovascular effects, clinical evidence shows negative correlations between irisin levels and coronary artery disease severity, with higher irisin associated with improved prognosis [48].”
- Authors
- Pan, J.-A., Zhang, H., Yu, Q., Zhang, J.-F., Wang, C.-Q., Gu, J., & Chen, K.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Gu, Jun
- Chen, Kan
- Venue
- The American Journal of the Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 362
- Issue
- 1
- Pages
- 63-71
- ISSN
- 0002-9629 (ISSN-L)
- OpenAlex
- W3135171592
- Cited by
- 34
- References
- 46
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 6 · 2023: 11 · 2022: 2 · 2021: 5
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of the Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shanghai Shenkang Hospital Development Center (16CR2034B)
- Science and Technology Commission of Shanghai Municipality (18411950500)
- National Natural Science Foundation of China (81670293, JYLJ201803)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- irisin, coronary artery disease, acute coronary syndrome, stable coronary artery disease, non-obstructive coronary artery disease, serum biomarkers, major adverse cardiovascular events, percutaneous coronary intervention, prognosis, event-free survival
- MeSH terms
- Aged, Coronary Artery Disease, Electrocardiography, Female, Fibronectins, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Biomarkers, Coronary Angiography
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